Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity.

scientific article published on 13 May 2013

Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.454470
P932PMC publication ID3696669
P698PubMed publication ID23671280

P50authorRuchira RanaweeraQ57731181
P2093author name stringXiaolu Yang
P2860cites workRING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitinationQ22010577
Critical role for Daxx in regulating Mdm2Q24297332
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrateQ24297635
Mdm2 promotes the rapid degradation of p53Q24322597
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substratesQ24322903
An essential function of the extreme C-terminus of MDM2 can be provided by MDMXQ24328822
Cell signaling by receptor tyrosine kinasesQ24598357
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transQ27649717
RING domain E3 ubiquitin ligasesQ27860546
Regulation of p53 stability by Mdm2Q27860744
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
MDM2 interacts with MDMX through their RING finger domainsQ28142437
Back to the future with ubiquitinQ28240711
E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transferQ28270616
Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivoQ28274471
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulationQ28508240
Blinded by the Light: The Growing Complexity of p53Q29547590
Ubiquitin-binding domainsQ29614358
Building ubiquitin chains: E2 enzymes at workQ29619578
Proteases for cell suicide: functions and regulation of caspasesQ33927179
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenaseQ35032943
The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivoQ35122947
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activityQ35610627
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.Q36347917
Interdimer processing mechanism of procaspase-8 activation.Q39832029
RING domain-mediated interaction is a requirement for MDM2's E3 ligase activityQ40110366
Mdm2 association with p53 targets its ubiquitinationQ42824389
Autoproteolytic activation of pro-caspases by oligomerizationQ47862735
Methylated ubiquitin inhibits cyclin degradation in clam embryo extractsQ50797700
The hydrophobic effect contributes to polyubiquitin chain recognitionQ74252439
A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitinationQ82857335
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P1104number of pages8
P304page(s)18939-18946
P577publication date2013-05-13
P1433published inJournal of Biological ChemistryQ867727
P1476titleAuto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity
P478volume288

Reverse relations

cites work (P2860)
Q42003660Anatomy of Mdm2 and Mdm4 in evolution.
Q47398481Autographa californica nucleopolyhedrovirus AC141 (Exon0), a potential E3 ubiquitin ligase, interacts with viral ubiquitin and AC66 to facilitate nucleocapsid egress
Q47164914BTK blocks the inhibitory effects of MDM2 on p53 activity
Q41966602Differential expression of microRNA501-5p affects the aggressiveness of clear cell renal carcinoma
Q26752818E2 enzymes: more than just middle men
Q92105561Enzymatic Logic of Ubiquitin Chain Assembly
Q38730588GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.
Q35803065Identification of a p53-based portable degron based on the MDM2-p53 binding region
Q89997332Post-translational regulation of ubiquitin signaling
Q58695073RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma
Q96348276Regulating tumor suppressor genes: post-translational modifications
Q60925253Regulation of Protein Degradation by Proteasomes in Cancer
Q61451115Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B~ubiquitin complex
Q38916854Structural insights into the catalysis and regulation of E3 ubiquitin ligases
Q57840406The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway
Q64991175The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.
Q34170749The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation
Q40909625Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy
Q58582569Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

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