20 years studying p53 functions in genetically engineered mice

scientific article published on 24 September 2009

20 years studying p53 functions in genetically engineered mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1046023103
P356DOI10.1038/NRC2731
P698PubMed publication ID19776746

P2093author name stringGuillermina Lozano
Lawrence A Donehower
P2860cites workCrystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
p53, the cellular gatekeeper for growth and divisionQ27860990
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Surfing the p53 networkQ28032484
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53Q28214793
p53 regulates maternal reproduction through LIFQ28259206
Altering the genome by homologous recombinationQ28270159
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumoursQ28513003
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
p63 is a p53 homologue required for limb and epidermal morphogenesisQ28588206
p63 deficiency activates a program of cellular senescence and leads to accelerated agingQ28592969
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53Q29614430
The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.Q40865245
The p53-deficient mouse: a model for basic and applied cancer studiesQ41436922
Gain of function mutations in p53.Q41557652
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndromeQ41816411
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppressionQ42062886
Temporal dissection of p53 function in vitro and in vivoQ44365729
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.Q44896717
p53 must be competent for transcriptional regulation to suppress tumor formationQ45306125
Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival.Q45871432
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethalityQ46111122
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.Q46200576
Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasisQ46557073
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.Q46706112
The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppressionQ46843477
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndromeQ48379673
High-frequency developmental abnormalities in p53-deficient mice.Q52206956
A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient miceQ52207983
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancerQ52544495
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndromeQ52561781
Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesisQ52567811
The p53 family in differentiation and tumorigenesis.Q53336172
Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic miceQ53385488
Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research toolQ53399551
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumorsQ53478233
Thymocyte apoptosis induced by p53-dependent and independent pathwaysQ54242475
p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure.Q54579010
Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant.Q55474891
The price of tumour suppression?Q56672523
Delayed ageing through damage protection by the Arf/p53 pathwayQ57562759
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 geneQ58423654
Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor SuppressorsQ63884137
Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strainQ64388914
p53-dependent apoptosis suppresses radiation-induced teratogenesisQ71046591
Enhanced proliferative potential in culture of cells from p53-deficient miceQ71600264
Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneysQ71627486
A subset of p53-deficient embryos exhibit exencephalyQ72031963
p53-dependent apoptosis suppresses tumor growth and progression in vivoQ72149266
Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar developmentQ72772605
Genetic background alters the spectrum of tumors that develop in p53-deficient miceQ72864214
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53Q72871721
The loss of mdm2 induces p53-mediated apoptosisQ73673966
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapyQ74117541
mdmx is a negative regulator of p53 activity in vivoQ74198977
The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null miceQ74428413
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant miceQ75217030
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndromeQ81166001
Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23Q81369426
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 familyQ81662172
Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null miceQ93924394
Regulating the p53 pathway: in vitro hypotheses, in vivo veritasQ29615658
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
Tumor spectrum analysis in p53-mutant miceQ29617436
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53Q29617850
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasmsQ29618586
Restoration of p53 function leads to tumour regression in vivoQ29618727
Effects of an Rb mutation in the mouseQ29619196
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisQ29619200
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
p53 mutant mice that display early ageing-associated phenotypesQ29622826
Modulation of mammalian life span by the short isoform of p53.Q30312095
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitorsQ33328820
Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progressionQ33493417
p53 regulates hematopoietic stem cell quiescence.Q33732098
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiationQ33733341
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formationQ33889285
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivationQ33900545
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.Q33931140
Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressQ33997846
Telomerase reverse transcriptase delays aging in cancer-resistant miceQ34014691
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 functionQ34015423
Cellular senescence: mitotic clock or culture shock?Q34019131
Germline TP53 mutations and Li-Fraumeni syndromeQ34181585
Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in miceQ34263387
Involvement of p53-dependent apoptosis in radiation teratogenesis and in the radioadaptive response in the late organogenesis of miceQ34274548
Tumor suppression and normal aging in mice with constitutively high p53 activityQ34324057
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.Q34347328
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normallyQ34369829
Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53+/- Mouse Model in Carcinogenicity TestingQ34429238
The p53 proto-oncogene can act as a suppressor of transformationQ34440370
The pathological response to DNA damage does not contribute to p53-mediated tumour suppressionQ34564198
The regulation of INK4/ARF in cancer and agingQ34575801
Modeling the therapeutic efficacy of p53 restoration in tumorsQ34593294
Crippling p53 activities via knock-in mutations in mouse modelsQ34614596
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.Q34694274
Rapid generation of inducible mouse mutantsQ34771977
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damageQ35071254
p21 delays tumor onset by preservation of chromosomal stabilityQ35225097
Phosphorylation of serine 18 regulates distinct p53 functions in miceQ35545143
The impact of altered p53 dosage on hematopoietic stem cell dynamics during agingQ35628919
High metastatic potential in mice inheriting a targeted p53 missense mutationQ35673678
Genetic manipulation of the mouse via gene targeting in embryonic stem cellsQ35784859
Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndromeQ35829654
Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signalingQ36117276
Probing p53 biological functions through the use of genetically engineered mouse modelsQ36204567
p63: oncogene or tumor suppressor?Q36344444
Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified miceQ36430180
Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescenceQ36446127
neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic miceQ36568624
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a lossQ36649149
The oncogenic roles of p53 mutants in mouse modelsQ36701574
Tumor suppressor dosage regulates stem cell dynamics during agingQ36716337
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human diseaseQ36720962
Coping with stress: multiple ways to activate p53.Q36745375
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogeneQ36760672
Cancer and ageing: convergent and divergent mechanismsQ36918634
TAp73 knockout shows genomic instability with infertility and tumor suppressor functionsQ36919913
Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineageQ36954453
p53 Family isoformsQ37090171
The impact of p53 and p73 on aneuploidy and cancerQ37136283
p53: a new player in reproductionQ37138983
The jury is in: p73 is a tumor suppressor after all.Q37285304
p53 and MDM2: antagonists or partners in crime?Q37403313
Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastomaQ37466499
Mdm2-mediated ubiquitylation: p53 and beyond.Q37508606
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.Q37524264
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.Q37527427
When mutants gain new powers: news from the mutant p53 field.Q37582777
p53 and E2f: partners in life and deathQ37602510
Genetics of human cancerQ39461610
Germ-line transformation of miceQ39757195
Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellumQ40442891
P433issue11
P304page(s)831-841
P577publication date2009-09-24
P13046publication type of scholarly workreview articleQ7318358
P1433published inNature Reviews CancerQ641657
P1476title20 years studying p53 functions in genetically engineered mice
P478volume9

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cites work (P2860)
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