CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis.

scientific article published on 07 June 2016

CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP27485
P932PMC publication ID4895392
P698PubMed publication ID27270835

P50authorFereshteh KarimzadehQ81232782
P2093author name stringNathalie Lamarche-Vane
Christine Caron
Patrick Fournier
Vilayphone Luangrath
Isabelle Royal
Jonathan DeGeer
Philippe M Duquette
Hidetaka Ishii
P2860cites workGain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomaliesQ24626495
Regulation of Small GTPases by GEFs, GAPs, and GDIsQ26825750
Rho GAPs and GEFs: controling switches in endothelial cell adhesionQ26992281
Molecular control of endothelial cell behaviour during blood vessel morphogenesisQ27007664
The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxisQ27315836
Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndromeQ28244970
The spectra of clinical phenotypes in aplasia cutis congenita and terminal transverse limb defectsQ28252346
Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams-Oliver Syndrome With Variable Cardiac AnomaliesQ28261852
Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver SyndromeQ28266515
RBPJ mutations identified in two families affected by Adams-Oliver syndromeQ28272822
Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndromeQ28287700
Essential role of endothelial Notch1 in angiogenesisQ28509482
Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activationQ28589835
Molecular mechanisms and clinical applications of angiogenesisQ29547314
Mechanisms of angiogenesisQ29547485
Angiogenesis in health and diseaseQ29614541
Basic and Therapeutic Aspects of AngiogenesisQ29615219
CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac.Q30176009
Therapeutic angiogenesis for critical limb ischaemiaQ30456666
CdGAP regulates cell migration and adhesion dynamics in two‐and three‐dimensional matrix environmentsQ30654973
A Snail1/Notch1 signalling axis controls embryonic vascular development.Q33736954
Rac regulates endothelial morphogenesis and capillary assemblyQ33893806
Initiation of hematopoiesis and vasculogenesis in murine yolk sac explantsQ52207278
DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomaliesQ52868262
Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion, and capillary formation.Q54490381
Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.Q54615405
CdGAP is required for transforming growth factor β- and Neu/ErbB-2-induced breast cancer cell motility and invasion.Q54636285
Diffuse angiopathy in Adams-Oliver syndrome associated with truncating DOCK6 mutations.Q55656450
Cardiovascular malformations in Adams-Oliver syndromeQ58193220
Use of the mouse aortic ring assay to study angiogenesisQ58313759
Isolated terminal limb reduction defects: Extending the clinical spectrum of Adams-Oliver syndrome andARHGAP31mutationsQ62937117
The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinaseQ64377712
Signal transduction by vascular endothelial growth factor receptorsQ84520249
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substratesQ34144300
Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafishQ34206023
Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1)Q34436701
The human orthologue of CdGAP is a phosphoprotein and a GTPase-activating protein for Cdc42 and Rac1 but not RhoA.Q34499924
Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathwayQ34582584
Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory siteQ34589399
Notch signaling in vascular development and physiologyQ34646081
Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociationQ34712138
Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesisQ34980011
Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery diseaseQ35752509
VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2Q36082465
Current knowledge of the large RhoGAP family of proteinsQ36707513
Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1.Q37041713
Angiogenesis: a team effort coordinated by notch.Q37393190
Regulation of angiogenesis by ETS transcription factorsQ37631641
Angiogenesis and vasculogenesis in rheumatoid arthritis.Q37715688
Developmental and pathological angiogenesisQ37901035
Regulation of Endothelial Cell Differentiation and SpecificationQ38101895
Genetics of aplasia cutis reveal novel regulators of skin morphogenesis.Q38263745
Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cellsQ39881261
The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.Q40193180
CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motilityQ40252534
Rac Regulates Vascular Endothelial Growth Factor Stimulated MotilityQ40759315
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesisQ42482049
An essential role for Rac1 in endothelial cell function and vascular development.Q46775495
Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo.Q46930160
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)27485
P577publication date2016-06-07
P1433published inScientific ReportsQ2261792
P1476titleCdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis
P478volume6

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cites work (P2860)
Q89910312CD226 deletion improves post-infarction healing via modulating macrophage polarization in mice
Q52653012CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.
Q88513806Cytosine methylation predicts renal function decline in American Indians
Q41592601Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats
Q38991996The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin transcriptional co-repressor with Zeb2 in breast cancer
Q41503844The scaffold protein Ajuba suppresses CdGAP activity in epithelia to maintain stable cell-cell contacts
Q89697179Weighted Single-Step Genome-Wide Association Study for Growth Traits in Chinese Simmental Beef Cattle

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