Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness

scientific article published on 8 March 2010

Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1045385506
P356DOI10.1038/ONC.2010.62
P932PMC publication ID2874642
P698PubMed publication ID20208568
P5875ResearchGate publication ID41809183

P50authorPatrick A Zweidler-McKayQ37386783
P2093author name stringP Zhang
Y Yang
R Nolo
D P M Hughes
P2860cites workHuman deltex is a conserved regulator of Notch signallingQ24317290
Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elementsQ24318691
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradationQ24548288
Notch signaling: cell fate control and signal integration in developmentQ27861061
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligasesQ28139237
HES and HERP families: multiple effectors of the Notch signaling pathwayQ28205103
Notch signaling in cancerQ28218759
The Notch signaling cascade in neuroblastoma: role of the basic helix-loop-helix proteins HASH-1 and HES-1Q28249698
Signalling downstream of activated mammalian NotchQ28289832
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by DeltaQ28646258
Nuclear access and action of notch in vivoQ28646384
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaQ29614269
Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signalingQ30167575
Deltex regulates T-cell activation by targeted degradation of active MEKK1.Q33823429
HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repressionQ33965118
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.Q34116313
Structure and Notch receptor binding of the tandem WWE domain of DeltexQ34465487
Gamma-secretase-mediated proteolysis in cell-surface-receptor signallingQ34810184
The role of Notch in tumorigenesis: oncogene or tumour suppressor?Q35564593
Notch and T cell malignancy.Q35853088
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7Q36699782
Context-dependent regulation of Groucho/TLE-mediated repressionQ37249996
Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcomaQ38448504
Critical role of notch signaling in osteosarcoma invasion and metastasisQ39352960
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignanciesQ40381941
Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.Q42438785
Regulation of Notch signalling by non-visual beta-arrestinQ45345847
Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathwayQ47071885
Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.Q52086514
Contact-dependent inhibition of cortical neurite growth mediated by notch signalingQ73106394
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)2916-2926
P577publication date2010-03-08
P1433published inOncogeneQ1568657
P1476titleRegulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness
P478volume29

Reverse relations

cites work (P2860)
Q41982806Aberrant ADAM10 expression correlates with osteosarcoma progression
Q40216465Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues
Q36447011Anti-tumor effects of the Notch pathway in gastrointestinal stromal tumors
Q99724872Bone Microenvironment and Osteosarcoma Metastasis
Q98498346Defective cell proliferation is an attribute of overexpressed Notch1 receptor and impaired autophagy in Fanconi Anemia
Q34603835Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival
Q36417076Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation
Q39595493Dysfunctional transforming growth factor-β signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma
Q36680241Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling
Q42732429Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer
Q37641671Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study
Q38914804HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer
Q34788468HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors
Q36213706Hes1: a key role in stemness, metastasis and multidrug resistance
Q35622015Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis
Q39216129Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.
Q35748649Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling
Q34475754Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program
Q38718489Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC
Q37730685Laminar flow downregulates Notch activity to promote lymphatic sprouting.
Q42557385Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma
Q30416383Manic fringe inhibits tumor growth by suppressing Notch3 degradation in lung cancer
Q42538934Mechanism of BMP9 promotes growth of osteosarcoma mediated by the Notch signaling pathway
Q33882085Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer
Q39393414MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling
Q38719449MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit
Q37692351MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 gene
Q34581673New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).
Q35013808New, tolerable γ-secretase inhibitor takes desmoid down a notch
Q36917462Notch Signaling is Associated with ALDH Activity and an Aggressive Metastatic Phenotype in Murine Osteosarcoma Cells
Q37861206Notch regulation of tumor angiogenesis
Q37625991Notch signaling in skeletal stem cells
Q39279019Notch-mediated induction of N-cadherin and α9-integrin confers higher invasive phenotype on rhabdomyosarcoma cells
Q50026410PI5P4Kγ functions in DTX1-mediated Notch signaling.
Q92421251Pericytes in Sarcomas and Other Mesenchymal Tumors
Q38528174Pericytes in sarcomas of bone
Q26745419Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration
Q89771851Regulation of Notch Signaling in Drosophila melanogaster: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex
Q33687647T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.
Q41602986The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling
Q37804446The multiple facets of ubiquitination in the regulation of notch signaling pathway.
Q37269941Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK
Q26829949Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression
Q38219834Understanding the role of Notch in osteosarcoma
Q57166421Up-regulation of microRNA-340 promotes osteosarcoma cell apoptosis while suppressing proliferation, migration, and invasion by inactivating the CTNNB1-mediated Notch signaling pathway

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