Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations.

scientific article published on 27 February 2014

Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP04223
P932PMC publication ID3936234
P698PubMed publication ID24573247
P5875ResearchGate publication ID260395045

P50authorJie XuQ47095324
P2093author name stringYe Hu
Jin Qian
Jing-Yuan Fang
Xiaolin Zhou
Haoyan Chen
Jilin Wang
P2860cites workGain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.Q52561781
Gain of function of mutant p53 by coaggregation with multiple tumor suppressorsQ57670523
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndromeQ81166001
Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafishQ85194197
RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domainQ39150487
Colorectal cancer cells refractory to anti-VEGF treatment are vulnerable to glycolytic blockade due to persistent impairment of mitochondriaQ39191124
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.Q39225768
Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.Q45341269
T antigen is bound to a host protein in SY40-transformed cellsQ29618321
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasionQ30537354
Discovery analysis of TCGA data reveals association between germline genotype and survival in ovarian cancer patientsQ30612061
Increased oxidative metabolism in the Li-Fraumeni syndromeQ34008143
Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 databaseQ34631589
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Q35227440
Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.Q35804653
Mutant p53: one name, many proteinsQ36070574
Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesisQ36920797
The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasisQ37031974
Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of renal cell carcinomaQ37087053
Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesisQ37269994
Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.Q37307220
The tumor suppressor p53: from structures to drug discoveryQ37762069
p53 mutations in cancerQ38069463
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectLi-Fraumeni syndromeQ187542
heterogeneityQ928498
P304page(s)4223
P577publication date2014-02-27
P1433published inScientific ReportsQ2261792
P1476titleHeterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations
P478volume4

Reverse relations

cites work (P2860)
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Q51623974Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H).
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Q47107350Mutant p53 partners in crime
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Q47833426Putting p53 in Context
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