Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta.

scientific article

Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1177/1470320316674875
P932PMC publication ID5465964
P698PubMed publication ID27765882

P50authorJay Sharan MishraQ83443172
Gary D. V. HankinsQ110265413
Sathish KumarQ57008736
P2860cites workHeart Disease and Stroke Statistics--2013 Update: A Report From the American Heart AssociationQ22306356
NIH Image to ImageJ: 25 years of image analysisQ23319322
Hypertension: what's sex got to do with it?Q26866656
International union of pharmacology. XXIII. The angiotensin II receptorsQ28138041
Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiologyQ28292037
Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo StudyQ33891351
Sex hormones as potential modulators of vascular function in hypertensionQ34074830
Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. Association with vascular cytokine releaseQ34255810
Role of the angiotensin AT2 receptor in blood pressure regulation and therapeutic implicationsQ34285593
Racial variation in sex steroid hormones and the insulin-like growth factor axis in umbilical cord blood of male neonatesQ34449580
Developmental changes in AT1 and AT2 receptor-protein expression in ratsQ34557839
Sex and gender differences in control of blood pressureQ34820497
A cross-sectional and 10-year prospective study of postmenopausal estrogen therapy and blood pressure, renal function, and albuminuria: the Rancho Bernardo StudyQ35068814
Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanismQ35079544
Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspringQ35127684
Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female ratsQ35166544
Prevalence and risk factors of hypertension among pre- and post-menopausal women: a cross-sectional study in a rural area of northeast ChinaQ35538943
Protein restriction during pregnancy induces hypertension in adult female rat offspring--influence of oestradiolQ35737038
Prenatal testosterone exposure leads to hypertension that is gonadal hormone-dependent in adult rat male and female offspringQ36000616
Sexual dimorphism in rodent models of hypertension and atherosclerosisQ36346910
Elevated Testosterone Reduces Uterine Blood Flow, Spiral Artery Elongation, and Placental Oxygenation in Pregnant Rats.Q36576567
Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat OffspringQ36734075
Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out miceQ36742531
Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant ratsQ37138957
17Beta-estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized ratsQ37338917
Gender Difference in Blood pressure, Blood Sugar, and Cholesterol in Young Adults with Comparable Routine Physical Exertion.Q37487543
Angiotensin II type 2 receptor agonists: where should they be applied?Q37986143
Sex differences in hypertension: contribution of the renin-angiotensin systemQ38026265
The "his and hers" of the renin-angiotensin systemQ38062455
Effects of hormone therapy on blood pressureQ38255514
Hyperandrogenism and Insulin Resistance, Not Changes in Body Weight, Mediate the Development of Endothelial Dysfunction in a Female Rat Model of Polycystic Ovary Syndrome (PCOS).Q40591264
Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilationQ40851849
Soluble ecto-domain mutant of thyrotropin (TSH) receptor incapable of binding TSH neutralizes the action of thyroid-stimulating antibodies from Graves' patientsQ41068421
Hypertension in Reproductive-Aged Women With Polycystic Ovary Syndrome and Association With ObesityQ41646937
High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive ratsQ41953838
Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilationQ43212328
Androgen dependent expression of AT1 receptor and its regulation of anion secretion in rat epididymisQ43846599
Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs.Q43852967
Gonadal effects on plasma ACE activity in miceQ43889869
Forearm vasodilator response to angiotensin II in elderly women receiving candesartan: role of AT(2)- receptorsQ43976707
Estrogen upregulates renal angiotensin II AT(2) receptorsQ44174214
Gender differences in cardiac ACE expression are normalized in androgen-deprived male miceQ44183021
Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusionQ45063924
The renin-angiotensin system plays a major role in voiding dysfunction of ovariectomized rats.Q45126636
Pregnancy hormone concentrations across ethnic groups: implications for later cancer riskQ46533342
Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17beta-oestradiol regulation of renal pathology in renal wrap hypertension in ratsQ46736490
A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive ratsQ47442057
Estrogen modulates AT1 receptor gene expression in vitro and in vivoQ47957759
Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats.Q51139374
Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension.Q51376910
The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent.Q51396235
Enhanced angiotensin II type 2 receptor mechanisms mediate decreases in arterial pressure attributable to chronic low-dose angiotensin II in female rats.Q51688078
Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries.Q52536660
Sex differences in the effectiveness of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in patients with congestive heart failure - A population studyQ58666697
Localization of the ANG II type 2 receptor in the microcirculation of skeletal muscleQ77328105
Estrogen regulation of angiotensin-converting enzyme mRNAQ77945642
Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHRQ77945673
Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker ratsQ79400718
Pressure-radius relationship in large blood vessels of manQ79443386
Why can't a woman be more like a man?: Is the angiotensin type 2 receptor to blame or to thank?Q81798099
P4510describes a project that usesImageJQ1659584
P433issue4
P921main subjectaortaQ101004
testosteroneQ27863114
P577publication date2016-10-19
P1433published inJournal of the Renin-Angiotensin-Aldosterone SystemQ6296180
P1476titleTestosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta
P478volume17

Reverse relations

cites work (P2860)
Q927080536β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice
Q38753813Effects of Intrauterine Growth Restriction and Female Sex on Future Blood Pressure and Cardiovascular Disease
Q39395252Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
Q90482437Mechanisms of Sex Disparities in Cardiovascular Function and Remodeling
Q92106758Neonatal Intermittent Hypoxia Induces Lasting Sex-Specific Augmentation of Rat Microglial Cytokine Expression
Q88960880Pregnancy upregulates angiotensin type 2 receptor expression and increases blood flow in uterine arteries of rats
Q97526846Systematic Review and Meta-Analysis of Sex-Specific COVID-19 Clinical Outcomes

Search more.