Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A.

scientific article

Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M605480200
P698PubMed publication ID17121863
P5875ResearchGate publication ID6675910

P2093author name stringYoung-Chul Choi
Young-Joo Jang
Jae-Hoon Ji
Chun Jeih Ryu
Seon-Yle Ko
P2860cites workMitotic regulation of the human anaphase-promoting complex by phosphorylationQ24301075
Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunitQ24304723
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomesQ24312101
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyQ24337413
Serine/threonine protein phosphatasesQ24528215
Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase cdc5pQ27940346
The DNA damage response: putting checkpoints in perspectiveQ28131713
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damageQ28145962
A role for Plk1 phosphorylation of NudC in cytokinesisQ28186163
Viral infections and cell cycle G2/M regulationQ28240818
Cell death by mitotic catastrophe: a molecular definitionQ28255830
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleationQ28612103
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
Polo-box motif targets a centrosome regulator, RanGTPase.Q31123817
Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevisQ33775042
DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin–CDC2 Complexes, and Reverses Cells to InterphaseQ39938210
Determination of substrate specificity and putative substrates of Chk2 kinaseQ40652755
Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinaseQ40703602
Protein phosphatases regulate DNA-dependent protein kinase activityQ40803158
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycinQ41109535
Polo kinase: the choreographer of the mitotic stage?Q41305017
PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.Q42828370
Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.Q43714118
Molecular cloning of mouse somatic and testis-specific H2B histone genes containing a methylated CpG islandQ48063806
The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.Q48073961
Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation.Q48566288
The polo-like kinase Plx1 prevents premature inactivation of the APC(Fizzy)-dependent pathway in the early Xenopus cell cycleQ48886104
A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.Q52546192
GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomesQ57277601
Polo-like kinase-1 is a target of the DNA damage checkpointQ57985159
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)2473-2482
P577publication date2006-11-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleRegulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A.
P478volume282

Reverse relations

cites work (P2860)
Q50296864Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.
Q37875377Beyond ATM: the protein kinase landscape of the DNA damage response
Q92636595Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins
Q35954486Genetic toxicology and toxicogenomic analysis of three cigarette smoke condensates in vitro reveals few differences among full-flavor, blonde, and light products
Q34777845Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair
Q33954404Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs
Q38760108Molecular interactions of polo-like kinase 1 in human cancers.
Q91646583PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages
Q38223676Pathways for genome integrity in G2 phase of the cell cycle
Q28477147Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy
Q38199282Polo-like kinase-1 in DNA damage response
Q34804703Polo-like kinases (plks), a key regulator of cell cycle and new potential target for cancer therapy
Q35836388Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.
Q33967150Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation
Q36908131Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response
Q34130984Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
Q36189395Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α
Q92932427Role of protein phosphatases PP1, PP2A, PP4 and Cdc14 in the DNA damage response
Q39365150Selective apoptotic effect of Zelkova serrata twig extract on mouth epidermoid carcinoma through p53 activation
Q38219980Stressing mitosis to death
Q28388816Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle
Q40913003The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11
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Q36811636Working hard for recovery: mitotic kinases in the DNA damage checkpoint
Q89862470Working on Genomic Stability: From the S-Phase to Mitosis
Q35741559p53 activates G₁ checkpoint following DNA damage by doxorubicin during transient mitotic arrest

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