Dissociation of the recombination control and the sequence-specific transactivation function of P53

scientific article published on 01 October 1999

Dissociation of the recombination control and the sequence-specific transactivation function of P53 is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1016605663
P356DOI10.1038/SJ.ONC.1202964
P698PubMed publication ID10523858

P2093author name stringL Wiesmüller
C Dudenhöffer
W Deppert
M Kurth
F Janus
P2860cites workThe p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
p53 modulation of TFIIH–associated nucleotide excision repair activityQ24336880
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent mannerQ24643993
BRCA1 regulates p53-dependent gene expressionQ24685083
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolismQ28245231
Oncogenic forms of p53 inhibit p53-regulated gene expressionQ28251120
p21 is a universal inhibitor of cyclin kinasesQ28257305
14-3-3sigma is a p53-regulated inhibitor of G2/M progressionQ28276061
Association of BRCA1 with Rad51 in mitotic and meiotic cellsQ28302118
p53 mutations in human cancersQ28302973
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryosQ28510071
Formation of stable p53 homotetramers and multiples of tetramersQ44277113
Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.Q52528383
Cell-cycle control and its watchman.Q53453500
p53 is linked directly to homologous recombination processes via RAD51/RecA protein interactionQ64386856
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53Q67521108
An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53Q67539546
A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiationQ71169980
p53 Protein exhibits 3'-to-5' exonuclease activityQ71170481
Human p53 binds Holliday junctions strongly and facilitates their cleavageQ73119545
DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53Q73615085
Signaling to p53: breaking the MDM2-p53 circuitQ77430977
p53 oligomerization and DNA looping are linked with transcriptional activationQ28639938
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA bindingQ28639955
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint controlQ29616465
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53Q29618277
Targeted disruption of the Rad51 gene leads to lethality in embryonic miceQ29618278
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiationQ33846651
The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesisQ33888765
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.Q33912006
Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.Q34055161
The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activityQ34252975
Inactivation of p53 results in high rates of homologous recombinationQ34426097
BRCA1 physically associates with p53 and stimulates its transcriptional activity.Q34467604
Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.Q34741387
p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.Q34972350
p53 function and dysfunctionQ35721291
A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteinsQ36122736
Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53.Q36546016
Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cellsQ36647653
p53 domains: structure, oligomerization, and transformationQ36662699
Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairingQ36796242
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminusQ38294071
p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatchesQ38294077
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 proteinQ38313694
Regulation of the specific DNA binding function of p53Q38324290
DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53.Q38345163
Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA bindingQ39444904
Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombinationQ39575932
In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomesQ39873297
Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acidsQ40021667
The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitroQ40023550
Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells.Q40043948
Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesisQ40647696
Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 moleculeQ40665592
Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.Q40792701
p53-catalyzed annealing of complementary single-stranded nucleic acidsQ40873109
Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cellsQ41121209
Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 proteinQ41121233
Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53Q42630918
Specific p53-DNA complexes contain an mdm2-related proteinQ42802655
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.Q43918911
P433issue42
P407language of work or nameEnglishQ1860
P304page(s)5773-5784
P577publication date1999-10-01
P1433published inOncogeneQ1568657
P1476titleDissociation of the recombination control and the sequence-specific transactivation function of P53
P478volume18

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cites work (P2860)
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Q40480309Discriminatory suppression of homologous recombination by p53.
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Q36161258The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
Q28206425The processing of Holliday junctions by BLM and WRN helicases is regulated by p53
Q55223212Transcriptional activation of p21Waf1 contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin.
Q44107661Wild-type p53 inhibits replication-associated homologous recombination
Q81554284Wild-type p53 stimulates homologous recombination upon sequence-specific binding to the ribosomal gene cluster repeat
Q38307731p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core
Q36210348p53 Specifically Binds Triplex DNA In Vitro and in Cells
Q40738842p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation
Q40544871p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance
Q36423948p53 in recombination and repair
Q39367978p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation
Q40344795p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene
Q42443549p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair
Q37126273p53 suppresses hyper-recombination by modulating BRCA1 function
Q36028209p53: traffic cop at the crossroads of DNA repair and recombination