| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1032802342 |
| P356 | DOI | 10.1038/NATURE02991 |
| P3181 | OpenCitations bibliographic resource ID | 716004 |
| P698 | PubMed publication ID | 15496927 |
| P5875 | ResearchGate publication ID | 8220007 |
| P50 | author | Klaus Okkenhaug | Q38546924 |
| Alexander Gray | Q40726945 | ||
| Emma Peskett | Q50983728 | ||
| Antonio Bilancio | Q56863262 | ||
| Bart Vanhaesebroeck | Q64481959 | ||
| Alasdair M Gilfillan | Q98184237 | ||
| P2093 | author name string | Wayne Pearce | |
| Christine Tkaczyk | |||
| Matthew Thomas | |||
| Nicolas Kuehn | |||
| Christoph Walker | |||
| Khaled Ali | |||
| Ian Bruce | |||
| Roy Fox | |||
| June Giddings | |||
| Peter Finan | |||
| Carol Sawyer | |||
| P2860 | cites work | p110δ, a novel phosphoinositide 3-kinase in leukocytes | Q24314825 |
| p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes | Q24319291 | ||
| Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase | Q24531326 | ||
| PI3K in lymphocyte development, differentiation and activation | Q28187880 | ||
| Synthesis and function of 3-phosphorylated inositol lipids | Q28200755 | ||
| Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes | Q28344700 | ||
| Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase | Q28589116 | ||
| The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology | Q33652544 | ||
| Macromolecular protein signaling complexes and mast cell responses: a view of the organization of IgE-dependent mast cell signaling | Q34148288 | ||
| Mast cells and basophils in acquired immunity | Q34255429 | ||
| p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity | Q34550411 | ||
| Phosphoinositide 3-kinase signalling--which way to target? | Q35181798 | ||
| Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies. | Q35203309 | ||
| Stem cell factor-induced airway hyperreactivity in allergic and normal mice | Q35786893 | ||
| The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor | Q36721161 | ||
| Adenosine and inosine increase cutaneous vasopermeability by activating A(3) receptors on mast cells | Q37175389 | ||
| Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. | Q37693932 | ||
| The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase | Q40634199 | ||
| Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts | Q42804753 | ||
| Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function | Q43930617 | ||
| Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice | Q43933405 | ||
| Pathways of anaphylaxis in the mouse | Q43952644 | ||
| Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation | Q44429969 | ||
| Selective role of PI3K delta in neutrophil inflammatory responses | Q44555476 | ||
| Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells | Q44951894 | ||
| Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products | Q52538092 | ||
| Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha | Q73150469 | ||
| Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells | Q78863090 | ||
| P433 | issue | 7011 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1007-1011 | |
| P577 | publication date | 2004-10-01 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Essential role for the p110delta phosphoinositide 3-kinase in the allergic response | |
| P478 | volume | 431 |
| Q36139665 | A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis |
| Q91341220 | A class of highly selective inhibitors bind to an active state of PI3Kγ |
| Q37123676 | A current understanding of Fc epsilon RI-dependent mast cell activation |
| Q33931796 | A key role for ATF3 in regulating mast cell survival and mediator release |
| Q34056402 | A membrane capture assay for lipid kinase activity |
| Q83350735 | A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16 |
| Q47117976 | AAV-CRISPR/Cas9-Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro |
| Q34822331 | Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function |
| Q37233311 | Activation and function of the mTORC1 pathway in mast cells |
| Q28584858 | Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma |
| Q37259631 | Amplification mechanisms for the enhancement of antigen-mediated mast cell activation |
| Q24676521 | An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response |
| Q34598995 | Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. |
| Q38124120 | B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies. |
| Q34706585 | Biochanin A, a Phytoestrogenic Isoflavone with Selective Inhibition of Phosphodiesterase 4, Suppresses Ovalbumin‐Induced Airway Hyperresponsiveness |
| Q46674143 | Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. |
| Q37175584 | Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3 |
| Q39642145 | CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability |
| Q36741180 | Ca-dependent nonsecretory vesicle fusion in a secretory cell |
| Q37159942 | Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation |
| Q54473465 | Chronic treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase, attenuates ischemia/reperfusion-induced cardiac dysfunction in normotensive and hypertensive diabetic animals. |
| Q37270450 | Class I PI3K in oncogenic cellular transformation. |
| Q35808718 | Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers |
| Q51466434 | Comprehensive attenuation of IL-25-induced airway hyperresponsiveness, inflammation and remodelling by the PI3K inhibitor LY294002. |
| Q37216023 | Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation |
| Q93167038 | Conformationally restricted quinazolone derivatives as PI3Kδ-selective inhibitors: the design, synthesis and biological evaluation |
| Q33298503 | Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase |
| Q92026594 | Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management |
| Q24549674 | Development, migration, and survival of mast cells |
| Q37257003 | Diacylglycerol kinases in immune cell function and self-tolerance |
| Q28482560 | Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury |
| Q36176976 | Differential Roles of Phospholipase D Proteins in FcεRI-Mediated Signaling and Mast Cell Function |
| Q40237912 | Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha |
| Q40165582 | Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs |
| Q35491013 | Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: “All or nothing” enhancement of antigen-dependent mediator release |
| Q34988445 | EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma |
| Q85555639 | Effects of Phosphoinositide 3-Kinase on Protease-Induced Acute and Chronic Lung Inflammation, Remodeling, and Emphysema in Rats |
| Q42137479 | Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption |
| Q33689775 | Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. |
| Q89467484 | Evaluation of the PIK3 pathway in peripheral T-cell lymphoma and NK/T-cell lymphoma |
| Q57266995 | Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project |
| Q43184180 | FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors |
| Q37278664 | FcepsilonRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation |
| Q38805002 | Frequency and amplitude control of cortical oscillations by phosphoinositide waves. |
| Q36168847 | G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation |
| Q28115545 | Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit |
| Q34221228 | Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts |
| Q34214029 | Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells |
| Q35566591 | Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis |
| Q34492548 | Highly specialized role of Forkhead box O transcription factors in the immune system. |
| Q37382448 | Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis |
| Q37907670 | Immunoglobulin E Receptor Signaling and Asthma |
| Q27334636 | Immunophenotypic and Ultrastructural Analysis of Mast Cells in Hermansky-Pudlak Syndrome Type-1: A Possible Connection to Pulmonary Fibrosis |
| Q36363079 | Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity |
| Q34575244 | Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. |
| Q46150766 | Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice |
| Q35897436 | Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production |
| Q38603120 | Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury |
| Q36392833 | Integrated signalling pathways for mast-cell activation |
| Q38202695 | Investigational drugs for the treatment of allergic rhinitis |
| Q35378129 | Involvement of class II phosphoinositide 3-kinase α-isoform in antigen-induced degranulation in RBL-2H3 cells |
| Q41881074 | Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo |
| Q28116266 | Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells |
| Q37064018 | Lipid signalling in disease. |
| Q39133112 | Lipid-rich enteral nutrition regulates mucosal mast cell activation via the vagal anti-inflammatory reflex |
| Q36100395 | Mast Cell Biology: Introduction and Overview |
| Q34430917 | Mast cell function: a new vision of an old cell |
| Q38633155 | Mast cells in asthma--state of the art. |
| Q37457346 | Mechanisms of mast cell signaling in anaphylaxis |
| Q37932157 | Mechanisms underlying the localisation of mast cells in tissues |
| Q37956534 | Mediators Released During Human Anaphylaxis |
| Q34572441 | Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions |
| Q38666875 | Molecules in medicine mini-review: isoforms of PI3K in biology and disease |
| Q26858885 | More Paths to PI3Kγ |
| Q38057021 | New Insights into the Pathogenesis, Diagnosis, and Management of Mastocytosis |
| Q80168002 | New developments in FcepsilonRI regulation, function and inhibition |
| Q37260865 | New insights on mast cell activation via the high affinity receptor for IgE |
| Q28568538 | Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptors |
| Q33945560 | Non-canonical functions of RGS proteins |
| Q42948871 | Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. |
| Q28546072 | Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells |
| Q46902768 | Oncogenic signaling of class I PI3K isoforms |
| Q37756117 | Overcoming reduced glucocorticoid sensitivity in airway disease: molecular mechanisms and therapeutic approaches. |
| Q83558732 | PI3-kinase regulates eosinophil and neutrophil degranulation in patients with allergic rhinitis and allergic asthma irrespective of allergen challenge model |
| Q24296651 | PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? |
| Q35260766 | PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting |
| Q89949166 | PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma |
| Q41367429 | PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans |
| Q37421254 | PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells |
| Q28201583 | PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? |
| Q35843746 | PI3Ks in lymphocyte signaling and development |
| Q99711572 | PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19 |
| Q41030989 | PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes |
| Q47117105 | PI3Kδ activates E2F1 synthesis in response to mRNA translation stress |
| Q38038238 | PI3Kδ and PI3Kγ as Targets for Autoimmune and Inflammatory Diseases |
| Q52674409 | PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD-RIG-I-NF-κB axis. |
| Q34409918 | PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model |
| Q27317259 | PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control |
| Q41456099 | Phosphatidlyinositol-3-kinase C2 beta (PI3KC2β) is a potential new target to treat IgE mediated disease |
| Q36601779 | Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections |
| Q37668864 | Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease. |
| Q34203861 | Phosphatidylinositol 3-kinase: the oncoprotein |
| Q36702291 | Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. |
| Q41941538 | Phosphatidylinositol-3-kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells |
| Q37010509 | Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse. |
| Q37018480 | Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity |
| Q24302466 | Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function |
| Q35225599 | Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury |
| Q33633092 | Phosphoinositide 3-kinase p110δ mediates estrogen- and FSH-stimulated ovarian follicle growth |
| Q36872061 | Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond. |
| Q40141682 | Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis |
| Q24631095 | Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion |
| Q37461480 | Phosphoinositide 3-kinases and their role in inflammation: potential clinical targets in atherosclerosis? |
| Q42112825 | Phosphoinositide 3-kinases gamma and delta, linkers of coordinate C5a receptor-Fcgamma receptor activation and immune complex-induced inflammation |
| Q37340915 | Phosphoinositide 3-kinases in cell migration |
| Q35078016 | Phosphoinositide signaling: new tools and insights. |
| Q37989035 | Phosphoinositides in Chemotaxis |
| Q27012953 | Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation |
| Q28566197 | Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway |
| Q37872280 | Progress in the Design and Development of Phosphoinositide 3-Kinase (PI3K) Inhibitors for the Treatment of Chronic Diseases |
| Q37886009 | Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors |
| Q55223778 | Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy. |
| Q48137615 | Quantitative profile of five murine core proteomes using label-free functional proteomics |
| Q38239275 | Regulation of FcεRI signaling by lipid phosphatases. |
| Q37204048 | Regulation of G-protein-coupled signaling pathways in allergic inflammation |
| Q36092456 | Regulation of Mast Cell Responses in Health and Disease |
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| Q36922987 | Role of phosphoinositide 3-kinase signaling in autoimmunity |
| Q37642294 | Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. |
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| Q94591368 | Roles of PI3K pan-inhibitors and PI3K-δ inhibitors in allergic lung inflammation: a systematic review and meta-analysis |
| Q34981983 | S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness |
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| Q41820658 | SWAP-70 regulates mast cell FcepsilonRI-mediated signaling and anaphylaxis |
| Q43214771 | Science amongst the vines. Meeting on signalling systems. |
| Q37174848 | Secretagogue stimulation enhances NBCe1 (electrogenic Na(+)/HCO(3)(-) cotransporter) surface expression in murine colonic crypts |
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| Q35750980 | T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. |
| Q37094686 | T-cell-targeted signaling inhibitors |
| Q38887103 | TLR-induced activation of neutrophils promotes histamine production via a PI3 kinase dependent mechanism. |
| Q37457673 | Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection. |
| Q37977184 | Targeting phosphoinositide 3-kinase δ for allergic asthma |
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