| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | M R Capecchi | |
| P2860 | cites work | Establishment in culture of pluripotential cells from mouse embryos | Q27860625 |
| HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells | Q28511588 | ||
| P433 | issue | 4910 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1288-92 | |
| P577 | publication date | 1989-06-16 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Altering the genome by homologous recombination | |
| P478 | volume | 244 |
| Q40412884 | "Magic" scissors for genome surgery |
| Q84583331 | 20 years studying p53 functions in genetically engineered mice |
| Q33836757 | 5-Lipoxygenase and leukotrienes. Transgenic mouse and nuclear targeting studies |
| Q46098688 | A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene |
| Q33674053 | A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse |
| Q40418924 | A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. |
| Q47151370 | A Method for the Acute and Rapid Degradation of Endogenous Proteins. |
| Q40531072 | A bacterial model system for chromosomal targeting |
| Q39687331 | A chromosomal position effect on gene targeting in human cells |
| Q41102629 | A conditionally immortalized cell line from murine proximal tubule |
| Q28280578 | A dual thrombin receptor system for platelet activation |
| Q35550198 | A future for transgenic livestock. |
| Q28511052 | A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder |
| Q36942027 | A genome editing primer for the hematologist |
| Q52241373 | A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. |
| Q33964573 | A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice |
| Q28591602 | A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development |
| Q40393488 | A modified single-strand annealing model best explains the joining of DNA double-strand breaks mammalian cells and cell extracts |
| Q34922338 | A molecular view on pluripotent stem cells |
| Q35129781 | A mouse B16 melanoma mutant deficient in glycolipids |
| Q36566796 | A mouse model for X-linked adrenoleukodystrophy |
| Q40406852 | A new method for specific cleavage of megabase-size chromosomal DNA by lambda-terminase |
| Q43534907 | A non-viral vector for potential DMD gene therapy study by targeting a minidystrophin-GFP fusion gene into the hrDNA locus |
| Q34200585 | A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells |
| Q37522969 | A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells |
| Q33336284 | A promoter trap in embryonic stem (ES) cells selects for integration of DNA into CpG islands |
| Q50646033 | A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond. |
| Q28300225 | A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen |
| Q33992917 | A rapid approach to high-resolution fluorescence imaging in semi-thick brain slices |
| Q37679774 | A review of current large-scale mouse knockout efforts |
| Q33726463 | A ribozyme-mediated, gene "knockdown" strategy for the identification of gene function in zebrafish |
| Q24798215 | A sensitive and rapid assay for homologous recombination in mosquito cells: impact of vector topology and implications for gene targeting |
| Q37207583 | A simple method for measuring interstitial fluid pressure in cancer tissues |
| Q41352964 | A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination. |
| Q30698657 | A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice |
| Q73384471 | A telomere-mediated chromosome fragmentation approach to assess mitotic stability and ploidy alterations of Leishmania chromosomes |
| Q24813890 | A trial of somatic gene targeting in vivo with an adenovirus vector |
| Q30748450 | A vital role for glycosphingolipid synthesis during development and differentiation |
| Q36229591 | A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification |
| Q30748534 | Ablation of a specific cell population by the replacement of a uniquely expressed gene with a toxin gene |
| Q28508494 | Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL |
| Q74729938 | Accessibility control of V(D)J recombination: lessons from gene targeting |
| Q89419306 | Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize |
| Q34013197 | Adeno-associated virus effectively mediates conditional gene modification in the brain |
| Q39334045 | Adeno-associated virus inverted terminal repeats stimulate gene editing |
| Q27498163 | Adeno-associated virus: from defective virus to effective vector |
| Q36784440 | Adopting the good reFLEXes when generating conditional alterations in the mouse genome |
| Q33732295 | Advanced transgenic and gene-targeting approaches |
| Q36185470 | Agrobacterium and plant genetic engineering |
| Q36294632 | Alteration of Caenorhabditis elegans gene expression by targeted transformation |
| Q36566543 | Alterations in differentiation and behavior of monocytic phagocytes in transgenic mice that express dominant suppressors of ras signaling |
| Q28593574 | Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway |
| Q34837322 | Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice |
| Q36377123 | Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice |
| Q36534473 | An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region |
| Q30838882 | An E3-ligase-based method for ablating inhibitory synapses |
| Q29615355 | An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination |
| Q28379338 | An Oak Ridge legacy: the specific locus test and its role in mouse mutagenesis |
| Q90088501 | An Overview of the CRISPR-Based Genomic- and Epigenome-Editing System: Function, Applications, and Challenges |
| Q34288895 | An animal model for the study of the genetic bases of behaviour in men: the multiple marker strains (MMS). |
| Q90079374 | An efficient gene disruption method for the woody plant pathogen Botryosphaeria dothidea |
| Q34858268 | An efficient strategy for TALEN-mediated genome engineering in Drosophila |
| Q68283705 | An improved approach for transformation of plant cells by microinjection: molecular and genetic analysis |
| Q37592528 | An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus |
| Q51139631 | Analysis of CCN4 Function in Osteogenic and Osteoclastic Cells Using Gain and Loss of Function Approaches. |
| Q28508245 | Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae |
| Q52212191 | Analysis of tooth development in mice bearing a TGF-beta 1 null mutation. |
| Q26865437 | Animal and in silico models for the study of sarcomeric cardiomyopathies |
| Q36109764 | Animal embryonic stem (ES) cells: self-renewal, pluripotency, transgenesis and nuclear transfer |
| Q40480072 | Animal models for disorders of hepatic lipoprotein metabolism |
| Q37244294 | Animal models of gene-nutrient interactions |
| Q34608788 | Animal transgenesis: state of the art and applications |
| Q41685055 | Antisense approaches for investigating mechanisms of abnormal development |
| Q52121534 | Antisense inhibition of Xbrachyury impairs mesoderm formation in Xenopus embryos. |
| Q34671188 | Application of CRISPR/Cas9 for biomedical discoveries |
| Q55309854 | Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer. |
| Q38972892 | Application of viral vectors to the study of neural connectivities and neural circuits in the marmoset brain |
| Q38947491 | Applications of CRISPR Genome Engineering in Cell Biology |
| Q37969581 | Approaches for gene targeting and targeted gene expression in plants. |
| Q48420325 | Are adult learning mechanisms also used for development? |
| Q28507966 | Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits |
| Q35647378 | Averting abnormal inheritance: potential of gene therapy and preimplantation diagnosis |
| Q48146744 | BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin |
| Q35186506 | Behavioural and physiological characterization of inbred mouse strains: prospects for elucidating the molecular mechanisms of mammalian learning and memory |
| Q42547064 | Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis |
| Q36719581 | Biallelic editing of a lamprey genome using the CRISPR/Cas9 system |
| Q37335915 | Bidirectional-genetics platform, a dual-purpose mutagenesis strategy for filamentous fungi |
| Q35155977 | Biological effects of myeloid growth factors |
| Q40865882 | Biological therapy: approaches in colorectal cancer. Strategies to enhance carcinoembryonic antigen (CEA) as an immunogenic target |
| Q28269635 | Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor |
| Q40996519 | Bleomycin enhances random integration of transfected DNA into a human genome |
| Q52528672 | Blocking the ends of transforming DNA enhances gene targeting in Dictyostelium. |
| Q58326969 | Bone and haematopoietic defects in mice lacking c-fos |
| Q39578669 | Borna disease virus-induced neurological disorder in mice: infection of neonates results in immunopathology |
| Q26753206 | Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future |
| Q40636648 | Branched oligonucleotides induce in vivo gene conversion of a mutated EGFP reporter |
| Q38020955 | Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis |
| Q57811030 | Bridging the species gap in translational research for neurodevelopmental disorders |
| Q28594485 | CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs |
| Q21131779 | CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool |
| Q38645581 | CRISPR Editing in Biological and Biomedical Investigation. |
| Q46522290 | CRISPR Genome Engineering for Human Pluripotent Stem Cell Research |
| Q64074957 | CRISPR to fix bad blood: a new tool in basic and clinical hematology |
| Q91621374 | CRISPR tool modifies genes precisely by copying RNA into the genome |
| Q39014648 | CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes |
| Q38822073 | CRISPR-Cas9 technology and its application in haematological disorders |
| Q50442603 | CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development. |
| Q26782773 | CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling |
| Q38946079 | CRISPR/CAS9 Technologies |
| Q26744172 | CRISPR/Cas9 therapeutics: a cure for cancer and other genetic diseases |
| Q49823752 | CRISPR/Cas9-Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells. |
| Q50972002 | CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH. |
| Q64387796 | CRISPR/Cas9-mediated generic protein tagging in mammalian cells |
| Q89873570 | CRISPR/Cas9-mediated genome editing: From basic research to translational medicine |
| Q35579333 | Can zebrafish be used as a model to study the neurodevelopmental causes of autism? |
| Q91907215 | Cancer Stem Cells: From Historical Roots to a New Perspective |
| Q40456064 | Cancer gene therapy: principles, problems, and perspectives. |
| Q34186639 | Capitalizing on large-scale mouse mutagenesis screens |
| Q50056397 | Carboxypeptidase E and the Identification of Novel Neuropeptides as Potential Therapeutic Targets. |
| Q41276779 | Cartilage collagens: strategies for the study of their organisation and expression in the extracellular matrix |
| Q38391002 | Cell therapy worldwide: an incipient revolution |
| Q38812342 | Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience |
| Q37006621 | Centralized mouse repositories |
| Q40915778 | Cerebellar granule cell-specific and inducible expression of Cre recombinase in the mouse |
| Q36992604 | Cftr gene targeting in mouse embryonic stem cells mediated by Small Fragment Homologous Replacement (SFHR) |
| Q40443437 | Chapter 17 Genetic Approaches for Studying Programmed Cell Death during Development of the Laboratory Mouse |
| Q28587865 | Characterization of a gene trap insertion into a novel gene, cordon‐bleu, expressed in axial structures of the gastrulating mouse embryo |
| Q39594082 | Characterization of the proteases involved in the N-terminal clipping of glucagon-like-peptide-1-antibody fusion proteins |
| Q33853722 | Chromosome breaks and genomic instability |
| Q28588417 | Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2 |
| Q41002744 | Clonal selection and learning in the antibody system |
| Q28510779 | Cloning and functional expression of the mouse homologue of p47phox |
| Q46727912 | Cloning of a copper resistance gene cluster from the cyanobacterium Synechocystis sp. PCC 6803 by recombineering recovery |
| Q77731191 | Cloning of the PpMSH-2 cDNA of Physcomitrella patens, a moss in which gene targeting by homologous recombination occurs at high frequency |
| Q28592106 | Cloning, expression, purification, and characterization of the murine lysosomal acid alpha-mannosidase |
| Q30432123 | Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene |
| Q36829733 | Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha(1,3)Gal |
| Q40723863 | Comparing mutants, selective breeding, and transgenics in the dissection of aging processes of Caenorhabditis elegans |
| Q40965110 | Comparison of ES cell fate in sandwiched aggregates and co-cultured aggregates during blastocyst formation by monitored GFP expression |
| Q36560710 | Comparison of targeted-gene replacement frequencies in Drosophila melanogaster at the forked and white loci |
| Q34476881 | Completion of the swine genome will simplify the production of swine as a large animal biomedical model |
| Q28594933 | Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus |
| Q26852128 | Concise review: making and using clinically compliant pluripotent stem cell lines |
| Q52122090 | Conditional ablation of T-cell development by a novel viral ion channel transgene. |
| Q24811874 | Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference |
| Q41710751 | Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells |
| Q37598880 | Conserved sequence-tagged sites: a phylogenetic approach to genome mapping |
| Q37382216 | Constraints to progress in embryonic stem cells from domestic species. |
| Q35678076 | Construction and applications of exon-trapping gene-targeting vectors with a novel strategy for negative selection |
| Q41125480 | Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA. |
| Q71774011 | Contributions to somatic and germline lineages of chicken blastodermal cells maintained in culture |
| Q36517060 | Controlled and localized genetic manipulation in the brain. |
| Q41728785 | Controlling your losses: conditional gene silencing in mammals |
| Q39719850 | Cre-mediated somatic site-specific recombination in mice |
| Q37476238 | Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting |
| Q67753974 | Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein |
| Q35493015 | Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice |
| Q42801288 | Culture of embryonic stem cell lines from zebrafish. |
| Q37106378 | Current perspectives in zebrafish reverse genetics: moving forward |
| Q34067230 | Custom-designed zinc finger nucleases: what is next? |
| Q37808729 | Cytokine reporter mice in immunological research: perspectives and lessons learned |
| Q40427627 | Cytoplasmic injection of murine zygotes with Sleeping Beauty transposon plasmids and minicircles results in the efficient generation of germline transgenic mice |
| Q41024952 | DNA sequence motifs are associated with aberrant homologous recombination in the mouse macrophage migration inhibitory factor (Mif) locus |
| Q54168726 | Dd is the only gene that controls NK cell resistance of heterozygous H-2bd cells |
| Q40514851 | Death before birth: clues from gene knockouts and mutations |
| Q28507774 | Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice |
| Q28187682 | Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice |
| Q29620280 | Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase |
| Q52523363 | Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. |
| Q36668182 | Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy |
| Q36232637 | Deletion of an immunodominant Trypanosoma cruzi surface glycoprotein disrupts flagellum-cell adhesion |
| Q73954734 | Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep |
| Q56610090 | Delivering CRISPR: a review of the challenges and approaches |
| Q33809003 | Demystified ... gene knockouts |
| Q38166200 | Dendrimers for siRNA Delivery |
| Q34231338 | Derivation and long-term culture of an embryonic stem cell-like line from zebrafish blastomeres under feeder-free condition |
| Q38362528 | Design of a C/EBP-specific, dominant-negative bZIP protein with both inhibitory and gain-of-function properties. |
| Q37597006 | Designing and Cloning Molecular Constructs to Knock Out N-Acetylglucosamine Phosphatidylinositol De-N-Acetylase (GPI12) Gene in Leishmania major (MRHO/IR/75/ER). |
| Q35949604 | Developing genetically engineered mouse models to study tumor suppression |
| Q28241526 | Development and applications of CRISPR-Cas9 for genome engineering |
| Q33938706 | Development and function of T cells in mice with a disrupted CD2 gene |
| Q49329949 | Development of genome engineering technologies in cattle: from random to specific. |
| Q37201746 | Development of murine models to study Hepatitis C virus induced liver pathogenesis |
| Q52237180 | Developmental biology. Another hit for gene targeting. |
| Q48530157 | Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6 |
| Q35226497 | Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. |
| Q36191265 | Differentiation inhibiting activity () and mouse development |
| Q34994552 | Direct cloning of isogenic murine DNA in yeast and relevance of isogenicity for targeting in embryonic stem cells |
| Q73882571 | Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches |
| Q52516638 | Disruption of the CNTF gene results in motor neuron degeneration. |
| Q48654359 | Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression |
| Q41329252 | Disruption of the adenosine deaminase (ADA) gene using a dicistronic promoterless construct: Production of an ADA-deficient homozygote ES cell line |
| Q52231074 | Disruption of the cystic fibrosis transmembrane conductance regulator gene in embryonic stem cells by gene targeting. |
| Q28379331 | Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal |
| Q33890035 | Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase |
| Q28609142 | Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone |
| Q38034966 | Dissecting neural function using targeted genome engineering technologies. |
| Q34447811 | Distinct roles for the N- and C-terminal regions in the cytotoxicity of pierisin-1, a putative ADP-ribosylating toxin from cabbage butterfly, against mammalian cells |
| Q28587819 | Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice |
| Q33944600 | Distribution and function of prostanoid receptors: studies from knockout mice |
| Q35889884 | Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response |
| Q28585702 | Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses |
| Q37578939 | Double targeted gene replacement for creating null mutants |
| Q36730881 | Double-strand gap repair in a mammalian gene targeting reaction |
| Q38509211 | Drug discovery in prostate cancer mouse models |
| Q41001095 | Dual loss of human POLQ and LIG4 abolishes random integration |
| Q41600544 | Ectopic recombination within homologous immunoglobulin mu gene constant regions in a mouse hybridoma cell line |
| Q48330149 | Effect of phospholipase Cbeta4 lacking in thalamic neurons on electroencephalogram |
| Q40228894 | Effective detection of corrected dystrophin loci in mdx mouse myogenic precursors. |
| Q29619196 | Effects of an Rb mutation in the mouse |
| Q36501271 | Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells |
| Q41537202 | Efficient CRISPR/Cas9-Mediated Genome Editing Using a Chimeric Single-Guide RNA Molecule. |
| Q41994499 | Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination |
| Q33930324 | Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. |
| Q64389544 | Efficient gene targeting in the filamentous fungusAlternaria alternata |
| Q39787525 | Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks |
| Q35051026 | Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA. |
| Q41235801 | Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. |
| Q77567177 | Efficient repetitive alteration of the mouse Huntington's disease gene by management of background in the tag and exchange gene targeting strategy |
| Q41156978 | Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line |
| Q34331113 | Efficient, complete deletion of synaptic proteins using CRISPR. |
| Q28247895 | Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange |
| Q52524249 | Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. |
| Q83207620 | Embryonic stem cell cardiogenesis applications for cardiovascular research |
| Q39723020 | Embryonic stem cell gene targeting using bacteriophage lambda vectors generated by phage-plasmid recombination |
| Q41689654 | Embryonic stem cells and hematopoietic stem cell biology |
| Q47792166 | Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides |
| Q60982931 | Embryonic stem cells, creating transgenic animals |
| Q38209315 | Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells |
| Q37293062 | Emerging gene knockout technology in zebrafish: zinc-finger nucleases |
| Q40534281 | End extension repair of introduced targeting vectors mediated by homologous recombination in mammalian cells |
| Q34734999 | Endonuclease-induced, targeted homologous extrachromosomal recombination in Xenopus oocytes. |
| Q36140986 | Engineering lymphocyte subsets: tools, trials and tribulations |
| Q58120574 | Engineering molecular imaging strategies for regenerative medicine |
| Q38715912 | Enhanced CRISPR/Cas9-mediated biallelic genome targeting with dual surrogate reporter-integrated donors. |
| Q48915342 | Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence |
| Q41044413 | Enhanced bradykinin-stimulated phospholipase C activity in murine embryonic stem cells lacking the G-protein alphaq-subunit |
| Q36846554 | Enhanced selection for homologous-recombinant embryonic stem cell clones with a neomycin phosphotransferase gene in antisense orientation |
| Q28202461 | Enhancing Gene Targeting with Designed Zinc Finger Nucleases |
| Q78228400 | Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection maker |
| Q35286680 | Entrapment vectors: a new tool for mammalian genetics |
| Q52061868 | Environmental modulation of the autonomy of cytotoxic T lymphocytes. |
| Q28588637 | EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract |
| Q37106578 | Epigenetics: the study of embryonic stem cells by restriction landmark genomic scanning |
| Q37786731 | Epileptogenic ion channel mutations: From bedside to bench and, hopefully, back again |
| Q36700868 | Epstein-Barr virus (EBV)-negative B-lymphoma cell lines for clonal isolation and replication of EBV recombinants |
| Q33919156 | Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2 |
| Q41195823 | Escape and migration of nucleic acids between chloroplasts, mitochondria, and the nucleus |
| Q41382978 | Establishment of a novel embryonic stem cell line by a modified procedure |
| Q34412002 | Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos |
| Q45155438 | Evidence for a differential avidity model of T cell selection in the thymus |
| Q33792575 | Ex vivo magnetofection: a novel strategy for the study of gene function in mouse organogenesis |
| Q78581682 | Expectations and reality in gene repair |
| Q24314251 | Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis |
| Q41927667 | Expression of epidermal growth factor and its mRNA in pig kidney, pancreas and other tissues. |
| Q41225051 | Extrachromosomal homologous recombination and gene targeting in plant cells after Agrobacterium mediated transformation |
| Q47301635 | Extreme metal adapted, knockout and knockdown strains reveal a coordinated gene expression among different Tetrahymena thermophila metallothionein isoforms |
| Q57078475 | Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing |
| Q97595753 | Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning |
| Q24322706 | Fibroblast growth factor receptor 3 is a negative regulator of bone growth |
| Q36646871 | Fish ES cells and applications to biotechnology. |
| Q34933481 | Fish stem cell cultures |
| Q33877304 | Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11. |
| Q37316585 | Forward and reverse genetic approaches to behavior in the mouse |
| Q92609296 | Forward genetic approach for behavioral neuroscience using animal models |
| Q36143388 | Foundation Review: Transgenic animals and their impact on the drug discovery industry. |
| Q26781859 | From Gene Targeting to Genome Editing: Transgenic animals applications and beyond |
| Q38045180 | From mice to humans |
| Q34185283 | From phenotype to genotype. |
| Q37735158 | Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1. |
| Q33716358 | Functional analysis of newly discovered growth control genes: experimental approaches |
| Q34603818 | Functional and structural neural network characterization of serotonin transporter knockout rats. |
| Q40740212 | Functional correction of episomal mutations with short DNA fragments and RNA-DNA oligonucleotides. |
| Q36873978 | Functional genomics in mice by tagged sequence mutagenesis |
| Q38550839 | Functional genomics in the mouse: phenotype-based mutagenesis screens |
| Q28591720 | Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice |
| Q38596690 | Gene Targeting in Neuroendocrinology |
| Q40833658 | Gene and enhancer trapping: mutagenic strategies for developmental studies. |
| Q40861559 | Gene disruption in mice: models of development and disease |
| Q73368837 | Gene function |
| Q59096750 | Gene replacement in parasitic protozoa |
| Q36809329 | Gene replacement with one-sided homologous recombination |
| Q40659274 | Gene targeting in Arabidopsis |
| Q54281846 | Gene targeting in Arabidopsis thaliana |
| Q34168037 | Gene targeting in Physcomitrella patens |
| Q34114590 | Gene targeting in livestock: a preview |
| Q24802657 | Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays |
| Q44329217 | Gene targeting in mouse embryonic stem cells |
| Q41740740 | Gene targeting in normal and amplified cell lines |
| Q45872568 | Gene targeting in normal somatic cells: inactivation of the interferon-gamma receptor in myoblasts |
| Q38174163 | Gene targeting technologies in rats: zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats |
| Q28265983 | Gene targeting using zinc finger nucleases |
| Q39872000 | Gene targeting with a replication-defective adenovirus vector. |
| Q26768799 | Gene targeting, genome editing: from Dolly to editors |
| Q40892446 | Gene targeting--homing in on alpha 2-adrenoceptor-subtype function |
| Q40407411 | Gene therapy on renal-cell carcinoma: magic bullet or tragic insanity? |
| Q40530271 | Gene therapy vectors as drug delivery systems |
| Q30657334 | Gene trap: a way to identify novel genes and unravel their biological function |
| Q93116031 | Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos |
| Q37377341 | Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease |
| Q37763190 | Generation and genetic modification of induced pluripotent stem cells |
| Q39034071 | Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer |
| Q35965403 | Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. |
| Q92276523 | Generation of Tβ4 knock-in Cashmere goat using CRISPR/Cas9 |
| Q36239605 | Generation of a conditional analog-sensitive kinase in human cells using CRISPR/Cas9-mediated genome engineering |
| Q38307105 | Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells. |
| Q32079218 | Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation |
| Q34414632 | Generation of adenylyl cyclase knockout mice |
| Q24798553 | Generation of bovine transgenics using somatic cell nuclear transfer |
| Q24603863 | Generation of chimeric rhesus monkeys |
| Q48230875 | Generation of cloned calves and transgenic chimeric embryos from bovine embryonic stem-like cells |
| Q52195888 | Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection. |
| Q34135605 | Generation of improved humanized mouse models for human infectious diseases |
| Q39506695 | Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations |
| Q43090780 | Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT). |
| Q35702008 | Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas9 |
| Q28378560 | Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor |
| Q39841807 | Generation of pig induced pluripotent stem cells with a drug-inducible system |
| Q36796278 | Generation of transmitochondrial mice: development of xenomitochondrial mice to model neurodegenerative diseases |
| Q28248701 | Genes associated with tumor suppression and growth control in the human nervous system |
| Q41659418 | Genes involved in oncogenesis. |
| Q41159260 | Genetic Background Limits Generalizability of Genotype-Phenotype Relationships |
| Q52577303 | Genetic Dissection of Neural Circuits: A Decade of Progress. |
| Q91667304 | Genetic Engineering in Animal Models |
| Q24798750 | Genetic alteration and gene expression modulation during cancer progression |
| Q40393984 | Genetic analyses of cell-matrix interactions in development |
| Q39285656 | Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex |
| Q36925323 | Genetic approaches for changing the heart and dissecting complex syndromes |
| Q37868937 | Genetic approaches to reveal the connectivity of adult-born neurons |
| Q41036896 | Genetic approaches to the study of cytokine regulation of mucosal immunity |
| Q41508051 | Genetic aspects of the mechanisms of learning |
| Q38183368 | Genetic dissection of GABAergic neural circuits in mouse neocortex |
| Q37110384 | Genetic dissection of neural circuits |
| Q52193129 | Genetic interactions of Hox genes in limb development: learning from compound mutants. |
| Q40382136 | Genetic knockouts in mice: an update |
| Q27301380 | Genetic labeling of neuronal subsets through enhancer trapping in mice |
| Q41135003 | Genetic linkage analysis and homology relationships of genes located on human chromosome 11q |
| Q34058049 | Genetic modification of mammalian genome at chromosome level |
| Q37998987 | Genetic mouse models for skin research: strategies and resources |
| Q30499276 | Genetic predispositions and childhood cancer |
| Q30645249 | Genetic screens in mammalian cells by enhanced retroviral mutagens |
| Q26781566 | Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides |
| Q55345251 | Genetic tool development and systemic regulation in biosynthetic technology. |
| Q36282980 | Genetically Engineered Mice by Pronuclear DNA microinjection |
| Q34430085 | Genetically engineered mice and their use in aging research |
| Q41094472 | Genetically engineered mice: tools to understand craniofacial development |
| Q38991325 | Genome Editing Techniques and Their Therapeutic Applications |
| Q38691263 | Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions |
| Q58764784 | Genome Editing of Pigs for Agriculture and Biomedicine |
| Q91901314 | Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9 |
| Q42013016 | Genome editing and genetic engineering in livestock for advancing agricultural and biomedical applications |
| Q49586563 | Genome editing for the reproduction and remedy of human diseases in mice |
| Q39239599 | Genome editing: a robust technology for human stem cells |
| Q34401248 | Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology |
| Q38063161 | Genome-scale metabolic model in guiding metabolic engineering of microbial improvement |
| Q47445434 | Genomic Tagging of AGO1 Using CRISPR/Cas9-Mediated Homologous Recombination |
| Q46005770 | Genomic deletion of an imprint maintenance element abolishes imprinting of both insulin-like growth factor II and H19. |
| Q48037521 | Genomic organization of Drosophila poly(ADP-ribose) polymerase and distribution of its mRNA during development |
| Q52648448 | Germ cell mutations of the ascidian Ciona intestinalis with TALE nucleases. |
| Q47984675 | Germ cell regeneration-mediated, enhanced mutagenesis in the ascidian Ciona intestinalis reveals flexible germ cell formation from different somatic cells. |
| Q36775631 | Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells |
| Q34992247 | Germline competence of mouse ES and iPS cell lines: Chimera technologies and genetic background. |
| Q74268208 | Getting genes where we want them |
| Q36690809 | Glial cell line-derived neurotrophic factor promotes the development of adrenergic neurons in mouse neural crest cultures |
| Q36202083 | Gonadotropin gene targeting and biological implications |
| Q37959726 | Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control |
| Q41834913 | Grand challenges in the field of stem cell research. |
| Q41112432 | Hair follicle dermal papilla cell lines from p53-knockout mice |
| Q30193798 | Hematopoietic development of vav-/- mouse embryonic stem cells |
| Q37357884 | Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair |
| Q28585392 | High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice |
| Q33980532 | High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination |
| Q33922824 | High-frequency gene targeting in Arabidopsis plants expressing the yeast RAD54 gene |
| Q35193005 | High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells |
| Q28137594 | High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications |
| Q70128316 | High-velocity mechanical DNA transfer of the chloramphenicolacetyl transferase gene into rodent liver, kidney and mammary gland cells in organ explants and in vivo |
| Q61796506 | Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus |
| Q37045150 | Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs |
| Q58708467 | Highly efficient genome editing via CRISPR-Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression |
| Q57584512 | Holistic approaches to glycobiology |
| Q41649983 | Homeobox genes in embryogenesis and pathogenesis |
| Q24323758 | Homeosis and intestinal tumours in Cdx2 mutant mice |
| Q40571100 | Homologous recombination for gene replacement in mouse cell lines. |
| Q37388082 | Homologous recombination in Leishmania enriettii |
| Q38511214 | Homologous recombination in zebrafish ES cells |
| Q36713002 | Homologous recombination-mediated gene targeting in the liverwort Marchantia polymorpha L. |
| Q36667309 | Homology dependence of targeted recombination at the Chinese hamster APRT locus |
| Q35725071 | Homology-associated nonhomologous recombination in mammalian gene targeting. |
| Q44963125 | How sweet it is: selectin-mediating drugs |
| Q92574472 | How technical progress reshaped behavioral neuroendocrinology during the last 50 years… and some methodological remarks |
| Q29615235 | Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery |
| Q38505831 | INVITED REVIEW: Evolution of meat animal growth research during the past 50 years: Adipose and muscle stem cells. |
| Q33189762 | Identification and genetic mapping of a homeobox gene to the 4p16.1 region of human chromosome 4 |
| Q33557712 | Identification of novel loci for the generation of reporter mice |
| Q90496742 | Identification of the Sex of Pre-implantation Mouse Embryos Using a Marked Y Chromosome and CRISPR/Cas9 |
| Q57378026 | Identification of the renal erythropoietin-producing cells using transgenic mice |
| Q37585974 | Illegitimate recombination in Xenopus: characterization of end-joined junctions |
| Q35882128 | Immune function in mice lacking the perforin gene |
| Q28589085 | Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor |
| Q41180633 | Immunoglobulin deficient mice generated by gene targeting as models for studying the immune response |
| Q33908176 | Immunologic applications of conditional gene modification technology in the mouse |
| Q36729840 | Immunosympathectomy as the first phenotypic knockout with antibodies. |
| Q39932479 | Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting. |
| Q28507147 | Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice |
| Q42022116 | Improving high resolution retinal image quality using speckle illumination HiLo imaging. |
| Q22064303 | In Celebration of Dr. Mario R. Capecchi's Nobel Prize |
| Q39759664 | In vitro differentiation of murine embryonic stem cells. New approaches to old problems |
| Q51166922 | In vitro male germ cell cultures of zebrafish. |
| Q35859661 | In vivo analysis of Pim-1 deficiency |
| Q35757633 | In vivo construction of transgenes in Drosophila |
| Q36939459 | In vivo gene transfer into testis and sperm: developments and future application |
| Q36097040 | Inclusion of homologous DNA in nuclease-mediated gene targeting facilitates a higher incidence of bi-allelically modified cells |
| Q51090922 | Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. |
| Q46983099 | Induced pluripotent stem cells from goat fibroblasts |
| Q38029025 | Induced pluripotent stem cells from pigs and other ungulate species: an alternative to embryonic stem cells? |
| Q35131494 | Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre-LoxP system. |
| Q24652685 | Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae |
| Q64383165 | Inhibition of Xhox1A gene expression in Xenopus embryos by antisense RNA produced from an expression vector read by RNA polymerase III |
| Q33791854 | Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions |
| Q34838158 | Integration of DNA fragments by illegitimate recombination in Saccharomyces cerevisiae |
| Q33825918 | Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination |
| Q59064557 | Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells |
| Q42832099 | Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease |
| Q39717337 | Introduction of the negative selection marker into replacement vectors by a single ligation step |
| Q40655136 | Investigation of coelectroporation as a method for introducing small mutations into embryonic stem cells |
| Q90743302 | Investigation of the molecular biology underlying the pronounced high gene targeting frequency at the Myh9 gene locus in mouse embryonic stem cells |
| Q77343342 | Isolation and characterization of the gene encoding the mouse broad specificity lysosomal alpha-mannosidase1 |
| Q40621458 | Isolation of embryonic stem-like cells from equine blastocysts and their differentiation in vitro |
| Q28066477 | Killing of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer Proteins |
| Q28506450 | Knockout mouse model and gametogenic failure |
| Q42676790 | Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases |
| Q34616946 | Knockout targeting of the Drosophila nap1 gene and examination of DNA repair tracts in the recombination products |
| Q40409394 | Knockouts. Targeting the mouse genome: a compendium of knockouts (Part I) |
| Q89637806 | Know Your Model: A knockout does not always make a null |
| Q52163874 | Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. |
| Q26995406 | Learning and memory in zebrafish larvae |
| Q28589519 | Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein |
| Q28301573 | Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF |
| Q42176727 | Limitations to adaptive optics image quality in rodent eyes |
| Q28593362 | Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms |
| Q70613480 | Linkage of Van der Woude syndrome (VWS) to REN and exclusion of the candidate gene TGFB2 from the disease locus in a large pedigree |
| Q35665259 | Live diatom silica immobilization of multimeric and redox-active enzymes |
| Q43845860 | Localization and Induced Expression of Fusion Genes in the Rat Lung |
| Q24321697 | Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31 |
| Q41562649 | Location of crossovers during gene targeting with insertion and replacement vectors |
| Q38910562 | Long-term in vivo gene expression in mouse kidney using φC31 integrase and electroporation |
| Q37583559 | Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. |
| Q92689026 | Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner |
| Q36747439 | Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. off |
| Q40812614 | MHC class I-deficient mice |
| Q47717865 | Magic wands of CRISPR-lots of choices for gene knock-in. |
| Q35181342 | Magnetic resonance microscopy of mouse embryos |
| Q90019092 | Making ends meet: targeted integration of DNA fragments by genome editing |
| Q40371944 | Mammalian gene targeting with designed zinc finger nucleases |
| Q34048682 | Mammalian germ-line transgenesis by transposition. |
| Q40855958 | Mammalian glucokinase and its gene |
| Q57271413 | Manipulating DNA: from Cloning to Knockouts |
| Q74587447 | Manipulation of gene expression in the mammalian nervous system: application in the study of neurite outgrowth and neuroregeneration-related proteins |
| Q90217080 | Marked Diversity of Unique Cortical Enhancers Enables Neuron-Specific Tools by Enhancer-Driven Gene Expression |
| Q28593920 | Marked reduction of high density lipoprotein cholesterol in mice genetically modified to lack apolipoprotein A-I |
| Q55085733 | Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation. |
| Q40547805 | Mechanisms of intermolecular homologous recombination in plants as studied with single- and double-stranded DNA molecules |
| Q34228649 | Mechanisms underlying human motor system plasticity |
| Q38700095 | Mechanistic basis for increased human gene targeting by promoterless vectors-roles of homology arms and Rad54 paralogs. |
| Q24814997 | Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice |
| Q26741958 | Methods of Genome Engineering: a New Era of Molecular Biology |
| Q36778594 | Mice cloned from embryonic stem cells |
| Q28297172 | Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction |
| Q36399818 | Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects |
| Q28302232 | Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality |
| Q28379342 | Mice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedure |
| Q36064760 | Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis |
| Q39095144 | Modification of the Genome of Domestic Animals |
| Q35604201 | Modification of the apolipoprotein B gene in HepG2 cells by gene targeting |
| Q90571056 | Molecular Regulation of Carcinogenesis: Friend and Foe |
| Q37110295 | Molecular cloning of interferon receptors: a short review |
| Q33908456 | Molecular genetics and imaging technologies for circuit-based neuroanatomy |
| Q40585555 | More to learn from gene knockouts |
| Q43281852 | Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury |
| Q34326346 | Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. |
| Q41527091 | Mouse Models of Human CAG Repeat Disorders |
| Q42538101 | Mouse alleles: if you've seen one, you haven't seen them all. |
| Q48707463 | Mouse astrocytoma models: embryonic stem cell mediated transgenesis |
| Q40525835 | Mouse embryonic stem cells exhibit high levels of extrachromosomal homologous recombination in a chloramphenicol acetyltransferase assay system |
| Q35026154 | Mouse gene targeting in cardiovascular physiology |
| Q37895535 | Mouse models and type 2 diabetes: translational opportunities |
| Q34578754 | Mouse models for disorders of mitochondrial fatty acid beta-oxidation |
| Q33939045 | Mouse models for human disease |
| Q37084734 | Mouse models in male fertility research |
| Q38055069 | Mouse models of BRCA1 and their application to breast cancer research |
| Q28593406 | Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism |
| Q64983805 | Mouse models of cancer: does the strain matter? |
| Q35848828 | Mouse models of hypoxanthine phosphoribosyltransferase deficiency |
| Q58693513 | Mouse models of prostate cancer |
| Q36405539 | Mouse models of thyroid cancer: A 2015 update. |
| Q38506181 | Multicolour spectral karyotyping of mouse chromosomes |
| Q39034086 | Multiple copies of a linear donor fragment released in situ from a vector improve the efficiency of zinc-finger nuclease-mediated genome editing. |
| Q74825193 | Murine tumor suppressor models |
| Q36025880 | Mutant insulin receptors in syndromes of insulin resistance |
| Q35174980 | Myelin Po‐protein, more than just a structural protein? |
| Q37443477 | National Institutes of Health Center for Regenerative Medicine: putting science into practice |
| Q42800968 | Neomycin- and hygromycin-resistance expression cassettes containing an artificial triple-helix site and a synthetic lac operator facilitate restriction endonuclease cleavage at pre-defined sites and recovery of specific fragments from mammalian geno |
| Q44597931 | Neural cells without functional N-Methyl-d-Aspartate (NMDA) receptors contribute extensively to normal postnatal brain development in efficiently generated chimaeric NMDA R1 −/− → +/+ mice |
| Q24631889 | Neural stem cells: brain building blocks and beyond |
| Q73157676 | Neurological manifestations of knockout mice with beta-galactosidase deficiency |
| Q28592196 | Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice |
| Q35222165 | Neuropeptide gene expression in transgenic animals |
| Q35053404 | Neutralizing antibodies in gene-defective hosts |
| Q39474668 | New Bapx1(Cre-EGFP) mouse lines for lineage tracing and conditional knockout studies |
| Q36903592 | New technology for an old favorite: lentiviral transgenesis and RNAi in rats |
| Q33894536 | Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function |
| Q73224031 | Non-invasive transgenic mouse genotyping using stool analysis |
| Q42599635 | Non-recombinant background in gene targeting: illegitimate recombination between a hpt gene and a defective 5' deleted nptII gene can restore a Kmr phenotype in tobacco |
| Q36464139 | Nonreciprocal homologous recombination between Agrobacterium transferred DNA and a plant chromosomal locus. |
| Q28592319 | Noradrenaline is essential for mouse fetal development |
| Q39450655 | Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice |
| Q33982023 | Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor |
| Q33786969 | Normal spermatogenesis in mice lacking the testis-specific linker histone H1t. |
| Q38115497 | Novel GM animal technologies and their governance. |
| Q34547272 | Novel approaches for identifying genes regulating lymphocyte development and function |
| Q37402366 | Nucleosomes on linear duplex DNA allow homologous pairing but prevent strand exchange promoted by RecA protein |
| Q47225992 | Numt, a recent transfer and tandem amplification of mitochondrial DNA to the nuclear genome of the domestic cat. |
| Q52548960 | Odontoblast-specific expression of cre recombinase successfully deletes gene segments flanked by loxP sites in mouse teeth. |
| Q36737130 | Of fin and fur: mutational analysis of vertebrate embryonic development |
| Q28307657 | Oligo/polynucleotide-based gene modification: strategies and therapeutic potential |
| Q36856667 | Oligonucleotide-directed site-specific mutagenesis in Drosophila melanogaster |
| Q34807121 | Oligonucleotide-mediated gene therapy for muscular dystrophies |
| Q48080975 | One of the retinoic acid-inducible cDNA clones in mouse embryonal carcinoma F9 cells encodes a novel isoenzyme of fructose 1,6-bisphosphatase |
| Q42740079 | Ontogeny and Homeostasis of Adult Epithelial Skin Stem Cells |
| Q49565648 | Optogenetic and chemogenetic techniques for neurogastroenterology. |
| Q38716335 | Organoid technologies meet genome engineering |
| Q26778501 | Origins of Programmable Nucleases for Genome Engineering |
| Q89174568 | Overview of Genetically Engineered Mouse Models of Prostate Cancer and Their Applications in Drug Discovery |
| Q41541408 | PKA isoforms, neural pathways, and behaviour: making the connection |
| Q28506744 | Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy |
| Q24817099 | Parameters determining the efficiency of gene targeting in the moss Physcomitrella patens |
| Q30578270 | Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits |
| Q34312222 | Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan |
| Q35112502 | Personal pathways to embryonic stem cells |
| Q40768907 | Phage R4 integrase mediates site-specific integration in human cells |
| Q45874809 | Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders. |
| Q48795377 | Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells. |
| Q24645047 | Plant nuclear gene knockout reveals a role in plastid division for the homolog of the bacterial cell division protein FtsZ, an ancestral tubulin |
| Q41469674 | Platelet-derived growth factor: a key regulator of connective tissue cells in embryogenesis and pathogenesis |
| Q26827643 | Pluripotent stem cells and gene therapy |
| Q35024330 | Pluripotent stem cells--model of embryonic development, tool for gene targeting, and basis of cell therapy |
| Q36530568 | Polarized and functional epithelia can form after the targeted inactivation of both mouse keratin 8 alleles |
| Q41544220 | Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells. |
| Q64389064 | Potential Roles of the Retinoblastoma Protein in Regulating Genome Editing |
| Q36804572 | Potential application of embryonic stem cells in Parkinson's disease: drug screening and cell therapy |
| Q35805345 | Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs. |
| Q35259366 | Precise BAC targeting of genetically polymorphic mouse ES cells |
| Q99417940 | Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation |
| Q26829230 | Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms |
| Q34934319 | Preclinical models: status of basic research in depression |
| Q50096902 | Preclinical mouse solid tumour models: status quo, challenges and perspectives. |
| Q36274361 | Precocious mammary gland development in P-cadherin-deficient mice. |
| Q37425652 | Probing human cardiovascular congenital disease using transgenic mouse models |
| Q40022608 | Processing of DNA prior to illegitimate recombination in mouse cells |
| Q35556392 | Production of calves by transfer of nuclei from cultured inner cell mass cells |
| Q52132143 | Production of germ-line chimeras in rainbow trout by blastomere transplantation. |
| Q34650006 | Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. |
| Q34380381 | Production of maternal-zygotic mutant zebrafish by germ-line replacement |
| Q37373817 | Production of pharmaceutical proteins in milk |
| Q34466729 | Production of zebrafish germ-line chimeras from embryo cell cultures |
| Q81154604 | Production of zebrafish germline chimeras by using cultured embryonic stem (ES) cells |
| Q60912966 | Programmable Molecular Scissors: Applications of a New Tool for Genome Editing in Biotech |
| Q38761853 | Programmable Site-Specific Nucleases for Targeted Genome Engineering in Higher Eukaryotes |
| Q37821231 | Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application. |
| Q37356657 | Progress in gene transfer by germ cells in mammals |
| Q24289028 | Progress in genetic studies of pain and analgesia |
| Q38224243 | Promising future for the transgenic rat in transplantation research |
| Q37223531 | Prospects for homologous recombination in human gene therapy |
| Q33737226 | Prospects for the precise engineering of plant genomes by homologous recombination. |
| Q33192279 | Protein engineering of antibodies |
| Q36333763 | Proto-oncogenes in mammalian development |
| Q40431920 | P‐Selectin Knockout: A Mouse Model for Various Human Diseases |
| Q28592133 | RAG-1-deficient mice have no mature B and T lymphocytes |
| Q58493817 | RNA interference in postimplantation mouse embryos |
| Q37381729 | RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable. |
| Q29620237 | Radiation-induced cell cycle arrest compromised by p21 deficiency |
| Q33737390 | Rare homologous gene targeting in Histoplasma capsulatum: disruption of the URA5Hc gene by allelic replacement. |
| Q34514412 | Rat genetics: attaching physiology and pharmacology to the genome |
| Q89668253 | Recent Advances of CRISPR/Cas9-Based Genetic Engineering and Transcriptional Regulation in Industrial Biology |
| Q40892666 | Recent advances in transgenic technology |
| Q37412106 | Recent molecular approaches to understanding astrocyte function in vivo |
| Q51092342 | Recent progress in identifying genes regulating hematopoietic stem cell function and fate. |
| Q40771987 | Recombinant antibody technology: its advent and advances |
| Q38345420 | Recombinational Repair of Genetic Mutations |
| Q40655712 | Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus |
| Q39227008 | Refining strategies to translate genome editing to the clinic |
| Q34531248 | Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5 |
| Q40872594 | Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. |
| Q49613950 | Regulation of G1 cyclin-dependent kinases in liver regeneration |
| Q36004270 | Regulation of gene expression and its role in long-term memory and synaptic plasticity |
| Q52126452 | Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo. |
| Q27012688 | Repair of strand breaks by homologous recombination |
| Q41483363 | Replacement-like recombination induced by an integration vector with a murine homology flank at the immunoglobulin heavy-chain locus in mouse and rat hybridoma cells |
| Q24814865 | Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange |
| Q36776248 | Reprogrammed cells for disease modeling and regenerative medicine |
| Q35469117 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors |
| Q44462954 | Requirement for a functional Rb-1 gene in murine development |
| Q36973971 | Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides |
| Q28510862 | Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells |
| Q38318230 | Ribosomal gene disruption in the extreme thermophile Thermus thermophilus HB8. Generation of a mutant lacking ribosomal protein S17. |
| Q36486953 | Role of the retinoblastoma gene in the oncogenesis of human breast carcinoma |
| Q35261019 | Rosa26 locus supports tissue-specific promoter driving transgene expression specifically in pig. |
| Q24603083 | S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway |
| Q41399533 | Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts |
| Q34110518 | Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases |
| Q40641407 | Sequencing and comparison of the Rickettsia genomes from the whitefly Bemisia tabaci Middle East Asia Minor I. |
| Q46337068 | Sequential targeting of the genes encoding immunoglobulin-mu and prion protein in cattle |
| Q37403970 | Serine kinases of insulin receptor substrate proteins |
| Q35142244 | Sexy transgenes: the impact of gene transfer and gene inactivation technologies on the understanding of mammalian sex determination |
| Q47136671 | Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells. |
| Q44233119 | Simultaneous targeted alteration of the tyrosinase and c-kit genes by single-stranded oligonucleotides |
| Q34425356 | Single neuron labeling and genetic manipulation |
| Q33644920 | Single-stranded heteroduplex intermediates in lambda Red homologous recombination |
| Q29029547 | Site-directed mutagenesis in Arabidopsis using custom-designed zinc finger nucleases |
| Q30872432 | Site-directed recombination via bifunctional PNA-DNA conjugates |
| Q47100925 | Site-specific chromosomal gene insertion: Flp recombinase versus Cas9 nuclease |
| Q40394253 | Site-specific cleavage of chromosomesin vitrothrough Cre-loxrecombination |
| Q54528961 | Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes. |
| Q33968428 | Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase |
| Q34977843 | Site-specific integrase-mediated transgenesis in mice via pronuclear injection |
| Q35625296 | Somatic gene therapy for genetic disease |
| Q42102982 | Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice. |
| Q37827488 | Sperm and testis mediated DNA transfer as a means of gene therapy. |
| Q35907473 | Spermatogenesis following male germ-cell transplantation |
| Q37428860 | Stable integration and expression in mouse cells of yeast artificial chromosomes harboring human genes |
| Q34530477 | Stem cell pluripotency and transcription factor Oct4. |
| Q33886477 | Stem cell therapy and gene transfer for regeneration |
| Q59356657 | Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing |
| Q34706451 | Stem cells and small molecule screening: haploid embryonic stem cells as a new tool |
| Q36486937 | Steroid modulation of the expression of growth factors and oncogenes in breast cancer |
| Q33927812 | Stimulation of homologous recombination through targeted cleavage by chimeric nucleases |
| Q37385910 | Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease. |
| Q24629084 | Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation) |
| Q24337556 | Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6 |
| Q72124283 | Studies on homologous recombination in the green alga Chlamydomonas reinhardtii |
| Q28300369 | Subregion- and cell type-restricted gene knockout in mouse brain |
| Q24337933 | Subtle Cerebellar Phenotype in Mice Homozygous for a Targeted Deletion of the En-2 Homeobox |
| Q37146717 | Surgical method to create vocal fold injuries in mice |
| Q48622186 | Swaying is a mutant allele of the proto-oncogene Wnt-1 |
| Q48790941 | Synaptic plasticity, place cells and spatial memory: study with second generation knockouts |
| Q40846780 | Synapto-pHluorins: chimeras between pH-sensitive mutants of green fluorescent protein and synaptic vesicle membrane proteins as reporters of neurotransmitter release |
| Q43597101 | Synthetic hydrogels as carriers in antisense therapy: preliminary evaluation of an oligodeoxynucleotide covalent conjugate with a copolymer of 1-vinyl-2-pyrrolidinone and 2-hydroxyethyl methacrylate |
| Q40410980 | T cell differentiation: control by the pre-TCR and alpha beta TCR. |
| Q57557410 | T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes |
| Q35839422 | T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development |
| Q28589574 | TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells |
| Q59007783 | Tapping the cellular telephone |
| Q33209956 | Target-selected gene inactivation in zebrafish. |
| Q34231869 | Targeted breakage of a human chromosome mediated by cloned human telomeric DNA |
| Q34615432 | Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases |
| Q30671185 | Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide |
| Q52510530 | Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. |
| Q24630841 | Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone |
| Q28592824 | Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease |
| Q29618278 | Targeted disruption of the Rad51 gene leads to lethality in embryonic mice |
| Q28593581 | Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development |
| Q34462862 | Targeted disruption of the murine zyxin gene |
| Q28571640 | Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line |
| Q37628748 | Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse |
| Q34630211 | Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments |
| Q37709530 | Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide |
| Q45889735 | Targeted gene correction: a new strategy for molecular medicine |
| Q36732788 | Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions |
| Q37745308 | Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein |
| Q38356899 | Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides |
| Q34365422 | Targeted gene regulation and gene ablation |
| Q37521138 | Targeted inactivation of the insulin receptor gene in mouse 3T3-L1 fibroblasts via homologous recombination |
| Q35631789 | Targeted insertions of two exogenous collagen genes into both alleles of their endogenous loci in cultured human cells: the insertions are directed by relatively short fragments containing the promoters and the 5' ends of the genes |
| Q37349104 | Targeted manipulation of mammalian genomes using designed zinc finger nucleases |
| Q36550138 | Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation |
| Q33968594 | Targeted mutagenesis of a candidate t complex responder gene in mouse t haplotypes does not eliminate transmission ratio distortion |
| Q36655246 | Targeted mutagenesis of simian virus 40 DNA mediated by a triple helix-forming oligonucleotide |
| Q33836378 | Targeted mutagenesis using zinc-finger nucleases in Arabidopsis |
| Q37352926 | Targeted mutagenesis: analysis of phenotype without germ line transmission |
| Q28131773 | Targeted mutation of the DNA methyltransferase gene results in embryonic lethality |
| Q40404914 | Targeted recombination with single-stranded DNA vectors in mammalian cells |
| Q44241902 | Targeted replacement of mouse apolipoprotein A-I with human ApoA-I or the mutant ApoA-IMilano. Evidence of APOA-IM impaired hepatic secretion. |
| Q37258802 | Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene |
| Q33252817 | Targeting pericytes diminishes neovascularization in orthotopic uveal melanoma in nerve/glial antigen 2 proteoglycan knockout mouse |
| Q53471667 | Targeting the hexosaminidase genes: mouse models of the GM2 gangliosidoses. |
| Q64929446 | Technical advances contribute to the study of genomic imprinting. |
| Q41592910 | Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis |
| Q74788639 | The Anti-nptII Gene (A Potential Negative Selectable Marker for Plants) |
| Q55233775 | The CRISPR tool kit for genome editing and beyond. |
| Q57630584 | The Role of Angiotensin-Converting Enzyme in Blood Pressure Control, Renal Function, and Male Fertility |
| Q61054042 | The Time Is Ripe for Somatic Genome Editing: NIH Program to Strengthen Translation |
| Q41751623 | The beta-hexosaminidase deficiency disorders: development of a clinical paradigm in the mouse |
| Q33601052 | The contribution of homologous recombination in preserving genome integrity in mammalian cells |
| Q37755505 | The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation |
| Q34978228 | The effects of terminal heterologies on gene targeting by insertion vectors in embryonic stem cells |
| Q43864135 | The enigma of morphine tolerance: recent insights |
| Q28300376 | The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory |
| Q67527592 | The food safety of transgenic animals |
| Q34916191 | The frequency of gene targeting in yeast depends on the number of target copies |
| Q40418173 | The gene knockout technology for the analysis of learning and memory, and neural development |
| Q45778785 | The herpes simplex virus thymidine kinase gene as a conditional negative-selection marker gene in Arabidopsis thaliana |
| Q24596814 | The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain |
| Q28587308 | The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland |
| Q37310625 | The immune boundaries for stem cell based therapies: problems and prospective solutions. |
| Q41180651 | The lambda B cell repertoire of kappa-deficient mice. |
| Q24559881 | The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome |
| Q44079492 | The methods to generate transgenic animals and to control transgene expression |
| Q40488037 | The molecular genetics of myelination: An update |
| Q33373699 | The mouse androgen receptor. Functional analysis of the protein and characterization of the gene |
| Q44095614 | The murine gene for cellular retinoic acid-binding protein type II. Genomic organization, chromosomal localization, and post-transcriptional regulation by retinoic acid |
| Q39258129 | The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting. |
| Q35886794 | The nucleotide sequence of greA, a suppressor gene that restores growth of an Escherichia coli RNA polymerase mutant at high temperature |
| Q28504676 | The p47phox mouse knock-out model of chronic granulomatous disease |
| Q40638243 | The pas de deux of viruses and CD8 T cells |
| Q36976444 | The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells |
| Q72643685 | The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model |
| Q38840267 | The present and future of genome editing in cancer research |
| Q36058466 | The promise of genetically engineered mice for cancer prevention studies |
| Q58795260 | The road less traveled: strategies to enhance the frequency of homology-directed repair (HDR) for increased efficiency of CRISPR/Cas-mediated transgenesis |
| Q40654945 | The role and fate of DNA ends for homologous recombination in embryonic stem cells |
| Q35884370 | The role of Cdx genes in the mammalian gut. |
| Q61774232 | The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox |
| Q48852592 | The role of sperm-mediated gene transfer in genome mutation and evolution |
| Q36555869 | The role of ‘tumor suppressor’ genes in neural tumors |
| Q26766232 | The therapeutic potential of genome editing for β-thalassemia |
| Q73822798 | The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin |
| Q41074292 | The use of null mutant mice to study complex learning and memory processes |
| Q34473470 | The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. |
| Q36844564 | The use of transgenic animals to study the role of growth factors in endocrinology |
| Q44308364 | The vector void in gene therapy |
| Q21999077 | Tissue- and site-specific DNA recombination in transgenic mice |
| Q31085125 | Tissue-specific knockout model for study of mitochondrial DNA mutation disorders |
| Q35099712 | To nick or not to nick: comparison of I-SceI single- and double-strand break-induced recombination in yeast and human cells |
| Q24646675 | Totipotency, pluripotency and nuclear reprogramming |
| Q34404518 | Toward gene therapy for disorders of globin synthesis |
| Q37532023 | Towards transgenic primates: What can we learn from mouse genetics? |
| Q35078374 | Transcriptional tools for aging research |
| Q24563654 | Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death |
| Q35832956 | Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. |
| Q41074600 | Transgenesis in rats: technical aspects and models |
| Q36232344 | Transgenic Mice as Models for Heritable Diseases |
| Q40781025 | Transgenic animals as models for human disease--report of an EC Study Group |
| Q40845596 | Transgenic animals in endocrinological investigation |
| Q40377650 | Transgenic animals in the study of blood pressure regulation and hypertension. |
| Q41004106 | Transgenic animals: how they are made and their role in animal production and research |
| Q36029215 | Transgenic mice in the study of cytokine function |
| Q33949108 | Transgenic mice produced by retroviral transduction of male germ-line stem cells |
| Q28591212 | Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone |
| Q40942349 | Transgenic models for eye malformations |
| Q37350120 | Transgenic models of nerve repair and nerve regeneration. |
| Q40482045 | Transgenic mouse models for tumour‐suppressor genes |
| Q34471905 | Transgenic technology and applications in swine. |
| Q36017616 | Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm. |
| Q35220727 | Transplacental RNAi: deciphering gene function in the postimplantation-staged embryo |
| Q30679435 | Transposition and gene disruption in the male germline of the mouse |
| Q37264246 | Trends in large-scale mouse mutagenesis: from genetics to functional genomics |
| Q101411062 | Trim-Away mediated knock down uncovers a new function for Lbh during gastrulation of Xenopus laevis |
| Q41710099 | Triplex-directed modification of genes and gene activity |
| Q30661706 | Triplex-induced recombination in human cell-free extracts. Dependence on XPA and HsRad51. |
| Q40274606 | Triplex-stimulated intermolecular recombination at a single-copy genomic target |
| Q42813262 | Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells |
| Q71129252 | Tumor induction and tissue atrophy in mice lacking E2F-1 |
| Q29617436 | Tumor spectrum analysis in p53-mutant mice |
| Q37613877 | Two different but related mechanisms are used in plants for the repair of genomic double-strand breaks by homologous recombination |
| Q28115771 | Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins |
| Q73848500 | Two vectors for the insertion of mammalian selectable genes into yeast artificial chromosome cloned DNA |
| Q28585555 | Tyro-3 family receptors are essential regulators of mammalian spermatogenesis |
| Q39266499 | Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation. |
| Q34579564 | Ultrasound backscatter microscope analysis of early mouse embryonic brain development |
| Q57166261 | Understanding Tendons: Lessons from Transgenic Mouse Models |
| Q55711095 | Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation. |
| Q42990759 | Unraveling the transcriptional network controlling ES cell pluripotency |
| Q29029045 | Use of Transgenic Animals to Improve Human Health and Animal Production |
| Q26799592 | Use of designer nucleases for targeted gene and genome editing in plants |
| Q40994008 | Use of genetically engineered mice as models for understanding human neurodegenerative disease. |
| Q34590536 | Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio |
| Q50860656 | Use of the CRISPR-Cas9 system for genome editing in cultured Drosophila ovarian somatic cells. |
| Q34439148 | Use of transgenic mice model for understanding the placentation: towards clinical applications in human obstetrical pathologies? |
| Q48315111 | Using genetic mutations to study the neural basis of behavior |
| Q37024699 | Using homologous recombination to manipulate the genome of human somatic cells |
| Q51990334 | Using knockout and transgenic mice to study neurophysiology and behavior. |
| Q27011507 | Using mouse models to study function of transcriptional factors in T cell development |
| Q45349187 | Variable expression of the herpes simplex virus thymidine kinase gene in Nicotiana tabacum affects negative selection |
| Q57292443 | Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches |
| Q42052747 | Virus-mediated Genetic Surgery: Homologous Recombination With a Little "Helper" From My Friends |
| Q33633904 | Visualizing the distribution of synapses from individual neurons in the mouse brain |
| Q34578774 | Welfare issues of genetically modified animals |
| Q57638621 | What Can the Genetics Revolution Offer the Meat Industry? |
| Q79776669 | What history tells us VII. Twenty-five years ago: the production of mouse embryonic stem cells |
| Q28259705 | Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice |
| Q40757591 | Will the transgenic mouse serve as a Rosetta Stone to glycoconjugate function? |
| Q28591574 | Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention |
| Q40202019 | Zebrafish embryonic stem cells |
| Q41285984 | Zebrafish make a big splash |
| Q37241457 | Zinc Finger Nucleases: Tailor-made for Gene Therapy |
| Q24535831 | Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells |
| Q73972606 | [The knockout mouse--a revolutionizing model in biomedical research] |
| Q28513530 | alpha-Galactosidase A deficient mice: a model of Fabry disease |
| Q92642815 | p21 in Cancer Research |
| Q28589437 | p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment |
| Q28513003 | p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours |
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