Tumor suppressor p53 gene forms multiple isoforms: evidence for single locus origin and cytoplasmic complex formation with heat shock proteins.

scientific article published in November 1996

Tumor suppressor p53 gene forms multiple isoforms: evidence for single locus origin and cytoplasmic complex formation with heat shock proteins. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ELPS.1150171114
P8608Fatcat IDrelease_uziz4ymicrdvrb7lyr2m3v5dam
P698PubMed publication ID8982609

P2093author name stringHe C
Patterson RM
Merrick BA
Selkirk JK
P2860cites workMutations in the p53 gene occur in diverse human tumour typesQ28249770
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Protein folding in the cellQ29547792
Suppression of human colorectal carcinoma cell growth by wild-type p53Q29618318
T antigen is bound to a host protein in SY40-transformed cellsQ29618321
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.Q33740135
p53 functions as a cell cycle control protein in osteosarcomasQ34254691
The p53 proto-oncogene can act as a suppressor of transformationQ34440370
Speculations on the functions of the major heat shock and glucose-regulated proteinsQ34562570
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-lifeQ36782441
Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP.Q36785161
Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complexQ36867104
Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell linesQ36919740
Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancersQ36954741
Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed CellsQ36966578
Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53Q36980764
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouseQ37331246
The p53 protein and its interactions with the oncogene products of the small DNA tumor virusesQ37855772
Polypeptide chain binding proteins: catalysts of protein folding and related processes in cellsQ38367129
Monoclonal antibody analysis of p53 expression in normal and transformed cellsQ40127251
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cellsQ40237209
Evidence that wild-type TP53, and not genes on either chromosome 1 or 11, controls the tumorigenic phenotype of the human fibrosarcoma HT1080.Q41478681
Genetic mechanisms of tumor suppression by the human p53 geneQ41710706
Specific interaction between the p53 cellular tumour antigen and major heat shock proteinsQ43512047
HSP86 and HSP84 exhibit cellular specificity of expression and co-precipitate with an HSP70 family member in the murine testis.Q52227811
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.Q53548575
Participation of p53 cellular tumour antigen in transformation of normal embryonic cellsQ53548581
Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformationQ70168032
P433issue11
P304page(s)1764-1771
P577publication date1996-11-01
P1433published inElectrophoresisQ3050608
P1476titleTumor suppressor p53 gene forms multiple isoforms: evidence for single locus origin and cytoplasmic complex formation with heat shock proteins.
P478volume17

Reverse relations

cites work (P2860)
Q35313406Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygium
Q34095732Chaperones in cell cycle regulation and mitogenic signal transduction: a review
Q34369172Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors
Q43682981Decreased in vitro interaction between p53 and nuclear stress proteins in the p53-deficient mouse
Q40588000Effects of hyperthermia on p53 protein expression and activity
Q28345134Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia
Q24650438Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound
Q40938040Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
Q77830062The relationship of p53 and stress proteins in response to bleomycin and retinoic acid in the p53 heterozygous mouse
Q42829713p53 protein accumulation in addition to the transactivation activity is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin.

Search more.