Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

scientific article published on 09 October 2007

Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1124/JPET.107.125237
P932PMC publication ID2692100
P698PubMed publication ID17925481
P5875ResearchGate publication ID5920526

P50authorBettina M JensenQ89544602
Dean D. MetcalfeQ90856971
Alasdair M GilfillanQ98184237
Shoko IwakiQ114441406
Michael A BeavenQ114441411
P2860cites workMolecular regulation of mast cell activationQ36496363
Targeting kit activation: a potential therapeutic approach in the treatment of allergic inflammationQ36757680
EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutationQ40243206
Effects of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, on human mast cells bearing wild-type or mutated codon 816 c-kitQ40263124
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survivalQ40290700
Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosisQ40325513
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.Q40442570
The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinaseQ40634199
Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasmsQ40672695
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor.Q40866333
A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI.Q43545361
Pathways of anaphylaxis in the mouseQ43952644
Determination of protein phosphorylation in Fc epsilon RI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditionsQ44127938
Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cellsQ44951894
Treatment of cockroach allergen asthma model with imatinib attenuates airway responsesQ45063930
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent mannerQ45168860
Temporal quantitation of mutant Kit tyrosine kinase signaling attenuated by a novel thiophene kinase inhibitor OSI-930.Q46644439
PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effectsQ46724516
Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignanciesQ46882720
Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthmaQ52666713
Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13)Q73023303
Down-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivoQ77399446
The mastocyte: the "other" inflammatory cell in immunopathogenesisQ80305936
Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kitQ81245378
Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248Q83862094
Signaling by Kit protein-tyrosine kinase--the stem cell factor receptorQ24318673
Development, migration, and survival of mast cellsQ24549674
Structural mechanism for STI-571 inhibition of abelson tyrosine kinaseQ27627097
Stem cell factor and its receptor c-Kit as targets for inflammatory diseasesQ28115994
Early signaling pathways activated by c-Kit in hematopoietic cellsQ28139288
NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregationQ28249353
Mast cellsQ28253429
Essential role for the p110delta phosphoinositide 3-kinase in the allergic responseQ28288981
Essential role for Gab2 in the allergic responseQ28586578
Chemistry and biology of resorcylic acid lactonesQ29039248
Omalizumab-induced reductions in mast cell Fce psilon RI expression and functionQ33981258
Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody.Q34414866
A comprehensive review of imatinib mesylate (Gleevec) for dermatological diseases.Q34495587
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides.Q34573054
The ins and outs of IgE-dependent mast-cell exocytosisQ35751914
FcepsilonR1 and toll-like receptors mediate synergistic signals to markedly augment production of inflammatory cytokines in murine mast cellsQ35849299
Silica-directed mast cell activation is enhanced by scavenger receptorsQ35855252
Mast cells in the development of adaptive immune responsesQ36015885
c-kit ligand: a unique potentiator of mediator release by human lung mast cellsQ36230802
Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptorQ36287291
Integrated signalling pathways for mast-cell activationQ36392833
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine productionQ36400671
Anaphylaxis: clinical concepts and research priorities.Q36466735
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmast cellQ191989
P304page(s)128-138
P577publication date2007-10-09
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleConcurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation
P478volume324

Reverse relations

cites work (P2860)
Q34476441Adapters in the organization of mast cell signaling
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Q54530121Anti-allergic effects of nilotinib on mast cell-mediated anaphylaxis like reactions
Q42665868Assessing anaphylactic risk? Consider mast cell clonality
Q27332182CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells
Q33811207Chiral kinase inhibitors
Q33358546Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition
Q34073540Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood.
Q34214029Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells
Q35680494Lipoxin B₄ promotes the resolution of allergic inflammation in the upper and lower airways of mice
Q42177446Mast cell chemotaxis - chemoattractants and signaling pathways
Q34017091Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype
Q34572441Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions
Q24603534Narrative review: the systemic capillary leak syndrome
Q36842503Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders
Q26748784Pharmacological treatment options for mast cell activation disease
Q38068961Role of mast cells in mucosal diseases: current concepts and strategies for treatment
Q38737251Subvisible Particle Content, Formulation, and Dose of an Erythropoietin Peptide Mimetic Product Are Associated With Severe Adverse Postmarketing Events
Q54497833Targeting c-kit in the therapy of mast cell disorders: Current update
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Q37848482Tec family kinases: regulation of FcεRI-mediated mast-cell activation
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Q34035784Twenty-first century mast cell stabilizers.
Q54558599Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen-induced anaphylaxes in mice

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