Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

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Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia is …
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P819ADS bibcode2012PLoSO...730059H
P356DOI10.1371/JOURNAL.PONE.0030059
P932PMC publication ID3256196
P698PubMed publication ID22253878
P5875ResearchGate publication ID221755778

P50authorCameron BrennanQ30502649
Eric C HollandQ89747805
P2093author name stringJohn A Boockvar
Jan-Karl Burkhardt
Christoph P Hofstetter
Benjamin J Shin
Demirkan B Gürsel
Lynn Mubita
Ramana Gorrepati
P2860cites workHIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingQ24291102
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PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant gliomaQ24322118
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingQ24532278
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Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1Q56798186
Multivariate survival analysis using Cox's regression modelQ69445976
Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiaeQ72969204
Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genesQ74415871
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Hypoxic conversion of SMAD7 function from an inhibitor into a promoter of cell invasionQ84413538
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Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint responseQ36908131
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Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanismsQ37261795
Hypoxia helps glioma to fight therapyQ37481545
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.Q37605239
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Hypoxia-activated Smad3-specific dephosphorylation by PP2A.Q39768636
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screensQ39842716
Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis.Q40135797
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repairQ40347113
Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell populationQ40590816
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Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivationQ40814714
Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compoundsQ40856599
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Platelet-derived growth factor in human gliomaQ40961503
Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetateQ42066833
Identification of high levels of type 1 and type 2A protein phosphatases in higher plantsQ42802447
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional elementQ42834668
Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampusQ43794811
Hypoxia-induced cell death in human malignant glioma cells: energy deprivation promotes decoupling of mitochondrial cytochrome c release from caspase processing and necrotic cell deathQ44483599
Erasure of kinase phosphorylation in astrocytes during oxygen-glucose deprivation is controlled by ATP levels and activation of phosphatases.Q44545161
Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for biasQ46634561
Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosisQ47401764
Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrestQ48049861
Regional metabolism of experimental brain tumorsQ48387775
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial originQ48536258
Expression of tissue factor in glioma.Q48871336
Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG1 2.2) of rat brainQ48924776
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
glioblastomaQ282142
P304page(s)e30059
P577publication date2012-01-11
P1433published inPLOS OneQ564954
P1476titleProtein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
P478volume7