Transcription factor IIH: a key player in the cellular response to DNA damage

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Transcription factor IIH: a key player in the cellular response to DNA damage is …
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P356DOI10.1016/S0300-9084(99)80035-2
P698PubMed publication ID10214907

P2093author name stringEgly JM
Bergmann E
Frit P
P2860cites workA presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndromeQ24306514
Cdk-activating kinase complex is a component of human transcription factor TFIIHQ24306759
Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIHQ24309302
Human cyclin-dependent kinase-activating kinase exists in three distinct complexesQ24309353
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repairQ24312736
Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase IIQ24314310
p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repairQ24315493
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIHQ24315819
Cockayne syndrome group B protein enhances elongation by RNA polymerase IIQ24317053
Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG proteinQ38348603
Reaction mechanism of human DNA repair excision nucleaseQ38359257
TATA binding protein discriminates between different lesions on DNA, resulting in a transcription decreaseQ39575189
Yeast RNA polymerase II transcription in vitro is inhibited in the presence of nucleotide excision repair: complementation of inhibition by Holo-TFIIH and requirement for RAD26.Q39583863
RNA polymerase II stalled at a thymine dimer: footprint and effect on excision repairQ39719255
Saccharomyces cerevisiae mms19 mutants are deficient in transcription-coupled and global nucleotide excision repair.Q39721487
A three-step pathway of transcription initiation leading to promoter clearance at an activation RNA polymerase II promoterQ40018556
The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due to defective transcription-coupled repair of active genesQ40019597
Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcriptionQ40020418
The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitroQ40023550
An interaction between the Tfb1 and Ssl1 subunits of yeast TFIIH correlates with DNA repair activityQ40393247
Phosphorylation of the C-terminal domain of RNA polymerase II.Q40503251
Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK.Q40790211
The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA.Q40805836
The transcription-repair coupling factor CSA is required for efficient repair only during the elongation stages of RNA polymerase II transcriptionQ41020602
Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repairQ41056225
Relationships between DNA repair and transcriptionQ41114776
Mammalian nucleotide excision repair and syndromesQ41370274
Reconstitution of human DNA repair excision nuclease in a highly defined systemQ41370395
Three Unusual Repair Deficiencies Associated with Transcription Factor BTF2(TFIIH): Evidence for the Existence of a Transcription SyndromeQ41506150
Nucleotide excision repair in mammalian cellsQ41593250
Regulation of CDK/cyclin complexes during the cell cycleQ41639250
The p53 networkQ41673584
Multiple ATP-dependent steps in RNA polymerase II promoter melting and initiationQ42172995
Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling Xenopus egg extracts?Q42444931
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factorQ42494377
Promoter escape by RNA polymerase II. A role for an ATP cofactor in suppression of arrest by polymerase at promoter-proximal sitesQ42522949
SSL1, a suppressor of a HIS4 5'-UTR stem-loop mutation, is essential for translation initiation and affects UV resistance in yeastQ44662542
Different forms of TFIIH for transcription and DNA repair: holo-TFIIH and a nucleotide excision repairosomeQ46391372
Alternative mechanisms of CAK assembly require an assembly factor or an activating kinaseQ46760600
Lethality in yeast of trichothiodystrophy (TTD) mutations in the human xeroderma pigmentosum group D gene. Implications for transcriptional defect in TTD.Q52014722
DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall.Q54455838
Structure and function of transcription-repair coupling factor. I. Structural domains and binding properties.Q54615768
Molecular mechanism of transcription-repair coupling.Q54659174
Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeastQ58318854
Genetic homogeneity between acute and chronic forms of spinal muscular atrophyQ59092681
Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding proteinQ68133927
The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinaseQ71823410
Inhibition of Rad3 DNA helicase activity by DNA adducts and abasic sites: implications for the role of a DNA helicase in damage-specific incision of DNAQ72941188
Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIHQ74263600
Lack of transcription-coupled repair of acetylaminofluorene DNA adducts in human fibroblasts contrasts their efficient inhibition of transcriptionQ74567408
Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunitsQ27938329
KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activityQ27938422
Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repairQ27940170
Reconstitution of yeast nucleotide excision repair with purified Rad proteins, replication protein A, and transcription factor TFIIH.Q27940221
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genesQ28213725
The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factorQ28235620
Association of Cdk-activating kinase subunits with transcription factor TFIIHQ28236002
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIKQ28243206
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinaseQ28247022
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase IIQ28251866
The guanylyltransferase domain of mammalian mRNA capping enzyme binds to the phosphorylated carboxyl-terminal domain of RNA polymerase IIQ28267712
A human RNA polymerase II complex associated with SRB and DNA-repair proteinsQ28276653
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIHQ28285305
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62Q28285490
Requirement for TFIIH kinase activity in transcription by RNA polymerase IIQ28289887
The general transcription factors of RNA polymerase IIQ28298663
The C-terminal domain of RNA polymerase II couples mRNA processing to transcriptionQ28301744
A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiationQ28569992
The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteinsQ28570708
5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase IIQ28623635
Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA templateQ28628394
Recycling of the general transcription factors during RNA polymerase II transcriptionQ28646829
Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase IIQ28646845
A role for TFIIH in controlling the activity of early RNA polymerase II elongation complexesQ28646872
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factorQ29619833
Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR geneQ30054509
The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.Q33640104
Repression of TFIIH transcriptional activity and TFIIH-associated cdk7 kinase activity at mitosisQ33772499
Regulation of CDK7 substrate specificity by MAT1 and TFIIH.Q33886335
The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complexQ33887586
A kinase-deficient transcription factor TFIIH is functional in basal and activated transcriptionQ34295542
An RNA polymerase II transcription factor has an associated DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promotersQ34306436
A multicopy transcription-repair gene, BTF2p44, maps to the SMA region and demonstrates SMA associated deletions.Q34419163
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) proteinQ24317182
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcriptionQ24320802
ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3Q24321908
A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase IIQ24322515
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathwayQ24336089
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factorQ24336424
p53 modulation of TFIIH–associated nucleotide excision repair activityQ24336880
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIHQ24336968
Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIHQ24532143
Cockayne syndrome: defective repair of transcription?Q24532391
Three transitions in the RNA polymerase II transcription complex during initiationQ24532893
Factors associated with the mammalian RNA polymerase II holoenzymeQ24546284
TFIIH-mediated nucleotide excision repair and initiation of mRNA transcription in an optimized cell-free DNA repair and RNA transcription assayQ24548165
MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIHQ24563127
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factorQ24595611
mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domainQ24602633
UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cellsQ24605185
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53Q24609153
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent mannerQ24643993
Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexesQ24644162
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)Q24673102
RAD25 is a DNA helicase required for DNA repair and RNA polymerase II transcriptionQ27930190
Civ1 (CAK in vivo), a novel Cdk-activating kinaseQ27930216
Nucleotide excision repair in yeast is mediated by sequential assembly of repair factors and not by a pre-assembled repairosomeQ27930912
The Cdk-activating kinase (CAK) from budding yeast.Q27932735
The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpb1p CTD.Q27932917
The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and RNA polymerase II transcriptionQ27934367
A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK.Q27935027
Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndromeQ27935884
RAD26, the yeast homolog of human Cockayne's syndrome group B gene, encodes a DNA-dependent ATPaseQ27936827
DNA repair deficiencies associated with mutations in genes encoding subunits of transcription initiation factor TFIIH in yeastQ34594438
Reduced RNA polymerase II transcription in extracts of cockayne syndrome and xeroderma pigmentosum/Cockayne syndrome cellsQ34636040
Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.Q35190030
The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNAQ35907237
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cellsQ36128504
A functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-mRNA splicingQ36254478
Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNAQ36254517
Transitions in the coupling of transcription and nucleotide excision repair within RNA polymerase II-transcribed genes of Saccharomyces cerevisiaeQ36300531
Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domainsQ36382489
TFIIH functions in regulating transcriptional elongation by RNA polymerase II in Xenopus oocytesQ36560509
Mammalian DNA nucleotide excision repair reconstituted with purified protein components.Q36697936
Sequence-specific and domain-specific DNA repair in xeroderma pigmentosum and Cockayne syndrome cellsQ36875627
DNA damage recognition by XPA protein promotes efficient recruitment of transcription factor II H.Q36881305
Mechanism of open complex and dual incision formation by human nucleotide excision repair factorsQ36888668
Characterization of reaction intermediates of human excision repair nuclease.Q36889922
RAD25 (SSL2), the yeast homolog of the human xeroderma pigmentosum group B DNA repair gene, is essential for viabilityQ37323177
MAT1 ('menage à trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.Q37623860
Identification of a cdk-activating kinase in fission yeast.Q37626433
Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair: in vitro complementation with purified coupling factorQ37653163
Yeast nucleotide excision repair proteins Rad2 and Rad4 interact with RNA polymerase II basal transcription factor b (TFIIH)Q38307487
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repairQ38313225
Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP.Q38339920
Rig2, a RING finger protein that interacts with the Kin28/Ccl1 CTD kinase in yeastQ38343781
Model for XPC-independent transcription-coupled repair of pyrimidine dimers in humansQ38347606
P433issue1-2
P921main subjectDNA damageQ5205747
P304page(s)27-38
P577publication date1999-01-01
P1433published inBiochimieQ2904035
P1476titleTranscription factor IIH: a key player in the cellular response to DNA damage
P478volume81