| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1016/S1383-5742(00)00035-1 |
| P698 | PubMed publication ID | 10767629 |
| P2093 | author name string | J C Barrett | |
| C A Afshari | |||
| M S Colman | |||
| P2860 | cites work | A role for ATR in the DNA damage-induced phosphorylation of p53 | Q22008733 |
| Interaction of p53 with the human Rad51 protein | Q24309466 | ||
| Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 | Q24311891 | ||
| A model for p53-induced apoptosis | Q24313374 | ||
| Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 | ||
| Identification of redox/repair protein Ref-1 as a potent activator of p53 | Q24316161 | ||
| ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways | Q24321528 | ||
| Mdm2 promotes the rapid degradation of p53 | Q24322597 | ||
| Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 | Q24328775 | ||
| The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression | Q24533291 | ||
| Regulation of p53 function and stability by phosphorylation | Q24554530 | ||
| The BRCA2 gene product functionally interacts with p53 and RAD51 | Q24650406 | ||
| p53 regulates a G2 checkpoint through cyclin B1 | Q24652586 | ||
| Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53 | Q24672736 | ||
| Regulation of p53 stability by Mdm2 | Q27860744 | ||
| p53, the cellular gatekeeper for growth and division | Q27860990 | ||
| MDM2 interacts with MDMX through their RING finger domains | Q28142437 | ||
| DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 | Q28254119 | ||
| JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases | Q28256056 | ||
| The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 | Q28266637 | ||
| 14-3-3sigma is a p53-regulated inhibitor of G2/M progression | Q28276061 | ||
| Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit | Q28379354 | ||
| Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. | Q28590239 | ||
| Requirement for p53 and p21 to sustain G2 arrest after DNA damage | Q29547667 | ||
| Cancer cell cycles | Q29547756 | ||
| DNA damage activates p53 through a phosphorylation-acetylation cascade | Q29616294 | ||
| p53: puzzle and paradigm | Q29618407 | ||
| Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains | Q30175992 | ||
| Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. | Q33888123 | ||
| The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. | Q33889383 | ||
| Reactive oxygen species are downstream mediators of p53-dependent apoptosis | Q34403292 | ||
| BRCA1 physically associates with p53 and stimulates its transcriptional activity. | Q34467604 | ||
| The role of ATM in DNA damage responses and cancer | Q34489164 | ||
| DNA damage induces phosphorylation of the amino terminus of p53 | Q35199554 | ||
| Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function | Q35204136 | ||
| Stabilization and activation of p53 are regulated independently by different phosphorylation events | Q35912100 | ||
| Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation | Q35973184 | ||
| Proteolytic cleavage of the mdm2 oncoprotein during apoptosis | Q38343171 | ||
| Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6 | Q39576878 | ||
| The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro | Q40023550 | ||
| Activation of an MDM2-specific caspase by p53 in the absence of apoptosis | Q40954121 | ||
| Transcriptional activation of the human glutathione peroxidase promoter by p53. | Q40960162 | ||
| Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. | Q40960693 | ||
| c-Abl neutralizes the inhibitory effect of Mdm2 on p53. | Q40966247 | ||
| DNA-dependent protein kinase acts upstream of p53 in response to DNA damage | Q41013003 | ||
| Involvement of p85 in p53-dependent apoptotic response to oxidative stress | Q41061530 | ||
| Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene. | Q41101036 | ||
| Mdm2: keeping p53 under control | Q41585894 | ||
| Three distinct signalling responses by murine fibroblasts to genotoxic stress | Q42807014 | ||
| DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation | Q42816808 | ||
| p53 and genetic susceptibility to cervical cancer | Q43646240 | ||
| PIK3CA is implicated as an oncogene in ovarian cancer. | Q46015944 | ||
| Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors | Q48375426 | ||
| Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. | Q53425055 | ||
| p53 polymorphism and risk of cervical cancer | Q59072735 | ||
| p53 gene mutation: software and database | Q59526222 | ||
| p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction | Q64386856 | ||
| Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases | Q73413438 | ||
| The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo | Q73903403 | ||
| Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis | Q74371562 | ||
| DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site | Q77332011 | ||
| The ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNA-dependent protein kinase | Q77388156 | ||
| Signaling to p53: breaking the MDM2-p53 circuit | Q77430977 | ||
| Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers | Q77463982 | ||
| Phosphorylation of p53 serine 15 increases interaction with CBP | Q77604720 | ||
| A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells | Q77640395 | ||
| Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity | Q77733994 | ||
| Abnormal expression or mutation of TP53 and HPV in vulvar cancer | Q78128720 | ||
| P433 | issue | 2-3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | genotoxicity | Q1009245 |
| P304 | page(s) | 179-188 | |
| P577 | publication date | 2000-04-01 | |
| P1433 | published in | Mutation Research | Q6943732 |
| P1476 | title | Regulation of p53 stability and activity in response to genotoxic stress | |
| P478 | volume | 462 |
| Q28201456 | ATM: genome stability, neuronal development, and cancer cross paths |
| Q39090201 | An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells |
| Q52720134 | Anticancer efficacies of arsenic disulfide through apoptosis induction, cell cycle arrest, and pro-survival signal inhibition in human breast cancer cells. |
| Q83014574 | B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation |
| Q34945155 | Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways |
| Q41569674 | Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis |
| Q43581020 | Cell differentiation and chemotherapy influence p53 and Mdm2 immunoreactivity in human HT29 colon cancer cells grown in scid mice |
| Q49358639 | Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells |
| Q38359899 | Constitutive DNase I hypersensitivity of p53-regulated promoters |
| Q33833344 | Cyanobacterial Toxins of the Laurentian Great Lakes, Their Toxicological Effects, and Numerical Limits in Drinking Water |
| Q28360667 | Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells |
| Q35614620 | Effects of all-trans retinoic acid (ATRA) on human myeloma cells |
| Q40798772 | Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity |
| Q40702017 | Establishment of a novel clonal murine bone marrow stromal cell line for assessment of p53 responses to genotoxic stress |
| Q35079922 | Expression of the stress-associated protein p8 is a requisite for tumor development |
| Q33647720 | Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells |
| Q39629849 | Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension |
| Q40767550 | HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation |
| Q28475918 | Homeodomain interacting protein kinase 2 activation compromises endothelial cell response to laminar flow: protective role of p21(waf1,cip1,sdi1) |
| Q27004438 | Hydrogen peroxide sensing, signaling and regulation of transcription factors |
| Q44512396 | Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells |
| Q43814130 | Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction. |
| Q39386130 | Lack of p53 induction in fish cells by model chemotherapeutics |
| Q35008387 | MTA1 coregulator regulates p53 stability and function |
| Q41911349 | MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response |
| Q40492947 | Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C. |
| Q34299540 | Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis |
| Q33632673 | New insights on NOX enzymes in the central nervous system |
| Q50754258 | Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway. |
| Q26206708 | Oxidative stress/antioxidant status in health and disease |
| Q35184378 | Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells |
| Q44366709 | Profiling of differentially expressed apoptosis-related genes by cDNA arrays in human cord blood CD34+ cells treated with etoposide |
| Q27006998 | Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53 |
| Q46803682 | Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis |
| Q35141843 | Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis |
| Q39047050 | Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells |
| Q36015695 | Stress-induced corneal epithelial apoptosis mediated by K+ channel activation |
| Q35078737 | TP53 mutations in workers exposed to occupational carcinogens |
| Q28199928 | The molecular biology of cancer |
| Q23919656 | Transcriptional responses to oxidative stress: pathological and toxicological implications |
| Q41970188 | Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells |
| Q36560478 | hnRNP Q regulates translation of p53 in normal and stress conditions |
| Q34280222 | mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53 |
| Q42446561 | p53 and MDM2 protein expression in actinic cheilitis |
| Q28587813 | p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis |
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