Fibroblast Activation Protein Regulates Lesion Burden and the Fibroinflammatory Response in Apoe-Deficient Mice in a Sexually Dimorphic Manner

scientific article published on 19 February 2020

Fibroblast Activation Protein Regulates Lesion Burden and the Fibroinflammatory Response in Apoe-Deficient Mice in a Sexually Dimorphic Manner is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.AJPATH.2020.01.004
P932PMC publication ID7237832
P698PubMed publication ID32084369

P50authorEllen PuréQ88789171
P2093author name stringJames Monslow
Leslie Todd
Richard K Assoian
John E Chojnowski
Priya K Govindaraju
P2860cites workFibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblastsQ22010913
Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alphaQ28243456
The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activationQ28360727
A major role for VCAM-1, but not ICAM-1, in early atherosclerosisQ28365883
Heart disease and stroke statistics--2011 update: a report from the American Heart AssociationQ29547236
Vascular Smooth Muscle Cells in AtherosclerosisQ30277316
Smooth muscle cell phenotypic switching in atherosclerosisQ30418243
Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flowQ30438030
Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosisQ30494712
Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sitesQ33311561
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicityQ33555573
Tumoral immune suppression by macrophages expressing fibroblast activation protein-α and heme oxygenase-1.Q33557006
Arterial stiffness and cardiovascular events: the Framingham Heart StudyQ33720064
Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancersQ33801657
Targeted disruption of mouse fibroblast activation proteinQ33961797
Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis.Q34307809
Macrophages in atherosclerosis: a dynamic balance.Q34368005
Lifestyle effects on hematopoiesis and atherosclerosisQ34668164
Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer.Q34816275
Vascular stiffness and increased pulse pressure in the aging cardiovascular systemQ35159119
Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromataQ35492880
Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.Q35573469
Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytesQ35630052
Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells.Q35862799
Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque ruptureQ35993294
Heme oxygenase-1, oxidation, inflammation, and atherosclerosisQ36103851
Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substratesQ36305029
Sexual dimorphism in rodent models of hypertension and atherosclerosisQ36346910
Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in MiceQ36778823
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in miceQ36799271
Arterial stiffness as a risk factor for coronary atherosclerosisQ36945227
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigrationQ36957712
Interfering with extracellular matrix degradation to blunt inflammationQ37112292
Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk.Q37266665
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in miceQ37452281
Cardiovascular risk in menopausal women and prevalent related co-morbid conditions: facing the post-Women's Health Initiative era.Q37584800
Cyclooxygenase-2 in endothelial and vascular smooth muscle cells restrains atherogenesis in hyperlipidemic miceQ37735500
TGFβ signaling and cardiovascular diseasesQ37976673
Estrogens and atherosclerosis: insights from animal models and cell systemsQ37987111
Fibroblast activation protein in remodeling tissuesQ38029752
Pathophysiology of atherosclerosis plaque progressionQ38094421
Use of Mouse Models in Atherosclerosis ResearchQ38601635
Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma.Q38753773
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alphaQ39635625
Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosisQ40334332
FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 SignalingQ40740027
Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffeningQ41929558
CD44 expressed on both bone marrow-derived and non-bone marrow-derived cells promotes atherogenesis in ApoE-deficient miceQ46638079
Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificityQ46946377
Extracellular matrix directs phenotypic heterogeneity of activated fibroblastsQ47285215
Prolyl hydroxylase 3 overexpression accelerates the progression of atherosclerosis in ApoE-/- mice.Q53142780
Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction.Q53363037
Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging.Q54175877
Fibroblast activation protein: A cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosisQ60617867
Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12Q64235518
Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosisQ64377816
Estrogen in vascular smooth muscle cells: A friend or a foe?Q64921426
Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham populationQ70009095
Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal originQ70463981
Expression of the adhesion molecules ICAM, VCAM, and ELAM in the arteriosclerotic plaqueQ71467460
Targeting fibroblast activation protein in cancer - Prospects and caveatsQ88717620
The role of smooth muscle cells in plaque stability: Therapeutic targeting potentialQ93119377
P921main subjectsexual dimorphismQ181497
P577publication date2020-02-19
P1433published inThe American Journal of PathologyQ4744259
P1476titleFibroblast Activation Protein Regulates Lesion Burden and the Fibroinflammatory Response in Apoe-Deficient Mice in a Sexually Dimorphic Manner

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