UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.

scientific article published on 10 January 2017

UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M116.749564
P932PMC publication ID5314184
P698PubMed publication ID28073915

P2093author name stringKeith Wheaton
Vivian Saridakis
Yi Sheng
Feroz Sarkari
Brian Raught
Olga Egorova
Lilia Kaustov
Beena Stanly Johns
Hossein Davarinejad
P2860cites workEBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replicationQ21131571
A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell divisionQ22009029
Regulation of cell cycle progression and gene expression by H2A deubiquitinationQ24296401
Human USP3 is a chromatin modifier required for S phase progression and genome stabilityQ24299488
Role of histone H2A ubiquitination in Polycomb silencingQ24305090
Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferationQ37175990
BAP1/ASXL1 recruitment and activation for H2A deubiquitination.Q38806099
USP7 cooperates with SCML2 to regulate the activity of PRC1.Q38918184
Regulation of the Polycomb protein RING1B ubiquitination by USP7.Q39662445
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identityQ40002662
Crystal structure of the PRC1 ubiquitylation module bound to the nucleosomeQ42001356
Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cellsQ42729081
Polycomb Group proteins: an evolutionary perspective.Q51971914
Stem cells primed for action: polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells.Q53610309
Characterization of nucleosome core particles containing histone proteins made in bacteriaQ73770026
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progressionQ24307439
TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoproteinQ24308021
Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexQ24315785
Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusQ24317899
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1bQ24337331
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressorQ24337508
Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complexQ24337578
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulationQ24337802
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibitionQ24554110
Isopeptide linkage between nonhistone and histone 2A polypeptides of chromosomal conjugate-protein A24Q24561817
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Cellular senescence and tumor suppressor gene p16Q24629853
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationQ24652976
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cellsQ24680814
A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function ScreenQ27678481
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosisQ28217365
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7Q28238126
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencingQ28287373
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivationQ28505166
Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressorQ28585873
Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylationQ28585918
Polycomb complexes repress developmental regulators in murine embryonic stem cellsQ29547274
TANDEM: matching proteins with tandem mass spectraQ29615238
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locusQ29619815
Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.Q30429637
Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cellsQ30480516
ProteoWizard: open source software for rapid proteomics tools developmentQ33349681
SAINT: probabilistic scoring of affinity purification-mass spectrometry dataQ33763365
ProHits: integrated software for mass spectrometry-based interaction proteomicsQ34211917
The regulation of INK4/ARF in cancer and agingQ34575801
Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.Q36421331
A conserved sequence in histone H2A which is a ubiquitination site in higher eucaryotes is not required for growth in Saccharomyces cerevisiaeQ36725358
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)2893-2902
P577publication date2017-01-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleUbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.
P478volume292

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cites work (P2860)
Q64986813Chromatin Architecture as an Essential Determinant of Dendritic Cell Function.
Q57037517OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination
Q92755025The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase
Q92771330The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growth
Q59797809UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment
Q96828977USP7 manipulation by viral proteins

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