High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.

scientific article published on July 1996

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID190386
P698PubMed publication ID8676476

P2093author name stringX Li
P Coffino
P2860cites workTranscriptional activation by wild-type but not transforming mutants of the p53 anti-oncogeneQ24298218
Inhibition of p53 DNA binding by human papillomavirus E6 proteinsQ24317013
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cellsQ24555806
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcriptionQ28187745
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytesQ28254780
p21 is a universal inhibitor of cyclin kinasesQ28257305
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spotsQ72693767
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility geneQ28281071
p53 mutations in human cancersQ28302973
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Q29547773
A 26 S protease subunit that binds ubiquitin conjugatesQ29614362
The ubiquitin system for protein degradationQ29614385
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
T antigen is bound to a host protein in SY40-transformed cellsQ29618321
Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteinsQ33292223
Analysis of a protein-binding domain of p53Q33292314
Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene productQ33589833
Monoclonal antibodies specific for simian virus 40 tumor antigensQ34249232
p53 functions as a cell cycle control protein in osteosarcomasQ34254691
Precise epitope mapping of the murine transformation-associated protein, p53.Q35006968
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18Q35937193
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathwayQ36648425
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.Q36660357
Use of the two-hybrid system to identify the domain of p53 involved in oligomerizationQ36783948
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytesQ36831207
Characterization of primary human keratinocytes transformed by human papillomavirus type 18.Q36868528
Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA.Q36886337
Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed CellsQ36966578
Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53Q36980764
The p53 tumour suppressor geneQ37751892
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 proteinQ38313694
Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activationQ38332737
The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest.Q40041446
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cellsQ40237209
Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesisQ40647696
Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant formQ41210647
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.Q41508377
A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerizationQ41612441
Presence of a potent transcription activating sequence in the p53 proteinQ41724404
The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motifQ41742127
Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory proteinQ41987593
Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA.Q42817558
Association of human papillomavirus types 16 and 18 E6 proteins with p53.Q43701619
Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells.Q44769248
Targeting and degradation of p53 by E6 of human papillomavirus type 16 is preferential for the 1620+ p53 conformationQ45037523
p53 domains: identification and characterization of two autonomous DNA-binding regions.Q52544476
Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins.Q53503674
Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression.Q54422442
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cellsQ64381309
The domain of p53 required for binding HPV 16 E6 is separable from the degradation domainQ72520479
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)4509-4516
P577publication date1996-07-01
P1433published inJournal of VirologyQ1251128
P1476titleHigh-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation
P478volume70

Reverse relations

cites work (P2860)
Q34509620A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation
Q33800021Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.
Q39153847An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein.
Q34251029Analysis of Tp53 codon 72 polymorphisms, Tp53 mutations, and HPV infection in cutaneous squamous cell carcinomas
Q33596688Association of intron and exon polymorphisms of p53 gene in Iranian patients with gastritis
Q30860353Cell-specific modulation of papovavirus replication by tumor suppressor protein p53
Q36989890Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses
Q36478774Clinicopathologic Features Associated With Human Papillomavirus/p16 in Patients With Metastatic Squamous Cell Carcinoma of the Anal Canal
Q37392961Common genetic variation in TP53 and risk of human papillomavirus persistence and progression to CIN3/cancer revisited
Q40103314Comprehensive Genomic Profiling of Metastatic Squamous Cell Carcinoma of the Anal Canal.
Q47153289Delineation of the HPV11E6 and HPV18E6 Pathways in Initiating Cellular Transformation.
Q39948840E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation
Q28652354Further Stimulation of Cellular Immune Responses through Association of HPV-16 E6, E7 and L1 Genes in order to produce more Effective Therapeutic DNA Vaccines in Cervical Cancer Model
Q28360379HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation
Q33384291HPV E6, E6AP and cervical cancer
Q26770487HPV-p53-miR-34a axis in HPV-associated cancers
Q93010911Human Papillomavirus 11 Early Protein E6 Activates Autophagy by Repressing AKT/mTOR and Erk/mTOR
Q34980270Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis
Q37769103Human papillomavirus oncoproteins: pathways to transformation
Q24551145Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
Q36897152In GFP with high risk HPV-18E6 fusion protein expressed 293T and MCF-7 cells, the endogenous wild-type p53 could be transiently phosphorylated at multiple sites
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Q33649218Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells
Q35870606Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation.
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Q37350446Papillomavirus E6 proteins
Q92715593Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
Q36527456Posttranslational phosphorylation of mutant p53 protein in tumor development
Q34064334Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain
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Q30277715Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Q35192650Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance
Q42727197The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2.
Q36064347Transcriptomic analyses of genes differentially expressed by high-risk and low-risk human papilloma virus E6 oncoproteins
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Q39576424Viral oncoproteins discriminate between p53 and the p53 homolog p73.
Q39460833c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination
Q39579847p53 protein is a suppressor of papillomavirus DNA amplificational replication

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