| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1111461177 |
| P356 | DOI | 10.1186/S12885-019-5288-Y |
| P932 | PMC publication ID | 6335761 |
| P698 | PubMed publication ID | 30651087 |
| P2093 | author name string | Paul W Erhardt | |
| Zehui Li | |||
| Christopher J Trabbic | |||
| William A Maltese | |||
| Jean H Overmeyer | |||
| Jeffrey G Sarver | |||
| Nneka E Mbah | |||
| Sage George | |||
| P2860 | cites work | MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines | Q24601753 |
| A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding | Q24645971 | ||
| PIKfyve: Partners, significance, debates and paradoxes | Q24652827 | ||
| Crosstalk between apoptosis, necrosis and autophagy | Q26829723 | ||
| Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death | Q27331666 | ||
| Methuosis: nonapoptotic cell death associated with vacuolization of macropinosome and endosome compartments | Q27692058 | ||
| Signal transduction by the JNK group of MAP kinases | Q28142592 | ||
| Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve | Q28210351 | ||
| PIKfyve: the road to PtdIns 5-P and PtdIns 3,5-P(2) | Q28212011 | ||
| Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects | Q28215734 | ||
| Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators | Q28252458 | ||
| Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer | Q28290629 | ||
| A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death | Q28300548 | ||
| The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells | Q28481359 | ||
| AP-1 function and regulation | Q29618422 | ||
| A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells | Q30501296 | ||
| Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. | Q30554728 | ||
| Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? | Q33948122 | ||
| BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. | Q33960826 | ||
| C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells | Q34097615 | ||
| Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death | Q34159322 | ||
| Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6 | Q34365365 | ||
| Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis | Q34365378 | ||
| Cell death independent of caspases: a review. | Q34415492 | ||
| Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation. | Q34963377 | ||
| Regulated cell death pathways: new twists in modulation of BCL2 family function | Q34967337 | ||
| Synthesis and biological evaluation of indolyl-pyridinyl-propenones having either methuosis or microtubule disruption activity | Q35179218 | ||
| Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis | Q35213377 | ||
| Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma | Q35774120 | ||
| Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation. | Q35911995 | ||
| Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis | Q35983626 | ||
| Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor | Q36228491 | ||
| Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. | Q36658322 | ||
| Molecular mechanisms and pathophysiology of necrotic cell death | Q37160842 | ||
| Targeting cancer cell metabolism: The combination of metformin and 2-Deoxyglucose regulates apoptosis in ovarian cancer cells via p38 MAPK/JNK signaling pathway | Q37448149 | ||
| CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling | Q37694869 | ||
| The role of the apoptotic machinery in tumor suppression | Q38057709 | ||
| Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. | Q38172752 | ||
| Astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes requires activator protein-1. | Q38318550 | ||
| Non-apoptotic cell death associated with perturbations of macropinocytosis | Q38374734 | ||
| Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase. | Q38701564 | ||
| Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency | Q38762724 | ||
| Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells | Q39345125 | ||
| Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells | Q39769933 | ||
| Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance | Q39923184 | ||
| Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. | Q40024031 | ||
| Differential activation of the JNK signal pathway by UV irradiation and glucose deprivation | Q40222274 | ||
| Regulation of IL-10 gene expression in Th2 cells by Jun proteins. | Q40460750 | ||
| miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma. | Q40720717 | ||
| Mechanism of action of a dominant-negative mutant of c-Jun. | Q41483975 | ||
| Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation | Q41769812 | ||
| PIKfyve regulation of endosome-linked pathways | Q41852844 | ||
| Differential Induction of Cytoplasmic Vacuolization and Methuosis by Novel 2-Indolyl-Substituted Pyridinylpropenones | Q41938084 | ||
| Establishing intracranial brain tumor xenografts with subsequent analysis of tumor growth and response to therapy using bioluminescence imaging | Q41969010 | ||
| Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide | Q43559310 | ||
| Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis | Q44359943 | ||
| Glucose uptake activity in murine red blood cells infected with Babesia microti and Babesia rodhaini | Q45048963 | ||
| Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer | Q45893690 | ||
| JNK-signaling: A multiplexing hub in programmed cell death | Q47095837 | ||
| Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines | Q48154511 | ||
| Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones | Q48940486 | ||
| Evaluating vacquinol-1 in rats carrying glioblastoma models RG2 and NS1. | Q51746207 | ||
| Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence. | Q52584739 | ||
| Cholesterol and phospholipids in cultured skin fibroblasts from patients with dystonia | Q70609695 | ||
| Taxol induces bcl-2 phosphorylation and death of prostate cancer cells | Q71102448 | ||
| Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways | Q73481016 | ||
| Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities | Q89024369 | ||
| Roles of PFKFB3 in cancer | Q89700549 | ||
| Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE | Q91474671 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | glioblastoma | Q282142 |
| apoptotic process | Q14599311 | ||
| P304 | page(s) | 77 | |
| P577 | publication date | 2019-01-16 | |
| P1433 | published in | BMC Cancer | Q326300 |
| P1476 | title | The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma | |
| P478 | volume | 19 |
| Q64060074 | Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide |
| Q90707744 | Investigating Nonapoptotic Cell Death Using Chemical Biology Approaches |
| Q90339605 | PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses |
| Q90080150 | Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells |
Search more.