Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.

scientific article

Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.ONC.1205909
P698PubMed publication ID12420220
P5875ResearchGate publication ID11046250

P50authorJolene WindleQ42708787
Wei-Guo ZhuQ42962893
P2093author name stringHuiming Zhang
Gregory A Otterson
Wenrui Duan
Gary D Stoner
Haiming Ding
Miguel A Villalona-Calero
Mark A Subler
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High metastatic potential in mice inheriting a targeted p53 missense mutationQ35673678
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA bindingQ36706865
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogeneQ36760672
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Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53Q38325583
Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformationQ39455963
Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domainQ39575066
Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acidsQ40021667
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Somatic activation of the K-ras oncogene causes early onset lung cancer in miceQ40809826
p53 and the Li-Fraumeni syndromeQ40910310
The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosisQ41211044
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Tumor suppressor p53: analysis of wild-type and mutant p53 complexesQ41878071
Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice.Q52235415
Similar incidence of K-ras mutations in lung carcinomas of FVB/N mice and FVB/N mice carrying a mutant p53 transgene.Q53442036
RT-PCR heteroduplex analysis permits differentiation of transgene and host gene expression in a transgenic animal modelQ57594686
Wild-type p53 activates transcription in vitroQ59054260
An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53Q67539546
Expression of SV40 T antigen under control of rabbit uteroglobin promoter in transgenic miceQ67944833
P433issue51
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
P304page(s)7831-7838
P577publication date2002-11-01
P1433published inOncogeneQ1568657
P1476titleLung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.
P478volume21

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cites work (P2860)
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Q40106083p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells

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