Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds

scientific article published on January 1993

Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0065-230X(08)60958-6
P698PubMed publication ID8394044

P2093author name stringFujiki H
Suganuma M
P2860cites workjun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-junQ24302170
Molecular cloning and expression of a receptor for human tumor necrosis factorQ24303604
Association of protein phosphatase 2A with polyoma virus medium tumor antigenQ24558730
Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigenQ24603984
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexesQ28277749
Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteinsQ28300112
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LRQ28320616
ras genesQ29547799
The role of protein kinase C in cell surface signal transduction and tumour promotionQ29618532
The structure and regulation of protein phosphatasesQ29618929
Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanismQ29619866
Structural characterization of toxic cyclic peptides from blue-green algae by tandem mass spectrometryQ30450854
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoterQ33559371
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptorQ33903826
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesisQ34162269
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.Q34181194
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plantsQ34188529
Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promotersQ34269711
Okadaic acid and dinophysistoxin-1, non-TPA-type tumor promoters, stimulate prostaglandin E2 production in rat peritoneal macrophagesQ69234415
Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promotersQ69241108
Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytesQ69334325
Calyculin A and okadaic acid: inhibitors of protein phosphatase activityQ69337324
Effects of okadaic acid on mouse hemopoietic cellsQ69392036
Preparation of monoclonal antibodies against okadaic acid prepared from the sponge Halichondria okadaiQ69454381
Vimentin, a cytoskeletal substrate of protein kinase CQ69818641
Effect of okadaic acid on phosphorylation-dephosphorylation of myosin light chain in aortic smooth muscle homogenateQ69828701
Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthraceneQ70332263
Diaplacental initiation of NMRI mice with 7,12-dimethylbenz[a]anthracene during gestation days 6--20 and postnatal treatment of the F1-generation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate: tumor incidence in organs other than the sQ71581300
Phosphorylation of intermediate filament proteins by cAMP-dependent protein kinasesQ72886404
Nodularin, microcystin, and the configuration of AddaQ78319628
Identification of 12 hepatotoxins from a Homer Lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: nine new microcystinsQ78328681
The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosaQ104246623
Evidence of liver damage by toxin from a bloom of the blue‐green alga, Microcystis aeruginosaQ104391898
Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2a, from the marine sponge discodermia calyxQ104397534
Bioactive marine metabolites. Part 16. Calyculin A. A novel antitumor metabolite from the marine sponge Discodermia calyxQ104996461
Acanthifolicin, a new episulfide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifoliumQ105205556
Flat reversion by okadaic acid of raf and ret-II transformantsQ34325946
Tumor necrosis factor (TNF).Q34378376
Allelotype of colorectal carcinomasQ34461209
Structure-Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein PhosphataseQ34507668
Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatasesQ34631024
Toxins contained in Microcystis species of cyanobacteria (blue-green algae).Q34686085
Mechanisms of action of okadaic acid class tumor promoters on mouse skinQ35034113
Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?Q35226651
Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New ZealandQ36071590
Dual regulation of intermediate filament phosphorylationQ36210185
Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and betaQ36218317
When worlds collide: immunosuppressants meet protein phosphatasesQ36680216
Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatasesQ36735394
Cytoskeletal integrity in interphase cells requires protein phosphatase activityQ37308359
Protein phosphatase inhibitor okadaic acid enhances transmitter release at neuromuscular junctionsQ37417185
Specific labeling of mouse brain membrane phospholipids with [20-3H]phorbol 12-p-azidobenzoate 13-benzoate, a photolabile phorbol esterQ37612325
Regulation of gene expression by tumor promotersQ38038962
Tumor necrosis, cachexia, shock, and inflammation: a common mediatorQ39532135
Molecular and cellular biology of intermediate filamentsQ39532153
The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cellsQ41129663
Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytesQ41646684
Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitorsQ41683430
Phosphorylation of nuclear protein is an early event in TGFβ1 actionQ41690730
Regulation of progesterone receptor-mediated transcription by phosphorylationQ41710148
Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentinQ41721264
Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxinQ41731167
The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cellsQ41739960
Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restrictionQ41740976
Computer modelling of the 3-dimensional structures of the cyanobacterial hepatotoxins microcystin-LR and nodularinQ41837487
Promotion of BALB/3T3 cell transformation by the okadaic acid class of tumor promoters, okadaic acid and dinophysistoxin-1.Q41867607
Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicityQ41901692
Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2AQ41973818
Specific binding of okadaic acid, a new tumor promoter in mouse skinQ42057482
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kineticsQ42163759
Phospholipids involved in specific binding of 12-O-(5-azido-2-nitrobenzoyl)phorbol-13-acetate to epidermal microsomes, a photolabeling studyQ42224354
The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expressionQ42796260
Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogeneQ42823403
Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblastsQ42829835
Okadaic acid and phorbol esters: comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitroQ42832457
Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2Q42860144
Characterization of chemically tritiated microcystin-LR and its distribution in miceQ43687348
The role of the kappa enhancer and its binding factor NF-kappa B in the developmental regulation of kappa gene transcriptionQ43814141
Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermisQ44242337
Binding competition of okadaic acid derivatives to anti-okadaic acid antibodyQ44404670
Apparent "activation" of protein kinases by okadaic acid class tumor promotersQ44550752
Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7-O-(4-azidobenzoyl)okadaateQ44796766
Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acidQ45035649
Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxinQ46175060
Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytesQ46473208
Rapid purification of protein phosphatase 2A from mouse brain by microcystin-affinity chromatographyQ48795241
The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neuronsQ48830106
Structure-activity relationship within a series of okadaic acid derivativesQ48890052
Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activityQ50791473
Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae).Q50883683
Naming of cyclic heptapeptide toxins of cyanobacteria (blue-green algae).Q50899038
Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane.Q53506577
Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin.Q53520166
Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis.Q53567537
A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.Q53858292
Okadaic acid is a potent angiogenesis inducerQ55260182
Poisonous Australian LakeQ56455113
Diarrhetic shellfish toxinsQ57310225
Okadaic acid, a cytotoxic polyether from two marine sponges of the genus HalichondriaQ57310226
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolismQ59067763
Tautomycin from the bacterium Streptomyces verticillatusQ61770148
Bioactive marine metabolites. 24. Isolation and structure elucidation of calyculins B, C, and D, novel antitumor metabolites, from the marine sponge Discodermia calyxQ61861448
Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acidQ62661150
Analysis and purification of toxic peptides from cyanobacteria by reversed-phase high-performance liquid chromatographyQ67237532
Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytesQ67466257
An alternative theory of tissue specificity by tumor promotion of okadaic acid in glandular stomach of SD ratsQ67505739
Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycinQ67925484
Production of antibodies and development of a radioimmunoassay for okadaic acidQ68103977
Increased activity of the eEF-2 specific, Ca2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cellsQ68263610
Structural determination of geometrical isomers of microcystins LR and RR from cyanobacteria by two-dimensional NMR spectroscopic techniquesQ68397042
How does interleukin 1 activate cells? Interleukin 1 signal transductionQ68440903
In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblastsQ68478485
Histopathological studies on experimental marine toxin poisoning. I. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1Q68976935
A new antibiotic, tautomycinQ69138351
P407language of work or nameEnglishQ1860
P921main subjectTumor promotionQ7852681
P304page(s)143-194
P577publication date1993-01-01
P1433published inAdvances in Cancer ResearchQ3113522
P1476titleTumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds
P478volume61

Reverse relations

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