PP2A as a master regulator of the cell cycle

scientific article published on 24 February 2016

PP2A as a master regulator of the cell cycle is …
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scholarly articleQ13442814

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P356DOI10.3109/10409238.2016.1143913
P932PMC publication ID4905575
P698PubMed publication ID26906453

P2093author name stringYongna Xing
Nathan Wlodarchak
P2860cites workMID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disordersQ21284182
Towards a proteome-scale map of the human protein–protein interaction networkQ21735930
The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKRQ22254335
Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.Q24291184
Protein phosphatase 2A interacts with and directly dephosphorylates RelAQ24291769
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cellsQ24293029
PR72, a novel regulator of Wnt signaling required for Naked cuticle functionQ24293468
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55Q24294369
The functional interactome landscape of the human histone deacetylase familyQ24294822
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cellsQ24295682
PTPN14 is required for the density-dependent control of YAP1Q24297998
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexQ24298111
Functional proteomics mapping of a human signaling pathwayQ24298398
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F releaseQ24299116
Global landscape of HIV-human protein complexesQ24300336
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7Q24300529
Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylationQ24300811
Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathwayQ24300875
PP2A regulates HDAC4 nuclear importQ24301735
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradationQ24301873
Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1Q24302537
Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.Q24302542
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERKQ24303557
A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130Q24306308
A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1Q24306896
The tumor suppressor PP2A Abeta regulates the RalA GTPaseQ24307546
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's diseaseQ24307593
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptorQ24307890
Shugoshin collaborates with protein phosphatase 2A to protect cohesinQ24307927
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxinsQ24307934
Ubiquitin-mediated proteolysis of HuR by heat shockQ24309514
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2AQ24310186
Identification of c-MYC as a target of the APC pathwayQ24310637
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behaviorQ24310712
PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticleQ24310866
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survivalQ24311448
A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2AQ24312822
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregationQ24312909
The Axin1 scaffold protein promotes formation of a degradation complex for c-MycQ24314734
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1Q24315566
Defining the human deubiquitinating enzyme interaction landscapeQ24315885
The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family membersQ24316289
Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2AQ24318289
An integrated workflow for charting the human interaction proteome: insights into the PP2A systemQ24318802
CIP2A inhibits PP2A in human malignanciesQ24319683
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85Q24319764
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expressionQ28139191
Substrate specificities and identification of putative substrates of ATM kinase family membersQ28141080
The Cdt1 protein is required to license DNA for replication in fission yeastQ28141890
Interaction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastic human T lymphocytesQ28177414
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulationQ28186950
Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS)Q28191134
Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatusQ28198531
Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2AQ28200942
Bestrophin interacts physically and functionally with protein phosphatase 2AQ28203796
Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathwayQ28205007
Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage displayQ28205200
The origin recognition complex: from simple origins to complex functionsQ28210087
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactionsQ28211695
Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2AQ28211744
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motifQ28211968
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinaseQ28212662
Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrestQ28214848
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2AQ28216798
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathwayQ28217024
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexQ28241786
A mammalian protein targeted by G1-arresting rapamycin-receptor complexQ28243712
The BioGRID interaction database: 2015 updateQ28252221
HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2AQ28253208
Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cellsQ28256891
Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acidQ28260445
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growthQ28262401
Serine/threonine phosphatases: mechanism through structureQ28263239
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2Q28277364
Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11Q28284284
Functional interaction of beta-catenin with the transcription factor LEF-1Q28286884
Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 proteinQ28295979
Identification of FAP locus genes from chromosome 5q21Q28300247
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patientsQ28300256
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MSQ24322828
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activationQ24324049
The protein kinase complement of the human genomeQ24324497
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4Q24324592
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNAQ24336740
Structure of the protein phosphatase 2A holoenzymeQ24337251
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degenerationQ24337490
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulumQ24337674
Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cellsQ24338461
The protein interaction landscape of the human CMGC kinase groupQ24338785
Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosisQ24339554
Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.Q24522790
PNUTS enhances in vitro chromosome decondensation in a PP1-dependent mannerQ24531854
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingQ24532278
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationQ24533531
Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcriptionQ24535568
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2Q24564605
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylationQ24601280
Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.Q24601712
B55α PP2A Holoenzymes Modulate the Phosphorylation Status of the Retinoblastoma-related Protein p107 and Its ActivationQ24604107
Protein kinases and phosphatases in the control of cell fateQ24604987
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availabilityQ24607244
WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2AQ24608094
Wnt/beta-catenin signaling: components, mechanisms, and diseasesQ24630938
mTOR signaling in growth control and diseaseQ24634174
The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein trafficQ24634247
Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunitQ24643937
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceQ24645668
p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2AQ24647806
Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigenQ34675213
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cellsQ34717817
Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migrationQ34718036
The many functions of SMC proteins in chromosome dynamicsQ34931800
Orchestrating nuclear envelope disassembly and reassembly during mitosisQ34950012
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.Q35023644
PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exitQ35082227
Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuitQ35131775
Condensin and cohesin: more than chromosome compactor and glueQ35167975
Regulation of the replication initiator protein p65cdc18 by CDK phosphorylationQ35195434
Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1betaQ35213446
A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeastQ35241532
Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.Q35614264
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunitQ35669844
Functional interaction of Aurora-A and PP2A during mitosisQ35723867
The B''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.Q35834456
Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus productionQ35878786
Protein phosphatases and their regulation in the control of mitosisQ35880406
Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosisQ35977354
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.Q36050995
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A.Q36082311
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.Q36124945
Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent mannerQ36172723
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.Q36288907
Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylationQ36421423
Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancerQ36447008
Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15Q36481737
Regulatory mechanisms and functions of MAP kinase signaling pathways.Q36497576
N-terminal phosphorylation of protein phosphatase 2A/Bβ2 regulates translocation to mitochondria, dynamin-related protein 1 dephosphorylation, and neuronal survival.Q36545195
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.Q36596124
E2F4 function in G2: maintaining G2-arrest to prevent mitotic entry with damaged DNA.Q36824489
BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congressionQ36844781
Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.Q36885712
Role of mitogen-activated protein kinase phosphatases (MKPs) in cancerQ36918684
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transitionQ28301955
HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpointQ28302213
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene productQ28316871
Phosphorylation-independent association of CXCR2 with the protein phosphatase 2A core enzymeQ28361616
A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRCQ28471792
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Q28506431
Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during developmentQ28507700
Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylationQ28566720
An NMDA receptor signaling complex with protein phosphatase 2AQ28568587
The alpha4-containing form of protein phosphatase 2A in liver and hepatic cellsQ28570863
Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2AQ28570987
Molecular interaction of NMDA receptor subunit NR3A with protein phosphatase 2AQ28572402
The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiationQ28573860
Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signalingQ28584278
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2AQ28609056
Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sitesQ28609103
Cyclin G recruits PP2A to dephosphorylate Mdm2Q28638418
TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activityQ28732118
The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assemblyQ28748241
A Ras-induced conformational switch in the Ras activator Son of sevenlessQ28914749
Molecular mechanisms of mTOR-mediated translational controlQ29615529
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformationQ29616396
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progressionQ29616821
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signalingQ29617453
PI3K and cancer: lessons, challenges and opportunitiesQ30080017
The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitmentQ30156856
Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactionsQ30443046
Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback PathwayQ30464719
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3betaQ30473576
NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.Q30668571
Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinasesQ32028781
A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.Q33226264
PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorderQ33245065
RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signalingQ33267561
Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channelQ33292538
Structure and function of the PP2A-shugoshin interactionQ24648497
Large-scale mapping of human protein-protein interactions by mass spectrometryQ24670192
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated proteinQ24675387
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1Q24682697
The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130Q24685935
Wnt/β-catenin signaling and diseaseQ26823272
PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activationQ26991427
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complexQ27640372
Structural mechanism of demethylation and inactivation of protein phosphatase 2AQ27650263
Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau DephosphorylationQ27652517
An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma proteinQ27663961
The structural basis for tight control of PP2A methylation and function by LCMT-1.Q27666843
Structural basis of protein phosphatase 2A stable latencyQ27677410
Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylationQ27678559
Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperoneQ27680173
Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2AQ27684630
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteinsQ27686798
Structural basis for PTPA interaction with the invariant C-terminal tail of PP2AQ27694491
The spindle-assembly checkpoint in space and timeQ27860766
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.Q27863647
A dimerization-dependent mechanism drives RAF catalytic activationQ27865239
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTORQ28115142
Finishing mitosis, one step at a time.Q36958864
Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cellsQ36999620
PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cellsQ37015029
DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontinQ37029660
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosisQ37060765
PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).Q37091364
Protein phosphatase 2A regulatory subunits and cancer.Q37202956
The origin recognition complex protein familyQ37213779
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylationQ37367473
PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation.Q37371627
From promiscuity to precision: protein phosphatases get a makeoverQ37414833
Mitotic division of the mammalian Golgi apparatusQ37512669
Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.Q37605239
Tumor suppression by ARF: gatekeeper and caretakerQ37656961
Mammalian target of rapamycin signaling in cardiac physiology and disease.Q37715817
Phosphatases: providing safe passage through mitotic exitQ37900486
Protein phosphorylation during meiotic maturation of Xenopus oocytes: cdc2 protein kinase targetsQ37950348
Phosphatases driving mitosis: pushing the gas and lifting the brakesQ37984845
PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substratesQ37990285
Regulatory modules: Coupling protein stability to phopshoregulation during cell division.Q38016034
Tau protein phosphatases in Alzheimer's disease: the leading role of PP2A.Q38024541
Emerging roles of RB family: new defense mechanisms against tumor progressionQ38034093
Deciphering the retinoblastoma protein phosphorylation codeQ38065487
Function and regulation of serine/threonine phosphatases in the healthy and diseased heart.Q38139729
From simple bacterial and archaeal replicons to replication N/U-domains.Q38149669
Making new contacts: the mTOR network in metabolism and signalling crosstalkQ38189969
Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disordersQ38198830
A high-throughput approach for measuring temporal changes in the interactomeQ38272522
Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayerQ38304743
Domains of axin and disheveled required for interaction and function in wnt signaling.Q38307651
All roads lead to PP2A: exploiting the therapeutic potential of this phosphataseQ38617799
Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphataseQ38625831
Feedback control of chromosome separation by a midzone Aurora B gradientQ38985265
Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.Q39108521
Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man.Q39142618
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Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin fluxQ33344655
Nuclear Import of Histone Deacetylase 5 by Requisite Nuclear Localization Signal PhosphorylationQ33748395
Charting the landscape of tandem BRCT domain-mediated protein interactionsQ33782757
cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.Q33799568
Eukaryotic translation termination factor 1 associates with protein phosphatase 2A and targets it to ribosomes.Q33825225
Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: role of protein phosphatase 2A.Q33840532
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interfaceQ33863228
Rb function in cell-cycle regulation and apoptosisQ33900128
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathwaysQ33920035
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.Q33928657
Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Q33957868
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzymeQ34000718
Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.Q34045261
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progressionQ34073836
ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.Q34093651
Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosisQ34155315
Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeresQ34164908
The Rb/E2F pathway and cancerQ34189004
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synucleinQ34207247
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2Q34286779
Phosphoprotein abundance changes in hypertensive cardiac remodelingQ34289975
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicityQ34358570
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cellsQ34378170
Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligaseQ34378600
OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activationQ34400001
The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidificationQ34413271
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomicsQ34433677
Molecular determinants for PP2A substrate specificity: charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B' regulatory subunitQ34449427
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysisQ34449803
A new role for protein methylation: switching partners at the phosphatase ballQ34467856
A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.Q34483664
Phosphorylation network dynamics in the control of cell cycle transitions.Q34504319
The B55α regulatory subunit of protein phosphatase 2A mediates fibroblast growth factor-induced p107 dephosphorylation and growth arrest in chondrocytesQ39146334
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradationQ39237609
Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replicationQ39458806
Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbateQ39626948
PP2A interaction with Rb2/p130 mediates translocation of Rb2/p130 into the nucleus in all‐Trans retinoic acid‐treated ovarian carcinoma cellsQ39653330
PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.Q39728074
Hypoxia-activated Smad3-specific dephosphorylation by PP2A.Q39768636
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.Q39774265
PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblastsQ39837256
Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle.Q39864578
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.Q40020748
Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activityQ40058260
Tumor necrosis factor-alpha-induced anterior pituitary folliculostellate TtT/GF cell uncoupling is mediated by connexin 43 dephosphorylationQ40080075
Protein phosphatase 2A and separase form a complex regulated by separase autocleavageQ40112941
Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A.Q40171692
Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cellsQ40195895
Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylationQ40282861
gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repairQ40347113
Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymesQ40359711
Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.Q40381392
Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability.Q40407389
Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteinsQ40407885
Role for protein phosphatase 2A in the regulation of Calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport functionQ40421016
Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor.Q40568268
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylationQ40578580
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.Q40586727
Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damageQ40601283
Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A.Q40691796
Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking.Q40833473
Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.Q40850011
The cdc25B phosphatase is essential for the G2/M phase transition in human cellsQ41021031
Cdc2-mediated phosphorylation of the gap junction protein, connexin43, during mitosisQ41070641
Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phaseQ41093702
Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cellsQ41100191
Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligaseQ41493079
Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complexQ41844088
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosisQ41888954
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative DiseasesQ41981157
Wnt signaling controls the phosphorylation status of beta-catenin.Q42162259
Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosisQ42238919
Identification of the PP2A-interacting region of heat shock transcription factor 2.Q42414573
Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neuronsQ42473195
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extractsQ42563373
Isolation and characterization of the Pin1/Ess1p homologue in Schizosaccharomyces pombeQ42663876
Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entryQ42691235
Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformationQ42803654
Role of mTOR in the degradation of IRS-1: regulation of PP2A activityQ42816608
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.Q42820035
Identification of proteins interacting with the catalytic subunit of PP2A by proteomicsQ42832893
Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulationQ43240765
The serine/threonine phosphatase, PP2A: endogenous regulator of inflammatory cell signaling.Q43516344
A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophilsQ44108466
Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.Q44350742
Regulation of minichromosome maintenance helicase activity by Cdc6.Q44499422
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.Q44705461
Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation.Q44938943
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.Q45138638
Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3.Q45166522
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cellsQ46396170
Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.Q46400040
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.Q46832201
Characterization of a protein phosphatase 2A holoenzyme that dephosphorylates the clathrin adaptors AP-1 and AP-2.Q46833949
Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.Q46903641
Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3.Q46971139
Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.Q48316651
A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.Q48445015
Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulationQ50336648
A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1.Q50711695
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner.Q50739208
The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions.Q53142860
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.Q53156970
Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II.Q53630806
Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments.Q54476624
Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling.Q54715563
PKA, PKC, and the Protein Phosphatase 2A Influence HAND Factor FunctionQ55879898
Identification of a Subunit of a Novel Kleisin-β/SMC Complex as a Potential Substrate of Protein Phosphatase 2AQ57444412
Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinaseQ57985211
Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic SubunitQ59385877
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genomeQ72295197
Identification of protein phosphatase 1 as a mitotic lamin phosphataseQ73877028
Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separaseQ84039111
P433issue3
P304page(s)162-184
P577publication date2016-02-24
P1433published inCritical Reviews in Biochemistry and Molecular BiologyQ5186661
P1476titlePP2A as a master regulator of the cell cycle
P478volume51

Reverse relations

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