Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo

scientific article

Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SREP08705
P932PMC publication ID4346796
P698PubMed publication ID25732051
P5875ResearchGate publication ID273156976

P2093author name stringFang Liu
Haitao Shang
Yunan Zhang
Yuhu Song
Qiu Zhao
Xingxing He
Qian Dou
Jingjun Yan
Junwei Yan
P2860cites workGlobal cancer statisticsQ22241238
p53-independent functions of the p19(ARF) tumor suppressorQ24600863
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Genetic and epigenetic characteristics of human multiple hepatocellular carcinomaQ33711037
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Spliceosome-mediated RNA trans-splicingQ33990703
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Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expressionQ46709821
Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomasQ47417305
Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency.Q51641132
p53 — Master and CommanderQ59238393
Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicingQ64379396
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p53 Isoforms: An Intracellular Microprocessor?Q34202703
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normallyQ34369829
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Allele-specific p53 mutant reactivationQ34638529
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Genetic medicine at the RNA level: modifications of the genetic repertoire for therapeutic purposes by pre-mRNA trans-splicingQ35928212
Mutant p53: one name, many proteinsQ36070574
Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a systematic review and meta-analysisQ36092123
Unleashing the power of p53: lessons from mice and men.Q36371033
Genetic medicines: treatment strategies for hereditary disordersQ36423907
Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cellsQ36591517
p53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?Q36646572
Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.Q36710840
Structure-function-rescue: the diverse nature of common p53 cancer mutantsQ36777367
Reactivation of mutant p53: molecular mechanisms and therapeutic potentialQ36777373
Modulating the expression of disease genes with RNA-based therapy.Q36866549
Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcriptsQ37230210
Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosisQ37295226
Molecular mechanisms of hepatocellular carcinomaQ37323726
30 years and a long way into p53 researchQ37589207
p53-based cancer therapyQ37750115
Translating p53 into the clinic.Q37803120
p53 mutations in cancerQ38069463
ARF tumor suppression in the nucleolusQ38187767
An algorithm for finding protein-DNA binding sites with applications to chromatin-immunoprecipitation microarray experimentsQ38287394
β-2 spectrin is involved in hepatocyte proliferation through the interaction of TGFβ/Smad and PI3K/AKT signallingQ39357385
MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivoQ39447513
Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy.Q39966300
Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA.Q40528526
Mouse models to study the interaction of risk factors for human liver cancer.Q40547714
Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicingQ40906944
Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancerQ45066172
Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinomaQ45858736
Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicingQ45863479
Chinese gene therapy. Splicing out the West?Q45864019
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)8705
P577publication date2015-03-03
P1433published inScientific ReportsQ2261792
P1476titleTrans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo
P478volume5

Reverse relations

cites work (P2860)
Q64240589Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma
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Q42491454Can we be SMaRT-er in our approach to cancer therapy?
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Q28078238Differential Impacts of Alternative Splicing Networks on Apoptosis
Q51745116Gene Therapy via Trans-Splicing for LMNA-Related Congenital Muscular Dystrophy.
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Q36557358MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1.
Q26799788Mouse models of liver cancer: Progress and recommendations
Q41585790NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity
Q92890849Silencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells
Q55387849Spliceosome-Mediated Pre-mRNA trans-Splicing Can Repair CEP290 mRNA.
Q26750650mRNA trans-splicing in gene therapy for genetic diseases
Q51738169β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin.

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