Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition.

scientific article published on 27 November 2017

Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS18122545
P932PMC publication ID5751148
P698PubMed publication ID29186909

P50authorMing-Jen HsuQ57051044
P2093author name stringJoen-Rong Sheu
Yi Chang
Thanasekaran Jayakumar
Manjunath Manubolu
Wei-Cheng Lee
Jiun-Yi Li
Shou-Huang Hung
P2860cites workA novel antioxidant, octyl caffeate, suppression of LPS/IFN-γ-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cellsQ44403220
Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathwayQ45714409
Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharideQ46755225
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processesQ46758917
Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteersQ48138664
Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic SubunitQ59385877
Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell deathQ63303664
Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expressionQ64377899
Autophosphorylation‐activated protein kinase inactivates the protein tyrosine phosphatase activity of protein phosphatase 2AQ71650129
Sedation in the intensive care unitQ83222051
PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cellsQ88079269
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingQ24532278
Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunitsQ24598280
Serine/threonine phosphatases: mechanism through structureQ28263239
Ketamine-induced neuronal cell death in the perinatal rhesus monkeyQ28297451
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylationQ28638545
The pathogenesis of atherosclerosis: a perspective for the 1990sQ29547827
Atherosclerosis. the road aheadQ29618972
Flicking the switches: phosphorylation of serine/threonine protein phosphatasesQ30467951
Atherosclerosis is an inflammatory diseaseQ33762068
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.Q34272789
Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cellsQ34675805
Pharmacological aspects and potential new clinical applications of ketamine: reevaluation of an old drugQ34988290
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.Q35023644
Synaptic modulation in pain pathways.Q36214190
General anesthetics and vascular smooth muscle: direct actions of general anesthetics on cellular mechanisms regulating vascular toneQ36723066
PKB and the mitochondria: AKTing on apoptosisQ36918414
Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activationQ37143323
Pathogenesis of atherosclerosis: A multifactorial process.Q37276377
Inflammation and plaque vulnerabilityQ37307660
Non-opioid IV adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoidsQ37981947
The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple rolesQ37998958
Structure, regulation, and pharmacological modulation of PP2A phosphatasesQ38122081
Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studiesQ38563397
All roads lead to PP2A: exploiting the therapeutic potential of this phosphataseQ38617799
Adenosine monophosphate-activated protein kinase regulates platelet-derived growth factor-BB-induced vascular smooth muscle cell migrationQ39214312
Autoregulation of protein phosphatase type 2A expressionQ41024570
An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?Q42204682
Alpha 2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cellsQ42453225
Plasma levels of ketamine and two of its metabolites in surgical patients using a gas chromatographic mass fragmentographic assayQ42670691
Reduction of protein phosphatase 2A Cα enhances bone formation and osteoblast differentiation through the expression of bone-specific transcription factor Osterix.Q42809218
Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cellsQ42811143
Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation.Q42987549
Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathwayQ44052627
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P577publication date2017-11-27
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleKetamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition
P478volume18

Reverse relations

cites work (P2860)
Q52605218Crocin prevents platelet‑derived growth factor BB‑induced vascular smooth muscle cells proliferation and phenotypic switch.
Q93197632MicroRNA-125a-3p affects smooth muscle cell function in vascular stenosis

Search more.