Sexual dimorphism in rodent models of hypertension and atherosclerosis

scientific article

Sexual dimorphism in rodent models of hypertension and atherosclerosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1476-5381.2012.02036.X
P932PMC publication ID3481039
P698PubMed publication ID22582712
P5875ResearchGate publication ID224955616

P2093author name stringAmrita Ahluwalia
Kristen J Bubb
Rayomand S Khambata
P2860cites workA human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidaseQ22254730
Prevalence of Hypertension in the US Adult Population : Results From the Third National Health and Nutrition Examination Survey, 1988-1991Q22306385
Atherosclerosis — An Inflammatory DiseaseQ26776972
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialQ27860743
Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lungQ28117226
Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II)Q28193306
Lessons from rat models of hypertension: from Goldblatt to genetic engineeringQ28284753
Dietary restriction in pregnant rats causes gender-related hypertension and vascular dysfunction in offspringQ28345440
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient miceQ28507847
Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 geneQ28588388
Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte contentQ71102869
WHHL-rabbit: a low density lipoprotein receptor-deficient animal model for familial hypercholesterolemiaQ71298520
Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemiaQ71659785
Gender and Dietary NaCl in Spontaneously Hypertensive and Wistar-Kyoto RatsQ71959197
Antihypertensive effects of a novel endothelin-A receptor antagonist in ratsQ72282301
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial treeQ72689998
Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient miceQ72996209
Placental insufficiency leads to development of hypertension in growth-restricted offspringQ73094626
Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin systemQ73371712
Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in ratsQ73662634
Differential response to myocardial reperfusion injury in eNOS-deficient miceQ74065248
C3H apoE(-/-) mice have less atherosclerosis than C57BL apoE(-/-) mice despite having a more atherogenic serum lipid profileQ74106071
Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient miceQ77340592
Rat models of hypertension, cardiac hypertrophy and failureQ77384270
Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgeneQ77801094
Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHRQ77945673
Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1)Q79214234
Ovariectomy augments hypertension in aging female Dahl salt-sensitive ratsQ80508770
Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosisQ82102394
Endothelial dysfunction and oxidative stress during estrogen deficiency in spontaneously hypertensive ratsQ95719565
Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats.Q50972885
Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats.Q51510294
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.Q51556849
Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice.Q51563866
Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats.Q51688078
Both estrogen receptor subtypes, alpha and beta, attenuate cardiovascular remodeling in aldosterone salt-treated rats.Q51750506
Sexual dimorphism in the renin-angiotensin system in aging spontaneously hypertensive rats.Q51790440
Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring.Q52009540
Modest maternal protein restriction fails to program adult hypertension in female rats.Q53620099
2007 Guidelines for the Management of Arterial HypertensionQ56970780
Adult Rabbit Offspring of Mothers With Secondary Hypertension Have Increased Blood PressureQ61625258
Estrogen attenuation of the development of hypertension in spontaneously hypertensive ratsQ67690023
Sexual dimorphism of blood pressure in spontaneously hypertensive rats is androgen dependentQ68180404
Endothelium-dependent relaxation in estrogen-treated spontaneously hypertensive ratsQ68288012
Hypertension in the spontaneously hypertensive rat is linked to the Y chromosomeQ68904511
Sex difference in the development of deoxycorticosterone-salt hypertension in the ratQ69751535
Gonadectomy abolishes the sexual dimorphism in DOC-salt hypertension in the ratQ69778472
Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham populationQ70009095
Ovariectomy, social status, and atherosclerosis in cynomolgus monkeysQ70069190
Postmenopausal estrogen use, cigarette smoking, and cardiovascular morbidity in women over 50. The Framingham StudyQ70102309
Sexual dimorphism in renal function and hormonal status of New Zealand genetically hypertensive ratsQ70112375
Electrolyte and water balance in young spontaneously hypertensive ratsQ70513580
Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive ratsQ70670469
Increased expression of endothelin-1 gene in blood vessels of deoxycorticosterone acetate-salt hypertensive ratsQ70744732
Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats.Q50910155
17 beta-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice.Q50917501
Sexual dimorphism of sodium-sensitive renal-wrap hypertension.Q50931287
Retardation in the development of spontaneous hypertension in SH rats by gonadectomyQ50941574
Heart disease and stroke statistics--2011 update: a report from the American Heart AssociationQ29547236
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participantsQ29614188
Effect of in utero and early-life conditions on adult health and diseaseQ29615797
Increased aortic atherosclerotic plaque development in female apolipoprotein E-null mice is associated with elevated thromboxane A2 and decreased prostacyclin production.Q30423459
Testosterone and blood pressure regulationQ33322436
Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic rootQ33580505
Generation and analysis of mice lacking the chemokine fractalkineQ33941435
Sex chromosome effects unmasked in angiotensin II-induced hypertensionQ34002303
Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosisQ34021675
Aromatase--a brief overviewQ34112633
Cardiac and vascular changes in elderly atherosclerotic mice: the influence of genderQ34114338
Chemokines, chemokine receptors and hematopoiesisQ34118764
Monocyte chemoattractant protein-1 in human atheromatous plaquesQ34203056
Postmenopausal hypertension: role of the Renin-Angiotensin systemQ34402355
Estrogen replacement therapy, atherosclerosis, and vascular functionQ34541886
Renin angiotensin system and gender differences in the cardiovascular systemQ34541898
Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors? Position paper from the working group on coronary pathophysiology and microcirculation of the European Society of CardiologyQ34682870
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanismQ34772312
Hypercholesterolaemia and its managementQ34811362
Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats.Q34943188
Gender differences in cardiovascular disease: hormonal and biochemical influences.Q35023822
Angiotensin (1-7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive ratsQ35093093
Y is there a risk to being male?Q35114588
Gender, sex hormones, and vascular toneQ35621001
Antihypertensive effect of an endothelin receptor antagonist in DOCA-salt spontaneously hypertensive ratsQ35872696
Hormone replacement therapy and cardiovascular disease: what went wrong and where do we go from here?Q35914826
Animal models of hypertension: an overviewQ36244652
Anatomical differences and atherosclerosis in apolipoprotein E-deficient mice with 129/SvEv and C57BL/6 genetic backgroundsQ36296729
Role of the gonads in hypertension-prone ratsQ36358409
Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclinQ36410132
Estrogen and hypertensionQ36590813
Elevated blood pressures in mice lacking endothelial nitric oxide synthase.Q36689446
Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injuryQ36805323
Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis ratsQ36807861
Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet.Q36948052
VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice.Q37089091
Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factorQ37168823
Sex differences in the developmental origins of hypertension and cardiorenal diseaseQ37200124
Dose-dependent cardiac effect of oestrogen replacement in mice post-myocardial infarctionQ37255529
Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient miceQ37322112
Absence of P-selectin delays fatty streak formation in miceQ37364649
The combined role of P- and E-selectins in atherosclerosisQ37387115
Cardiovascular disease and androgens: a reviewQ37634727
Inflammation in atherosclerosis: transition from theory to practiceQ37672113
Oxidative stress and endothelial dysfunction in hypertensionQ37867946
Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studiesQ37916895
Y are males so difficult to understand?: a case where "X" does not mark the spotQ37980113
Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertensionQ38505941
Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary diseaseQ38520485
Estrogen therapy and coronary-artery calcification.Q40201900
Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27.Q41078608
The emergence of mouse models of atherosclerosis and their relevance to clinical researchQ41582283
Pre-eclampsia and offspring's blood pressure, cognitive ability and physical development at 17-years-of-ageQ41942031
Sex as a profound modifier of atherosclerotic lesion development in apolipoprotein E-deficient mice with different genetic backgrounds.Q42165280
Gender differences in the attenuation of salt-induced hypertension by angiotensin (1-7).Q43628577
Ovarian hormones modulate endothelin-1 vascular reactivity and mRNA expression in DOCA-salt hypertensive ratsQ43744785
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health studyQ43776201
Abnormal vascular function and hypertension in mice deficient in estrogen receptor betaQ43859357
1A-779 attenuates angiotensin-(1-7) depressor response in salt-induced hypertensive ratsQ43868760
Gender differences in vascular expression of endothelin and ET(A)/ET(B) receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertensionQ44130182
The effect of 17beta-estradiol on endothelial and inflammatory markers in postmenopausal women: a randomized, controlled trialQ44205516
The atheroprotective effect of 17 beta-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice.Q44249441
Gender-linked hypertension in offspring of lard-fed pregnant ratsQ44269042
Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice: comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement).Q44542257
Postovariectomy hypertension is linked to increased renal AT1 receptor and salt sensitivity.Q44650529
Role of sex, gonadectomy and sex hormones in the development of nitric oxide inhibition-induced hypertensionQ44881011
Sex differences in the development of angiotensin II-induced hypertension in conscious miceQ45207394
Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.Q45256231
Gender differences in atherosclerosis: possible role of nitric oxide.Q45986763
Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice.Q46030815
Brief angiotensin converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure long-termQ46089734
Which Sry locus is the hypertensive Y chromosome locus?Q46202044
Gender differences in systemic inflammation and atheroma formation following Porphyromonas gingivalis infection in heterozygous apolipoprotein E-deficient miceQ46273367
Sexual dimorphism in angiotensin II-induced hypertension and vascular alterationsQ46494112
Sex differences in the pressor response to angiotensin II when the endogenous renin-angiotensin system is blockedQ46765345
Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphismQ46765373
Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel Keys LectureQ46836594
Androgens augment renal vascular responses to ANG II in New Zealand genetically hypertensive ratsQ46937432
A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive ratsQ47442057
Estrogen receptor-alpha mediates estrogen protection from angiotensin II-induced hypertension in conscious female miceQ48349334
24-h ambulatory blood pressure in 352 normal Danish subjects, related to age and gender.Q50559727
Menopause and risk of cardiovascular disease: the Framingham study.Q50870268
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectatherosclerosisQ12252367
arterial hypertensionQ41861
sexual dimorphismQ181497
P304page(s)298-312
P577publication date2012-09-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleSexual dimorphism in rodent models of hypertension and atherosclerosis
P478volume167

Reverse relations

cites work (P2860)
Q37545061Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
Q42388974Biological sex themed section: incorporating the female dimension into cardiovascular pharmacology
Q28081462Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes
Q46730696Earlier onset of diabesity-Induced adverse cardiac remodeling in female compared to male mice
Q26866520Effects of biological sex on the pathophysiology of the heart
Q36467010Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression
Q89831540Fibroblast Activation Protein Regulates Lesion Burden and the Fibroinflammatory Response in Apoe-Deficient Mice in a Sexually Dimorphic Manner
Q58559217Histone demethylase LSD1 and biological sex: impact on blood pressure and aldosterone production
Q26866656Hypertension: what's sex got to do with it?
Q35538600Mitochondrial maintenance failure in aging and role of sexual dimorphism
Q90569212Modeling Sex Differences in the Renin Angiotensin System and the Efficacy of Antihypertensive Therapies
Q59347457Pathophysiology of Hypertension
Q35641067Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats
Q47649529Sex differences in the role of phospholipase A2 -dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs.
Q38205052Sexually dimorphic actions of glucocorticoids: beyond chromosomes and sex hormones.
Q33782669Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta.
Q51124779The hypotensive effect of the ruthenium complex [Ru(terpy)(bdq)NO]³⁺ is higher in male than in female spontaneously hypertensive rats (SHR).
Q92388425Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling
Q89518311α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux