Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma.

scientific article published on 4 August 2016

Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1042141384
P356DOI10.1007/S13277-016-5274-9
P698PubMed publication ID27492457

P50authorAleksi ŠedoQ10768979
Petr BušekQ51030360
Zuzana ZemanováQ52150793
P2093author name stringEva Balaziova
Evzen Krepela
Robert Tomas
Martin Syrucek
Jaromir Belacek
Marek Hilser
Ivana Matrasova
P2860cites workIntegrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancerQ28181638
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cellsQ31018027
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies.Q31095363
Molecular characterization of human breast tumor vascular cellsQ33327647
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicityQ33555573
Tumoral immune suppression by macrophages expressing fibroblast activation protein-α and heme oxygenase-1.Q33557006
Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cellsQ33570788
Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinomaQ33654184
Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse modelQ34049485
Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer.Q34816275
Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysisQ35182174
Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastomaQ35678312
Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasionQ35749727
Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterationsQ35754294
Genetic pathways to primary and secondary glioblastomaQ35757144
Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells.Q35862799
A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in miceQ36470281
Fibrocytes: emerging effector cells in chronic inflammationQ36690680
Dipeptidyl peptidase-IV enzymatic activity bearing molecules in human brain tumors--good or evil?Q36992442
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in miceQ37452281
The brain tumor microenvironment.Q37858940
Fibroblast activation protein-α: a key modulator of the microenvironment in multiple pathologies.Q38011389
Fibroblast activation protein in remodeling tissuesQ38029752
Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features.Q38074100
Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy.Q38182507
Brain mesenchymal stem cells: The other stem cells of the brain?Q38207598
Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activityQ38498538
Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy.Q38797421
Effect of cancer-associated fibroblasts on the migration of glioma cells in vitroQ38906398
Fibroblast activation protein-α promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanismsQ39137886
Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.Q39538239
SOX2 expression and amplification in gliomas and glioma cell linesQ39553321
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alphaQ39635625
Expression and role of the cell surface protease seprase/fibroblast activation protein-α (FAP-α) in astroglial tumorsQ39667924
TWIST1 promotes invasion through mesenchymal change in human glioblastomaQ39677871
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screensQ39842716
Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer.Q40151296
Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancerQ40566263
Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor α2-antiplasminQ43090748
Fibroblast activation protein alpha identifies mesenchymal stromal cells from human bone marrowQ46569125
Tumor immunotherapy targeting fibroblast activation protein, a product expressed in tumor-associated fibroblastsQ46831061
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology.Q48405360
Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesisQ50324744
Glioblastoma-associated stromal cells (GASCs) from histologically normal surgical margins have a myofibroblast phenotype and angiogenic properties.Q55461236
Matrix metalloproteinase 2 attenuates brain tumour growth, while promoting macrophage recruitment and vascular repair.Q55463274
Expression and enzymatic activity of dipeptidyl peptidase-IV in human astrocytic tumours are associated with tumour grade.Q55467813
Collagens, integrins and the mesenchymal drift in glioblastomas: A comparison of biopsy specimens, spheroid and early monolayer culturesQ55481758
Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans isletsQ59446928
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)13961-13971
P577publication date2016-08-04
P1433published inTumor BiologyQ15757842
P1476titleFibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma
P478volume37

Reverse relations

cites work (P2860)
Q100751371Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy
Q47285215Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts
Q89831540Fibroblast Activation Protein Regulates Lesion Burden and the Fibroinflammatory Response in Apoe-Deficient Mice in a Sexually Dimorphic Manner
Q90323312Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
Q30241921Intercellular crosstalk in human malignant melanoma
Q47660087Low expression of miR-30a-5p induced the proliferation and invasion of oral cancer via promoting the expression of FAP.
Q41592822MM-BMSCs induce naïve CD4+ T lymphocytes dysfunction through fibroblast activation protein α
Q59446927Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics

Search more.