| scholarly article | Q13442814 |
| P50 | author | Carol Prives | Q28112996 |
| P2093 | author name string | Katherine L B Borden | |
| Nikola Pavletich | |||
| Zhen-Qiang Pan | |||
| Masha V Poyurovsky | |||
| Alex Kentsis | |||
| Christina Priest | |||
| P2860 | cites work | Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein | Q22010970 |
| Identification of a cryptic nucleolar-localization signal in MDM2 | Q22253304 | ||
| Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 | Q22253350 | ||
| Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex | Q24294734 | ||
| Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 | ||
| Mdm2 promotes the rapid degradation of p53 | Q24322597 | ||
| Does this have a familiar RING? | Q55920907 | ||
| Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53 | Q57078209 | ||
| The p53-associated protein MDM2 contains a newly characterized zinc-binding domain called the RING finger | Q72100609 | ||
| Signaling to p53: breaking the MDM2-p53 circuit | Q77430977 | ||
| Metal and RNA binding properties of the hdm2 RING finger domain | Q77628726 | ||
| Structural basis for non-covalent interaction between ubiquitin and the ubiquitin conjugating enzyme variant human MMS2 | Q82736653 | ||
| A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination | Q82857335 | ||
| An essential function of the extreme C-terminus of MDM2 can be provided by MDMX | Q24328822 | ||
| Control of biochemical reactions through supramolecular RING domain self-assembly | Q24539123 | ||
| Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex | Q24675257 | ||
| Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade | Q27620360 | ||
| Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases | Q27626747 | ||
| Structure of a BRCA1-BARD1 heterodimeric RING-RING complex | Q27635007 | ||
| Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase | Q27640370 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| Regulation of p53 stability by Mdm2 | Q27860744 | ||
| The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain | Q27937065 | ||
| Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase | Q28139082 | ||
| MDM2 interacts with MDMX through their RING finger domains | Q28142437 | ||
| Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha | Q28143121 | ||
| Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia | Q28143297 | ||
| Back to the future with ubiquitin | Q28240711 | ||
| The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation | Q28280958 | ||
| The p53 pathway: positive and negative feedback loops | Q29617535 | ||
| Does this have a familiar RING? | Q29620258 | ||
| The p53 pathway | Q33643359 | ||
| RING domains: master builders of molecular scaffolds? | Q33827485 | ||
| Self-assembly properties of a model RING domain | Q33894328 | ||
| A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination | Q33958478 | ||
| Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance | Q34132152 | ||
| The MDM2-p53 interaction. | Q34288001 | ||
| A structural basis for processivity | Q34342069 | ||
| Mdmx as an essential regulator of p53 activity | Q36113127 | ||
| Unleashing the power of p53: lessons from mice and men. | Q36371033 | ||
| The MDM2 oncoprotein binds specifically to RNA through its RING finger domain | Q36437940 | ||
| Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation | Q39540070 | ||
| Inhibition of p53 degradation by Mdm2 acetylation | Q40580015 | ||
| Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization | Q40622767 | ||
| Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms | Q40773986 | ||
| An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs | Q40957725 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 90-101 | |
| P577 | publication date | 2006-12-14 | |
| P1433 | published in | The EMBO Journal | Q1278554 |
| P1476 | title | The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity | |
| P478 | volume | 26 |
| Q41885302 | 5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2. |
| Q37365346 | A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restriction |
| Q64063524 | A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize |
| Q39632042 | A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis |
| Q35095241 | A Small-Molecule p53 Activator Induces Apoptosis through Inhibiting MDMX Expression in Breast Cancer Cells |
| Q24336529 | A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system |
| Q37494380 | A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer |
| Q37546075 | AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity |
| Q34619596 | APC/CCdc20targets E2F1 for degradation in prometaphase |
| Q33552958 | ATM activates p53 by regulating MDM2 oligomerization and E3 processivity |
| Q24646511 | Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 |
| Q49787526 | Activation of p53 and destabilization of androgen receptor by combinatorial inhibition of MDM2 and MDMX in prostate cancer cells |
| Q24336527 | Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase |
| Q24328822 | An essential function of the extreme C-terminus of MDM2 can be provided by MDMX |
| Q36967316 | Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity. |
| Q99551088 | CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells |
| Q38618179 | Caging the Beast: TRIM5α Binding to the HIV-1 Core |
| Q35192942 | Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha |
| Q34368142 | Deconstructing nucleotide binding activity of the Mdm2 RING domain |
| Q50316561 | Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis |
| Q27003153 | Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1 |
| Q34777828 | Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein. |
| Q39348126 | Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. |
| Q36387594 | Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity |
| Q51560838 | Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer. |
| Q38605937 | Dysfunction of the MDM2/p53 axis is linked to premature aging |
| Q39936932 | E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes |
| Q34360157 | Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice |
| Q37694816 | Epigallocatechin-3-gallate(EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity. |
| Q39879529 | Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. |
| Q36122076 | Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function |
| Q35916594 | Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells |
| Q37871861 | Functions of MDMX in the Modulation of the p53‐Response |
| Q40170945 | Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. |
| Q89967592 | How to Inactivate Human Ubiquitin E3 Ligases by Mutation |
| Q36033129 | Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein |
| Q50083521 | Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice |
| Q37379017 | Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases |
| Q35232862 | Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival |
| Q50421763 | Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects |
| Q42378976 | Involvement of Ubiquitin-Conjugating Enzyme (E2 Gene Family) in Ripening Process and Response to Cold and Heat Stress of Vitis vinifera |
| Q35637193 | MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4 |
| Q89807991 | MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling |
| Q28611422 | MDM2 and MDMX: Alone and together in regulation of p53 |
| Q33922100 | MDM2 oligomers: antagonizers of the guardian of the genome |
| Q28118946 | MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity |
| Q33897779 | MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change |
| Q34166049 | MDM2, MDMX and p53 in oncogenesis and cancer therapy |
| Q30380283 | MDM4 (MDMX) and its Transcript Variants. |
| Q38884006 | MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond |
| Q57498791 | MDMX under stress: the MDMX-MDM2 complex as stress signals hub |
| Q38976292 | Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4. |
| Q41269705 | Mdm2 and Mdm4 loss regulates distinct p53 activities |
| Q90471304 | Mdm2 enhances ligase activity of parkin and facilitates mitophagy |
| Q33788018 | Mdm2 links genotoxic stress and metabolism to p53 |
| Q37508606 | Mdm2-mediated ubiquitylation: p53 and beyond. |
| Q24316238 | Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase |
| Q34296531 | Mechanism of p53 stabilization by ATM after DNA damage |
| Q29615657 | Modes of p53 regulation |
| Q28074490 | Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma |
| Q38769323 | Mouse modelling of the MDM2/MDMX-p53 signalling axis |
| Q36782739 | Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination |
| Q39396732 | Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers |
| Q24337178 | Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability |
| Q40406254 | NMR assignment of the arenaviral protein Z from Lassa fever virus |
| Q34255787 | Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay |
| Q34037741 | Oligomeric structure of the MALT1 tandem Ig-like domains |
| Q38723764 | Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria |
| Q33878303 | PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination |
| Q37883939 | Parkin, A Top Level Manager in the Cells Sanitation Department |
| Q52663744 | Peli1 modulates the subcellular localization and activity of Mdmx |
| Q34198570 | Phosphatases in the cellular response to DNA damage. |
| Q28755220 | Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon? |
| Q24319027 | Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation |
| Q27690164 | Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor |
| Q35927931 | Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation |
| Q26850008 | RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination |
| Q26853207 | RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis |
| Q89793532 | Regulation of E3 ubiquitin ligases by homotypic and heterotypic assembly |
| Q35599086 | Regulation of MDM2 E3 Ligase Activity by Phosphorylation after DNA Damage |
| Q28510160 | Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage |
| Q37992789 | Regulation of p53: a collaboration between Mdm2 and MdmX |
| Q42089987 | Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif |
| Q39385222 | Ribosomal protein S14 unties the MDM2–p53 loop upon ribosomal stress |
| Q34178921 | Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis |
| Q39812243 | Ribosomal protein S7 is both a regulator and a substrate of MDM2 |
| Q35206381 | Signaling to p53: ribosomal proteins find their way. |
| Q34003810 | Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2. |
| Q53188125 | Small molecules that bind the Mdm2 RING stabilize and activate p53. |
| Q42510354 | Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity. |
| Q34575687 | Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2. |
| Q94461598 | Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain |
| Q27649717 | Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans |
| Q33906122 | Suppression of p53 activity by Siva1 |
| Q24312708 | Systematic Analysis of Dimeric E3-RING Interactions Reveals Increased Combinatorial Complexity in Human Ubiquitination Networks |
| Q98771287 | Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges |
| Q37068706 | Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry? |
| Q38059739 | Targeting the Ubiquitin-Mediated Proteasome Degradation of p53 for Cancer Therapy |
| Q42532759 | The C terminus of p53 binds the N-terminal domain of MDM2. |
| Q35608179 | The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization |
| Q34460686 | The MDM2 gene family |
| Q36387600 | The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53. |
| Q55517350 | The Roles of MDM2 and MDMX in Cancer. |
| Q24299062 | The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt |
| Q47116674 | The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2). |
| Q64107802 | The long and the short of it: the MDM4 tail so far |
| Q35122947 | The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo |
| Q34020353 | The p53 orchestra: Mdm2 and Mdmx set the tone |
| Q95650650 | The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges |
| Q37599707 | The regulation of MDM2 oncogene and its impact on human cancers |
| Q38112497 | The role of ubiquitin modification in the regulation of p53 |
| Q24295055 | Turning the RING domain protein MdmX into an active ubiquitin-protein ligase |
| Q34452497 | c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation |
| Q36387615 | p53 Regulation Goes Live-Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling |
Search more.