Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts

scientific article published on July 2000

Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2000PNAS...97.8490W
P356DOI10.1073/PNAS.150104097
P932PMC publication ID26975
P698PubMed publication ID10890910
P5875ResearchGate publication ID12428080

P2093author name stringT Watanabe
B A Sullenger
P2860cites workGain of function mutations in p53.Q41557652
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.Q41643433
Genetic mechanisms of tumor suppression by the human p53 geneQ41710706
Tagging ribozyme reaction sites to follow trans-splicing in mammalian cellsQ42812813
Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursorsQ45887644
Trans -splicing ribozymes for targeted gene delivery 1 1Edited by J. KarnQ57902856
Wild-type p53 activates transcription in vitroQ59054260
Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformationQ70168032
The dominating effect of mutant p53Q72293557
A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient miceQ72293593
Probing the interplay between the two steps of group I intron splicing: competition of exogenous guanosine with omega GQ77917378
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Definition of a consensus binding site for p53Q28207794
Oncogenic forms of p53 inhibit p53-regulated gene expressionQ28251120
Identification of p53 as a sequence-specific DNA-binding proteinQ28282745
p53 mutations in human cancersQ28302973
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
Suppression of human colorectal carcinoma cell growth by wild-type p53Q29618318
Self-splicing of the Tetrahymena intron from mRNA in mammalian cellsQ30304459
One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activityQ30461490
Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exonsQ30463369
Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA.Q30463740
Ribozyme-mediated repair of defective mRNA by targeted, trans-splicingQ30465698
p53 tumor suppressor gene therapy for cancer.Q33768194
Rearrangement of the p53 gene in human osteogenic sarcomasQ34360802
Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neuronsQ36256866
The biochemistry of P-glycoprotein-mediated multidrug resistanceQ38364215
Ribozyme-mediated trans-splicing of a trinucleotide repeat.Q41051948
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectribozymeQ205858
P304page(s)8490-8494
P577publication date2000-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleInduction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
P478volume97

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cites work (P2860)
Q343653895' exon replacement and repair by spliceosome-mediated RNA trans-splicing
Q59091650Achilles' heel of cancer?
Q34119859Advances in gene therapy for malignant melanoma
Q35597089Approaches for the sequence-specific knockdown of mRNA.
Q34580489Cancer chemoresistance: the relationship between p53 and multidrug transporters
Q35775827Computational prediction of efficient splice sites for trans-splicing ribozymes
Q34733424Defects in G1-S cell cycle control in head and neck cancer: a review
Q54604030Detection of mRNA in mammalian cells with a split ribozyme reporter.
Q90666977Diverse Mechanisms of RNA Recombination
Q33923881Effective suppression of dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain
Q34365376Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes
Q28214164Emerging clinical applications of RNA
Q35549357Engineered Ribozymes as Molecular Tools for Site‐Specific Alteration of RNA Sequence
Q47784889Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer
Q34417562Exploiting genetic alterations to design novel therapies for cancer
Q39740174Functional repair of a mutant chloride channel using a trans-splicing ribozyme
Q24792778Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives
Q79117427Gene therapy for lung cancer
Q24794819Group I aptazymes as genetic regulatory switches
Q44420167Hammerhead ribozyme-mediated destruction of nuclear foci in myotonic dystrophy myoblasts
Q34387772Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells
Q40093470In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells
Q79266288In-cell generation of antibody single-chain Fv transcripts by targeted RNA trans-splicing
Q37571729Irinotecan therapy and molecular targets in colorectal cancer: a systemic review
Q37311367Low selection pressure aids the evolution of cooperative ribozyme mutations in cells
Q79333360Mending the message
Q35202462Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing
Q37180948Molecular approaches to sarcoma therapy
Q38356388Molecular recognition properties of IGS-mediated reactions catalyzed by a Pneumocystis carinii group I intron.
Q34276988Mutations in apoptosis genes: a pathogenetic factor for human disease
Q35597613Novel cancer therapy by reactivation of the p53 apoptosis pathway.
Q42036073Nuclear group I introns in self-splicing and beyond
Q33267032Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: a five year follow-up analysis.
Q34079549RNA repair: a novel approach to gene therapy
Q36710840Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.
Q34234190Ribozyme gene therapy: applications for molecular medicine
Q40528526Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA.
Q35190983Ribozyme-mediated revision of RNA and DNA
Q43049074Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing
Q35107854Ribozymes: recent advances in the development of RNA tools
Q39698001Selections for constituting new RNA-protein interactions in catalytic RNP.
Q45867347Selective and efficient retardation of cancers expressing cytoskeleton-associated protein 2 by targeted RNA replacement
Q38718304Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement
Q45885374Specific regression of human cancer cells by ribozyme-mediated targeted replacement of tumor-specific transcript
Q35205340Spliceozymes: ribozymes that remove introns from pre-mRNAs in trans
Q24701733Suppression of the Arboviruses Dengue and Chikungunya Using a Dual-Acting Group-I Intron Coupled with Conditional Expression of the Bax C-Terminal Domain
Q35190980Targeted genetic repair: an emerging approach to genetic therapy
Q33747091Targeting of highly conserved Dengue virus sequences with anti-Dengue virus trans-splicing group I introns
Q34989790The genetic pathogenesis of colorectal cancer
Q28199928The molecular biology of cancer
Q36921977The molecular underpinnings of genetic phenomena
Q37417135The structure and function of catalytic RNAs
Q37081504The use of p53 as a tool for human cancer therapy
Q35138721Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo
Q38300895Transcriptional repression by p53 through direct binding to a novel DNA element

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