Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death

scientific article published on 4 September 2008

Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2008.071183
P932PMC publication ID2543085
P698PubMed publication ID18772337
P5875ResearchGate publication ID23238435

P50authorVincenzo CiminaleQ55270323
Elisabetta RossiQ55271242
Rita ZamarchiQ57316470
Elena FavaroQ58314073
Wolfgang Müller-KlieserQ110244170
Ulrike G. A. SattlerQ110244230
Lidia MoserleQ39186431
Stefano IndraccoloQ39186456
Luca PersanoQ43121424
P2093author name stringGiovanni Esposito
Mario Plebani
Alberto Amadori
Giorgia Nardo
Massimo Masiero
Thomas Mann
P2860cites workHIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activityQ24302129
Targeting HIF-1 for cancer therapyQ27860504
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastasesQ28139317
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapyQ28202355
p53 regulates mitochondrial respirationQ28242400
Inhibiting hypoxia-inducible factor 1 for cancer therapyQ28260828
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesisQ28279053
Why do cancers have high aerobic glycolysis?Q28290710
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxiaQ28300406
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumptionQ28300415
Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level.Q51103797
c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.Q51642930
Apoptosis in human adenocarcinoma HT29 cells induced by exposure to hypoxiaQ72134553
Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injuryQ74465213
Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondriaQ77669580
Hypoxia--a key regulatory factor in tumour growthQ29547318
On respiratory impairment in cancer cellsQ29617276
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumoursQ29618396
Angiogenesis as a therapeutic targetQ29619525
Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytesQ33178140
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.Q33705004
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growthQ33998089
Metabolic mapping with bioluminescence: basic and clinical relevanceQ34528060
Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment.Q34573041
Is HIF-1alpha a pro- or an anti-apoptotic protein?Q34816112
Dynamic balancing of the dual nature of HIF-1alpha for cell survivalQ35800593
Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncologyQ35848076
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosisQ35903445
Hypoxia-inducible factors and hypoxic cell death in tumour physiologyQ35932387
Hypoxia signalling in cancer and approaches to enforce tumour regressionQ36488739
Experience with bevacizumab in the management of epithelial ovarian cancerQ36873062
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxiaQ39698671
Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.Q40231967
Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -/- epithelial ovarian cancersQ40270449
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxiaQ40296414
Knockdown of hypoxia-inducible factor-1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexateQ40308761
Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.Q40380531
Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivoQ40384755
The role of hypoxia-inducible factor-1 in three-dimensional tumor growth, apoptosis, and regulation by the insulin-signaling pathwayQ40421162
Virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1.Q40442087
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.Q40479307
Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumorsQ40528127
Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturationQ40544944
Gene transfer in ovarian cancer cells: a comparison between retroviral and lentiviral vectorsQ40623489
Cyclin dependent kinase inhibitor p27Kip1 is upregulated by hypoxia via an ARNT dependent pathwayQ40629309
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.Q40861131
Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolismQ41857469
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomographyQ43851417
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinomaQ44132580
Hypoxia-induced cell death in human malignant glioma cells: energy deprivation promotes decoupling of mitochondrial cytochrome c release from caspase processing and necrotic cell deathQ44483599
Hypoxic cervical cancers with low apoptotic index are highly aggressive.Q45128481
Interferon-alpha gene therapy by lentiviral vectors contrasts ovarian cancer growth through angiogenesis inhibitionQ45885618
The hypoxic response of tumors is dependent on their microenvironment.Q45965473
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environmentQ46641433
Hypoxic injury to developing glial cells: protective effect of high glucoseQ49111546
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
cell deathQ2383867
P304page(s)1186-1201
P577publication date2008-09-04
P1433published inThe American Journal of PathologyQ4744259
P1476titleHypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death
P478volume173