Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells

scientific article published on January 1988

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.8.1.461
P932PMC publication ID363151
P698PubMed publication ID2827007

P2093author name stringD W Meek
W Eckhart
P2860cites workUV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse CellsQ24609948
T antigen is bound to a host protein in SY40-transformed cellsQ29618321
Transforming gene product of Rous sarcoma virus phosphorylates tyrosineQ29620005
Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serumQ34255887
A single gene and a pseudogene for the cellular tumour antigen p53.Q34265353
Complex of simian virus 40 large tumor antigen and 48,000-dalton host tumor antigenQ35299950
Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cellsQ35589990
Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cellsQ36316665
Characterization of Rous sarcoma virus src gene products synthesized in vitroQ36526354
Overproduction of protein p53 contributes to simian virus 40-mediated transformationQ36897747
Tumorigenicity of fibroblast lines expressing the adenovirus E1a, cellular p53, or normal c-myc genesQ36908146
Time-dependent maturation of the simian virus 40 large T antigen-p53 complex studied by using monoclonal antibodiesQ36926635
Protein kinase activities in immune complexes of simian virus 40 large T-antigen and transformation-associated cellular p53 proteinQ36941033
Role of the p53 Protein in Cell Proliferation as Studied by Microinjection of Monoclonal AntibodiesQ36941216
Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed CellsQ36966578
Staphylococcal Protease: A Proteolytic Enzyme Specific for Glutamoyl BondsQ37501676
Biological and molecular analysis of p53 cellular-encoded tumor antigenQ39819264
The p53 cellular tumor antigen: gene structure, expression and protein propertiesQ39831647
Monoclonal antibody analysis of p53 expression in normal and transformed cellsQ40127251
The 53,000-dalton cellular protein and its role in transformationQ40140396
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cellsQ40237209
Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53.Q40461080
Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigenQ40669975
Co-operation between the p53 protein tumor antigen and platelet-poor plasma in the induction of cellular DNA synthesis.Q42813234
Growth regulation of a cellular tumour antigen, p53, in nontransformed cellsQ42819146
Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53Q43927270
Organization of T Antigens in the Polyoma Virus GenomeQ45803141
Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytesQ51231745
The cellular oncogene p53 can be activated by mutagenesis.Q53542021
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.Q53548575
Participation of p53 cellular tumour antigen in transformation of normal embryonic cellsQ53548581
Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.Q53551443
Overproduction of p53 antigen makes established cells highly tumorigenicQ59053537
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cellsQ64381309
The amino acid sequence of murine p53 determined from a c-DNA cloneQ70421886
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
SV40Q734305
P304page(s)461-465
P577publication date1988-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlePhosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells
P478volume8

Reverse relations

cites work (P2860)
Q40064310Altered phosphorylation of free and bound forms of monkey p53 and simian virus 40 large T antigen during lytic infection
Q37286062Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations
Q24300162Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)
Q24603984Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen
Q41852020Evidence for allosteric variants of wild-type p53, a tumour suppressor protein
Q36872197Expression and complex formation of simian virus 40 large T antigen and mouse p53 in insect cells
Q44039342Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract
Q30450287Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
Q36774702Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
Q40678319Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae
Q40678382Human p53 inhibits growth in Schizosaccharomyces pombe
Q33643799Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2
Q35226651Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?
Q48026339Multisite phosphorylation and the integration of stress signals at p53.
Q42807102Mutation of phosphoserine 389 affects p53 function in vivo
Q40535104Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.
Q36803951Mutation of the serine 312 phosphorylation site does not alter the ability of mouse p53 to inhibit simian virus 40 DNA replication in vivo
Q48592349Neonatal transection of the infraorbital nerve increases the expression of proteins related to neuronal death in the principal sensory nucleus of the trigeminal nerve
Q35450130Nuclear protein phosphorylation and growth control
Q40129645Oligomerization of oncoprotein p53.
Q40686230Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates
Q36998330Phosphorylation sites in the amino-terminal region of mouse p53
Q38297617Phosphorylation studies on rat p53 using the baculovirus expression system. Manipulation of the phosphorylation state with okadaic acid and influence on DNA binding
Q33899450Posttranslational modification of p53: cooperative integrators of function
Q40964578Protein kinase CK2-dependent regulation of p53 function: evidence that the phosphorylation status of the serine 386 (CK2) site of p53 is constitutive and stable
Q36459445Protein phosphatases and DNA tumor viruses: transformation through the back door?
Q83855474Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis
Q35092610Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo
Q36797245Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding
Q40107778Simian virus 40 large T antigen induces or activates a protein kinase which phosphorylates the transformation-associated protein p53.
Q28396109Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease
Q36698395Species-specific phosphorylation of mouse and rat p53 in simian virus 40-transformed cells
Q40023550The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
Q33922153The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
Q34045809The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.
Q40677778The tumor suppressor p53 is bound to RNA by a stable covalent linkage
Q33968205Towards inferring time dimensionality in protein-protein interaction networks by integrating structures: the p53 example
Q34314048Tumor suppressor p53 mutations and breast cancer: a critical analysis
Q64236647Understanding p53 functions through p53 antibodies
Q33913536Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen
Q41313953p53 Phosphorylation: biochemical and functional consequences
Q34254691p53 functions as a cell cycle control protein in osteosarcomas
Q41595909p53 is covalently linked to 5.8S rRNA.
Q24643993p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner
Q41360603p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.
Q24672443p53-independent endoplasmic reticulum stress-mediated cytotoxicity of a Newcastle disease virus strain in tumor cell lines

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