Mutant p53 proteins: between loss and gain of function

scientific article published on May 2007

Mutant p53 proteins: between loss and gain of function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HED.20531
P698PubMed publication ID17123310
P5875ResearchGate publication ID6675423

P2093author name stringGiovanni Blandino
Sabrina Strano
Stefania Dell'Orso
Olimpia Monti
Silvia Di Agostino
Giulia Fontemaggi
Eleonora Lapi
Adriana Maria Mongiovi
P2860cites workThe tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damageQ22010200
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damageQ22010201
Physical interaction with Yes-associated protein enhances p73 transcriptional activityQ24291023
ASPP1 and ASPP2: common activators of p53 family membersQ24305256
Mdm2 promotes the rapid degradation of p53Q24322597
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutantsQ24530763
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
p53, the cellular gatekeeper for growth and divisionQ27860990
A common polymorphism acts as an intragenic modifier of mutant p53 behaviourQ28118809
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosisQ28138604
MDM2--master regulator of the p53 tumor suppressor proteinQ28138926
Cancer statistics, 2002Q28216788
Mutations in the p53 gene occur in diverse human tumour typesQ28249770
p53 mutations in human cancersQ28302973
Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosisQ28345092
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Cancer. p53, guardian of the genomeQ29615610
Tumor spectrum analysis in p53-mutant miceQ29617436
T antigen is bound to a host protein in SY40-transformed cellsQ29618321
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasmsQ29618586
Emerging molecular markers of cancer.Q30330271
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.Q31041084
Inactivate the remaining p53 allele or the alternate p73? Preferential selection of the Arg72 polymorphism in cancers with recessive p53 mutants but not transdominant mutantsQ32129086
a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancerQ33912833
P63 and P73: P53 mimics, menaces and moreQ34185768
An adenovirus mutant that replicates selectively in p53-deficient human tumor cellsQ34399844
The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growthQ34402080
Li-Fraumeni syndrome: a p53 family affairQ34421596
Li-Fraumeni syndrome – a molecular and clinical reviewQ34432117
Assessing TP53 status in human tumours to evaluate clinical outcomeQ34570100
TP53 and head and neck neoplasmsQ35078742
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulationQ35089377
Regulation of p53 responses by post-translational modificationsQ35116637
Decision making by p53: life, death and cancerQ35116663
Hot-spot mutants of p53 core domain evince characteristic local structural changes.Q35549859
Transcriptional activities of mutant p53: when mutations are more than a lossQ35902152
p53 mutation heterogeneity in cancerQ36113160
p53 mutation, but not p53 overexpression, correlates with survival in head and neck squamous cell carcinomaQ36115578
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptideQ37088668
Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.Q38291171
Transactivation of the EGR1 gene contributes to mutant p53 gain of functionQ38334166
Comparison of the effect of mutant and wild-type p53 on global gene expressionQ38334169
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domainQ39458140
p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.Q39610993
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cellsQ40237209
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.Q40439787
Modulation of gene expression by tumor-derived p53 mutantsQ40502644
ONYX-015 selectivity and the p14ARF pathwayQ40700227
Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressorQ41192780
Gain of function mutations in p53.Q41557652
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosisQ44426545
Induction chemotherapy with cisplatin and 5-fluorouracil followed by chemoradiotherapy or radiotherapy alone in the treatment of locoregionally advanced resectable cancers of the larynx and hypopharynx: results of single-center study of 45 patientsQ45130745
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).Q45180301
A prospective phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience).Q47587088
Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinomaQ47976180
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndromeQ52561781
p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.Q53411999
Biochemopreventive therapy for patients with premalignant lesions of the head and neck and p53 gene expressionQ53415195
A transgenic mouse model for mammary carcinogenesisQ53436081
Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73Q57778801
p63 and p73 are required for p53-dependent apoptosis in response to DNA damageQ59065672
Estimates of the worldwide frequency of sixteen major cancers in 1980Q68257962
Analysis of p53 serum antibodies in patients with head and neck squamous cell carcinomaQ71466524
Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neckQ72541492
Chemosensitivity linked to p73 functionQ73342473
p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neckQ73358736
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domainQ73400021
p53 gene mutations in sequential oral epithelial dysplasias and squamous cell carcinomasQ73504503
p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinomaQ73690528
TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancerQ74531141
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapyQ77932308
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndromeQ81166001
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)488-496
P577publication date2007-05-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inHead & NeckQ13703062
P1476titleMutant p53 proteins: between loss and gain of function
P478volume29

Reverse relations

cites work (P2860)
Q42730762A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage
Q53260896Alteration of G1/S transition regulators influences recurrences in head and neck squamous carcinomas
Q37344081Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients.
Q35653073Identification of genomic features in the classification of loss- and gain-of-function mutation.
Q48690318Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.
Q30354662Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.
Q26749382Oncogenic Intra-p53 Family Member Interactions in Human Cancers
Q30416701PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations
Q38286198Pharmacological reactivation of p53 as a strategy to treat cancer.
Q38956978Recognition of Local DNA Structures by p53 Protein.
Q34236112Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta
Q27006998Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53
Q24306101Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity
Q34159403Selective Depletion of Mutant p53 by Cancer Chemopreventive Isothiocyanates and Their Structure−Activity Relationships
Q35004008Selumetinib produces a central core of apoptosis in breast cancer bone metastases in mice
Q36941044Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.
Q42397956The Expression Levels of XLF and Mutant P53 Are Inversely Correlated in Head and Neck Cancer Cells.
Q36191906The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma
Q39794563The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.
Q47121352Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level.
Q38069463p53 mutations in cancer

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