Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival

scientific article

Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...857793H
P356DOI10.1371/JOURNAL.PONE.0057793
P932PMC publication ID3581491
P698PubMed publication ID23451269
P5875ResearchGate publication ID235758006

P50authorBalasubramanian SivasankaranQ55916206
P2093author name stringBrian A Hemmings
Adrian Merlo
Gerald Moncayo
Michal Rajski
Roland M Huber
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Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activationQ39441568
Notch inhibition of E47 supports the existence of a novel signaling pathwayQ39631179
Rho/ROCK and MAPK signaling pathways are involved in glioblastoma cell migration and proliferation.Q39866748
Tenascin-C is a novel RBPJkappa-induced target gene for Notch signaling in gliomasQ39894750
Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-kappaB/Snail1 pathway.Q39903905
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferationQ40444094
Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasivenessQ40691310
Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitroQ40712405
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in miceQ40881142
Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cellsQ42174577
Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosisQ42447740
Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.Q42823834
Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate.Q43806416
Regulation of Notch signalling by non-visual beta-arrestinQ45345847
NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytesQ47769650
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell linesQ48154511
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Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptorQ24291707
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulatorsQ24336898
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeatsQ24337414
Years of life lost (YLL) from cancer is an important measure of population burden--and should be considered when allocating research fundsQ24650750
A gene-expression signature as a predictor of survival in breast cancerQ27860945
Neural stem cells and the origin of gliomasQ28268847
GSK3beta regulates differentiation and growth arrest in glioblastomaQ28476300
DNER acts as a neuron-specific Notch ligand during Bergmann glial developmentQ28513299
Reduction of Akt2 inhibits migration and invasion of glioma cellsQ28572665
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturationQ28646270
limmaGUI: a graphical user interface for linear modeling of microarray dataQ33205531
Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumorsQ33288968
Notch signaling in cancer.Q33343524
Deltex regulates T-cell activation by targeted degradation of active MEKK1.Q33823429
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenograftsQ33883897
γ-Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft RecurrenceQ34101839
DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation.Q34111103
The functional role of Notch signaling in human gliomasQ34132722
LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegansQ34441379
Notching up another pathwayQ34631746
CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?Q34801905
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cellsQ34842477
Dual-specificity phosphatases: critical regulators with diverse cellular targetsQ34948186
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursorsQ35163647
Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomasQ35796211
Axoglial interaction via the notch receptor in oligodendrocyte differentiation.Q35942546
The extracellular space and matrix of gliomasQ36263108
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.Q37258559
Translating biology into clinic: the case of glioblastomaQ37393364
miR-21 as a key regulator of oncogenic processesQ37554678
Deregulated signalling networks in human brain tumoursQ37625147
Napthalimidobenzamide DB-51630: a novel DNA binding agent inducing p300 gene expression and exerting a potent anti-cancer activityQ38325952
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
limmaQ112236343
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
P304page(s)e57793
P577publication date2013-02-25
P1433published inPLOS OneQ564954
P1476titleDeltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival
P478volume8

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Q36417076Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation
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Q35109557Hydrogen sulfide accelerates cell cycle progression in oral squamous cell carcinoma cell lines
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