The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

scientific article published on October 1997

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.17.10.5923
P932PMC publication ID232440
P698PubMed publication ID9315650
P5875ResearchGate publication ID13906151

P2093author name stringLevine AJ
Bailey P
Lu H
Fisher RP
P2860cites workTranscriptional activation by wild-type but not transforming mutants of the p53 anti-oncogeneQ24298218
Cdk-activating kinase complex is a component of human transcription factor TFIIHQ24306759
In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger proteinQ24310168
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell deathQ24312211
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathwayQ24336089
p53 modulation of TFIIH–associated nucleotide excision repair activityQ24336880
Human TAFII31 protein is a transcriptional coactivator of the p53 proteinQ24562978
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factorQ24595611
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53Q24609153
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
p53, the cellular gatekeeper for growth and divisionQ27860990
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Association of Cdk-activating kinase subunits with transcription factor TFIIHQ28236002
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD proteinQ28238628
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinaseQ28247022
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase IIQ28251866
p21 is a universal inhibitor of cyclin kinasesQ28257305
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
Induction of the growth inhibitor IGF-binding protein 3 by p53Q28289896
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
The p53-mdm-2 autoregulatory feedback loopQ28609811
Mapping of the p53 and mdm-2 Interaction DomainsQ28609886
Allosteric activation of latent p53 tetramersQ28623087
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
Participation of p53 protein in the cellular response to DNA damageQ29618319
Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIHQ55043488
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase IIQ59098636
p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytesQ70993632
p53 Protein exhibits 3'-to-5' exonuclease activityQ71170481
Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosisQ71408610
Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinasesQ71614374
U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycleQ72185052
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spotsQ72693767
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumoursQ29618396
p53: puzzle and paradigmQ29618407
Atm-deficient mice: a paradigm of ataxia telangiectasiaQ29619532
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factorQ29619833
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2Q33643799
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologuesQ34057186
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.Q34057245
Monoclonal antibodies specific for simian virus 40 tumor antigensQ34249232
The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activityQ34252975
Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinasesQ34298718
Cloning of the 62-kilodalton component of basic transcription factor BTF2.Q34338584
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2Q34356650
Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cellsQ35589990
Mammalian DNA nucleotide excision repair reconstituted with purified protein components.Q36697936
The mdm-2 gene is induced in response to UV light in a p53-dependent mannerQ36717209
Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cellsQ36781515
Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding proteinQ37332768
Role of phosphorylation in p34cdc2 activation: identification of an activating kinaseQ37370012
The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complexQ37617641
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminusQ38294071
p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatchesQ38294077
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repairQ38313225
Regulation of the specific DNA binding function of p53Q38324290
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor proteinQ40018842
Where transcription meets repairQ40739628
The p53 tumor suppressor gene.Q40761463
p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytesQ40793691
p53 in growth control and neoplasiaQ41009705
Oxidative stress is involved in the UV activation of p53.Q41200949
p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.Q41360603
Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.Q41548662
Presence of a potent transcription activating sequence in the p53 proteinQ41724404
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factorQ42494377
Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetateQ42811171
Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzymeQ42818286
Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivoQ42827016
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.Q45041158
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.Q45985375
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.Q45993768
Alternative mechanisms of CAK assembly require an assembly factor or an activating kinaseQ46760600
Mutations in the p53 and SCID genes cooperate in tumorigenesis.Q52200235
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.Q52200236
Dual roles of ATM in the cellular response to radiation and in cell growth control.Q52521591
p53 induction, cell cycle checkpoints, and apoptosis in DNAPK-deficient scid mice.Q53449267
Small peptides activate the latent sequence-specific DNA binding function of p53.Q54601436
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)5923-5934
P577publication date1997-10-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
P478volume17

Reverse relations

cites work (P2860)
Q28203791A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1
Q90149996ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942
Q40613054Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2.
Q35907026Applications of gene therapy for familial amyloidotic polyneuropathy
Q42707122Arsenic-induced promoter hypomethylation and over-expression of ERCC2 reduces DNA repair capacity in humans by non-disjunction of the ERCC2-Cdk7 complex.
Q24298631BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase
Q27931743CTD kinase I is involved in RNA polymerase I transcription
Q40272241Cdk9 phosphorylates p53 on serine 392 independently of CKII.
Q33338375Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure
Q40960693Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.
Q38973176Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.
Q35199554DNA damage induces phosphorylation of the amino terminus of p53
Q39640818DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development
Q64389076DNA signals for G2 checkpoint response in diploid human fibroblasts
Q44487712Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone
Q33997846Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress
Q73088400Dissociation of the recombination control and the sequence-specific transactivation function of P53
Q46408733Docosahexaenoic acid induces apoptosis in proliferating human endothelial cells
Q40932282Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death
Q64059258Efficacy of the novel CDK7 inhibitor QS1189 in mantle cell lymphoma
Q24306430Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
Q41811880Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer
Q34417108Genotoxic and non-genotoxic pathways of p53 induction
Q73794909Human DNA repair genes
Q36907227Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities
Q52316521ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.
Q28388232Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates
Q33967914Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.
Q36073860Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
Q35857003Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest
Q33807813Mechanisms of switching on p53: a role for covalent modification?
Q24811971Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors
Q33704559Molecular interaction map of the mammalian cell cycle control and DNA repair systems
Q49964619Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
Q53422893Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
Q36485499Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53.
Q39292772PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway
Q40277059Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W-CDMA modulated radiation allocated to mobile radio base stations
Q36012544Phosphorylation at carboxyl-terminal S373 and S375 residues and 14-3-3 binding are not required for mouse p53 function
Q34093159Phosphorylation in transcription: the CTD and more
Q44513266Phosphorylation site interdependence of human p53 post-translational modifications in response to stress
Q36527456Posttranslational phosphorylation of mutant p53 protein in tumor development
Q40311425Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.
Q54075746RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells.
Q42509472Reconstitution of recombinant TFIIH that can mediate activator-dependent transcription
Q33892839Regulation of p53 stability and activity in response to genotoxic stress.
Q37636014Regulation of p53--insights into a complex process
Q34816680Regulation of transcription elongation by phosphorylation
Q43915766SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression
Q46302815Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis
Q64234008Small molecule activators of the p53 response
Q91738289TC2N, a novel oncogene, accelerates tumor progression by suppressing p53 signaling pathway in lung cancer
Q33552252TFIIH operates through an expanded proximal promoter to fine-tune c-myc expression
Q38008913TFIIH: when transcription met DNA repair.
Q35210621Targeted gene repair -- in the arena
Q46862330The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways.
Q33923593The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor
Q33771774The cellular response to p53: the decision between life and death
Q40715337The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H.
Q52319133The essential and multi-functional TFIIH complex.
Q33832707The initiative role of XPC protein in cisplatin DNA damaging treatment-mediated cell cycle regulation.
Q42819038The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.
Q38336958The involvement of XPC protein in the cisplatin DNA damaging treatment-mediated cellular response.
Q42454112The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter.
Q34187832The p53 tumour suppressor protein
Q36438161Transcription abnormalities potentiate apoptosis of normal human fibroblasts.
Q33601019Transcription factor IIH: a key player in the cellular response to DNA damage
Q37413761Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389
Q40827234Wild-type p53 inhibits protein kinase CK2 activity
Q36538872hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage
Q33632282p53 and the CNS: tumors and developmental abnormalities
Q28210026p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex
Q36163707p53: twenty five years understanding the mechanism of genome protection

Search more.