Exploiting tumor cell senescence in anticancer therapy

scientific article

Exploiting tumor cell senescence in anticancer therapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.5483/BMBREP.2014.47.2.005
P932PMC publication ID4163898
P698PubMed publication ID24411464
P5875ResearchGate publication ID264078164

P2093author name stringMinyoung Lee
Jae-Seon Lee
P2860cites workIL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factorQ72901004
Senescence induces a proangiogenic switch in human peritoneal mesothelial cellsQ81560080
How ageing processes influence cancerQ22251048
Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitmentQ24301358
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Cellular senescence and tumor suppressor gene p16Q24629853
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisQ24681977
Human conditions of insulin-like growth factor-I (IGF-I) deficiencyQ26822806
Roles and mechanisms of cellular senescence in regulation of tissue homeostasisQ26999018
The hallmarks of agingQ28131641
BET bromodomain inhibition as a therapeutic strategy to target c-MycQ28247024
Meta-analysis of age-related gene expression profiles identifies common signatures of aging.Q29347048
The serial cultivation of human diploid cell strainsQ29547356
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorQ29615559
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
Restoration of p53 function leads to tumour regression in vivoQ29618727
BRAFE600-associated senescence-like cell cycle arrest of human naeviQ29619550
The senescence-associated secretory phenotype: the dark side of tumor suppressionQ29620106
Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and CancerQ30395770
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.Q31041084
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesisQ33685619
Senescent cells as a source of inflammatory factors for tumor progressionQ33833881
Cellular senescence: A link between cancer and age-related degenerative disease?Q34028588
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytesQ34106524
Aging, Cellular Senescence, and CancerQ34199776
Therapy-Induced Senescence in CancerQ34212773
Proteolyzed matrix as a template for the regulation of tumor progressionQ34218154
The p53 network: cellular and systemic DNA damage responses in aging and cancerQ34248711
The essence of senescenceQ34288983
Secretome analysis of ionizing radiation‐induced senescent cancer cells reveals that secreted RKIP plays a critical role in neighboring cell migrationQ34352155
The expression signature of in vitro senescence resembles mouse but not human agingQ34481078
Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblastsQ34552889
The regulation of INK4/ARF in cancer and agingQ34575801
The identification of senescence-specific genes during the induction of senescence in prostate cancer cellsQ34769742
SASP reflects senescence.Q34945503
Oncogenic Braf induces melanocyte senescence and melanoma in miceQ34974162
PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiationQ35092641
The ARF-p53 senescence pathway in mouse and human cellsQ35619087
The normal response to RAS: senescence or transformation?Q35778503
The signals and pathways activating cellular senescenceQ36060167
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapyQ36414978
Senescence surveillance of pre-malignant hepatocytes limits liver cancer developmentQ53206297
Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells.Q53365811
Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast originQ53536765
Molecular signature of oncogenic ras-induced senescenceQ53632631
Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cellsQ70890742
Role of telomeres and telomerase in genomic instability, senescence and cancerQ36927502
Evolving role of uPA/uPAR system in human cancersQ37046231
Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapyQ37064796
Senescent stromal-derived osteopontin promotes preneoplastic cell growthQ37078729
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiationQ37082277
Cellular senescence in oral cancer and precancer and treatment implications: a reviewQ37209689
Control of senescence by CXCR2 and its ligandsQ37288307
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine networkQ37385995
The role of epigenetics in aging and age-related diseasesQ37589034
Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescenceQ37612255
Tumor suppression by ARF: gatekeeper and caretakerQ37656961
Oncogene-induced senescence: the bright and dark side of the responseQ37784324
Extracellular signals in young and aging breast epithelial cells and possible connections to age-associated breast cancer developmentQ37867199
Pro-senescence therapy for cancer treatmentQ37893959
Oncogene- and tumor suppressor gene-mediated suppression of cellular senescenceQ37950784
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).Q37969844
Senescence: a new weapon for cancer therapyQ37975834
Emerging roles of RB family: new defense mechanisms against tumor progressionQ38034093
p21WAF1 and tumourigenesis: 20 years afterQ38060451
Stressing the cell cycle in senescence and agingQ38126692
Immunosurveillance of senescent cells: the bright side of the senescence programQ38151547
A novel telomerase template antagonist (GRN163) as a potential anticancer agentQ38352368
alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cellsQ39748375
Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen speciesQ39783612
Cytokine expression and signaling in drug-induced cellular senescence.Q39791621
Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescenceQ39844229
Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner.Q39923052
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiationQ39957013
Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretionQ40149352
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescenceQ40249487
The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosisQ40300478
Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironmentQ40390428
Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epitheliumQ40840841
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.Q40928334
Replicative senescence: an old lives' tale?Q40968415
Characterization of IGFBP-3, PAI-1 and SPARC mRNA expression in senescent fibroblastsQ41144365
AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture.Q41284390
Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing pathsQ41438730
Interleukin 1 alpha is a marker of endothelial cellular senescent.Q41676538
Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cellsQ41726147
Epithelial-Mesenchymal Transition Induced by Senescent FibroblastsQ41835409
Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinasesQ42801129
Tumour biology: senescence in premalignant tumoursQ42802962
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.Q43455466
Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperationQ47349068
Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylationQ48673271
The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanismsQ51285272
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P433issue2
P921main subjectcellular senescenceQ9075999
neoplasmQ1216998
antineoplasticQ2853144
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)51-59
P577publication date2014-02-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inBMB ReportsQ15764027
P1476titleExploiting tumor cell senescence in anticancer therapy
P478volume47

Reverse relations

cites work (P2860)
Q38694968A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds
Q61453530CD38 affects the biological behavior and energy metabolism of nasopharyngeal carcinoma cells
Q40988747Caveolin-1 deficiency induces premature senescence with mitochondrial dysfunction
Q94476206Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problem
Q64272067Cellular senescence: a promising strategy for cancer therapy
Q38690908Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe
Q37353998Heparan sulfation is essential for the prevention of cellular senescence
Q64883108High COX-2 expression contributes to a poor prognosis through the inhibition of chemotherapy-induced senescence in nasopharyngeal carcinoma.
Q88768081Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues
Q26865711LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential
Q41294329Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases
Q35769198Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
Q35739627NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence
Q41170174P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment
Q26822819Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies
Q35779447Programmed cell death in aging
Q91211185Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition

Search more.