Modes of p53 regulation (scientific article (publication date: 15 May 2009))

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Q36149306	Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth
Q36801098	Inauhzin sensitizes p53-dependent cytotoxicity and tumor suppression of chemotherapeutic agents
Q37406388	Increased apoptosis rate of human decidual cells and cytotrophoblasts in patients with recurrent spontaneous abortion as a result of abnormal expression of CDKN1A and Bax.
Q39508688	Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice
Q39336132	Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage.
Q28573948	Inflammatory cells regulate p53 and caspases in acute pancreatitis
Q36138010	Influence of Human p53 on Plant Development
Q34565153	Inherited germline TP53 mutation encodes a protein with an aberrant C-terminal motif in a case of pediatric adrenocortical tumor
Q90635071	Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells
Q35868154	Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1.
Q50421763	Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects
Q89739763	Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity
Q41810049	Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.
Q36589313	Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway
Q38796979	Inhibition of cell proliferation, migration and invasion by a glioma-targeted fusion protein combining the p53 C terminus and MDM2-binding domain
Q33570316	Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2
Q34009402	Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.
Q38322114	Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Q39418221	Interaction between ZBP-89 and p53 mutants and its contribution to effects of HDACi on hepatocellular carcinoma
Q90604823	Interaction with AEG-1 and MDM2 is associated with glioma development and progression and correlates with poor prognosis
Q39723681	Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53.
Q33656086	Interplay between Mdm2 and HIPK2 in the DNA damage response
Q35922756	Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined
Q34990640	Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation
Q35510300	Intrinsically disordered proteins in cellular signalling and regulation.
Q36006961	Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation
Q54303856	Involvement of Wnt signaling in the injury of murine mesenchymal stem cells exposed to X-radiation.
Q38162722	Ionizing radiation-induced responses in human cells with differing TP53 status
Q35131133	JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation
Q57805010	K120R mutation inactivates p53 by creating an aberrant splice site leading to nonsense-mediated mRNA decay
Q34409029	KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes
Q58544657	KDM5A Regulates a Translational Program that Controls p53 Protein Expression
Q57590598	KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells
Q41949624	Keeping p53 in check: a high-stakes balancing act.
Q99712014	Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy
Q24306115	Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation
Q38738109	Knockdown of High Mobility Group-Box 3 (HMGB3) Expression Inhibits Proliferation, Reduces Migration, and Affects Chemosensitivity in Gastric Cancer Cells.
Q49651549	LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress
Q42253318	Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion
Q37765653	Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.
Q92316046	Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation
Q47107585	Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells
Q47138075	Long non-coding RNAs in Colorectal Cancer: Progression and Future Directions
Q92423983	Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer
Q40652796	Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53.
Q45393476	Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response
Q54198378	Loss of MIR15A and MIR16-1 at 13q14 is associated with increased TP53 mRNA, de-repression of BCL2 and adverse outcome in chronic lymphocytic leukaemia.
Q64106666	Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo
Q34409141	Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway
Q37022020	Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
Q28548585	Low-Dose, Long-Wave UV Light Does Not Affect Gene Expression of Human Mesenchymal Stem Cells
Q38019558	Lysine methylation and the regulation of p53.
Q37970950	Lysine methylation: beyond histones
Q38769335	Lysines in the tetramerization domain of p53 selectively modulate G1 arrest
Q55245371	MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches.
Q34386033	MAP/ERK kinase kinase 1 (MEKK1) mediates transcriptional repression by interacting with polycystic kidney disease-1 (PKD1) promoter-bound p53 tumor suppressor protein
Q85072453	MDM4 overexpression contributes to synoviocyte proliferation in patients with rheumatoid arthritis
Q38907224	MDMX exerts its oncogenic activity via suppression of retinoblastoma protein
Q35695025	MG132 inhibition of proteasome blocks apoptosis induced by severe DNA damage
Q90571091	MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance
Q40459014	MKK7 and ARF: new players in the DNA damage response scenery.
Q59326864	MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance
Q39078439	Maintenance of pluripotency in mouse ES cells without Trp53.
Q34503497	Making sense of ubiquitin ligases that regulate p53
Q46063736	Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases
Q37465881	Mathematical model of dynamic protein interactions regulating p53 protein stability for tumor suppression
Q38059700	Mdm2 and MdmX as Regulators of Gene Expression
Q41287457	Mdm2 and tumorigenesis: evolving theories and unsolved mysteries
Q40680755	Mdm2's dilemma: to degrade or to translate p53?
Q39404029	MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress
Q35084991	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination
Q39646906	Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology
Q28392953	Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721
Q35900622	Mechanisms of p53 activation and physiological relevance in the developing kidney.
Q38865504	Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.
Q43871288	Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy.
Q37298047	Metabolic regulation by p53 family members.
Q60052866	Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) is Underexpressed in Clear Cell Renal Cell Carcinoma Tissue and Transfection and Overexpression in Caki-1 Cells Inhibits Cell Proliferation and Increases Apoptosis
Q64242213	MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer
Q36130066	MiR-1246: a new link of the p53 family with cancer and Down syndrome
Q38924922	MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation
Q40337181	MicroRNA-191 acts as a tumor promoter by modulating the TET1-p53 pathway in intrahepatic cholangiocarcinoma
Q38035144	MicroRNAs in the p53 network: micromanagement of tumour suppression
Q41281675	Mild electrical stimulation at 0.1-ms pulse width induces p53 protein phosphorylation and G2 arrest in human epithelial cells.
Q34328693	Minichromosome maintenance 2 bound with retroviral Gp70 is localized to cytoplasm and enhances DNA-damage-induced apoptosis
Q38587869	Mitochondrial dynamics regulating chemoresistance in gynecological cancers
Q28818349	Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2
Q37725579	Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response
Q91663732	Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations
Q28546597	Modulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutations
Q41277033	Modulation of the p53 family network by RNA-binding proteins
Q26776299	Molecular mechanisms of etoposide
Q50934772	Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner.
Q37596373	Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.
Q38616107	Moonlighting proteins in cancer.
Q33997232	Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia
Q33818479	Mutant TP53 posttranslational modifications: challenges and opportunities.
Q37665360	NAD(+) Metabolism in Age-Related Hearing Loss
Q41585790	NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity
Q41993999	NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.
Q46292577	NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
Q38061832	NRF2 and p53: Januses in cancer?
Q52579667	Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.
Q34166515	Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest.
Q39077362	Negative auto-regulators trap p53 in their web.
Q37000550	Negative regulation of the acetyltransferase TIP60-p53 interplay by UHRF1 (ubiquitin-like with PHD and RING finger domains 1).
Q36156998	Negative regulation of the p300-p53 interplay by DDX24.
Q34142778	Negative regulation of the tumor suppressor p53 gene by microRNAs.
Q34153536	Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage
Q47299905	Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats
Q26765483	New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity
Q34758670	New insights into p53 activation
Q38205171	New insights into p53 functions through its target microRNAs
Q38389967	New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy.
Q24622202	Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
Q41993883	Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy.
Q37445903	Novel HIV-1 therapeutics through targeting altered host cell pathways
Q26777988	Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2
Q24299137	Novel nucleolar pathway connecting intracellular energy status with p53 activation
Q42591177	Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1)
Q42424178	Nucleostemin: Another nucleolar "Twister" of the p53-MDM2 loop
Q24595171	Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol
Q34379057	OTUD5 regulates p53 stability by deubiquitinating p53.
Q34149922	Oncogenes and tumor suppressor genes
Q26749382	Oncogenic Intra-p53 Family Member Interactions in Human Cancers
Q38156100	Oncoprotein stabilization in brain tumors.
Q59329506	Orchestration of protein acetylation as a toggle for cellular defense and virus replication
Q39453113	Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation
Q38723764	Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria
Q38045766	Overexpression of p53 protein in human tumors
Q27024861	Oxidative stress and pulmonary fibrosis
Q38171333	Oxygen regulates molecular mechanisms of cancer progression and metastasis
Q37769295	Oxygenomics in environmental stress.
Q36522722	P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells.
Q28586356	PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis
Q47701502	PANDAR: a pivotal cancer-related long non-coding RNA in human cancers
Q92163668	PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth
Q46242652	PEPD is a pivotal regulator of p53 tumor suppressor
Q38842390	PHD1 regulates p53-mediated colorectal cancer chemoresistance.
Q39713494	PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage.
Q92459709	PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing
Q42668728	PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer
Q54603551	Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation.
Q46243356	Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells
Q52663744	Peli1 modulates the subcellular localization and activity of Mdmx.
Q26991867	Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis
Q92155477	Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis
Q51372112	Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study.
Q37366864	Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma
Q37191174	Pharmacological activation of p53 in cancer cells
Q36618617	Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model
Q35196159	Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
Q35252479	Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53
Q35149631	Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage
Q28114977	Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response
Q35213271	Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein
Q26823798	Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)
Q39763520	Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
Q55346775	Plakoglobin restores tumor suppressor activity of p53R175H mutant by sequestering the oncogenic potential of β-catenin.
Q37541596	Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53.
Q36508707	Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis
Q33899450	Posttranslational modification of p53: cooperative integrators of function
Q52584348	Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer.
Q33595368	Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor.
Q33594076	Preferential autoimmune response in prostate cancer to cyclin B1 in a panel of tumor-associated antigens
Q37978967	Present status and perspectives in functional analysis of p53 in chronic lymphocytic leukemia
Q46477265	Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis
Q92565645	Prognostic value of chloride channel accessory mRNA expression in colon cancer
Q35813589	Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response
Q28239216	Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response
Q51129826	Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a.
Q37800060	Protein acetylation within the cellular response to radiation.
Q91825036	Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice
Q38266035	Proteomics for systems toxicology
Q28591824	Puma is required for p53-induced depletion of adult stem cells
Q37341983	Punicalagin, a polyphenol in pomegranate juice, downregulates p53 and attenuates hypoxia-induced apoptosis in cultured human placental syncytiotrophoblasts
Q38133962	Push back to respond better: regulatory inhibition of the DNA double-strand break response
Q42414248	Putting the brakes on p53-driven apoptosis
Q35665695	RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms
Q47860453	RCC2 is a novel p53 target in suppressing metastasis
Q39597077	RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
Q34993091	RNA polymerase III transcription in cancer: the BRF2 connection
Q39456968	RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance
Q51097612	RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
Q38766269	Radon-induced alterations in p53-mediated energy metabolism of malignantly transformed human bronchial epithelial cells
Q36351105	Rap2b siRNA significantly enhances the anticancer therapeutic efficacy of adriamycin in a gold nanoshell-based drug/gene co-delivery system
Q36906255	Rap2b, a novel p53 target, regulates p53-mediated pro-survival function
Q34230578	Rapid and sensitive detection of an intracellular pathogen in human peripheral leukocytes with hybridizing magnetic relaxation nanosensors
Q42498067	Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program
Q41960009	Reactivating the ARF-p53 axis in AML cells by targeting ULF.
Q37233582	Reactivation of mutant p53 by capsaicin, the major constituent of peppers
Q28537881	Reactive oxygen species mediate Epstein-Barr virus reactivation by N-methyl-N'-nitro-N-nitrosoguanidine
Q38433099	Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit.
Q92860226	Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer
Q36756039	Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.
Q39256295	Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner
Q26740191	Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy
Q37861632	Redox modulation of p53: mechanisms and functional significance
Q36088612	Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells.
Q34771336	Regulation of DNA damage responses and cell cycle progression by hMOB2.
Q24294656	Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
Q39322285	Regulation of Metabolic Activity by p53.
Q26770579	Regulation of Mutant p53 Protein Expression
Q45316783	Regulation of TP53 Activity
Q45316786	Regulation of TP53 Degradation
Q38170004	Regulation of cancer metabolism by O-GlcNAcylation
Q34949637	Regulation of cell differentiation by the DNA damage response
Q57594615	Regulation of p53 acetylation
Q28510160	Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage
Q41838045	Regulation of p53 during senescence in normal human keratinocytes.
Q41908224	Regulation of p53 in NIH3T3 mouse fibroblasts following hyperosmotic stress
Q37992789	Regulation of p53: a collaboration between Mdm2 and Mdmx
Q29976922	Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Q37394276	Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress
Q38302449	Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO
Q90706140	Regulators of Oncogenic Mutant TP53 Gain of Function
Q28066784	Regulatory non-coding RNA: new instruments in the orchestration of cell death
Q49916296	Repair kinetics of DNA double-strand breaks and incidence of apoptosis in mouse neural stem/progenitor cells and their differentiated neurons exposed to ionizing radiation
Q24337798	Repression of Puma by scratch2 is required for neuronal survival during embryonic development
Q36733743	Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway
Q39205536	Reviving the guardian of the genome: Small molecule activators of p53.
Q39385222	Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress
Q34178921	Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis
Q34850281	Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network
Q37690890	Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer
Q37612283	Role of HDAC1 in senescence, aging, and cancer
Q33828002	Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis
Q34085616	Role of Pirh2 in mediating the regulation of p53 and c-Myc
Q39283898	Role of citrullination modification catalyzed by peptidylarginine deiminase 4 in gene transcriptional regulation.
Q61801121	Role of p53 in pseudorabies virus replication, pathogenicity, and host immune responses
Q38203736	Role of the lncRNA-p53 regulatory network in cancer
Q42355766	Roles of Polo-like kinase 3 in suppressing tumor angiogenesis.
Q92257837	Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation
Q37123340	Roles of p53 in herpes simplex virus 1 replication
Q34413441	Roles of tumor suppressors in regulating tumor-associated inflammation
Q24339585	Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma
Q53283601	S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence.
Q34313327	S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde
Q28509658	S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response
Q51011770	SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress.
Q24310032	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
Q35064623	SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells
Q24297333	SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60
Q37525832	SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways
Q39555703	SMG7 is a critical regulator of p53 stability and function in DNA damage stress response.
Q34316449	SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
Q36544196	STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation
Q28594151	SUMO-specific protease 2 in Mdm2-mediated regulation of p53
Q24301634	SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
Q34077127	Scintillation proximity assay for total p53 protein as an alternative to ELISA.
Q38059701	Scission of the p53-MDM2 Loop by Ribosomal Proteins
Q41459790	Selective targeting p53WT lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA.
Q39484755	Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells
Q26828473	Self-consumption: the interplay of autophagy and apoptosis
Q35518170	Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.
Q35206381	Signaling to p53: ribosomal proteins find their way.
Q36901939	Silencing of CD24 Enhances the PRIMA-1-Induced Restoration of Mutant p53 in Prostate Cancer Cells
Q28481334	Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamics
Q41768808	Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53
Q38993512	SirT3 and p53 Deacetylation in Aging and Cancer
Q34028698	Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest
Q45738787	Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts.
Q50575365	Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity.
Q37839534	Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.
Q27014977	Smoking, p53 mutation, and lung cancer
Q37498910	SnoN activates p53 directly to regulate aging and tumorigenesis
Q37007086	Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis
Q38262589	Squaring up to DNA: pentapeptide repeat proteins and DNA mimicry
Q38838490	Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α.
Q35178418	Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.
Q36870100	Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.
Q36119624	Structural Insight into the Critical Role of the N-Terminal Region in the Catalytic Activity of Dual-Specificity Phosphatase 26.
Q91850861	Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes
Q34475801	Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1α and PKR.
Q27683532	Structural basis for the site-specific incorporation of lysine derivatives into proteins
Q27701526	Structural basis of how stress-induced MDMX phosphorylation activates p53
Q28484540	Structure and activity analysis of Inauhzin analogs as novel antitumor compounds that induce p53 and inhibit cell growth
Q27658473	Structure of the Taz2 domain of p300: insights into ligand binding
Q36741049	Structure, functional regulation and signaling properties of Rap2B.
Q29994717	Structures of closed and open conformations of dimeric human ATM
Q27680171	Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue
Q34675969	Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.
Q35967111	Surf the post-translational modification network of p53 regulation
Q38821561	Synergistic Effect and Molecular Mechanism of Homoharringtonine and Bortezomib on SKM-1 Cell Apoptosis
Q47160964	Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis
Q35274495	T-cell intracellular antigens function as tumor suppressor genes
Q36719443	TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene
Q41499355	TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription
Q37741025	TGFbeta and cancer metastasis: an inflammation link.
Q41991646	TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
Q60916058	TP53LNC-DB, the database of lncRNAs in the p53 signalling network
Q38732652	TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression
Q33899861	TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage
Q37261753	TRIMming p53 for ubiquitination
Q90524104	TSPYL2 is a novel regulator of SIRT1 and p300 activity in response to DNA damage
Q34568811	Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury
Q59132125	Targeted p53 on Small-Molecules-Induced Ferroptosis in Cancers
Q36020398	Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept
Q48570977	Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma
Q38247168	Targeting p53-MDM2-MDMX loop for cancer therapy
Q38059739	Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy
Q33657519	Targeting tumor suppressor networks for cancer therapeutics
Q95301002	Tau affects P53 function and cell fate during the DNA damage response
Q34624486	Tethering function of the caspase cleavage fragment of Golgi protein p115 promotes apoptosis via a p53-dependent pathway
Q51060945	The "readers" of unacetylated p53 represent a new class of acidic domain proteins.
Q28507164	The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo
Q33870522	The DNA damage response: the omics era and its impact
Q33725241	The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage
Q91710491	The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents
Q24298474	The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum
Q39005319	The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization
Q47215879	The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †.
Q42322261	The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination.
Q38329840	The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells.
Q36980558	The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells
Q34030117	The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
Q38888153	The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.
Q52715352	The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest.
Q57166264	The Nucleolus
Q47150239	The Oncogenic Role of Tribbles 1 in Hepatocellular Carcinoma Is Mediated by a Feedback Loop Involving microRNA-23a and p53.
Q94322163	The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling
Q35232574	The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.
Q47307122	The Roles of P53 and its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis Stage Mouse Embryos.
Q36607243	The TP53 fertility network
Q99708992	The Undervalued Avenue to Reinstate Tumor Suppressor Functionality of the p53 Protein Family for Improved Cancer Therapy-Drug Repurposing
Q36766027	The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells
Q34504101	The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells
Q33827703	The complex landscape of pancreatic cancer metabolism
Q38486293	The critical molecular interconnections in regulating apoptosis and autophagy.
Q37859721	The dual role of p53: DNA protection and antioxidant.
Q37665224	The effect of epigenetic silencing and TP53 mutation on the expression of DLL4 in human cancer stem disorder
Q34554010	The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro
Q37897323	The emerging role of Mule and ARF in the regulation of base excision repair
Q26853164	The functional diversity of protein lysine methylation
Q38061848	The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes
Q34429176	The genomic landscape of TP53 and p53 annotated high grade ovarian serous carcinomas from a defined founder population associated with patient outcome
Q39233244	The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage
Q40562742	The impact of TP53 mutations and TP53 deletions on survival varies between AML, ALL, MDS and CLL: an analysis of 3307 cases
Q34199692	The impact of acetylation and deacetylation on the p53 pathway
Q38786667	The importance of p53 pathway genetics in inherited and somatic cancer genomes.
Q28483781	The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment
Q35786347	The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury
Q34846077	The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.
Q37526379	The multiple levels of regulation by p53 ubiquitination
Q30356852	The next level of complexity: crosstalk of posttranslational modifications.
Q38515093	The nucleolar interface of RNA viruses
Q37596345	The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption
Q24597470	The nucleolus under stress
Q37359180	The origin of allosteric functional modulation: multiple pre-existing pathways
Q35122947	The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo
Q34020353	The p53 orchestra: Mdm2 and Mdmx set the tone
Q27690770	The p53 pathway as a target in cancer therapeutics: obstacles and promise
Q35046887	The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold
Q58780971	The p53/Adipose-Tissue/Cancer Nexus
Q33685413	The regulation of the p53-mediated stress response by MDM2 and MDM4.
Q45395590	The ribosomal protein S26 regulates p53 activity in response to DNA damage
Q96764448	The role of MDM2-p53 axis dysfunction in the hepatocellular carcinoma transformation
Q36392179	The transcription factor CREBZF is a novel positive regulator of p53.
Q42917239	The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism
Q37762069	The tumor suppressor p53: from structures to drug discovery
Q24644208	The ubiquitin proteasome system in neuropathology
Q48000346	The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities
Q38795765	The viral non-structural protein 1 alpha (Nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells
Q36833275	Therapeutic targeting of the p53 pathway in cancer stem cells.
Q41807243	Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
Q41126970	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells.
Q36889843	Tissue Inhibitor of Matrix Metalloproteinases-1 Knockdown Suppresses the Proliferation of Human Adipose-Derived Stem Cells
Q34838208	Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function
Q39242429	Tissue-Specific Functions of p53 During Kidney Development
Q35783751	Towards an understanding of the role of p53 in adrenocortical carcinogenesis
Q38838992	Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53
Q35138721	Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo
Q38541481	Transcription factors that interact with p53 and Mdm2
Q24301836	Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
Q92636264	Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence
Q37777267	Transcriptional regulation by p53.
Q34171267	Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits
Q38594197	Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2.
Q38919143	Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing
Q39505445	Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas
Q96135302	Trisenox Disrupts MDM2-DAXX-HAUSP Complex and Induces Apoptosis in a Mouse Model of Acute Leukemia
Q35198383	Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients.
Q36161900	Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line
Q26992094	Tumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signaling
Q43120565	Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
Q37412688	Tumor suppressive functions of p53
Q33833892	Tumor suppressor RASSF1A promoter: p53 binding and methylation
Q44608082	Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.
Q28477217	Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation
Q38966981	Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD
Q39708546	Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.
Q37810431	Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention
Q38824332	Tumor-Suppressor Functions of the TP53 Pathway
Q24295055	Turning the RING domain protein MdmX into an active ubiquitin-protein ligase
Q35022037	Two-phase dynamics of p53 in the DNA damage response.
Q36771960	UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation
Q38941587	UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.
Q98513730	UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination
Q34696209	USP11 regulates p53 stability by deubiquitinating p53.
Q52723469	USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.
Q24300434	USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1
Q36944526	USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation
Q37577477	USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis
Q42714232	USP7/HAUSP stimulates repair of oxidative DNA lesions
Q36232109	UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity
Q34503492	Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets
Q39032658	Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma
Q39221079	Ubiquitination/deubiquitination and acetylation/deacetylation: making DNMT1 stability more coordinated
Q36485242	Ubiquitylation of p53 by the APC/C inhibitor Trim39.
Q35615172	Uncovering ubiquitin and ubiquitin-like signaling networks
Q37802195	Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies
Q38128769	Unraveling DNA damage response-signaling networks through systems approaches
Q52586740	Upregulation of HOXA1 promotes tumorigenesis and development of non‑small cell lung cancer: A comprehensive investigation based on reverse transcription-quantitative polymerase chain reaction and bioinformatics analysis.
Q37380800	Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity
Q64950512	Using a panel of multiple tumor-associated antigens to enhance autoantibody detection for immunodiagnosis of gastric cancer.
Q33895858	Using immunomic approach to enhance tumor-associated autoantibody detection in diagnosis of hepatocellular carcinoma
Q37748214	Using mice to examine p53 functions in cancer, aging, and longevity
Q34209099	Validation of MdmX as a therapeutic target for reactivating p53 in tumors
Q35275179	Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent
Q64387425	Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin
Q33815907	WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway
Q33913340	WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death
Q39989125	WTX: an unexpected regulator for p53.
Q33947783	Wheel running, skeletal muscle aerobic capacity and 1-methyl-1-nitrosourea induced mammary carcinogenesis in the rat.
Q34248659	When ribosomes go bad: diseases of ribosome biogenesis
Q39030008	Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ.
Q35146343	Wild type p53 reactivation: from lab bench to clinic.
Q38266298	Wip1 phosphatase in breast cancer
Q35984061	Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio
Q58782264	Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells
Q89862470	Working on Genomic Stability: From the S-Phase to Mitosis
Q34441993	XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313
Q36655029	hSSB1 regulates both the stability and the transcriptional activity of p53
Q92508193	iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
Q33998215	mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes
Q58600725	mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
Q33599315	miR-600 inhibits cell proliferation, migration and invasion by targeting p53 in mutant p53-expressing human colorectal cancer cell lines
Q58918367	p53
Q28085076	p53 Acetylation: Regulation and Consequences
Q37378360	p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens
Q37093496	p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis
Q60907996	p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value
Q64071826	p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX
Q39242999	p53 acetylation enhances Taxol-induced apoptosis in human cancer cells
Q36882319	p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells
Q84583329	p53 ancestry: gazing through an evolutionary lens
Q34001316	p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization
Q37874926	p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies
Q39328814	p53 and Sp1 cooperate to regulate the expression of Epstein-Barr viral Zta protein
Q37510423	p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation
Q38255171	p53 and the PWWP domain containing effector proteins in chromatin damage repair
Q51761242	p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine.
Q34029735	p53 at a glance
Q36052576	p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes
Q47096055	p53 dynamics orchestrates with binding affinity to target genes for cell fate decision.
Q35228392	p53 in stem cells
Q38540071	p53 in survival, death and metabolic health: a lifeguard with a licence to kill
Q24306453	p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
Q36347218	p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling
Q87895880	p53 keeps bystanders at the gates
Q91701515	p53 modifications: exquisite decorations of the powerful guardian
Q35063064	p53 negatively regulates RGS13 protein expression in immune cells
Q30275107	p53 pathway is involved in cell competition during mouse embryogenesis
Q34300569	p53 post-translational modification: deregulated in tumorigenesis
Q46251110	p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a
Q37882073	p53 regulation by ubiquitin
Q40715545	p53 requires an intact C-terminal domain for DNA binding and transactivation
Q35169245	p53 requires the stress sensor USF1 to direct appropriate cell fate decision.
Q35855525	p53 staining correlates with tumor type and location in sebaceous neoplasms
Q36567469	p53 sumoylation: mechanistic insights from reconstitution studies
Q39061575	p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3.
Q42371457	p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B.
Q64106681	p53 β-hydroxybutyrylation attenuates p53 activity
Q42122625	p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.
Q42362115	p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance
Q64921751	p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and its Combination Effect with RITA or Doxorubicin.
Q44935692	p53-Pathway activity and apoptosis in hydrogen sulfide-exposed stem cells separated from human gingival epithelium
Q37727778	p53-family proteins and their regulators: hubs and spokes in tumor suppression
Q38247164	p53-independent effects of Mdm2.
Q34397020	p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
Q55322510	p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms.
Q28611414	p73 as a pharmaceutical target for cancer therapy
Q28590571	p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response
Q37163437	β-Catenin C-terminal signals suppress p53 and are essential for artery formation
Q28389986	Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pat

review article	Q7318358
scholarly article	Q13442814

P356	DOI	10.1016/J.CELL.2009.04.050
P3181	OpenCitations bibliographic resource ID	633424
P932	PMC publication ID	3737742
P698	PubMed publication ID	19450511
P5875	ResearchGate publication ID	24435350

P2093	author name string	Gu W
		Kruse JP
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		Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy	Q34478557
		p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.	Q34585107
		Crippling p53 activities via knock-in mutations in mouse models	Q34614596
		The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network	Q34825957
		Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.	Q37524264
		Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation	Q37543781
		An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors	Q38315892
		Regulation of the specific DNA binding function of p53	Q38324290
		Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses	Q38351593
		KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.	Q39859206
		MSL2 promotes Mdm2-independent cytoplasmic localization of p53	Q39912357
		C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.	Q40157263
		Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells	Q40237209
		Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation	Q40251109
		Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.	Q40290190
		WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.	Q40323754
		Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells	Q40410781
		The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.	Q40491393
		Yin Yang 1 is a negative regulator of p53.	Q40542917
		Inhibition of p53 degradation by Mdm2 acetylation	Q40580015
		Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53.	Q40911280
		Mdm2 and Mdm4 loss regulates distinct p53 activities	Q41269705
		The N terminus of p53 regulates its dissociation from DNA.	Q42055738
		Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression	Q42062886
		DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation	Q42816808
		Acetylation of the p53 DNA-binding domain regulates apoptosis induction	Q43019120
		SnapShot: p53 posttranslational modifications	Q43118019
		Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.	Q43594592
		Acetylation of p53 inhibits its ubiquitination by Mdm2.	Q44209228
		Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication	Q44703400
		Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.	Q44896717
		Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis	Q45345472
		The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality	Q46111122
		Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.	Q52590496
		Latent and active p53 are identical in conformation	Q58002479
		Dual-site regulation of MDM2 E3-ubiquitin ligase activity	Q79954190
		Facilitated search for specific genomic targets by p53 C-terminal basic DNA binding domain	Q80826872
P433	issue	4
P407	language of work or name	English	Q1860
P304	page(s)	609-22
P577	publication date	2009-05-15
P1433	published in	Cell	Q655814
P1476	title	Modes of p53 regulation
P478	volume	137

Modes of p53 regulation

scientific article (publication date: 15 May 2009)

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