Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis

scientific article

Endothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00018-016-2347-2
P932PMC publication ID5243150
P698PubMed publication ID27572288

P50authorHong ChenQ96249488
P2093author name stringHao Wu
Diane R Bielenberg
Kai Song
Scott Wong
Yunzhou Dong
Aiyun Wen
H N Ashiqur Rahman
Megan L Brophy
Sukyoung Kwak
P2860cites workModes of resistance to anti-angiogenic therapyQ24608005
Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sproutingQ24685542
Molecular control of endothelial cell behaviour during blood vessel morphogenesisQ27007664
Therapeutic antibody targeting of individual Notch receptorsQ27660544
Tumor angiogenesis: therapeutic implicationsQ27860595
Epsins: adaptors in endocytosis?Q27939888
Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosisQ28115833
Epsin Family of Endocytic Adaptor Proteins as Oncogenic Regulators of Cancer ProgressionQ28307353
Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculiQ28511738
The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein moduleQ28566047
Spatial regulation of VEGF receptor endocytosis in angiogenesisQ28585752
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in miceQ28586389
Epsin potentiates Notch pathway activity in Drosophila and C. elegansQ47071284
Developmental selection of var gene expression in Plasmodium falciparumQ47741507
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesisQ50730548
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.Q52855186
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signallingQ28587298
Molecular mechanisms and clinical applications of angiogenesisQ29547314
Signals for sorting of transmembrane proteins to endosomes and lysosomesQ29547469
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteinsQ29616733
Notch signaling is essential for vascular morphogenesis in miceQ29620377
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancerQ29622818
Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregationQ30167778
Normalization of the vasculature for treatment of cancer and other diseasesQ30471456
Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channelsQ33592643
An inside view: VEGF receptor trafficking and signalingQ33682832
The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrinQ33864158
Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugsQ33897492
A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systemsQ33951379
Sunitinib malate for the treatment of pancreatic neuroendocrine tumorsQ34163515
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pitsQ34164071
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer developmentQ34471536
Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and functionQ34483937
Tissue-penetrating delivery of compounds and nanoparticles into tumorsQ35016106
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumorsQ35064894
Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selectionQ35569243
Motif mimetic of epsin perturbs tumor growth and metastasisQ36335923
Lessons from phase III clinical trials on anti-VEGF therapy for cancerQ36366446
VEGF directly suppresses activation of T cells from ascites secondary to ovarian cancer via VEGF receptor type 2Q36419140
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signalingQ36498075
A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesisQ36949613
Pathways mediating resistance to vascular endothelial growth factor-targeted therapyQ37300871
Angiogenesis: a team effort coordinated by notch.Q37393190
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.Q37594746
Tumor angiogenesis: molecular pathways and therapeutic targetsQ37953773
Forty-year journey of angiogenesis translational researchQ37970646
Endosomal crosstalk: meeting points for signaling pathways.Q38026339
Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis.Q39185970
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer.Q39186300
Endocytic adaptor protein epsin is elevated in prostate cancer and required for cancer progressionQ39415229
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesisQ40191484
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesisQ40191493
Are epsins a therapeutic target for tumor angiogenesis?Q41844357
Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiencyQ41945502
Angiogenesis: A happy medium?Q43660164
Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cellsQ44370252
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
tumor angiogenesisQ110495869
P304page(s)393-398
P577publication date2016-08-29
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleEndothelial epsins as regulators and potential therapeutic targets of tumor angiogenesis
P478volume74

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cites work (P2860)
Q96431012A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
Q37706572Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation
Q47138631Overlapping Mechanisms of Peripheral Nerve Regeneration and Angiogenesis Following Sciatic Nerve Transection

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