AAV-CRISPR/Cas9-Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro

scientific article published in December 2017

AAV-CRISPR/Cas9-Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1167/IOVS.17-21902
P932PMC publication ID5714046
P698PubMed publication ID29204648

P2093author name stringHetian Lei
Patricia A D'Amore
Gaoen Ma
Guohong Zhou
Wenyi Wu
Yajian Duan
Cindy Park-Windhol
P2860cites workSrc Family Kinases Promote Vessel Stability by Antagonizing the Rho/ROCK PathwayQ57372719
In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extractQ83181157
Signal transduction by vascular endothelial growth factor receptorsQ84520249
Combination therapy for the treatment of ocular neovascularizationQ36764604
Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote AngiogenesisQ37175153
Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube FormationQ37682513
Association between MDM2 rs 2279744 polymorphism and breast cancer susceptibility: a meta-analysis based on 9,788 cases and 11,195 controlsQ37722658
Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA ModificationQ37827234
TAL effectors: customizable proteins for DNA targetingQ37940951
Mechanisms and regulation of endothelial VEGF receptor signalling.Q38909541
GPER mediates activation of HIF1α/VEGF signaling by estrogensQ38988553
The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of CellsQ39720539
Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activationQ39819854
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cellsQ39898210
Genome editing abrogates angiogenesis in vivoQ40109925
Structures of the CRISPR genome integration complexQ40114138
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.Q40571016
An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction.Q41396968
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathyQ41526638
Temporal requirement of RPE-derived VEGF in the development of choroidal vasculatureQ42087568
CRISPR-Cas9: Prospects and ChallengesQ42426695
Regulating angiogenesis at the level of PtdIns-4,5-P2.Q42532910
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectorsQ24538483
Safety and efficacy of gene transfer for Leber's congenital amaurosisQ24634724
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivoQ24648140
Therapeutic genome editing: prospects and challengesQ28087380
Axl is essential for VEGF-A-dependent activation of PI3K/AktQ28116976
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesisQ28140740
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibitionQ28238040
Development and applications of CRISPR-Cas9 for genome engineeringQ28241526
Genome editing. The new frontier of genome engineering with CRISPR-Cas9Q28252298
Effect of gene therapy on visual function in Leber's congenital amaurosisQ28277981
Essential role for the p110delta phosphoinositide 3-kinase in the allergic responseQ28288981
Genome editing with engineered zinc finger nucleasesQ28290795
RNA-guided gene activation by CRISPR-Cas9-based transcription factorsQ28295458
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphateQ28301966
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesisQ28594191
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificityQ29615792
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitroQ29617927
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseQ29618387
Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune ResponseQ30275154
A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptorQ31104595
Vesicle-associated membrane protein 2 (VAMP2) but Not VAMP3 mediates cAMP-stimulated trafficking of the renal Na+-K+-2Cl- co-transporter NKCC2 in thick ascending limbsQ34140945
Identification of PDGFR as a receptor for AAV-5 transductionQ34264144
Angiogenesis-dependent diseases and angiogenesis therapyQ34310550
RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and PathologyQ34465364
Circadian organization of the mammalian retinaQ34687175
Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1Q35065442
Improved vectors and genome-wide libraries for CRISPR screeningQ35215629
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9Q35820051
Semaphorin signaling in angiogenesis, lymphangiogenesis and cancerQ35958869
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factorQ36681701
A survey of ex vivo/in vitro transduction efficiency of mammalian primary cells and cell lines with Nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotypeQ36715338
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectCRISPRQ412563
Cas9Q16965677
CRISPR-Cas methodQ17310682
P304page(s)6082-6090
P577publication date2017-12-01
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleAAV-CRISPR/Cas9-Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro
P478volume58

Reverse relations

cites work (P2860)
Q90484087Biallelic CCM3 mutations cause a clonogenic survival advantage and endothelial cell stiffening
Q57171979CRISPR/Cas9 genome surgery for retinal diseases
Q58579972Diabetic Retinopathy: A complex pathophysiology requiring novel therapeutic strategies
Q97567741Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update
Q92262796Precise CCM1 gene correction and inactivation in patient-derived endothelial cells: Modeling Knudson's two-hit hypothesis in vitro
Q55078229The Janus Face of VEGF in Stroke.

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