Reconstitution of yeast nucleotide excision repair with purified Rad proteins, replication protein A, and transcription factor TFIIH.

scientific article

Reconstitution of yeast nucleotide excision repair with purified Rad proteins, replication protein A, and transcription factor TFIIH. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.270.22.12973
P698PubMed publication ID7768886

P2093author name stringP Sung
L Prakash
S Prakash
Y Habraken
S N Guzder
P2860cites workA role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repairQ24337036
RAD3 protein of Saccharomyces cerevisiae is a DNA helicaseQ27929894
RAD25 is a DNA helicase required for DNA repair and RNA polymerase II transcriptionQ27930190
Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replicationQ27930450
Yeast DNA-repair gene RAD14 encodes a zinc metalloprotein with affinity for ultraviolet-damaged DNA.Q27931297
Yeast excision repair gene RAD2 encodes a single-stranded DNA endonucleaseQ27934231
Renaturation of DNA catalysed by yeast DNA repair and recombination protein RAD1OQ27935245
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase IIQ28251866
The RAD3 gene of Saccharomyces cerevisiae encodes a DNA-dependent ATPaseQ34341814
The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological functionQ36828110
Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5' and the 6th phosphodiester bond 3' to the photodimerQ36968114
Specific complex formation between proteins encoded by the yeast DNA repair and recombination genes RAD1 and RAD10Q37186939
DNA.RNA helicase activity of RAD3 protein of Saccharomyces cerevisiaeQ37613253
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repairQ38313225
DNA repair genes and proteins of Saccharomyces cerevisiaeQ40722184
Reconstitution of human DNA repair excision nuclease in a highly defined systemQ41370395
Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonucleaseQ43986392
Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeastQ58318854
DNA repair gene RAD3 of S. cerevisiae is essential for transcription by RNA polymerase IIQ59097138
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectRad4p YER162CQ27548618
Rad23p YEL037CQ27549370
P304page(s)12973-6
P577publication date1995-06-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleReconstitution of yeast nucleotide excision repair with purified Rad proteins, replication protein A, and transcription factor TFIIH.
P478volume270

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cites work (P2860)
Q24320802A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription
Q47760224A fragment of the yeast DNA repair protein Rad4 confers toxicity to E. coli and is required for its interaction with Rad7 protein
Q27938547A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription.
Q42876928A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.
Q74662210Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen species and lipid peroxidation product
Q27935363Affinity of yeast nucleotide excision repair factor 2, consisting of the Rad4 and Rad23 proteins, for ultraviolet damaged DNA.
Q27934957Affinity purification and partial characterization of a yeast multiprotein complex for nucleotide excision repair using histidine-tagged Rad14 protein
Q41066042Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein
Q36805976An affinity of human replication protein A for ultraviolet-damaged DNA.
Q27930860Apurinic endonuclease activity of yeast Apn2 protein
Q32061670Assembly, subunit composition, and footprint of human DNA repair excision nuclease
Q27930310Assessing the requirements for nucleotide excision repair proteins of Saccharomyces cerevisiae in an in vitro system
Q37536456Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 (hHR23A) requires its xeroderma pigmentosum complementation group C binding (XPCB) domain as well as the ubiquitin-associated 2 (UBA2) domain
Q36889922Characterization of reaction intermediates of human excision repair nuclease.
Q27930225Complementary roles of yeast Rad4p and Rad34p in nucleotide excision repair of active and inactive rRNA gene chromatin
Q34302443Complex formation with damage recognition protein Rad14 is essential for Saccharomyces cerevisiae Rad1-Rad10 nuclease to perform its function in nucleotide excision repair in vivo
Q41239058Cyclin dependent kinase activating kinases
Q32062848DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA
Q30969773DNA damage in the nucleosome core is refractory to repair by human excision nuclease
Q31271134DNA damage recognition during nucleotide excision repair in mammalian cells
Q73406613DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae
Q41044019DNA repair and transcription
Q34594438DNA repair deficiencies associated with mutations in genes encoding subunits of transcription initiation factor TFIIH in yeast
Q35844637DNA repair domains within a human gene: selective repair of sequences near the transcription initiation site
Q24813820DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation
Q28709604DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae
Q30653070DNA replication but not nucleotide excision repair is required for UVC-induced replication protein A phosphorylation in mammalian cells
Q30839135Damage recognition in nucleotide excision repair of DNA.
Q30661666Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A.
Q45935591Deciphering the DNA repair protein, Rad23 from kuruma shrimp Marsupenaeus japonicus: full-length cDNA cloning and characterization.
Q50994474Def1 and Dst1 play distinct roles in repair of AP lesions in highly transcribed genomic regions.
Q38329870Defective Kin28, a subunit of yeast TFIIH, impairs transcription-coupled but not global genome nucleotide excision repair.
Q33940642Deletion of the CSB homolog, RAD26, yields Spt(-) strains with proficient transcription-coupled repair
Q39458321Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control
Q38362404Double mutants of Saccharomyces cerevisiae with alterations in global genome and transcription-coupled repair
Q40020418Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription
Q73105762Effect of age on DNA binding of the ku protein in irradiated human peripheral blood mononuclear cells (PBMC)
Q39756598Effect of damage type on stimulation of human excision nuclease by SWI/SNF chromatin remodeling factor
Q39982171Effects of genomic context and chromatin structure on transcription-coupled and global genomic repair in mammalian cells
Q33963362Evidence for the involvement of nucleotide excision repair in the removal of abasic sites in yeast
Q74610856Excision repair invades the territory of mismatch repair
Q38994555Facilitators and Repressors of Transcription-coupled DNA Repair in Saccharomyces cerevisiae
Q36579359Five repair pathways in one context: chromatin modification during DNA repair
Q99548787Formation and Recognition of UV-Induced DNA Damage within Genome Complexity
Q36526349Functional analysis of Rad14p, a DNA damage recognition factor in nucleotide excision repair, in regulation of transcription in vivo
Q32069526Functional analysis of human replication protein A in nucleotide excision repair
Q36800447Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system
Q33846318Genetic factors in immunity and aging
Q40019757HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro
Q45875729Host factors that promote retrotransposon integration are similar in distantly related eukaryotes.
Q34568150How nucleotide excision repair protects against cancer
Q24653439Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair
Q38341326Identification and characterization of XPC-binding domain of hHR23B.
Q33865346Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.
Q38353906Identification of functional domains within the RAD1.RAD10 repair and recombination endonuclease of Saccharomyces cerevisiae
Q74326166Immunoaffinity purification of the human multisubunit transcription factor IIH
Q28610870In vitro analysis of the zinc-finger motif in human replication protein A
Q38303101Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 at the active site
Q72036862Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21
Q34147089Initiation of eukaryotic DNA replication: regulation and mechanisms
Q44317451Investigating the importance of proteasome-interaction for Rad23 function
Q30638467Involvement of DNA-dependent protein kinase in UV-induced replication arrest
Q24309302Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
Q33304951Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair
Q34626949Isolation of human complexes proficient in nucleotide excision repair
Q89825438Methodologies for detecting environmentally induced DNA damage and repair
Q31097811Molecular anatomy of the human excision nuclease assembled at sites of DNA damage
Q54220203Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans.
Q24793663Nucleotide Excision Repair, Genome Stability, and Human Disease: New Insight from Model Systems
Q36866140Nucleotide excision repair by dual incisions in plants.
Q39568480Nucleotide excision repair in the third kingdom
Q30890380Nucleotide excision repair in yeast
Q27930912Nucleotide excision repair in yeast is mediated by sequential assembly of repair factors and not by a pre-assembled repairosome
Q24609992Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK
Q33601014Nucleotide excision repair: from E. coli to man.
Q41175756Overproduction, purification, and characterization of the XPC subunit of the human DNA repair excision nuclease
Q34607631Pleiotropic defects caused by loss of the proteasome-interacting factors Rad23 and Rpn10 of Saccharomyces cerevisiae.
Q38958950PostExcision Events in Human Nucleotide Excision Repair
Q27932299Preferential binding of yeast Rad4.Rad23 complex to damaged DNA.
Q39716441Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.
Q34025948Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes
Q28626852Protein complexes in nucleotide excision repair
Q27936827RAD26, the yeast homolog of human Cockayne's syndrome group B gene, encodes a DNA-dependent ATPase
Q39444647RNA polymerase II transcription suppresses nucleosomal modulation of UV-induced (6-4) photoproduct and cyclobutane pyrimidine dimer repair in yeast
Q37341165Rad1, rad10 and rad52 mutations reduce the increase of microhomology length during radiation-induced microhomology-mediated illegitimate recombination in saccharomyces cerevisiae
Q36559434Rad23 is required for transcription-coupled repair and efficient overrall repair in Saccharomyces cerevisiae
Q29614361Rad23 links DNA repair to the ubiquitin/proteasome pathway
Q34283029Rad23 promotes the targeting of proteolytic substrates to the proteasome
Q38303135Rad23 provides a link between the Png1 deglycosylating enzyme and the 26 S proteasome in yeast.
Q33754377Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway
Q38359257Reaction mechanism of human DNA repair excision nuclease
Q36565271Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems
Q31004989Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease
Q27940170Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair
Q24316902Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex
Q24793777Regulation of repair by the 26Sproteasome
Q27940110Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes
Q32064326Relationship of the xeroderma pigmentosum group E DNA repair defect to the chromatin and DNA binding proteins UV-DDB and replication protein A.
Q43628290Repair of DNA lesions: mechanisms and relative repair efficiencies
Q38360489Repair of rDNA in Saccharomyces cerevisiae: RAD4-independent strand-specific nucleotide excision repair of RNA polymerase I transcribed genes
Q38357913Replication protein A confers structure-specific endonuclease activities to the XPF-ERCC1 and XPG subunits of human DNA repair excision nuclease
Q27931166Replication protein A is required for meiotic recombination in Saccharomyces cerevisiae.
Q27930029Requirement of ELC1 for RNA polymerase II polyubiquitylation and degradation in response to DNA damage in Saccharomyces cerevisiae
Q37522535Requirement of yeast Rad1-Rad10 nuclease for the removal of 3'-blocked termini from DNA strand breaks induced by reactive oxygen species
Q34626556Rodent UV-sensitive mutant cell lines in complementation groups 6-10 have normal general excision repair activity
Q40605830Roles of Rad23 protein in yeast nucleotide excision repair
Q35829416Rous-Whipple Award Lecture. Nucleotide excision repair and cancer predisposition: A journey from man to yeast to mice
Q39721487Saccharomyces cerevisiae mms19 mutants are deficient in transcription-coupled and global nucleotide excision repair.
Q42021686Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER.
Q88181627Single-nucleotide resolution dynamic repair maps of UV damage in Saccharomyces cerevisiae genome
Q32060621Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA.
Q33698685Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association
Q78122382Synergistic interaction between yeast nucleotide excision repair factors NEF2 and NEF4 in the binding of ultraviolet-damaged DNA
Q36174139Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast.
Q27937965The 19S complex of the proteasome regulates nucleotide excision repair in yeast.
Q38316669The 26S proteasome negatively regulates the level of overall genomic nucleotide excision repair
Q36823107The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast
Q39722689The C-terminal region of the Escherichia coli UvrC protein, which is homologous to the C-terminal region of the human ERCC1 protein, is involved in DNA binding and 5'-incision
Q24313616The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21
Q74298282The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assembly
Q27935780The DNA-dependent ATPase activity of yeast nucleotide excision repair factor 4 and its role in DNA damage recognition
Q41157072The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair
Q27938658The N-degron protein degradation strategy for investigating the function of essential genes: requirement for replication protein A and proliferating cell nuclear antigen proteins for nucleotide excision repair in yeast extracts
Q27936146The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair
Q40020852The RAD7, RAD16, and RAD23 genes of Saccharomyces cerevisiae: requirement for transcription-independent nucleotide excision repair in vitro and interactions between the gene products
Q33671306The RNA polymerase II general transcription factors: past, present, and future.
Q27935757The Rad4 homologue YDR314C is essential for strand-specific repair of RNA polymerase I-transcribed rDNA in Saccharomyces cerevisiae
Q44267647The S. cerevisiae Mag1 3-methyladenine DNA glycosylase modulates susceptibility to homologous recombination.
Q30846029The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle
Q34608831The Saccharomyces cerevisiae DNA recombination and repair functions of the RAD52 epistasis group inhibit Ty1 transposition
Q22253377The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA
Q38331963The yeast RAD7 and RAD16 genes are required for postincision events during nucleotide excision repair. In vitro and in vivo studies with rad7 and rad16 mutants and purification of a Rad7/Rad16-containing protein complex
Q39687383Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1.
Q33601019Transcription factor IIH: a key player in the cellular response to DNA damage
Q27935884Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome
Q33614239Transcription-coupled DNA repair in yeast transcription factor IIE (TFIIE) mutants
Q77732327Transcriptional effects of the potent enediyne anti-cancer agent Calicheamicin gamma(I)(1)
Q36300531Transitions in the coupling of transcription and nucleotide excision repair within RNA polymerase II-transcribed genes of Saccharomyces cerevisiae
Q38358612Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage.
Q24308740Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity
Q38335164Two isoforms of plant RAD23 complement a UV-sensitive rad23 mutant in yeast
Q28253282UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair
Q24522596Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly
Q27940060Yeast Rad7-Rad16 complex, specific for the nucleotide excision repair of the nontranscribed DNA strand, is an ATP-dependent DNA damage sensor

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