Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.

scientific article published on 9 November 2015

Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1039005211
P356DOI10.1038/SREP16355
P932PMC publication ID4817527
P698PubMed publication ID26549310
P5875ResearchGate publication ID284104169

P2093author name stringJing Yang
Bin Li
Lei Han
Xiuwen Wang
Peng Xu
Zuojia Chen
Andy Tsun
Yayi Gao
Jia Nie
Ling Lv
Jijia Shen
Qingsi Wu
Qijuan Sun
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SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53Q24310032
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genesQ24321949
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1Q24336199
Acetylation of Sirt2 by p300 attenuates its deacetylase activityQ24336353
USP22 is a positive regulator of NFATc2 on promoting IL2 expressionQ24338120
Negative and positive regulation of gene expression by mouse histone deacetylase 1Q24672508
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainQ27860534
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TH17 cells in development: an updated view of their molecular identity and genetic programmingQ28276449
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T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
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IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.Q30439073
MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammationQ33919580
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.Q34089148
The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cellsQ34170660
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.Q34190044
Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).Q34520098
RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosisQ34613664
The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosisQ34636005
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.Q35006610
Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2.Q35724805
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPKQ35749976
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cellsQ36652900
Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryosQ36777934
60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cellsQ36890566
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanismQ36929766
Identification of IL-17-producing FOXP3+ regulatory T cells in humans.Q37122868
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.Q37222190
Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytesQ37602097
Histone deacetylase inhibitors modulate interleukin 6-dependent CD4+ T cell polarization in vitro and in vivoQ37608561
Protein acetylation in the cardiorenal axis: the promise of histone deacetylase inhibitorsQ37687716
Histone deacetylase inhibitors: keeping momentum for neuromuscular and cardiovascular diseases treatmentQ37708759
Physical and functional HAT/HDAC interplay regulates protein acetylation balanceQ37820140
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.Q39765588
Trichostatin A promotes the generation and suppressive functions of regulatory T cellsQ40964294
Green tea polyphenols causes cell cycle arrest and apoptosis in prostate cancer cells by suppressing class I histone deacetylasesQ41128716
Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cellsQ42923536
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)16355
P577publication date2015-11-09
P1433published inScientific ReportsQ2261792
P1476titleReciprocal regulation of RORγt acetylation and function by p300 and HDAC1.
P478volume5

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cites work (P2860)
Q64118226Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses
Q92072015Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate
Q58747685GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease
Q57143889Histone deacetylase function in CD4 T cells
Q64914861Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy.
Q89725150JQ1, a bromodomain inhibitor, suppresses Th17 effectors by blocking p300-mediated acetylation of RORγt
Q48098684Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Q47097758Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.
Q26740155Post-translational regulation of RORγt-A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases
Q55354251Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells.
Q43523326Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt
Q58097712SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
Q57712790Targeting transcription factor lysine acetylation in inflammatory airway diseases
Q39015080Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders.

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