Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate

scientific article published on March 1993

Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ2900545
P932PMC publication ID1132308
P698PubMed publication ID8452545
P5875ResearchGate publication ID14745856

P2093author name stringA E Nel
A M Casillas
K Amaral
S Chegini-Farahani
P2860cites workERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGFQ24304344
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodiesQ24595084
Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinaseQ24607466
The structure and regulation of protein phosphatasesQ29618929
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinaseQ30453375
Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cellsQ30460872
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.Q30460881
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoterQ33559371
MAP kinase by any other name smells just as sweetQ35224916
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activationQ37547362
Okadaic acid: a new probe for the study of cellular regulationQ37876246
Tyrosyl Phosphorylation and Activation of MAP Kinases by p56lckQ41640086
Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinaseQ41661546
The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium releaseQ41699635
Okadaic acid activates microtubule-associated protein kinase in quiescent fibroblastic cellsQ41714888
Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cellsQ41728098
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle controlQ41728250
Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.Q41739100
Protein kinase C plays a role in the induction of tyrosine phosphorylation of lymphoid microtubule-associated protein-2 kinase. Evidence for a CD3-associated cascade that includes pp56lck and that is defective in HPB-ALLQ41813085
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kineticsQ42163759
Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinaseQ42828873
Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2.Q42833011
Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cellsQ43425143
Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cellsQ44678407
Phosphatases PP1 and PP2A act after the G0/G1 interface in lymphocyte activationQ44826202
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase.Q50798217
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinasesQ59097215
The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferationQ67657679
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinaseQ68248825
CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinaseQ68469024
Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signalQ68476719
Phorbol ester induces tyrosine phosphorylation in normal and abnormal human B lymphocytesQ69873504
P407language of work or nameEnglishQ1860
P304page(s)545-550
P577publication date1993-03-01
P1433published inBiochemical JournalQ864221
P1476titleOkadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate
P478volume290 ( Pt 2)

Reverse relations

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Q36838567Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages
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