Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice

scientific article published on 9 November 2017

Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.RA117.000122
P932PMC publication ID5766955
P698PubMed publication ID29123033

P2093author name stringYanping Zhang
Hui Tian
Junnian Zheng
Aiwen Jin
Nicole R Tackmann
P2860cites workPUMA, a novel proapoptotic gene, is induced by p53Q24291463
RING domain-mediated interaction is a requirement for MDM2's E3 ligase activityQ40110366
Inhibition of p53 degradation by Mdm2 acetylationQ40580015
DNA damage-induced MDMX degradation is mediated by MDM2.Q40636352
Temporal dissection of p53 function in vitro and in vivoQ44365729
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.Q44896717
The MDM2 RING-finger domain is required to promote p53 nuclear exportQ45301160
20 years studying p53 functions in genetically engineered miceQ84583331
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilizationQ24292930
Acetylation is indispensable for p53 activationQ24313477
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domainQ24314763
Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligaseQ24316238
MDMX: a novel p53-binding protein with some functional properties of MDM2Q24561971
The first 30 years of p53: growing ever more complexQ24645732
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
p53, the cellular gatekeeper for growth and divisionQ27860990
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53Q28214793
MDMX inhibits the p300/CBP-mediated acetylation of p53Q28216910
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulationQ28508240
Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damageQ28510160
Blinded by the Light: The Growing Complexity of p53Q29547590
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53Q29614430
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsQ29615006
Modes of p53 regulationQ29615657
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53Q29615851
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53Q29617850
The p53 orchestra: Mdm2 and Mdmx set the toneQ34020353
Validation of MdmX as a therapeutic target for reactivating p53 in tumorsQ34209099
p300/CBP/p53 interaction and regulation of the p53 responseQ34254607
Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interactionQ34292937
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.Q34585107
MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitinationQ35084991
The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivoQ35122947
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stabilityQ35123240
MDM2 promotes ubiquitination and degradation of MDMXQ35161842
The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerizationQ35608179
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activityQ35610627
p53 regulation: teamwork between RING domains of Mdm2 and MdmX.Q37963700
p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway.Q39187173
MdmX protects p53 from Mdm2-mediated degradationQ39450800
P4510describes a project that usesImageJQ1659584
P433issue52
P407language of work or nameEnglishQ1860
P304page(s)21614-21622
P577publication date2017-11-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleInactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice
P478volume292

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cites work (P2860)
Q89967592How to Inactivate Human Ubiquitin E3 Ligases by Mutation
Q96348276Regulating tumor suppressor genes: post-translational modifications

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