Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis

scientific article published on April 2002

Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/GUT.50.4.507
P932PMC publication ID1773163
P698PubMed publication ID11889071
P5875ResearchGate publication ID277369292

P2093author name stringM P Peppelenbosch
B van den Blink
I Pronk
P Drillenburg
S J H van Deventer
T ten Hove
P2860cites workA protein kinase involved in the regulation of inflammatory cytokine biosynthesisQ24311139
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factorQ24563111
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonineQ28287650
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient miceQ28509000
p38 MAPK signalling cascades in inflammatory diseaseQ28678986
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteinsQ29617438
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1Q29620495
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathwayQ33888844
p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neuronsQ36334008
Inflammatory bowel disease (1)Q37278321
Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cellsQ39450773
Phenotypic and functional heterogeneity of CD4+ T cellsQ39473418
Current concepts of the pathogenesis of inflammatory bowel diseaseQ40584499
Cytokines in intestinal inflammation: pathophysiological and clinical considerations.Q40810565
T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes.Q40978696
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.Q41105516
Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-alpha and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinasesQ41109906
A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 productionQ41112102
Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease.Q41113522
Tumour necrosis factor and Crohn's diseaseQ41491900
Tumour necrosis factor and inflammatory bowel diseaseQ41581913
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP siteQ42550034
Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responsesQ42944018
An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's diseaseQ43478061
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.Q44556255
Inflammatory bowel disease: etiology and pathogenesisQ47899867
Evidence of a central role for p38 map kinase induction of tumor necrosis factor alpha in pancreatitis-associated pulmonary injury.Q50517258
Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.Q54074094
Predominant pathogenic role of tumor necrosis factor in experimental colitis in miceQ59276550
Role of Interleukin (IL)-2 Receptor β-Chain Subdomains and Shc in p38 Mitogen-activated Protein (MAP) Kinase and p54 MAP Kinase (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) ActivationQ60683152
p38 Mitogen-Activated Protein Kinase Inhibition Increases Cytokine Release by Macrophages In Vitro and During Infection In VivoQ63916239
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune functionQ71901083
p38 mitogen-activated protein kinase regulates human T cell IL-5 synthesisQ73098769
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritisQ73374754
Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammationQ73407117
SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistenceQ73586335
Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient miceQ73812520
Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease modelsQ74138408
A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on CD28 signaling and preferential inhibition of IL-10 productionQ74624937
p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cellsQ77320317
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcolitisQ2453464
P304page(s)507-512
P577publication date2002-04-01
P1433published inGutQ5621669
P1476titleDichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis
P478volume50

Reverse relations

cites work (P2860)
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