Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats

scientific article published on 26 May 2015

Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1027515D
P356DOI10.1371/JOURNAL.PONE.0127515
P932PMC publication ID4444272
P698PubMed publication ID26010093
P5875ResearchGate publication ID277881633

P50authorTadeu Uggere AndradeQ55318687
Rogerio F RibeiroQ82255268
Adriana K CarmonaQ92072817
P2093author name stringA Z Lamas
N S Bissoli
S A Gouvea
G R Abreu
M R Moyses
M F Alves
I F Caliman
P L M Dalpiaz
P2860cites workHypertension: what's sex got to do with it?Q26866656
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Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expressionQ28583180
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Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseasesQ33677369
Gender differences in the regulation of blood pressureQ33947308
Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressureQ33951980
Sex hormones as potential modulators of vascular function in hypertensionQ34074830
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Androgen regulation of rat renal angiotensinogen messenger RNA expressionQ34574911
Blood pressure and mesenteric vascular reactivity in spontaneously hypertensive rats 7 months after gonadectomyQ34815888
Vasopeptidase inhibition: a double-edged sword?Q35080519
Angiotensin (1-7) receptor antagonism equalizes angiotensin II-induced hypertension in male and female spontaneously hypertensive ratsQ35093093
Pharmacological modulation of cardiovascular remodeling: a guide to heart failure therapyQ35584025
ACE2, a new regulator of the renin-angiotensin systemQ35756519
Strategies and methods for research on sex differences in brain and behaviorQ35993249
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Sex differences in angiotensin-converting enzyme modulation of Ang (1-7) levels in normotensive WKY ratsQ36853835
Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibitionQ37089449
The role of oxidative stress and lipid peroxidation in ventricular remodeling induced by tobacco smoke exposure after myocardial infarction.Q37261274
Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathyQ50502374
Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive ratsQ50910155
Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension.Q51611884
Use of tibial length to quantify cardiac hypertrophy: application in the aging rat.Q52434004
Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats.Q53120561
Sex differences in the effectiveness of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in patients with congestive heart failure - A population studyQ58666697
Modulation of blood pressure and the renin-angiotensin system in transgenic and spontaneously hypertensive rats afer ovariectomyQ72364410
Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin systemQ73371712
The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractilityQ73457987
Estrogen protects transgenic hypertensive rats by shifting the vasoconstrictor-vasodilator balance of RASQ74065824
Na(+)influx via Na(+)/H(+)exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytesQ78050105
Local RAS and inflammatory factors are involved in cardiovascular hypertrophy in spontaneously hypertensive ratsQ81666701
ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarctionQ84314698
Chronic treatment with the G protein-coupled receptor 30 agonist G-1 decreases blood pressure in ovariectomized mRen2.Lewis rats.Q37281123
Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic miceQ37350650
The chronic blockade of angiotensin I-converting enzyme eliminates the sex differences of serum cytokine levels of spontaneously hypertensive rats.Q37371365
Sex-related differences in myocardial remodeling.Q37707569
Gender and the renin-angiotensin-aldosterone systemQ37770594
Anti-Hypertensive Drugs Have Different Effects on Ventricular Hypertrophy RegressionQ37776417
Sex differences in hypertension: contribution of the renin-angiotensin systemQ38026265
The "his and hers" of the renin-angiotensin systemQ38062455
Gender differences in sarcoplasmic reticulum calcium loading after isoproterenolQ42446779
A new piece in the hypertension puzzle: central blood pressure regulation by sex steroidsQ42660396
Ovariectomy does not affect the cardiac sympathovagal balance of female SHR but estradiol doesQ42859547
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarctionQ43266255
17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats.Q43277846
Gonadal effects on plasma ACE activity in miceQ43889869
Characterization of cardiac hypertrophy and heart failure due to volume overload in the rat.Q44280991
Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2. Lewis rat.Q44521138
Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in miceQ44760479
Sex differences in the development of angiotensin II-induced hypertension in conscious miceQ45207394
Myocardial infarction increases ACE2 expression in rat and humans.Q45238600
Stimulation of cardiac apoptosis in ovariectomized hypertensive rats: potential role of the renin-angiotensin system.Q45953342
Sex differences in expression of calcium-handling proteins and beta-adrenergic receptors in rat heart ventricleQ46406161
A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity.Q46525732
The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive ratsQ46540535
Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytesQ46715078
Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat.Q46735122
Effects of losartan in women with hypertension and left ventricular hypertrophy: results from the Losartan Intervention for Endpoint Reduction in Hypertension StudyQ46765330
Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiologyQ46771630
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e0127515
P577publication date2015-05-26
P1433published inPLOS OneQ564954
P1476titleSex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats
P478volume10

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cites work (P2860)
Q94930122Androgen sensitivity gateway to COVID-19 disease severity
Q106638260COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms
Q99637359COVID-19 in adult patients with pre-existing chronic cardiac, respiratory and metabolic disease: a critical literature review with clinical recommendations
Q42336195Correction: Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats
Q95828245Impact of sex and gender on COVID-19 outcomes in Europe
Q98774280Is Sex a Determinant of COVID-19 Infection? Truth or Myth?
Q97568408Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic
Q99612915SARS-CoV-2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors
Q38924269Sex differences in obesity-induced hypertension and vascular dysfunction: a protective role for estrogen in adipose tissue inflammation?
Q94476163The Dermatologist's Perspective: Why is COVID-19 mortality lower in females than males?

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