Hypoxia-induced cell death in human malignant glioma cells: energy deprivation promotes decoupling of mitochondrial cytochrome c release from caspase processing and necrotic cell death

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Hypoxia-induced cell death in human malignant glioma cells: energy deprivation promotes decoupling of mitochondrial cytochrome c release from caspase processing and necrotic cell death is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1037572435
P356DOI10.1038/SJ.CDD.4401252
P698PubMed publication ID12815465
P5875ResearchGate publication ID10701433

P2093author name stringWolburg H
Weller M
Steinbach JP
Probst H
Klumpp A
P2860cites workHypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level.Q51103797
Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue.Q51419552
Vascular apoptosis and involution in gliomas precede neovascularization: a novel concept for glioma growth and angiogenesis.Q52539830
Sensitization to CD95 ligand-induced apoptosis in human glioma cells by hyperthermia involves enhanced cytochrome c release.Q55475629
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.Q55476886
Apoptosis and cell proliferation in human neuroepithelial tumors.Q55480555
Tumor oxygenation: a new predictive parameter in locally advanced cancer of the uterine cervixQ72693845
Energy status and radiobiological hypoxia at specified oxygen concentrationsQ72822354
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlationQ73034285
Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injuryQ74465213
Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondriaQ77669580
Mechanisms of cell death in hypoxia/reoxygenation injuryQ77900376
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent mannerQ22008727
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
Two distinct pathways leading to nuclear apoptosisQ24676123
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanismsQ28361631
Mitochondria and apoptosisQ29547905
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumoursQ29618396
Calpain and caspase: can you tell the difference?Q33815206
Local endostatin treatment of gliomas administered by microencapsulated producer cellsQ33929689
Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokinesQ34182237
Four deaths and a funeral: from caspases to alternative mechanisms.Q34325335
Mechanisms of apoptosis in central nervous system tumors: application to theoryQ34590759
Physiological properties of malignant tumoursQ35538297
Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.Q36368462
Prognostic value of tumour associated antigen immunoreactivity and apoptosis in cerebral glioblastomas: an analysis of 168 casesQ37228212
Hypoxia and drug resistanceQ40630925
Response of tumour cells to hypoxia: role of p53 and NFkB.Q40794432
Calpain activation is upstream of caspases in radiation-induced apoptosis.Q40979319
Necrogenesis and Fas/APO-1 (CD95) expression in primary (de novo) and secondary glioblastomasQ41040663
Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosisQ41115305
Synchronous replication of SV 40 DNA in virus infected TC 7 cells induced by transient hypoxiaQ41508000
Cytochrome c: can't live with it--can't live without it.Q41657950
Death ligand/receptor-independent caspase activation mediates drug-induced cytotoxic cell death in human malignant glioma cellsQ43475118
Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cellsQ43718776
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.Q44393459
Antiangiogenic gene therapy in a rat glioma model using a dominant-negative vascular endothelial growth factor receptor 2.Q45858366
Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumorsQ48105624
Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant gliomaQ48178186
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.Q48334505
Regional metabolism of experimental brain tumorsQ48387775
Biological evaluation of biopsies from adult cerebral astrocytomas: cell-growth/cell-suicide ratios and their relationship to patient survivalQ48404395
Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeuticsQ48778469
Preferential expression of Fas/APO1 (CD95) and apoptotic cell death in perinecrotic cells of glioblastoma multiformeQ48879202
Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG1 2.2) of rat brainQ48924776
Hypoxic injury to developing glial cells: protective effect of high glucoseQ49111546
P433issue7
P921main subjecthypoxiaQ105688
cell deathQ2383867
P304page(s)823-832
P577publication date2003-07-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleHypoxia-induced cell death in human malignant glioma cells: energy deprivation promotes decoupling of mitochondrial cytochrome c release from caspase processing and necrotic cell death
P478volume10

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cites work (P2860)
Q93173271AMPK activation protects astrocytes from hypoxia‑induced cell death
Q40511785Alkylphosphocholine-induced glioma cell death is BCL-X(L)-sensitive, caspase-independent and characterized by massive cytoplasmic vacuole formation
Q46024830Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death.
Q33198297Anti-neoplastic efficacy of Haimiding on gastric carcinoma and its mechanisms
Q36021584Apoptosis in gliomas: molecular mechanisms and therapeutic implications
Q53275548Aqp 9 and brain tumour stem cells.
Q40357070BCL-xL: time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells
Q36787654BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells
Q93172023Calreticulin expression in human cardiac myocytes induces ER stress-associated apoptosis
Q57809694Comparing the effects of different cell death programs in tumor progression and immunotherapy
Q48015053Dabrafenib in patients with recurrent, BRAF V600E mutated malignant glioma and leptomeningeal disease.
Q33972116Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
Q90711231Disruption of peroxisome proliferator-activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells
Q48497497Double immunofluorescence shows coexpression of Bcl-x with GFAP in a variety of glial lesions
Q33778107ERGO: a pilot study of ketogenic diet in recurrent glioblastoma
Q38430999Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype
Q89888349Ferroptosis: Final destination for cancer?
Q35392528Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survival
Q43413760Gallic acid exhibits risks of inducing muscular hemorrhagic liposis and cerebral hemorrhage--its action mechanism and preventive strategy
Q38782380Hypoxia Modulates the Swelling-Activated Cl Current in Human Glioblastoma Cells: Role in Volume Regulation and Cell Survival
Q53083871Hypoxia can impair doxorubicin resistance of non-small cell lung cancer cells by inhibiting MRP1 and P-gp expression and boosting the chemosensitizing effects of MRP1 and P-gp blockers.
Q35152103Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid
Q36891578Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death
Q46296960Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
Q89587161Necrosis in the Tumor Microenvironment and Its Role in Cancer Recurrence
Q50579012Observation on the ultrastructure morphology of HeLa cells treated with ethanol: Statistical analysis.
Q35987408Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma.
Q93043640Population Dynamics in Cell Death: Mechanisms of Propagation
Q34130984Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
Q52720171Regulation of Tumor Progression by Programmed Necrosis.
Q45272582Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells
Q90590045Serine-dependent redox homeostasis regulates glioblastoma cell survival
Q39436606Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death
Q47440128Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems
Q64061395The Volume-Regulated Anion Channel in Glioblastoma
Q34293667Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis
Q79577457Transduction of the anti-apoptotic PTD-FNK protein improves the efficiency of transplantation of bone marrow mononuclear cells
Q42131856Transforming growth factor-β signaling enhancement by long-term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells
Q46246505Vitamin K2 Prevents Lymphoma in Drosophila

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