Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

article

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NG0994-22
P698PubMed publication ID7987388

P50authorRosalind EelesQ24640445
Nelleke A GruisQ42392971
P2093author name stringKamb A
Liu Q
Tran T
Ding W
Miki Y
Hussey C
Shattuck-Eidens D
Weaver-Feldhaus J
P2860cites workA new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Q24322196
Mutation and cancer: statistical study of retinoblastomaQ24618185
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancersQ28251857
A cell cycle regulator potentially involved in genesis of many tumor typesQ28251933
Mammalian G1 cyclinsQ29618855
Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p.Q34046828
Localization of a putative tumor suppressor gene by using homozygous deletions in melanomasQ35648205
Homozygous deletions within human chromosome band 9p21 in melanomaQ37286548
p53: at the crossroads of molecular carcinogenesis and risk assessmentQ40793098
Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22Q44552643
Clinical and genetic studies in six Dutch kindreds with the dysplastic naevus syndromeQ47410441
Exclusion of the familial melanoma locus (MLM) from the PND/D1S47 and MYCL1 regions of chromosome arm 1p in 7 Australian pedigrees.Q54261736
Hereditary melanoma in Australia variable association with dysplastic nevi andQ58025042
P16 gene in uncultured tumoursQ59058147
Exclusion of the dysplastic nevus syndrome (DNS) locus from the short arm of chromosome 1 by linkage studies in Dutch familiesQ69225441
Rates of p16 (MTS1) mutations in primary tumors with 9p lossQ72041274
All in the (cancer) familyQ72635284
ResponseQ94596609
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectsusceptibility locusQ62091149
P304page(s)23-26
P577publication date1994-09-01
P1433published inNature GeneticsQ976454
P1476titleAnalysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
P478volume8

Reverse relations

cites work (P2860)
Q554806735′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Q36687252A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids
Q55670980A Familial Syndrome of Pancreatic Cancer and Melanoma with a Mutation in theCDKN2Tumor-Suppressor Gene
Q88371437A Nonsynonymous Variant in the GOLM1 Gene in Cutaneous Malignant Melanoma
Q36808635A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL).
Q48498516A comprehensive survey of cancer risks in extended families.
Q48825624A genome-wide association study identifies novel single nucleotide polymorphisms associated with dermal shank pigmentation in chickens
Q38442858A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation
Q34390025A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs
Q34283555A novel p16(INK4A) mutation associated with esophageal squamous cell carcinoma in a high risk population
Q40227530A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family
Q37104946A population-based analysis of clustering identifies a strong genetic contribution to lethal prostate cancer
Q45769777A research shortcut from a common cold virus to human cancer
Q34142079A single genetic origin for the G101W CDKN2A mutation in 20 melanoma-prone families
Q53237784A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q.
Q77658607Aberrations in the MTS1 tumor suppressor locus in oral squamous cell carcinoma lines preferentially affect the INK4A gene and result in increased cdk6 activity
Q36843805Absence of germline CDKN2A mutation in Sicilian patients with familial malignant melanoma: Could it be a population-specific genetic signature?
Q58485779Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma
Q74268765Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus
Q73504522Allelic loss at the D9S171 locus on chromosome 9p13 is associated with progression of papillary renal cell carcinoma
Q78757756Allelic loss on chromosomes 2q, 3p and 21q: possibly a poor prognostic factor in oral squamous cell carcinoma
Q56418625Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia
Q48877020Alterations of cell cycle regulators in gliomatosis cerebri
Q38861630Altered microRNA Expression Profiles and Regulation of INK4A/CDKN2A Tumor Suppressor Genes in Canine Breast Cancer Models
Q28253911An automated procedure to identify biomedical articles that contain cancer-associated gene variants
Q38705693An interstitial deletion within 9p21.3 and extending beyond CDKN2A predisposes to melanoma, neural system tumours and possible haematological malignancies.
Q37204679Applications of genomics in melanoma oncogene discovery
Q33680576Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma
Q34212766Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study
Q35090029BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model
Q89499162Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
Q50610892Bilateral primary uveal melanoma. Bad luck or bad genes?
Q28281959Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines
Q28294919Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase
Q57571832CDK4 inhibitors an emerging strategy for the treatment of melanoma
Q30353881CDKN2A exon-wise deletion status and novel somatic mutations in Indian glioma patients.
Q39012719CDKN2A unclassified variants in familial malignant melanoma: combining functional and computational approaches for their assessment.
Q57282544CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters
Q34322773Cancer-associated genodermatoses and familial cancer syndromes with cutaneous manifestations
Q42064477Cancer-associated mis-sense and deletion mutations impair p16INK4 CDK inhibitory activity
Q43123105Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene Expression
Q41099892Cdk inhibitors in development and cancer
Q34076478Cell cycle checkpoints and their inactivation in human cancer
Q38466264Cell cycle proteins and the development of oral squamous cell carcinoma.
Q33895611Cell-cycle inhibitors: three families united by a common cause
Q40514881Cell-cycle regulators and cancer
Q28280872Characterization of the human p57KIP2 gene: alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis
Q35746432Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups
Q38503862Chromosomal and genetic alterations of 7,12-dimethylbenz[a]anthracene-induced melanoma from TP-ras transgenic mice
Q35644518Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene.
Q41285090Clinical implications of cytogenetic abnormalities in melanoma
Q28544919Clonal architectures and driver mutations in metastatic melanomas
Q36880772Coexisting NRAS and BRAF mutations in primary familial melanomas with specific CDKN2A germline alterations
Q37355423Comprehensive analysis of the 9p21 region in neuroblastoma suggests a role for genes mapping to 9p21-23 in the biology of favourable stage 4 tumours
Q57461758Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine
Q24563733Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21
Q55388589Contribution of Chromosome 9p21‐22 Deletion to the Progression of Human Renal Cell Carcinoma
Q34553243Creation of a national resource with linked genealogy and phenotypic data: the Veterans Genealogy Project
Q26782090Cross-species models of human melanoma
Q26781652Current State of Animal (Mouse) Modeling in Melanoma Research
Q37890286Current status of genome-wide association studies in cancer
Q59377158Cutaneous Melanoma in Childhood and Adolescence Shows Frequent Loss of INK4A and Gain of KIT
Q34155632Cyclin-dependent kinase 1 expression is inhibited by p16(INK4a) at the post-transcriptional level through the microRNA pathway
Q77747524Cytogenetic characterization of 22 human renal cell tumors in relation to a histopathological classification
Q40803117DNA Methylation Levels of Melanoma Risk Genes Are Associated with Clinical Characteristics of Melanoma Patients
Q36621655Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases. The Melanoma Cooperative Group.
Q88660687Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma
Q42415481Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma
Q87822617Deletion of the MGMT gene in familial melanoma
Q36317675Deoxyribonucleic acid (DNA) methyltransferase contributes to p16 promoter CpG island methylation in lung adenocarcinoma with smoking
Q34093068Differentiation therapy of human cancer: basic science and clinical applications
Q30203298Discussion of photoprotection, screening, and risk behaviors with children and grandchildren after melanoma genetic testing
Q34537149Disruption of oncogene/tumor suppressor networks during human carcinogenesis
Q55397223Dissecting the Mutational Landscape of Cutaneous Melanoma: An Omic Analysis Based on Patients from Greece.
Q37667766Doxycycline-Regulated p16MTS1 Expression Suppresses the Anchorage-Independence and Tumorigenicity of Breast Cancer Cell Lines that Lack Endogenous p16.
Q48092515Emerging Biomarkers in Cutaneous Melanoma.
Q35105665Epidemiology of malignant melanoma
Q33914379Evidence for a heritable predisposition to Chronic Fatigue Syndrome
Q36796431Evidence for an Environmental and Inherited Predisposition Contributing to the Risk for Global Tendinopathies or Compression Neuropathies in Patients With Rotator Cuff Tears
Q41947566Evidence for an inherited predisposition contributing to the risk for rotator cuff disease
Q40876018Expression and role of p27(kip1) in neuronal differentiation of embryonal carcinoma cells
Q38475192Expression of p 16 protein in prostatic adenocarcinomas, intraepithelial neoplasia, and benign/hyperplastic glands
Q35746653Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas
Q61804952Familial Melanoma: Diagnostic and Management Implications
Q38671435Familial Pancreatic Cancer and the Future of Directed Screening
Q80638828Familial aggregation of age-related macular degeneration in the Utah population
Q40900637Familial atypical multiple mole melanoma (FAMMM) syndrome: history, genetics, and heterogeneity
Q33880310Familial clustering of endometrial cancer in a well-defined population
Q28391589Familial malignant melanoma - overview
Q72874151Familial melanoma and p16--a hung jury
Q42370555Familial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history
Q37178980Familiality in brain tumors
Q71721193Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
Q60895673Frequent allelic losses of 9p21 markers and low incidence of mutations at p16(CDKN2) gene in non-Hodgkin lymphomas of B-cell lineage
Q48154511Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
Q35541602Frequent p16-independent inactivation of p14ARF in human melanoma
Q30322978Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.
Q74788541Gain of 9p in the pathogenesis of polycythemia vera
Q37137000Genetic Determinants of Cutaneous Melanoma Predisposition
Q28285050Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
Q31146223Genetic analysis of low BMI phenotype in the Utah Population Database
Q34568604Genetic and environmental factors in cutaneous malignant melanoma
Q37196687Genetic and environmental factors in head and neck cancer genesis
Q56893927Genetic and epidemiological risk factors for a malignant melanoma-predisposing phenotype: The great number of nevi
Q36612446Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.
Q48057808Genetic and functional evaluation of MITF as a candidate gene for cutaneous melanoma predisposition in pigs
Q36314787Genetic counseling in melanoma.
Q34783505Genetic insights into familial cancers-- update and recent discoveries
Q44633779Genetic markers of oral malignant melanoma analysed by fluorescence in situ hybridisation (FISH).
Q31889996Genetic mechanisms in squamous cell carcinoma of the head and neck
Q33681811Genetic predisposition to ocular melanoma
Q37544403Genetic risk factors for melanoma
Q37409032Genetics and genomics of melanoma
Q34449957Genetics of familial melanoma: 20 years after CDKN2A.
Q36563659Genetics of melanoma
Q36216850Genetics of primary intraocular tumors
Q40638691Genistein enhances the cisplatin-induced inhibition of cell growth and apoptosis in human malignant melanoma cells
Q45194373Genital and anorectal mucosal melanoma is associated with cutaneous melanoma in patients and in families
Q93270780Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
Q33814805Genome-wide association studies in cancer--current and future directions
Q34114293Genome-wide association study identifies five new breast cancer susceptibility loci
Q37341178Genome-wide association study identifies three loci associated with melanoma risk
Q41170258Genomic instability in 1p and human malignancies
Q56438333Germline Mutations of the CDKN2 Gene in UK Melanoma Families
Q28270834Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
Q36694476Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma
Q38359923HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.
Q34622718Hereditary Pancreatic Cancer
Q73412079High frequency of homozygous deletion and methylation of p16(INK4A) gene in oral squamous cell carcinomas
Q36619726High prevalence of p16 genetic alterations in head and neck tumours
Q36499211High- and low-penetrance cutaneous melanoma susceptibility genes.
Q57948954Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
Q39507954Homozygous deletions of p16(INK4) occur frequently in bilharziasis-associated bladder cancer
Q74266124How is the mutational status for tumor suppressors p53 and p16(INK4A) in MFH of the bone?
Q35435625Identification of PTEN mutations in metastatic melanoma specimens
Q36304955Identification, genetic testing, and management of hereditary melanoma.
Q36055045Impact of melanoma genetic test reporting on perceived control over melanoma prevention
Q40902031Inactivation of cyclin-dependent kinase inhibitor genes and development of human acute leukemias
Q40694393Inactivation of p16INK4a expression in malignant mesothelioma by methylation
Q73212035Increase in radiation sensitivity of human malignant melanoma cells by expression of wild-type p16 gene
Q59548753Increased Melanocytic Nevi and Nevus Density in a G-34T CDKN2A/p16 Melanoma-Prone Pedigree
Q36641299Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16INK4A, P14ARF or cdk4 genes
Q55029059Infrequent somatic mutation of the MTS1 gene in primary bladder carcinomas.
Q28289708Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
Q42182349Inhibitor of differentiation-4 (Id4) stimulates pigmentation in melanoma leading to histiocyte infiltration
Q40958606Inhibitors of cyclin-dependent kinase and cancer
Q54104985Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma.
Q41236837Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization
Q36502322Linkage analysis of extended high-risk pedigrees replicates a cutaneous malignant melanoma predisposition locus on chromosome 9q21.
Q42661850Linkage analysis of familial melanoma and chromosome 6 in 14 Australian kindreds
Q27852814Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines
Q73496858Loss of Heterozygosity at Chromosome 9p21 in Primary Neuroblastomas: Evidence for Two Deleted Regions
Q57287558Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors
Q52526330Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage.
Q41130523Loss of heterozygosity on chromosome 9q21 (p16 gene) uncommon in soft-tissue sarcomas
Q34020538MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations
Q37211362Malignant melanoma in the 21st century: the emerging molecular landscape
Q36695641Management of familial melanoma
Q55078672Mapping of melanoma modifier loci in RET transgenic mice.
Q35098019Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway
Q34020543Melanocortin-1 receptor variant R151C modifies melanoma risk in Dutch families with melanoma.
Q38730348Melanocytic nevi and melanoma: unraveling a complex relationship
Q38646092Melanoma Epidemiology and Prevention
Q37334503Melanoma genetic counseling and test reporting improve screening adherence among unaffected carriers 2 years later
Q33726956Melanoma genetics and the development of rational therapeutics
Q50501346Melanoma in adolescents: a case-control study of risk factors in Queensland, Australia.
Q36712918Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants
Q56435948Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK
Q35137163Melanoma: Molecular Pathogenesis and Therapeutic Management
Q46071071Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors
Q77441892Mitotic cyclins and cyclin-dependent kinases in melanocytic lesions
Q33739273Modeling human lung cancer in mice: similarities and shortcomings
Q35844857Modeling inheritance of malignant melanoma with DNA markers in Sinclair swine
Q57781575Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma
Q77619102Molecular biology of human melanoma development and progression
Q41528285Molecular diagnosis of pancreas carcinoma
Q41262814Molecular genetic approaches to non-melanoma and melanoma skin cancer
Q22010017Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1
Q26795735Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets
Q57269052Mutation analysis of theCDKN2A promoter in Australian melanoma families
Q40978415Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma
Q24649783Mutation testing in melanoma families: INK4A, CDK4 and INK4D
Q41332196Mutational analysis of CDKN2 (CDK4I/MTS1) gene in tissues and cell lines of human prostate cancer
Q42631112Mutational analysis of CDKN2A gene in a group of 390 larynx cancer patients
Q70888925Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas
Q73258368Mutational analysis of the p16 gene in human neuroblastomas
Q52537796Mutations associated with familial melanoma impair p16INK4 function.
Q47691368Mutations in context: implications of BRCA testing in diverse populations
Q34107950New developments in melanoma genetics
Q55513422New susceptibility loci for cutaneous melanoma risk and progression revealed using a porcine model.
Q36643968No germline mutations in CDKN2A (p16) in patients with squamous cell cancer of the head and neck and second primary tumours.
Q64108542Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors
Q24652510Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
Q51000569Nuclear morphometry, immunohistochemical staining with Ki-67 antibody and mitotic index in the assessment of proliferative activity and prognosis of primary malignant melanomas of the skin.
Q57228797Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
Q61978803P16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem
Q35739446POLE mutations in families predisposed to cutaneous melanoma
Q26865736Pathways and therapeutic targets in melanoma
Q33638941Perceived risk following melanoma genetic testing: a 2-year prospective study distinguishing subjective estimates from recall
Q35574952Pharmacogenetic candidate genes for melanoma
Q24806439Polymorphisms of the BRAF gene predispose males to malignant melanoma
Q35180844Prevalence and predictors of germline CDKN2A mutations for melanoma cases from Australia, Spain and the United Kingdom
Q52857616Prevalence of 9p21 deletions in UK melanoma families.
Q34694716Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling
Q37409666Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population
Q41520554Prognostic Factors in Malignant Melanoma
Q33538422Prognostic implications of expression of the cell cycle inhibitor protein p27Kip1.
Q35856673Promoter methylation of p16 and RASSF1A genes may contribute to the risk of papillary thyroid cancer: A meta-analysis
Q74020575Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors
Q41488826Recent insights into the functions of the retinoblastoma susceptibility gene product
Q34138129Recessive oncogenes: current status
Q92106577Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective
Q41095685Retroviral introduction of the p16 gene into murine cell lines to elicit marked antiproliferative effects
Q58283406Risk of cutaneous melanoma associated with a family history of the disease
Q41710434Role of the cyclin-dependent kinase inhibitor CDKN2A in familial melanoma
Q45150040Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL).
Q36615991Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours.
Q35840024Selection criteria for genetic assessment of patients with familial melanoma
Q73836193Selective deletion of p14(ARF) exon 1beta of the INK4a locus in oral squamous cell carcinomas of Indians
Q36007325Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death.
Q39737975Signatures of mutation and selection in the cancer genome
Q34218180Significant evidence for a heritable contribution to cancer predisposition: a review of cancer familiality by site
Q73631577Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck
Q35019588Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats.
Q44490652Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
Q56893701Sporadic multiple primary melanoma cases:CDKN2Agermline mutations with a founder effect
Q35015059Strong evidence for a genetic contribution to late-onset Alzheimer's disease mortality: a population-based study
Q24316348Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
Q27639756Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity
Q40955001Suppression of Ras-mediated NIH3T3 transformation by p19ARF does not involve alterations of cell growth properties
Q52539731Targeting the duality of cancer.
Q40019366Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma
Q36437816The CDKN2A (p16) gene and human cancer.
Q40483208The CDKN2A database: Integrating allelic variants with evolution, structure, function, and disease association
Q28145080The INK4 family of cell cycle inhibitors in cancer
Q33540080The INK4A/ARF locus and its two gene products
Q35146563The INK4a/ARF locus and melanoma
Q77362259The INK4a/ARF tumor suppressor: one gene--two products--two pathways
Q79435498The M53I mutation in CDKN2A is a founder mutation that predominates in melanoma patients with Scottish ancestry
Q45955388The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis.
Q60909457The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities
Q34804764The RB and p53 pathways in cancer
Q74116641The Xiphophorus-derived antibody, XMEL, shows sensitivity and specificity for human cutaneous melanoma but is not a prognostic marker
Q38261369The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer
Q41226231The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
Q36785968The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma
Q35938292The effects of transferring tumor suppressor gene p16INK4A to p16INK4A-deleted cancer cells
Q40525768The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity
Q33813969The genetics of hereditary melanoma and nevi. 1998 update
Q35190150The genetics of malignant melanoma: lessons from mouse and man.
Q73256080The genetics of melanoma
Q38718904The genomic landscape of cutaneous melanoma
Q64240247The interplay of CDK4 and CDK6 in melanoma
Q41175188The mammalian cell cycle in normal and abnormal growth
Q54317457The p16INK4a/CDKN2A tumor suppressor and its relatives.
Q54791332The presence of candidate tumor suppressor gene loci at chromosome 3p for oral squamous cell carcinomas.
Q38165149The role of polo-like kinase 1 in carcinogenesis: cause or consequence?
Q73582017The search for cancer risk factors: when can we stop looking?
Q40223298The synergic effect of HPV infection and epigenetic anomaly of the p16 gene in the development of cervical cancer
Q26782222Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?
Q40935835Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus
Q24793291Transforming growth factor-beta and breast cancer: Cell cycle arrest by transforming growth factor-beta and its disruption in cancer
Q47557700Truncating mutations of TP53AIP1 gene predispose to cutaneous melanoma.
Q40494447Tumor Suppression: Lessons in p16 from phylum Falconium
Q38306855Tumour suppressors and cellular senescence
Q41335802Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
Q42628813Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.
Q35787900UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
Q34401911Unaffected family members report improvements in daily routine sun protection 2 years following melanoma genetic testing
Q35739822Unfolding the mutational landscape of human melanoma
Q37710143Uptake of genetic counseling, genetic testing and surveillance in hereditary malignant melanoma (CDKN2A) in Norway
Q38089070Use of SNPs in cancer predisposition analysis, diagnosis and prognosis: tools and prospects.
Q47228666Use of a genealogical database demonstrates heritability of pulmonary fibrosis
Q34716087Use of human tissue to assess the oncogenic activity of melanoma-associated mutations
Q36909926Utilizing of Adsorptive Transfer Stripping Technique Brdicka Reaction for Determination of Metallothioneins Level in Melanoma Cells, Blood Serum and Tissues.
Q40062598Variants of the MATP/SLC45A2 gene are protective for melanoma in the French population
Q37287025Wnt-signaling and senescence: A tug of war in early neoplasia?
Q55476928cDNA expression array reveals heterogeneous gene expression profiles in three glioblastoma cell lines.
Q60077083p16 and melanoma
Q77402846p16INK4a inactivation is not frequent in uncultured sporadic primary cutaneous melanoma
Q41047190p16ink4a gene and hematological malignancies.
Q52540552p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.

Search more.