The regulation of INK4/ARF in cancer and aging

scientific article

The regulation of INK4/ARF in cancer and aging is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2006.10.003
P698PubMed publication ID17055429
P5875ResearchGate publication ID6741311

P50authorNorman SharplessQ21260355
P2093author name stringWilliam Y Kim
P2860cites workOncogenic activity of Cdc6 through repression of the INK4/ARF locusQ40298342
Induction of DNA methylation and gene silencing by short interfering RNAs in human cellsQ40525501
Tumour biology: senescence in premalignant tumoursQ42802962
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)265-275
P577publication date2006-10-01
P1433published inCellQ655814
P1476titleThe regulation of INK4/ARF in cancer and aging
P478volume127

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cites work (P2860)
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Q30572259Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion
Q37629613Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer
Q37869366Polycomb group proteins in hematopoietic stem cell aging and malignancies
Q37175962Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.
Q37718268Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication
Q38069050Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms
Q46006380Polymorphism in ANRIL is associated with relapse in patients with multiple myeloma after autologous stem cell transplant.
Q36973723Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence program
Q38119789Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
Q24607181Pro-tumorigenic effects of miR-31 loss in mesothelioma
Q34127512Progeria syndromes and ageing: what is the connection?
Q90529098Promoter methylation analysis of CDH1 and p14ARF genes in patients with urothelial bladder cancer
Q24298437Proteomic analysis of p16ink4a-binding proteins
Q39395750Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells
Q36785987Quantitative methylation analyses of resection margins predict local recurrences and disease-specific deaths in patients with head and neck squamous cell carcinomas
Q37602305RAS in cellular transformation and senescence
Q39293634RING1B ubiquitination and stability are regulated by ARF.
Q38906940RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line
Q40144689RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.
Q39368650RNA processing as an alternative route to attack glioblastoma.
Q57085790RNA processing is altered in skeletal muscle nuclei of patients affected by myotonic dystrophy
Q39168515Radiation-induced cellular senescence results from a slippage of long-term G2 arrested cells into G1 phase
Q24682671Rapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its function
Q43877274Ras signaling is essential for skin development.
Q37309123Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.
Q42917409Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals
Q37310063Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications
Q33274149Recurrent chromosomal copy number alterations in sporadic chordomas
Q34665706Regulation of senescence in cancer and aging
Q52582577Regulatory Network of ARF in Cancer Development.
Q37880852Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer
Q38981139Rejuvenating Strategies for Stem Cell-Based Therapies in Aging
Q36611480Relationships between stem cell exhaustion, tumour suppression and ageing
Q37295463Repair of senescent myocardium by mesenchymal stem cells is dependent on the age of donor mice
Q42931458Replication stress, a source of epigenetic aberrations in cancer?
Q37323104Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia
Q37156959Replicative stress, stem cells and aging
Q38728895Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block in acute promyelocytic leukemia
Q37149722Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities
Q36766325Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer
Q28535352Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a Sirt1-dependent manner
Q39213950Reversal of hepatocyte senescence after continuous in vivo cell proliferation
Q38889012Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice
Q39693855Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
Q37111920Role of DMP1 and its future in lung cancer diagnostics
Q39693770Role of DNA methyltransferase 1 in hormone-resistant prostate cancer.
Q36479612Role of senescence marker p16 INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults
Q51097608Runx3 and Cell Fate Decisions in Pancreas Cancer.
Q39149962SATB1 collaborates with loss of p16 in cellular transformation
Q37820200SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression
Q35223877Sal-like protein 2 upregulates p16 expression through a proximal promoter element
Q40284051Sav1 Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis.
Q48347290Senescence and aging: Causes, consequences, and therapeutic avenues
Q38603571Senescence and cancer: An evolving inflammatory paradox
Q90271850Senescence in post-mitotic cells: a driver of ageing?
Q38072351Senescence regulation by the p53 protein family
Q92937373Senescence-associated β-galactosidase activity in the developing avian retina
Q50745945Senescence-related genes possibly responsible for poor liver regeneration after hepatectomy in elderly patients.
Q30436210Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke
Q35181050Signal transduction involving the dmp1 transcription factor and its alteration in human cancer
Q92892162Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging
Q54705317Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells.
Q39112654Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53/p21 pathway.
Q47628821Skin differences based on age and chronicity of ultraviolet exposure: results from a gene expression profiling study.
Q24627126Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Q35549516Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence
Q34429099Somatic p16(INK4a) loss accelerates melanomagenesis
Q33828861Specific age-associated DNA methylation changes in human dermal fibroblasts
Q38838490Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α.
Q42095359Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors
Q37005066Stem cell ageing: does it happen and can we intervene?
Q42428328Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins
Q58762403Structural insights into the functional diversity of the CDK-cyclin family
Q37245042Studying chromosome instability in the mouse
Q58804396Systemic Treatment of Advanced Hepatocellular Carcinoma in Older Adults
Q64122182TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway
Q28069910Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers
Q90211132Telomerase Biology Associations offer Keys to Cancer and Aging Therapeutics
Q34424261Telomere deficiencies on chromosomes 9p, 15p, 15q and Xp: potential biomarkers for breast cancer risk
Q37171810Telomere dysfunction and tumour suppression: the senescence connection
Q37627017Telomeres and telomerase in cancer
Q57277022Telomeres, p21 and the cancer-aging hypothesis
Q90473411Testis-specific Arf promoter expression in a transposase-aided BAC transgenic mouse model
Q52659598The BMI1 polycomb protein represses cyclin G2-induced autophagy to support proliferation in chronic myeloid leukemia cells.
Q40740405The Beginning of the Road for Non-Coding RNAs in Normal Hematopoiesis and Hematologic Malignancies
Q54561402The CDKN2A/CDKN2B/CDK4/CCND1 pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis: an analysis of 104 tumors.
Q37220014The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis
Q47132545The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy.
Q57276930The Impact of Aging on Cancer Progression and Treatment
Q34162817The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation
Q38184520The Mdm network and its regulation of p53 activities: a rheostat of cancer risk
Q38723756The New Immortalized Uroepithelial Cell Line HBLAK Contains Defined Genetic Aberrations Typical of Early Stage Urothelial Tumors.
Q24680814The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
Q39454240The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer
Q28505604The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage
Q37436067The cell cycle and acute kidney injury
Q39664652The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program
Q36911187The common biology of cancer and ageing
Q26782620The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value
Q38061186The genetics of type 2 diabetes and its clinical relevance
Q28649974The genome landscape of the african green monkey kidney-derived vero cell line
Q37089478The impact of aging on kidney repair
Q38045210The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine
Q34592870The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells
Q34038585The molecular balancing act of p16(INK4a) in cancer and aging
Q42128558The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme
Q37726457The regulation of protein synthesis in cancer
Q33876036The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm
Q26783814The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications
Q34341080The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system
Q56891289The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Q37861625The tumor suppressor role of CTCF.
Q30426400The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence
Q28071309Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases
Q35230162Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour
Q33493417Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression
Q38896940To clear, or not to clear (senescent cells)? That is the question
Q33510472Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation
Q36291101Transcriptional repression of CDKN2D by PML/RARα contributes to the altered proliferation and differentiation block of acute promyelocytic leukemia cells
Q38493248Transcriptome analysis of neoplastic hemocytes in soft-shell clams Mya arenaria: Focus on cell cycle molecular mechanism
Q91139907Transformation of mature mouse B cells into malignant plasma cells in vitro via introduction of defined genetic elements
Q34235226Trithorax group proteins: switching genes on and keeping them active
Q55056740Truncated Isoforms of lncRNA ANRIL Are Overexpressed in Bladder Cancer, But Do Not Contribute to Repression of INK4 Tumor Suppressors.
Q36292997Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals
Q37522773Tumor suppressor mechanisms in immune aging
Q54657364Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model.
Q41977782Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors
Q38266066Tumor suppressors in follicular lymphoma
Q24618747Tumor suppressors: enhancers or suppressors of regeneration?
Q39200828Tumor-specific RNA interference targeting Pokemon suppresses tumor growth and induces apoptosis in prostate cancer
Q54330859UHRF1 promotes cell growth and metastasis through repression of p16(ink⁴a) in colorectal cancer.
Q38722022UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.
Q24310413Ubiquitin ligase ARF-BP1/Mule modulates base excision repair
Q35097799Umbilical cord mesenchymal stromal cells affected by gestational diabetes mellitus display premature aging and mitochondrial dysfunction
Q34031710Uncovering the role of genomic "dark matter" in human disease
Q28071384Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities
Q37748214Using mice to examine p53 functions in cancer, aging, and longevity
Q33675252Utility of p16 immunohistochemistry for the identification of Lynch syndrome
Q43228579Validation and use of a computer-assisted counting procedure to quantify BrdU-labeled proliferating cells in the early postnatal mouse hippocampus
Q50190309Variants in 9p21 Predicts Severity of Coronary Artery Disease in a Chinese Han Population.
Q49936366Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp.
Q98460381Well-differentiated liposarcoma primary from thymic stroma: Case report and literature review
Q37599387Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.
Q54400552YB1 binds to and represses the p16 tumor suppressor gene.
Q39325305ZRF1 controls oncogene-induced senescence through the INK4-ARF locus
Q34653709Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels
Q39623471p14(ARF) inhibits the functions of adenovirus E1A oncoprotein.
Q45781889p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma.
Q40090783p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a
Q36482470p16 Hypermethylation and KRAS Mutation Are Independent Predictors of Cetuximab Plus FOLFIRI Chemotherapy in Patients with Metastatic Colorectal Cancer
Q50088453p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia
Q54542242p16 expression as a surrogate marker for HPV-related oropharyngeal carcinoma: a guide for interpretative relevance and consistency.
Q37200881p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses
Q21092220p16(INK4a) translation suppressed by miR-24
Q38788371p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
Q35133362p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors
Q51532861p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1.
Q24306350p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis
Q39488131p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb
Q36890276p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia.
Q61798614p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation

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