Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.

scientific article

Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1136/GUT.52.1.144
P932PMC publication ID1773518
P698PubMed publication ID12477778
P5875ResearchGate publication ID277548708

P50authorMaikel P PeppelenboschQ51363232
P2093author name stringD W Hommes
S J H van Deventer
P2860cites workSignal Transduction and the Control of Gene ExpressionQ22065837
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGFQ24304344
Selective interaction of JNK protein kinase isoforms with transcription factorsQ24317346
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substratesQ24322852
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2Q24532154
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokinesQ24601753
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathwayQ28142838
Oncogenic kinase signallingQ28189493
NFAT signaling: choreographing the social lives of cellsQ28216151
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to developmentQ28268881
Transcription factor ATF2 regulation by the JNK signal transduction pathwayQ28305631
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritisQ28343409
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoQ28368373
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesisQ28593865
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
Variations on the Notch pathway in neural developmentQ28610123
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functionsQ29547189
Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42HsQ29547308
STATs and gene regulationQ29547796
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathwayQ29614258
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivoQ29615244
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathwayQ29616436
Identification of a novel inhibitor of mitogen-activated protein kinase kinaseQ29616448
Signaling--2000 and beyondQ29617413
How cells read TGF-beta signalsQ29619993
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1Q29620495
The p38 signal transduction pathway: activation and functionQ33838955
Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophilsQ33844346
Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's diseaseQ33956768
The Rel/NF-kappa B family: friend and foe.Q34023268
The tubby-like proteins, a family with roles in neuronal development and function.Q34110325
An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethalityQ34367944
CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.Q34380078
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazoneQ34381322
The critical role of p38 MAP kinase in T cell HIV-1 replication.Q34430963
Farnesyltransferase inhibitors: mechanism and applicationsQ34481874
The JNK signal transduction pathwayQ34493098
MAP kinases in the immune responseQ34542231
Deciphering the role of Notch signaling in lymphopoiesisQ34547205
Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological interventionQ34583868
An invitation to T and more: notch signaling in lymphopoiesisQ34619778
Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitisQ35594482
NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesionQ36258529
Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathwaysQ38349161
Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinaseQ40924686
IkappaBalpha degradation and nuclear factor-kappaB DNA binding are insufficient for interleukin-1beta and tumor necrosis factor-alpha-induced kappaB-dependent transcription. Requirement for an additional activation pathwayQ41050922
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle controlQ41728250
Signal transduction through MAP kinase cascadesQ41750250
Stress kinase inhibition modulates acute experimental pancreatitisQ43073031
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.Q43590657
Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activityQ47900805
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.Q48009840
Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effectsQ48648179
Extracellular signal-regulated kinase and c-Jun N-terminal protein kinase in ischemic toleranceQ48696039
P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional LevelQ57243702
Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-alpha) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in ratsQ57351157
Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNFQ57910019
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune functionQ71901083
Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathwayQ73025247
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritisQ73374754
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEKQ73495196
Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndromeQ74096429
Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease modelsQ74138408
p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulationQ74196042
The role of p38 MAP kinase in TGF-beta1-induced signal transduction in human neutrophilsQ74585964
Role of ERK and p38 mitogen-activated protein kinase cascades in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharideQ77142811
The physiologic consequences of macrophage pacification during severe acute pancreatitisQ77322763
p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel diseaseQ78058025
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)144-151
P577publication date2003-01-01
P1433published inGutQ5621669
P1476titleMitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
P478volume52

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