T antigen is bound to a host protein in SY40-transformed cells

scientific article (publication date: 15 March 1979)

T antigen is bound to a host protein in SY40-transformed cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1001770301
P356DOI10.1038/278261A0
P953full work available at URLhttp://www.nature.com/articles/278261a0
http://www.nature.com/articles/278261a0.pdf
P3181OpenCitations bibliographic resource ID1347156
P698PubMed publication ID218111

P50authorDavid P. LaneQ909289
P2093author name stringL. V. Crawford
P2860cites workTransformation of BALB/c-3T3 cells by tsA mutants of simian virus 40: temperature sensitivity of the transformed phenotype and retransofrmation by wild-type virusQ37602234
An immunochemical investigation of SV40 T antigens. 1. Production properties and specificity of rabbit antibody to purified simian virus 40 large-T antigenQ39495337
The genome of simian virus 40.Q40142651
Antiserum to polyacrylamide gel-purified simian virus 40 T antigenQ40155471
Mutants of SV40 with an altered small t protein are reduced in their ability to transform cellsQ40158462
Methods for fractionation and scintillation counting of radioisotope-labeled polyacrylamide gelsQ71587915
Organization and expression of early genes of simian virus 40Q33954047
Spliced early mRNAs of simian virus 40Q33967138
Complete nucleotide sequence of SV40 DNAQ34122821
Initiation and maintenance of cell transformation by simian virus 40: a viral genetic propertyQ35070561
Expression of simian virus 40 early genes in transformed rat cells is correlated with maintenance of the transformed phenotypeQ35995573
The small subunit of HL-A antigens is beta 2-microglobulinQ36272738
Phosphorylation of T-antigen and control T-antigen expression in cells transformed by wild-type and tsA mutants of simian virus 40Q36493723
Simian virus 40 functions required for the establishment and maintenance of malignant transformationQ36532307
Regulation of tumor antigen synthesis by simain virus 40 gene AQ36537613
Studies on nondefective adenovirus-simian virus 40 hybrid viruses. I. A newly characterized simian virus 40 antigen induced by the Ad2+ND 1 virusQ36578182
Identification of simian virus 40 tumor and U antigensQ37581413
Cell-free translation of simian virus 40 early messenger RNA coding for viral T-antigenQ37581427
Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map unitsQ37585547
P433issue5701
P407language of work or nameEnglishQ1860
P921main subjectviral antigensQ66058032
neoplasm antigensQ76832457
viral transformationQ17162815
P304page(s)261-3
P577publication date1979-03-15
P1433published inNatureQ180445
P1476titleT antigen is bound to a host protein in SV40-transformed cells
T antigen is bound to a host protein in SY40-transformed cells
P478volume278

Reverse relations

cites work (P2860)
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Q35941628Deregulation of the cell cycle by the Epstein-Barr virus
Q35235163Detection and characterization of multiple forms of simian virus 40 large T antigen
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Q45613582Detection and expression of human BK virus sequences in neoplastic prostate tissues
Q72608634Detection of P53 tumor-suppressor-gene protein in bladder tumors and prostate cancer: possible clinical implications
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Q36940094Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA
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Q36888762Differential ability of a T-antigen transport-defective mutant of simian virus 40 to transform primary and established rodent cells.
Q35871078Differential interaction of temperature-sensitive simian virus 40 T antigens with tumor suppressors pRb and p53
Q40829313Differential phosphorylation of mitogen-activated protein kinase families by epidermal growth factor and ultraviolet B irradiation in SV40-transformed human keratinocytes
Q28572538Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescence
Q40131883Dimers and complexes with p53 are the prevalent oligomeric forms of a transforming nonkaryophilic T antigen of simian virus 40.
Q36841865Discontinuous native protein gel electrophoresis: pros and cons
Q33738750Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53
Q34060590Discovery of a p53 variant that controls metastasis
Q36921966Discrete regions of simian virus 40 large T antigen are required for nonspecific and viral origin-specific DNA binding
Q64956138Discussion of some 'knowns' and some 'unknowns' about the tumour suppressor p53.
Q34537149Disruption of oncogene/tumor suppressor networks during human carcinogenesis
Q40554501Distinct functions for WRN and TP53 in a shared pathway of cellular response to 1-beta-D-arabinofuranosylcytosine and bleomycin.
Q39744147Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus Lymphomas
Q42072409Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2.
Q73960260Does p53 immunostaining improve diagnostic accuracy in urine cytology?
Q37229811Double immunostaining for p53 and molecular chaperone hsp72/73 in gastric carcinoma
Q42945496Down-regulation of p53 by double-stranded RNA modulates the antiviral response
Q35101871Drug discovery and p53.
Q36387594Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity
Q36910554Dynamic nature of the association of large tumor antigen and p53 cellular protein with the surfaces of simian virus 40-transformed cells
Q35206764E1A signaling to p53 involves the p19(ARF) tumor suppressor
Q40896659E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage
Q36358319EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.
Q33915487Effect of a tsA mutation of simian virus 40 late gene expression: variations between host cell lines
Q45807849Effect of simian virus 40 infection on albumin production by hepatocytes cultured in chemically defined medium and plated on collagen and non-collagen attachment surfaces
Q38348780Effects of 2-amino-4,6-dinitrotoluene on p53 tumor suppressor gene expression
Q29619196Effects of an Rb mutation in the mouse
Q35993764Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck.
Q42510424Elevated levels of the p53 tumour suppressor protein in the basal layer of recurrent laryngeal papillomas
Q28077156Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness
Q35551117Emerging roles of DNA tumor viruses in cell proliferation: new insights into genomic instability.
Q64374614Encounters with adenovirus
Q36941962Energy Requirement for Degradation of Tumor-Associated Protein p53
Q34050026Enhanced degradation of p53 protein in HPV-6 and BPV-1 E6-immortalized human mammary epithelial cells.
Q92860212Enzymatic Degradation of Biofilm by Metalloprotease From Microbacterium sp. SKS10
Q33839135Epidemiology and molecular genetics of colorectal cancer
Q40136771Epstein-Barr virus (EBV), lymphocytes and transformation
Q38356037Epstein-Barr virus nuclear antigen 2 and latent membrane protein independently transactivate p53 through induction of NF-kappaB activity
Q34326542Epstein-Barr virus/complement fragment C3d receptor (CR2) reacts with p53, a cellular antioncogene-encoded membrane phosphoprotein: detection by polyclonal anti-idiotypic anti-CR2 antibodies
Q55395428Evaluation of an indicator for lymph node metastasis of esophageal squamous cell carcinoma invading the submucosal layer.
Q36845840Evidence for a structural relationship between BRCT domains and the helicase domains of the replication initiators encoded by the Polyomaviridae and Papillomaviridae families of DNA tumor viruses.
Q42930582Evidence for modulation of BAG3 by polyomavirus JC early protein.
Q36830520Evolutionary conservation of the biochemical properties of p53: specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70
Q36724486Excess wild-type p53 blocks initiation and maintenance of simian virus 40 transformation
Q36547790Exploiting the p53 pathway for the diagnosis and therapy of human cancer.
Q37083966Expression and interactions of human adenovirus oncoproteins
Q36859189Expression of 100,000-Mr simian virus 40 (SV40) tumor antigen in mouse fibroblasts transfected with replication-defective SV40 genomes
Q73719734Expression of PCNA and p53 in esophageal dysplasia and esophageal carcinoma
Q45801095Expression of SV40 T antigen polypeptides in cells biochemically transformed by plasmids containing the herpes simplex virus thymidine kinase gene and the genome of an SV40tsA mutant
Q40675623Expression of Simian Virus 40 Large T Antigen in Embryonal Carcinoma Cell Hybrids
Q28287375Expression of a candidate ataxia-telangiectasia group D gene in cultured fibroblast cell lines and human tissues
Q36932745Expression of a transformation-related protein (p53) in the malignant stage of Friend virus-induced diseases
Q34378463Expression of mutant p53 protein in hepatocellular carcinoma
Q35984818Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder
Q35903258Expression of p24, a novel p21Waf1/Cip1/Sdi1-related protein, correlates with measurement of the finite proliferative potential of rodent embryo fibroblasts
Q35522870Expression of p53 mutant nuclear phosphoprotein in oral carcinoma and potentially malignant oral lesions
Q72089540Expression of p53 product in Chinese human bladder carcinoma
Q36235611Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype
Q37428803Extensive post-translational modification of active and inactivated forms of endogenous p53.
Q38363488F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4.
Q40466587Familial breast cancer and genes involved in breast carcinogenesis
Q30669552Feedback regulation between orphan nuclear receptor TR2 and human papilloma virus type 16.
Q73102796Flow cytometry and quantitative immunohistochemical study of cell cycle regulation proteins in invasive breast carcinoma: prognostic significance
Q36309667Fragments of the simian virus 40 transforming gene facilitate transformation of rat embryo cells
Q36863092Free and viral chromosome-bound simian virus 40 T antigen: changes in reactivity of specific antigenic determinants during lytic infection
Q36729673Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines
Q38705286Friend virus-induced erythroleukemia: a multistage malignancy
Q36686649From growth arrest to growth suppression
Q34164614From p63 to p53 across p73.
Q64102183Functional Diversity of p53 in Human and Wild Animals
Q36648185Functional and physical interaction between p53 and BZLF1: implications for Epstein-Barr virus latency
Q36637002Functional characterization of Xenopus laevis p53: evidence of temperature-sensitive transactivation but not of repression
Q36685139Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen
Q43772756Functional consequences of oncogene-induced photoreceptor degeneration in transgenic mice
Q36698048Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression
Q38300638Functional inactivation but not structural mutation of p53 causes liver cancer.
Q40107890Functional interaction of nuclear transport-defective simian virus 40 large T antigen with chromatin and nuclear matrix
Q36873869Functional role of BK virus tumor antigens in transformation
Q40101353Functions of T antigens of SV40 and polyomavirus
Q35976056Gastric cancer with p53 overexpression has high potential for metastasising to lymph nodes
Q72661833Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method
Q41844172Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines
Q40849028Gene therapy for colon cancer.
Q33755140Gene therapy using SV40-derived vectors: what does the future hold?
Q41051771Generation and characterization of an immortal cell line of xeroderma pigmentosum group E.
Q36845425Generation of murine stromal cell lines supporting hematopoietic stem cell proliferation by use of recombinant retrovirus vectors encoding simian virus 40 large T antigen
Q54966492Genetic Alteration of p53 in Some Patients with Adult T-Cell Leukemia
Q34813092Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients.
Q35861223Genetic analysis of polyomavirus large T nuclear localization: nuclear localization is required for productive association with pRb family members.
Q36903846Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants
Q34438119Genetic predisposition to cancer and familial cancer syndromes
Q38068825Genome guardian p53 and viral infections
Q36642204Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts
Q36493335Genotype phenotype correlation in Li-Fraumeni syndrome kindreds and its implications for management.
Q34057911Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes.
Q41816411Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
Q33534212Gliomas
Q35230883Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
Q42819146Growth regulation of a cellular tumour antigen, p53, in nontransformed cells
Q37421517Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression
Q40720204HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis
Q36872778HSP70 binding sites in the tumor suppressor protein p53.
Q40794530Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis
Q35101216Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
Q28569202Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3
Q38309880Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability
Q50856462Hepatocellular proliferation and development of hepatocellular carcinoma: a case-control study in chronic hepatitis C.
Q56928447Hereditary breast cancer
Q40970549Hereditary cancer: two hits revisited
Q41562003Herpes simplex virus infection causes the accumulation of a heat-shock protein
Q40755915Hetero-oligomerization does not compromise 'gain of function' of tumor-derived p53 mutants
Q34091002Heterochromatin silencing of p53 target genes by a small viral protein
Q37605827Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations.
Q53418672Heterotopic endochondrial ossification with mixed tumor formation in C3(1)/Tag transgenic mice is associated with elevated TGF-beta1 and BMP-2 expression.
Q55037712High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papillomavirus infection.
Q36760672High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
Q35833598High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma
Q35823973High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas
Q39875158High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.
Q38019869History of protein-protein interactions: from egg-white to complex networks
Q70197165Hormone-dependent enhancement of neoplastic phenotype expression by MuMTV-infected heterologous cells, and MuMTV-induced cellular antigens
Q36350356Host nuclear proteins expressed in simian virus 40-transformed and -infected cells
Q36667622Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle
Q91701456How TP53 (almost) became an oncogene
Q38170081How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis
Q38367375How do viruses control mitochondria-mediated apoptosis?
Q74266124How is the mutational status for tumor suppressors p53 and p16(INK4A) in MFH of the bone?
Q91533177How mutant p53 empowers Foxh1 fostering leukaemogenesis?
Q36102815Human BK Polyomavirus-The Potential for Head and Neck Malignancy and Disease
Q24609227Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
Q24562978Human TAFII31 protein is a transcriptional coactivator of the p53 protein
Q35873729Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription
Q40046680Human oncogenic viruses: nature and discovery
Q58131437Human p53 and Hdm2: Cloning and Construction of Expression Plasmid
Q40678382Human p53 inhibits growth in Schizosaccharomyces pombe
Q33643799Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2
Q41098425Human papillomavirus (HPV) 16 E6 sensitizes cells to atractyloside-induced apoptosis: role of p53, ICE-like proteases and the mitochondrial permeability transition
Q28187745Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription
Q36893766Human polyomavirus JC virus genome
Q45137833Human thymic epithelial cells are frequently transformed by retroviral vectors encoding simian virus 40
Q36507591Identification and initial characterization of a new low-molecular-weight virus-encoded T antigen in a line of simian virus 40-transformed cells
Q36930790Identification of B-lymphotropic papovavirus-coded proteins.
Q37068526Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes
Q24337360Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus
Q29620442Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
Q37212448Identification of new p53 acetylation sites in COS-1 cells
Q36867104Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex
Q37731374Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response
Q30987442Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression
Q38045922Imidazoline derivatives: a patent review (2006--present).
Q34019492Immortalization of a primate bipotent epithelial liver stem cell
Q26829548Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons
Q53482889Immunization of mice with baculovirus-derived recombinant SV40 large tumour antigen induces protective tumour immunity to a lethal challenge with SV40-transformed cells
Q73223966Immunohistochemical Detection of p53 and c-erbB-2 Proteins: Prognostic Significance in Operable Breast Cancer
Q70641343Immunohistochemical detection of the p53 oncoprotein in tumours of melanocytic origin
Q71797512Immunohistochemical expression of p53 protein and proliferating cell nuclear antigen in hepatocellular carcinoma
Q35832962Immunohistochemical study of p53 in human lung carcinomas.
Q43444816Immunophenotype of SV40-T gene transfected epithelial cell lines derived from human benign breast tumors
Q36918852Immunoprecipitation of some forms of simian virus 40 large-T antigen by antibodies to synthetic peptides
Q62631293Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
Q35111076Impact of the adenoviral E4 Orf3 protein on the activity and posttranslational modification of p53.
Q35123468Improving cancer therapy by non-genotoxic activation of p53.
Q33767424In situ detection of apoptosis at sites of chronic bacterially induced inflammation in human gingiva
Q55240856In situ polymerase chain reaction detection of HTLV-I provirus and expression of the p53 tumor suppressor gene in infiltrating cells in skeletal muscle from a patient with adult T cell leukemia.
Q40666508In vitro expression of human p53 cDNA clones and characterization of the cloned human p53 gene
Q72399727In vitro mutagenesis of a putative DNA binding domain of SV40 large-T
Q39873297In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes
Q33629594In vivo recombinant adenovirus-mediated p53 gene therapy in a syngeneic rat model for colorectal cancer
Q40675444Inactivation of p53 Gene Expression by an Insertion of Moloney Murine Leukemia Virus-Like DNA Sequences
Q39870530Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen.
Q35237286Increased concentration of an apparently identical cellular protein in cells transformed by either Abelson murine leukemia virus or other transforming agents
Q35609543Increased expression of p53 protein in human leukemia cells
Q37013182Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.
Q36891202Induction of cellular DNA synthesis by a simian virus 40 mutant defective in nuclear transport of T antigen
Q34127232Induction of interferon-stimulated genes by Simian virus 40 T antigens
Q41371638Induction of interleukin-2 transcription by the hamster polyomavirus middle T antigen: a role for Fyn in T cell signal transduction
Q33656171Induction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells
Q42281248Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer
Q24317013Inhibition of p53 DNA binding by human papillomavirus E6 proteins
Q39606488Inhibition of p53 tumor suppressor by viral interferon regulatory factor
Q40038319Inhibition of p53-mediated transactivation by E6 of type 1, but not type 5, 8, or 47, human papillomavirus of cutaneous origin.
Q40066650Inhibition of viral and cellular promoters by human wild-type p53
Q37855826Inhibitors of MDM2 and MDMX: a structural perspective.
Q41500820Initiation of autoimmunity to self-proteins complexed with viral antigens
Q36362919Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen
Q43131463Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins
Q41461437Integration of Ecogpt and SV40 early region sequences into human chromosome 17: a dominant selection system in whole cell and microcell human-mouse hybrids
Q36935658Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex
Q24547088Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen
Q36579279Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses
Q33292223Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins
Q22008057Interaction of the single-stranded DNA-binding protein Puralpha with the human polyomavirus JC virus early protein T-antigen
Q28776004Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway
Q36920345Interactions between polyomavirus medium T antigen and three cellular proteins of 88, 61, and 37 kilodaltons
Q45806859Intercellular communication and the control of growth: XII. Alteration of junctional permeability by simian virus 40. Roles of the large and small T antigens
Q42818894Intermolecular phosphorylation between insulin holoreceptors does not stimulate substrate kinase activity
Q36604805Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors
Q36384554Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.
Q40134237Intracellular location and kinetics of complex formation between simian virus 40 T antigen and cellular protein p53
Q34812489Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53
Q35103185Introduction: The Changing Directions of p53 Research
Q37352771Investigations on a clinically and functionally unusual and novel germline p53 mutation
Q36318172Involvement of PP2A in viral and cellular transformation
Q41592444Involvement of p53 in cell differentiation and development
Q36167487Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis.
Q24555633Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene
Q24318228Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
Q44645744Isolation and partial characterization of a 55,000-dalton protein induced in cells transformed by the ml strain of moloney murine sarcoma virus
Q40665592Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule
Q39585155J domain-independent regulation of the Rb family by polyomavirus large T antigen
Q42828333JC virus large T protein transforms rodent cells but is not involved in human medulloblastoma
Q40849418Karyotypic and molecular abnormalities in chronic lymphocytic leukaemia
Q41188296Laboratory probing of oncogenes from human liquid and solid specimens as markers of exposure to toxicants
Q41249912Lack of p53 mutations and loss of heterozygosity in non-cultured human melanocytic lesions
Q40820817Lack of ultraviolet-light inducibility of the medakafish (Oryzias latipes) tumor suppressor gene p53.
Q36867876Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts
Q34432117Li-Fraumeni syndrome – a molecular and clinical review
Q34618683Likelihood Models of Somatic Mutation and Codon Substitution in Cancer Genes
Q36831658Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene
Q33870289Liver-directed gene therapy: promises, problems and prospects at the turn of the century
Q59057697Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells
Q36938740Localization of the Adenovirus E1Aa Protein, a Positive-Acting Transcriptional Factor, in Infected Cells Infected Cells
Q36695353Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
Q36685600Long-term gene expression in dividing and nondividing cells using SV40-derived vectors.
Q80586970Loss of c-abl facilitates anchorage-independent growth of p53- and RB- deficient primary mouse embryonic fibroblasts
Q39455963Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation
Q36828231Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells
Q40794489Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
Q53385488Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.
Q36897933MC29 virus-coded protein occurs as monomers and dimers in transformed cells
Q41633106MDM2--arbiter of p53's destruction
Q52340395MDM2-p53 Interactions in Human Hepatocellular Carcinoma: What Is the Role of Nutlins and New Therapeutic Options?
Q24561971MDMX: a novel p53-binding protein with some functional properties of MDM2
Q37676784Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells
Q35977776Malignant progression of SV40-immortalised human milk epithelial cells
Q35589990Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells
Q28609886Mapping of the p53 and mdm-2 Interaction Domains
Q35235117Mapping of the viral mRNA encoding a super-T antigen of 115,000 daltons expressed in simian virus 40-transformed rat cell lines
Q27025941Matrix and backstage: cellular substrates for viral vaccines
Q36386557Mechanism of interferon action: Simian virus 40-specific early polypeptides synthesized in untreated and interferon-treated monkey kidney cells
Q73320007Mechanism of p53 degradation
Q36273391Mechanisms and markers of carcinogenesis and neoplastic progression
Q40667913Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function
Q36698827Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen
Q33722859Mechanisms of p53 loss in human sarcomas
Q36884544Medium tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with 73-kilodalton heat shock protein
Q37067101Merkel cell carcinoma: a virus-induced human cancer
Q34947967Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus
Q36468289Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential
Q34309882Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus
Q64078232Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
Q43665417Metastasizing neuroblastomas from taste buds in rats transgenic for the Simian virus 40 large T antigen under control of the probasin gene promoter
Q29547697Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Q26785743Microbial Regulation of p53 Tumor Suppressor
Q36316665Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells
Q37576004Micrometastasis expressing insulin arise in lung and spleen at advanced stage of rip1-tag2 transgenic mice
Q90421599Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila
Q40399548Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K.
Q58695374Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
Q29615657Modes of p53 regulation
Q37512255Modulation of autophagy-like processes by tumor viruses
Q40062749Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.
Q36925553Modulation of p53 protein expression during cellular transformation with simian virus 40
Q35367195Molecular biology in the diagnosis and prognosis of solid and lymphoid tumors
Q41131665Molecular biology of pediatric gliomas
Q39726667Molecular biology of the cell cycle
Q36489098Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.
Q41353388Molecular genetics of colorectal cancer (part 1).
Q30495393Molecular genetics of neurological tumours
Q36827597Molecular mechanisms in lung pathogenesis
Q30498610Molecular mechanisms of cancer
Q33368199Molecular pathogenesis of colorectal cancer
Q29616471Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
Q33920832Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens
Q35235589Monoclonal antibodies against simian virus 40 tumor antigens: analysis of antigenic binding sites, using adenovirus type 2-simian virus 40 hybrid viruses
Q33933776Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein, p53.
Q34249232Monoclonal antibodies specific for simian virus 40 tumor antigens
Q36347553Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny
Q40127251Monoclonal antibody analysis of p53 expression in normal and transformed cells
Q40116257Monoclonal antibody analysis of simian virus 40 small t-antigen expression in infected and transformed cells
Q26746524Mouse Models in Prostate Cancer Translational Research: From Xenograft to PDX
Q38351451Mouse RAD50 has limited epitopic homology to p53 and is expressed in the adult myocardium
Q36436702Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo
Q38447567Mouse lung neuroendocrine carcinomas: distinct morphologies, same transcription factors.
Q58693513Mouse models of prostate cancer
Q46905586Mouse p53 inhibits SV40 origin-dependent DNA replication
Q44673371Mouse polyomavirus large T antigen inhibits cell growth and alters cell and colony morphology in Saccharomyces cerevisiae.
Q42526715Multiple mechanisms contribute to the activation of RNA polymerase III transcription in cells transformed by papovaviruses
Q48026339Multisite phosphorylation and the integration of stress signals at p53.
Q36736774Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication
Q40410709Murine models of neoplasia: functional analysis of the tumour suppressor genes Rb-1 and p53.
Q41519041Musculoskeletal oncology--advances in cytogenetics and molecular genetics and their clinical implications
Q30354662Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.
Q36920336Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1
Q36698822Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity
Q35081210Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells
Q38204111Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks
Q36661775Mutant p53 proteins: between loss and gain of function
Q36777355Mutant p53: an oncogenic transcription factor
Q36070574Mutant p53: one name, many proteins
Q40951665Mutation and cancer: a personal odyssey
Q36780709Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation
Q40535104Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.
Q36803951Mutation of the serine 312 phosphorylation site does not alter the ability of mouse p53 to inhibit simian virus 40 DNA replication in vivo
Q36936356Mutational Analysis of Simian Virus 40 T Antigen: Isolation and Characterization of Mutants with Deletions in the T-Antigen Gene
Q33940332Mutational analysis of simian virus 40 large T antigen DNA binding sites
Q47691368Mutations in context: implications of BRCA testing in diverse populations
Q35982987Mutations in p53 do not account for heritable breast cancer: a study in five affected families
Q37599484Mutations in the bovine leukemia virus Tax protein can abrogate the long terminal repeat-directed transactivating activity without concomitant loss of transforming potential
Q74597212Mutations in the p53 gene in acute myeloid leukemia patients correlate with poor prognosis
Q28249770Mutations in the p53 gene occur in diverse human tumour types
Q40771480Mutations of the p53 gene in B-cell lymphoma
Q40924895Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis.
Q40062939Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator
Q39077362Negative auto-regulators trap p53 in their web.
Q45869640Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy
Q33740135Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.
Q39007820Neomorphic mutations create therapeutic challenges in cancer.
Q46821463Neoplastic transformation and angiogenesis in the thymus of transgenic mice expressing SV40 T and t antigen under an L-pyruvate kinase promoter (SV12 mice).
Q26825296Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator
Q36976531New Properties of Simian Virus 40 Large T Antigen
Q54169975New aspects of cell biology in osteosarcoma.
Q34047246New insights into p53 regulation and gene therapy for cancer.
Q38389967New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy.
Q41741132No requirement for src family kinases for PDGF signaling in fibroblasts expressing SV40 large T antigen
Q94475905Non-disruptive mutation in TP53 DNA-binding domain is a beneficial factor of esophageal squamous cell carcinoma
Q36969363Nonlytic Simian Virus 40-Specific 100K Phosphoprotein Is Associated with Anchorage-Independent Growth in Simian Virus 40-Transformed and Revertant Mouse Cell Lines
Q36288245Nonselective expression of simian virus 40 large tumor antigen fragments in mouse cells
Q40647696Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis
Q36346972Nuclear antigen detected in hepatoma cell lines containing integrated hepatitis B virus DNA
Q24310625Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
Q55282601Nuclear p53 Immunoreaction Associated with Poor Prognosis of Breast Cancer
Q40818113Nuclear protein p68 is an RNA-dependent ATPase
Q40115140Nuclear subcompartmentalization of simian virus 40 large T antigen: evidence for in vivo regulation of biochemical activities
Q34115253ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus
Q40129645Oligomerization of oncoprotein p53.
Q26830643Oncogenes and RNA splicing of human tumor viruses
Q36874460Oncogenes and anti-oncogenes; the molecular basis of tumour behaviour
Q41485266Oncogenes and antioncogenes in the development of HPV associated tumors
Q35034093Oncogenes and tumor-suppressor genes
Q39743389Oncogenes, cancer and analytical cytology
Q26749382Oncogenic Intra-p53 Family Member Interactions in Human Cancers
Q64517981Oncogenic intelligence: Cell immortalization and transformation by the p53 gene
Q37857673One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor
Q37817494Oral lichen planus and the p53 family: what do we know?
Q39007931Osteocytes serve as a progenitor cell of osteosarcoma
Q67970173Overexpression of p53 in head and neck cancer
Q38045766Overexpression of p53 protein in human tumors
Q43972822Overexpression of p73 causes apoptosis in vascular smooth muscle cells
Q41489317Overexpression of the MDM2 oncogene in leukemia and lymphoma
Q35992950Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma
Q37058260Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I
Q36897747Overproduction of protein p53 contributes to simian virus 40-mediated transformation
Q41108776P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?
Q72350615P53 accumulation and proliferating-cell nuclear antigen expression in human lung cancer
Q92732638P53 and The Immune Response: 40 Years of Exploration-A Plan for the Future
Q53418486P53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations.
Q44327720P53 family proteins provide new insights into lung carcinogenesis and clinical treatment
Q26771603P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development
Q40958072P53 gene mutations in lymphoid diseases and their possible relevance to drug resistance
Q36216684P53 in cancer: a paradigm for modern management of cancer
Q34546732P53 is a tumor suppressor gene
Q34287830P53 mdm2 inhibitors
Q33899383P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines.
Q71219510P53 protein expression in pancreatic tumors and its relationship to clinicopathological factors and prognosis
Q78792241P53 protein expression in transitional cell carcinoma of the bladder - experience of the University of Malaya Medical Centre
Q33933630P53 transformation-related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non-transformed fibroblasts
Q28611354P53, apoptosis, and breast cancer
Q28611435P53, cell cycle control and apoptosis: Implications for cancer
Q36346951P80: a tumor-related protein found in many lymphomas of mice
Q35832827Pancreatic adenocarcinomas frequently show p53 gene mutations.
Q42065661Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens
Q37680961Patented inhibitors of p53-Mdm2 interaction (2006 - 2008).
Q41510725Pathways of p53-dependent apoptosis.
Q33932090Permanent expression of p53 in FR 3T3 rat cells but cell cycle-dependent association with large-T antigen in simian virus 40 transformants
Q40135384Phenotypic and Cytogenetic Characteristics of Human B-Lymphoid Cell Lines and Their Relevance for the Etiology of Burkitt'S Lymphoma
Q54723898Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.
Q36781515Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells
Q36933037Phosphorylation patterns of tumour antigens in cells lytically infected or transformed by simian virus 40
Q58073315Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73
Q36943796Polyoma Middle T Antigen Requires Cooperation from Another Gene to Express the Malignant Phenotype In Vivo
Q27310118Polyoma small T antigen triggers cell death via mitotic catastrophe
Q35013225Polyoma virus middle T antigen and its role in identifying cancer-related molecules
Q38574112Polyomavirus BK and prostate cancer: a complex interaction of potential clinical relevance.
Q36913417Polyomavirus and simian virus 40 large T antigens bind to common DNA sequences.
Q33336307Positive selection of candidate tumor-suppressor genes by subtractive hybridization
Q74453662Possible Relation of p53 and mdm-2 Oncoprotein Expression in Thyroid Carcinoma: A Molecular-Pathological and Immunohistochemical Study on Paraffin-Embedded Tissue
Q36966578Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells
Q42754709Post-thymic T cell lymphomas frequently overexpress p53 protein but infrequently exhibit p53 gene mutations
Q40528510Potential approaches for myocardial regeneration
Q45878491Potential role of DNA polymerase beta in gene therapy against cancer: a case for colorectal cancer
Q37349314Pre-crisis mouse cells show strain-specific covariation in the amount of 54-kilodalton phosphoprotein and in susceptibility to transformation by simian virus 40
Q35006968Precise epitope mapping of the murine transformation-associated protein, p53.
Q36941888Presence in growth-arrested cells of cellular proteins that interact with simian virus 40 small-t antigen
Q41366110Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53
Q28240740Principles of tumor suppression
Q59140486Production of a polyclonal antibody raised against recombinant flounder p53 protein
Q87945234Profiling of Germline Mutations in Major Hotspot Codons of TP53 Using PCR-RFLP
Q93001945Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma
Q36135501Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas
Q34285565Prognostic significance of p53-expression in colorectal carcinoma as measured by a luminometric immunoassay
Q52348330Programmed Cell Death, from a Cancer Perspective: An Overview.
Q42499203Proliferative (MIB1, mdm2) Versus Anti-Proliferative (p53) Markers in Head and Neck Cancer. An Immunohistochemical Study
Q39219310Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers
Q34444393Prostate cancer in a transgenic mouse
Q40964578Protein kinase CK2-dependent regulation of p53 function: evidence that the phosphorylation status of the serine 386 (CK2) site of p53 is constitutive and stable
Q37514996Protein p53 and inducer-mediated erythroleukemia cell commitment to terminal cell division
Q45966278Protein-to-protein interactions: criteria defining the assembly of the enamel organic matrix.
Q35586902Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells
Q36468283Proteomic approaches to the study of papillomavirus-host interactions.
Q40462999Proto‐oncogenes and oncogenes in epidermal neoplasia
Q33924762Purification and biochemical characterization of the Epstein-Barr virus-determined nuclear antigen and an associated protein with a 53,000-dalton subunit.
Q41464734Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells
Q40214503Purification of p53/55 kinase from nuclear ribonucleoproteins of Namalwa cells
Q47833426Putting p53 in Context
Q36379182Quantitation and characterization of a species-specific and embryo stage-dependent 55-kilodalton phosphoprotein also present in cells transformed by simian virus 40
Q36973813Quantitation of a 55K Cellular Protein: Similar Amount and Instability in Normal and Malignant Mouse Cells
Q36503933Quantitative Proteomic Analysis of Enriched Nuclear Fractions from BK Polyomavirus-Infected Primary Renal Proximal Tubule Epithelial Cells
Q38147113RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response
Q33928142Radioimmunoassay of the cellular protein p53 in mouse and human cell lines.
Q35237803Rapid and sensitive quantitative immunoassay for the large simian virus 40 T antigen
Q34360802Rearrangement of the p53 gene in human osteogenic sarcomas
Q34469114Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
Q34441608Recombinant human MFG-E8 attenuates intestinal injury and mortality in severe whole body irradiation in rats
Q36912292Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens
Q39322285Regulation of Metabolic Activity by p53.
Q33928759Regulation of SV40 DNA replication by phosphorylation of T antigen
Q34252765Regulation of Viral Transcription and DNA Replication by the SV40 Large T Antigen
Q35108767Regulation of p53 level by UBE4B in breast cancer
Q36972504Regulation of the Cellular p53 Tumor Antigen in Teratocarcinoma Cells and Their Differentiated Progeny
Q33943437Regulation of the G2/M transition by p53.
Q33920419Relationship among Tau antigens isolated from various lines of simian virus 40-transformed cells
Q28645822Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
Q36832377Requirements for species-specific papovavirus DNA replication.
Q30329984Rescuing the function of mutant p53.
Q45152311Resistance to viral infection of super p53 mice.
Q36710840Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.
Q30831001Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.
Q39169881Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype.
Q38213115Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy.
Q36277435Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells
Q45203088Retinoblastoma in transgenic mice
Q33693631Retinoblastoma in transgenic mice: models of hereditary retinoblastoma
Q36692841Retinoblastoma protein and simian virus 40-dependent immortalization of human fibroblasts
Q54033603Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain.
Q39205536Reviving the guardian of the genome: Small molecule activators of p53.
Q37690890Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer
Q33603506Role of p53 assessment in management of Barrett's esophagus
Q41515342Role of p53 in apoptosis.
Q38883419Role of p53 isoforms and aggregations in cancer
Q36941216Role of the p53 Protein in Cell Proliferation as Studied by Microinjection of Monoclonal Antibodies
Q92257837Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
Q36400820Roles of the tumor suppressor p53 and the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in receptor-mediated apoptosis of WEHI 231 B lymphoma cells
Q40936277Roots and perspectives of contemporary papillomavirus research
Q24338301Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53
Q67240449SV40 Early mutants that are defective for viral DNA synthesis but competent for transformation of cultured rat and simian cells
Q41396801SV40 T antigen and the exocytotic pathway
Q59082218SV40 T antigen binds specifically to a cellular 53 K protein in vitro
Q38295645SV40 T-antigen as a dual oncogene: structure and function of the plasma membrane-associated population
Q72646037SV40 antitumor sera that directly immunoprecipitate small-t-associated cellular proteins
Q28282761SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation
Q47289313SV40 large T shares an antigenic determinant with a cellular protein of molecular weight 68,000.
Q43749432SV40-transformed cells express SV40 T antigen-related antigens on the cell surface
Q37345587SV40: Cell transformation and tumorigenesis
Q38072351Senescence regulation by the p53 protein family
Q35237665Separation of lytic and transforming functions of the simian virus 40 A region: two mutants which are temperature sensitive for lytic functions have opposite effects on transformation
Q36854935Sequences from polyomavirus and simian virus 40 large T genes capable of immortalizing primary rat embryo fibroblasts
Q35688697Sequential stimulation of cellular RNA synthesis in polyoma-infected mouse kidney cell cultures
Q36924904Signal-dependent translocation of simian virus 40 large-T antigen into rat liver nuclei in a cell-free system
Q39748728Simian Virus 40 Infection of Humans
Q36686025Simian virus 40 (SV40) T-antigen mutations in tumorigenic transformation of SV40-immortalized human uroepithelial cells
Q33292433Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53.
Q36802646Simian virus 40 T antigen can transcriptionally activate and mediate viral DNA replication in cells which lack the retinoblastoma susceptibility gene product
Q37333985Simian virus 40 T-antigen-mediated gene regulation in enterocytes is controlled primarily by the Rb-E2F pathway
Q40307810Simian virus 40 T-antigen-related cell surface antigen: serological demonstration on simian virus 40-transformed monolayer cells in situ
Q40307207Simian virus 40 T-antigen: identification of tryptic peptides in the C-terminal region and definition of the reading frame
Q36797245Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding
Q35236017Simian virus 40 gene A regulation of cellular DNA synthesis. II. In nonpermissive cells
Q36832198Simian virus 40 host range/helper function mutations cause multiple defects in viral late gene expression
Q24308996Simian virus 40 large T antigen affects the Saccharomyces cerevisiae cell cycle and interacts with p34CDC28
Q35831951Simian virus 40 large T antigen contains two independent activities that cooperate with a ras oncogene to transform rat embryo fibroblasts
Q36854039Simian virus 40 large T antigen oligomers: analysis of electrophoresis in the absence of detergent
Q40064685Simian virus 40 large T antigen stably complexes with a 185-kilodalton host protein
Q24305356Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1
Q36945232Simian virus 40 large T-antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation
Q40108931Simian virus 40 large T-antigen-dependent DNA replication is activated by protein phosphatase 2A in vitro.
Q36688604Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products
Q42599235Simian virus 40 mutants with amino-acid substitutions near the amino terminus of large T antigen
Q36855375Simian virus 40 origin DNA-binding domain on large T antigen.
Q36905896Simian virus 40 sequences between 0.168 and 0.424 map units are not required for abortive transformation
Q39876425Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.
Q36906843Simian virus 40 tumor antigen: isolation of the origin-specific DNA-binding domain
Q34255887Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum
Q45734015Simian virus-40 infection inhibits DNA damage-induced enhancement of CD95 expression and function.
Q38993512SirT3 and p53 Deacetylation in Aging and Cancer
Q36902524Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation
Q37142905Small DNA tumor viruses: large contributors to biomedical sciences
Q64374754Small size, big impact: how studies of small DNA tumour viruses revolutionized biology
Q34714730Small tumor antigen of polyomaviruses: role in viral life cycle and cell transformation
Q24651380Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy
Q27014977Smoking, p53 mutation, and lung cancer
Q33964955Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40
Q67290242Specific DNA binding activity of T antigen subclasses varies among different SV40-transformed cell lines
Q40141165Specific interaction of simian virus 40 large T antigen with cellular chromatin and nuclear matrix during the course of infection
Q72924819Specific interaction of the SV40 T antigen-cellular p53 protein complex with SV40 DNA
Q33999909Split T cell tolerance against a self/tumor antigen: spontaneous CD4+ but not CD8+ T cell responses against p53 in cancer patients and healthy donors
Q36780095Spontaneous rearrangement of integrated simian virus 40 DNA in nine transformed rodent cell lines
Q38335406Sprouty 2 binds ESCRT-II factor Eap20 and facilitates HIV-1 gag release
Q41020740Stabilization of p53 by adenovirus E1A occurs through its amino-terminal region by modification of the ubiquitin-proteasome pathway
Q36936688Stabilization of the 53,000-Dalton Nonviral Tumor Antigen Is Not Required for Transformation by Simian Virus 40
Q36907734Stabilization of the large T protein in temperature-independent (type A) FR 3T3 rat cells transformed with the simian virus 40 tsA30 mutant
Q40040456Stabilization of the tumor suppressor p53 during cellular transformation by simian virus 40: influence of viral and cellular factors and biological consequences
Q36730106Stoichiometry of cellular and viral components in the polyomavirus middle-T antigen-tyrosine kinase complex
Q36932873Stoichiometry of large T antigen and pp53 in complexes isolated from simian virus 40-transformed rat cells
Q34076012Strategies for manipulating the p53 pathway in the treatment of human cancer.
Q37794096Stressin' Sestrins take an aging fight
Q36882128Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma
Q41792117Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
Q41428303Structural prerequisites of simian virus 40 large T antigen for the maintenance of cell transformation
Q36924945Structure and biochemical functions of four simian virus 40 truncated large-T antigens
Q36927941Structure and synthesis of a simian virus 40 super T-antigen
Q36931075Study of the Functional Activities Concomitantly Retained by the 115,000 M r Super T Antigen, an Evolutionary Variant of Simian Virus 40 Large T Antigen Expressed in Transformed Rat Cells
Q41484312Studying the interaction of polyoma virus middle T antigen with cellular proteins
Q41648413Suppression of human nasopharyngeal carcinoma cell growth in nude mice by the wild-type p53 gene
Q36350167Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies.
Q44910351Suppression of platelet-derived growth factor alpha- and beta-receptor mRNA levels in human fibroblasts by SV40 T/t antigen
Q80212337Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model
Q35967111Surf the post-translational modification network of p53 regulation
Q31904803Surface plasmon resonance measurements reveal stable complex formation between p53 and DNA polymerase alpha
Q45798213Synthesis and processing of simian virus 40-specific RNA in adenovirus-infected, simian virus 40-transformed human cells
Q44247769Systemic lupus erythematosus and uterine cervical neoplasia
Q24645091T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
Q34662543T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis
Q36900316T-antigen-DNA polymerase alpha complex implicated in simian virus 40 DNA replication
Q55483973TP53 Gene Mutations and 17p Deletions in Human Astrocytomas
Q36081911TP53 gene mutations and protein accumulation in primary vaginal carcinomas
Q36135944TP53 mutation analyses on breast carcinomas: a study of paraffin-embedded archival material
Q38199075TP53 mutations in human cancer: database reassessment and prospects for the next decade
Q34559185TP53 mutations in nonsmall cell lung cancer
Q40742654TP53 tumor-suppressor gene and human carcinogenesis
Q46408321TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear.
Q33937962Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins
Q33655329Targeting p53 for Novel Anticancer Therapy
Q37177586Targeting the MDM2-p53 interaction for cancer therapy
Q91643844Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors
Q35795073Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils
Q33657519Targeting tumor suppressor networks for cancer therapeutics
Q36831228Temperature-sensitive mutants identify crucial structural regions of simian virus 40 large T antigen
Q40722479The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.
Q24300207The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53
Q34246710The DNA damage response in viral-induced cellular transformation
Q37785502The DNA damage response—Repair or despair?
Q91816686The Diverse Functions of Mutant 53, Its Family Members and Isoforms in Cancer
Q35851139The Epstein-Barr virus bZIP transcription factor Zta causes G0/G1 cell cycle arrest through induction of cyclin-dependent kinase inhibitors
Q33817088The Epstein-Barr virus protein BRLF1 activates S phase entry through E2F1 induction
Q42323049The Evolution of TP53 Mutations: From Loss-of-Function to Separation-of-Function Mutants
Q50448531The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene.
Q55180659The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure.
Q24317677The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
Q28079490The Importance of Physiologically Relevant Cell Lines for Studying Virus-Host Interactions
Q36430168The P53 pathway: what questions remain to be explored?
Q38896065The Paradox of p53: What, How, and Why?
Q34549700The Promise of Proteomics in the Study of Oncogenic Viruses
Q41528803The Retinoblastoma Protein: A Master Regulator of Cell Cycle, Differentiation and Apoptosis
Q40271232The SV40 a gene product is required for the production of a 54,000 MW cellular tumor antigen
Q36827839The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40.
Q33932011The abnormal location of cytoplasmic SV40 large T is not caused by failure to bind to DNA or to p53.
Q38186535The aggregation of mutant p53 produces prion-like properties in cancer
Q40039307The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.
Q31816068The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.
Q53542021The cellular oncogene p53 can be activated by mutagenesis.
Q40627208The clinical relevance of the p53 tumour suppressor gene
Q36764924The clinical significance of autoantibodies in gastrointestinal malignancies: an overview
Q40381238The clinical significance of p53 aberrations in human tumours
Q34903861The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53.
Q35191541The complex interactions of p53 with target DNA: we learn as we go.
Q43941701The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo
Q37808166The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication
Q37859721The dual role of p53: DNA protection and antioxidant.
Q34402080The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth
Q33593937The emerging p53 gene family
Q26742058The expanding regulatory universe of p53 in gastrointestinal cancer
Q24645732The first 30 years of p53: growing ever more complex
Q34180336The genetics and genomics of cancer
Q40279927The genome of human papovavirus BKV
Q34142403The history of p53. A perfect example of the drawbacks of scientific paradigms
Q24610004The history of tumor virology
Q33888765The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis
Q39595067The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300.
Q40138359The immunopathology of SV40-induced transformation
Q40088889The impact of p53 on the early stage replication of retrovirus.
Q39729519The implications of embryonic gene expression in neoplasia
Q37182764The individualization of cancer therapy: the unexpected role of p53.
Q41690979The initiation of simian virus 40 DNA replication in vitro
Q28252021The interaction of the hnRNP family member E1B-AP5 with p53
Q33693832The isoforms of the p53 protein
Q36832483The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions
Q92701432The many faces of p53: something for everyone
Q36659029The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
Q40076287The mechanism of cell transformation by SV40 and Polyoma virus
Q40867777The molecular and genetic characterization of human soft tissue tumors.
Q92062954The multiple mechanisms that regulate p53 activity and cell fate
Q40605944The origins of the small DNA tumor viruses
Q28259725The p53 circuit board
Q36781766The p53 complex from monkey cells modulates the biochemical activities of simian virus 40 large T antigen
Q36521923The p53 family in nervous system development and disease
Q48678761The p53 family: guardians of maternal reproduction
Q40961528The p53 gene and its role in human brain tumors.
Q53601235The p53 knowledgebase: an integrated information resource for p53 research.
Q67469552The p53 tumor suppressor gene. A preliminary clinical study in breast cancer patients
Q37887629The p53 tumor suppressor protein regulates hematopoietic stem cell fate
Q37751892The p53 tumour suppressor gene
Q38548852The p53 tumour suppressor gene
Q34187832The p53 tumour suppressor protein
Q33922153The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
Q41489275The p53-Bcl-2 connection
Q37503463The p53-MDM2/MDMX axis - A chemotype perspective
Q35371834The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation
Q40130414The pathogenesis of Abelson virus lymphomas of the mouse
Q62497458The predictive power of semiquantitative immunohistochemical assessment of p53 and c-erb B-2 in lymph node-negative breast cancer
Q53560080The presence of p53 transformation-related protein in Ab-MuLV transformed cells is required for their development into lethal tumors in mice
Q72314536The prevalence of different human papillomavirus types and p53 mutations in laryngeal carcinomas: is there a reciprocal relationship?
Q51342055The prognostic implication of the expression of EGFR, p53, cyclin D1, Bcl-2 and p16 in primary locally advanced oral squamous cell carcinoma cases: a tissue microarray study.
Q35978470The prognostic significance of the accumulation of p53 tumour-suppressor gene protein in gastric adenocarcinoma
Q34629128The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology
Q42125689The relationship of p53 immunostaining to survival in carcinoma of the lung
Q72700246The relationship of p53 protein and lymph node metastases in invasive breast cancer
Q41193565The role of DNA repair in the prevention of cancer
Q78244648The role of autosomal cell apoptosis regulator genes in human spermatogenesis
Q24793695The role of circulating anti-p53 antibodies in patients with advanced non-small cell lung cancer and their correlation to clinical parameters and survival
Q53569200The role of gene dosage and genetic transpositions in carcinogenesis
Q35034088The role of non-ras transforming genes in chemical carcinogenesis
Q41176248The role of p53 in cell cycle regulation
Q41486644The role of p53 in growth of mouse fibroblast lines
Q34283469The role of p53 in human cancer
Q33807833The role of the E6-p53 interaction in the molecular pathogenesis of HPV.
Q34602545The significance of immunohistochemistry in the diagnosis and therapy of neoplasms
Q45801434The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins
Q37537138The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
Q33938629The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein
Q40276689The transforming genes of SV40 and polyoma
Q41457444The transforming protein of the MC29-related virus CMII is a nuclear DNA-binding protein whereas MH2 codes for a cytoplasmic RNA-DNA binding polyprotein
Q33490078The tsA58 simian virus 40 large tumor antigen disrupts megakaryocyte differentiation in transgenic mice.
Q38314522The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein
Q40677778The tumor suppressor p53 is bound to RNA by a stable covalent linkage
Q28131694The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest
Q33384295The ubiquitin system, disease, and drug discovery
Q33566355The v-rel oncogene product is complexed to a 40-kDa phosphoprotein in transformed lymphoid cells
Q36779984The zinc finger region of simian virus 40 large T antigen
Q36695049The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting
Q84961734Therapeutic options for treatment of Merkel cell carcinoma
Q38042630Therapeutic strategies for head and neck cancer based on p53 status
Q91898958Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia
Q47742599Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
Q33302913Thirty years into the genomics era: tumor viruses led the way.
Q37188430Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222
Q36926635Time-dependent maturation of the simian virus 40 large T antigen-p53 complex studied by using monoclonal antibodies
Q28255819To die or not to die: how does p53 decide?
Q34983824To kill or be killed: viral evasion of apoptosis
Q34979520Topoisomerase activity associated with SV40 large tumor antigen
Q38486723Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation
Q35127707Transactivation of Human cdc2 Promoter by Adenovirus E1A
Q27679224Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code
Q38341700Transcription factor E4TF1 contains two subunits with different functions
Q36777349Transcription regulation by mutant p53.
Q39005896Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.
Q37113939Transcriptional and Transforming Activities of the Adenovirus E1A Proteins
Q38408993Transcriptome profiling the gills of amoebic gill disease (AGD)-affected Atlantic salmon (Salmo salar L.): a role for tumor suppressor p53 in AGD pathogenesis?
Q36217854Transfection of neonatal rat Schwann cells with SV-40 large T antigen gene under control of the metallothionein promoter
Q41601530Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains
Q44840448Transformation and radiosensitivity of human diploid skin fibroblasts transfected with activated ras oncogene and SV40 T-antigen
Q40307671Transformation of Primary Hamster Brain Cells with JC Virus and Its DNA
Q36919634Transformation of precrisis human cells by the simian virus 40 cytoplasmic-localization mutant pSVCT3 is accompanied by nuclear T antigen
Q40106989Transformation-Associated Tumor Antigens
Q41505517Transforming growth factor-beta 1 enhances serum-induced dephosphorylation of the P53 protein in cell lines growth-inhibited by this factor
Q83169251Transgenic models for prostate cancer research
Q34164124Transgenic models of retinoblastoma: what they tell us about its cause and treatment
Q47973774Transgenic rodent mutation/cancer bioassays: cell cycle control, cell proliferation and apoptosis as modifiers of outcome
Q80221850Treatment options for the recurrent odontogenic keratocyst
Q35902311Truncated N-terminal mutants of SV40 large T antigen as minimal immortalizing agents for CNS cells
Q34324683Tumor protein p53 (TP53) testing and Li-Fraumeni syndrome : current status of clinical applications and future directions
Q38026794Tumor suppressive pathways in the control of neurogenesis.
Q37289549Tumor suppressor genes and cancer of the human nervous system
Q41625163Tumor suppressor genes and human cancer
Q40568049Tumor suppressor genes and their roles in breast cancer
Q40456928Tumor suppressor genes in human thyroid neoplasms: p53 mutations are associated undifferentiated thyroid cancers
Q36847017Tumor suppressor genes: a new era for molecular genetic studies of cancer
Q53449845Tumor suppressor p53 gene forms multiple isoforms: evidence for single locus origin and cytoplasmic complex formation with heat shock proteins.
Q34314048Tumor suppressor p53 mutations and breast cancer: a critical analysis
Q40130058Tumor viruses and early mouse embryos
Q38824332Tumor-Suppressor Functions of the TP53 Pathway
Q30499489Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancers
Q41575783Tumorigenic conversion of human mesothelial cells as a consequence of platelet-derived growth factor-A chain overexpression
Q40044331Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation.
Q41809596Tumourigenesis associated with the p53 tumour suppressor gene
Q48033225Turning the key on p53.
Q33807787Twenty years of p53 research: structural and functional aspects of the p53 protein
Q36980764Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53
Q44676897Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus
Q36896709Two classes of transformation-deficient, immortalization-positive simian virus 40 mutants constructed by making three-base insertions in the T antigen gene
Q59074470Two different viral transforming proteins bind the same host tumour antigen
Q33865112Two different, mutually exclusively distributed, TP53 mutations in ovarian and peritoneal tumor tissues of a serous ovarian cancer patient: indicative for tumor origin?
Q40129418Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen.
Q22251289Two genetic hits (more or less) to cancer
Q36887574Two integrated partial repeats of simian virus 40 together code for a super-T antigen
Q24609948UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells
Q27015641Uncovering the role of p53 splice variants in human malignancy: a clinical perspective
Q64236647Understanding p53 functions through p53 antibodies
Q37680206Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity
Q34322386Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
Q36743177Uniform cell-autonomous tumorigenesis of the choroid plexus by papovavirus large T antigens
Q34110697Update on human polyomaviruses and cancer
Q47111189Updates from the TP53 universe
Q34170074Vaccines and immunotherapeutics for the treatment of malignant disease
Q37496628Variability in APOE genotype status in human-derived cell lines: a cause for concern in cell culture studies?
Q37087404Versatile functions of p53 protein in multicellular organisms
Q33894872View and review on viral oncology research
Q41708689Viral and cellular oncogene expression during progressive malignant transformation of SV40 transformed human fibroblasts
Q33846198Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease
Q44491628Viral genotypes and p53 expression in Epstein-Barr virus-associated primary malignant lymphomas of the intestines
Q41510729Viral inhibitors of apoptosis
Q24538223Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death.
Q39576424Viral oncoproteins discriminate between p53 and the p53 homolog p73.
Q41374895Virocrine transformation
Q36318145Viruses - seeking and destroying the tumor program
Q30384388Viruses and human cancers: a long road of discovery of molecular paradigms.
Q24653900Viruses associated with human cancer
Q36304840Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy
Q73066904WAF1 expression and p53 mutations in human colorectal cancers
Q38043443What We Know about the Molecular Genetics of Central Nervous System (CNS) Tumours in Malaysia
Q91771327What's knowledge is prologue: celebrating the 40th anniversary of the p53 discovery
Q37582777When mutants gain new powers: news from the mutant p53 field.
Q37788083Whether to target single or multiple CDKs for therapy? That is the question
Q37811898Why do viruses cause cancer? Highlights of the first century of human tumour virology
Q35830939Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue
Q36618628Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9
Q44703400Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication
Q40872252Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.
Q39822156Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation
Q40043948Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells.
Q26999402Zebrafish sex: a complicated affair
Q90108778Zinc-finger protein p52-ZER6 accelerates colorectal cancer cell proliferation and tumour progression through promoting p53 ubiquitination
Q73571149[An immunohistochemistry study of p53 protein in squamous cell carcinoma of the larynx]
Q80076298[Molecular biological and immunohistochemical analysis of tp53 in human ameloblastomas]
Q90070454[Update on Li-Fraumeni syndrome]
Q33807825mdm2: a bridge over the two tumour suppressors, p53 and Rb.
Q28565821p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen
Q35326348p53 Family: Role of Protein Isoforms in Human Cancer
Q90510724p53 Overexpression in Oral Mucosa in Relation to Shisha Smoking in Syria and Lebanon
Q41313953p53 Phosphorylation: biochemical and functional consequences
Q34313764p53 Research: the past thirty years and the next thirty years.
Q73215749p53 abnormalities are rare events in neuroendocrine (Merkel cell) carcinoma of the skin. An immunohistochemical and SSCP analysis
Q72680112p53 accumulation in polynuclear-giant-cells
Q44581576p53 and DNA polymerase alpha compete for binding to SV40 T antigen
Q35185411p53 and E2F-1 cooperate to mediate apoptosis
Q33853843p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes
Q38294077p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
Q37502697p53 and little brother p53/47: linking IRES activities with protein functions
Q55002919p53 and metabolism: from mechanism to therapeutics.
Q36915110p53 and retinoblastoma pathways in bladder cancer.
Q55084411p53 and the Viral Connection: Back into the Future ‡.
Q37242078p53 as a therapeutic target.
Q36356298p53 attenuates AKT signaling by modulating membrane phospholipid composition
Q37619644p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression.
Q42281236p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas
Q74122440p53 expression and p53 gene mutation in oral cancer and dysplasia
Q41947345p53 expression in colorectal tumors.
Q71603631p53 expression in odontogenic keratocyst epithelium
Q44259985p53 expression is common in malignant mesothelioma
Q34206213p53 functional assays: detecting p53 mutations in both the germline and in sporadic tumours
Q34254691p53 functions as a cell cycle control protein in osteosarcomas
Q40370722p53 gene mutations and photocarcinogenesis
Q48428560p53 gene mutations in primary lung tumors are conserved in brain metastases
Q42787579p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma
Q36079809p53 immunohistochemistry as an independent prognostic factor for superficial transitional cell carcinoma of the bladder
Q42281269p53 immunoreaction in endoscopic biopsy specimens of colorectal cancer, and its prognostic significance
Q73130677p53 immunostaining and image cytometry DNA analysis in precancerous and cancerous squamous epithelial lesions of the larynx
Q33358202p53 in cell invasion, podosomes, and invadopodia
Q35982948p53 in colorectal cancer: clinicopathological correlation and prognostic significance
Q77957211p53 induction in normal human skin in vitro following exposure to solar simulated UV and UV-B irradiation
Q24319034p53 isoforms can regulate p53 transcriptional activity.
Q91701515p53 modifications: exquisite decorations of the powerful guardian
Q33750337p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer
Q36690312p53 mutations are not selected for in simian virus 40 T-antigen-induced tumors from transgenic mice
Q36622335p53 mutations in urinary bladder cancer.
Q49164152p53 mutations occur in clinical, but not latent, human prostate carcinoma
Q41607022p53 mutations, methylation and genomic instability in the progression of chronic myeloid leukaemia
Q48243360p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways.
Q40848687p53 overexpression in Ewing's sarcoma/primitive neuroectodermal tumour is an uncommon event
Q53559051p53 protein and control of growth.
Q55483225p53 protein expression in central nervous system tumors: an immunohistochemical study with CM1 polyvalent and DO-7 monoclonal antibodies.
Q72046282p53 protein expression in cutaneous T-cell lymphomas
Q73144803p53 protein expression in ductal carcinoma in situ (DCIS) of the breast
Q35994464p53 protein expression in human breast carcinoma: relationship to expression of epidermal growth factor receptor, c-erbB-2 protein overexpression, and oestrogen receptor
Q36294933p53 protein expression in nephroblastomas: a predictor of poor prognosis
Q37107115p53 protein in odontogenic cysts: increased expression in some odontogenic keratocysts
Q45122733p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation.
Q37821711p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells
Q35329162p53 transformation-related protein: detection by monoclonal antibody in mouse and human cells
Q35360570p53 transformation-related protein: detection of an associated phosphotransferase activity
Q42440449p53 tumor suppressor gene protein expression in premalignant and malignant skin lesions of kidney transplant recipients
Q37049524p53 tumor suppressor gene: a critical molecular target for UV induction and prevention of skin cancer
Q41640484p53 tumor-suppressor gene: clues to molecular carcinogenesis
Q89783061p53's Extended Reach: The Mutant p53 Secretome
Q47702659p53, Bax and Bcl-2 expression, and apoptosis in gestational trophoblast of complete hydatidiform mole
Q42362115p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance
Q35103179p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome
Q37610416p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells
Q38102472p53-based therapeutics for head and neck squamous cell carcinoma
Q40873109p53-catalyzed annealing of complementary single-stranded nucleic acids
Q34305233p53-dependent apoptosis pathways.
Q34424487p53-dependent growth arrest of REF52 cells containing newly amplified DNA.
Q34609247p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus
Q36443527p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.
Q24338379p53: 25 years after its discovery
Q94671691p53: 800 million years of evolution and 40 years of discovery
Q40564007p53: a cellular Achilles' heel revealed.
Q37248542p53: a molecular marker for the detection of cancer.
Q91651435p53: a tumor suppressor hiding in plain sight
Q45888635p53: balancing tumour suppression and implications for the clinic
Q83365205p53: more research and more questions
Q91771321p53: not just a tumor suppressor
Q37824262p53: the attractive tumor suppressor in the cancer research field
Q36163707p53: twenty five years understanding the mechanism of genome protection
Q30595453p63 and p73: old members of a new family
Q35227440p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.
Q40774641p73 is a growth-regulated protein in vascular smooth muscle cells and is present at high levels in human atherosclerotic plaque
Q39589009pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression
Q40650649trans activation of type 1 interferon promoters by simian virus 40 T antigen

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