| P2093 | author name string | Brad Bolon | |
| | Elizabeth Galbreath | |
| P2860 | cites work | Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex | Q22008642 |
| | Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean | Q22254752 |
| | Osteoprotegerin: a novel secreted protein involved in the regulation of bone density | Q24313918 |
| | Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes | Q24530710 |
| | Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta) | Q24553125 |
| | RANK is essential for osteoclast and lymph node development | Q24598872 |
| | osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification | Q24603266 |
| | Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy | Q24603756 |
| | Adenovirus-mediated gene transfer during initial organogenesis in the mammalian embryo is promoter-dependent and tissue-specific | Q43558046 |
| | Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis | Q44920044 |
| | An adenovirus vector for gene transfer into neurons and glia in the brain | Q45874317 |
| | Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues | Q45876587 |
| | Going the distance: a current view of enhancer action | Q46076458 |
| | Structural and functional impact of the transgenic expression of cytokines in the CNS. | Q47966845 |
| | Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation | Q48087848 |
| | Near-microscopic magnetic resonance imaging of the brains of phenylalanine hydroxylase-deficient mice, normal littermates, and of normal BALB/c mice at 9.4 Tesla | Q48107598 |
| | 5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders | Q48157750 |
| | Rescue of angiotensinogen-knockout mice | Q48338135 |
| | Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase | Q48830271 |
| | Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography | Q49063066 |
| | Reinforcing and neurochemical effects of cocaine: differences among C57, DBA, and 129 mice. | Q51417511 |
| | Age-related psychomotor and spatial learning deficits in 129/SvJ mice. | Q52032339 |
| | Maternal care, hippocampal synaptogenesis and cognitive development in rats. | Q52166697 |
| | The broken mouse: the role of development, plasticity and environment in the interpretation of phenotypic changes in knockout mice. | Q52170870 |
| | Transgenesis by adenovirus-mediated gene transfer into mouse zona-free eggs. | Q52200291 |
| | Legless, a Novel Mutation Found in PHT1-1 Transgenic Mice | Q52250592 |
| | Transgenic mice in drug dependence research. | Q52276428 |
| | An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness. | Q53431585 |
| | Dermal carcinogenicity in transgenic mice: relative responsiveness of male and female hemizygous and homozygous Tg.AC mice to 12-O-tetradecanoylphorbol 13-acetate (TPA) and benzene. | Q53431588 |
| | Differential Gene Expression of Renin and Angiotensinogen in the TGR(mREN-2)27 Transgenic Rat | Q56963828 |
| | Magnetic resonance microscopy of the C57BL mouse brain | Q57188775 |
| | Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells | Q59064557 |
| | Maternal age and traits in offspring | Q59090092 |
| | Non-injection methods for the production of embryonic stem cell-embryo chimaeras | Q59092151 |
| | Increased anxiety of mice lacking the serotonin1A receptor | Q24655613 |
| | Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants | Q28139368 |
| | The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development | Q28142247 |
| | Altering the genome by homologous recombination | Q28270159 |
| | Pathophysiology of gene-targeted mouse models for cystic fibrosis | Q28295602 |
| | Subregion- and cell type-restricted gene knockout in mouse brain | Q28300369 |
| | Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis | Q28374103 |
| | Qualitative and quantitative decline in spermatogenesis of the follicle-stimulating hormone receptor knockout (FORKO) mouse | Q28504533 |
| | Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2 | Q28506189 |
| | Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism | Q28510829 |
| | GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion | Q28511785 |
| | Generation and reproductive phenotypes of mice lacking estrogen receptor beta | Q28513765 |
| | Female embryonic lethality in mice nullizygous for both Msh2 and p53 | Q28587400 |
| | OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis | Q28589430 |
| | Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2 | Q28591646 |
| | Serotonin receptor 1A knockout: an animal model of anxiety-related disorder | Q28592514 |
| | An inherited limb deformity created by insertional mutagenesis in a transgenic mouse | Q28592717 |
| | Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP | Q29547505 |
| | Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting | Q29614543 |
| | Inducible gene targeting in mice | Q29614544 |
| | Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress | Q29616820 |
| | Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion | Q29618089 |
| | Nongenomic transmission across generations of maternal behavior and stress responses in the rat | Q29618867 |
| | Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand | Q29619331 |
| | Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57black/6 and SV129 mice | Q30640307 |
| | A transgenic mouse expressing human CYP1A2 in the pancreas | Q31423344 |
| | In vivo visualization of gene expression using magnetic resonance imaging | Q31553757 |
| | In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives | Q33678501 |
| | Genetically modified animals in pharmacological research: future trends | Q33709310 |
| | Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests | Q33711537 |
| | Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha | Q33711550 |
| | Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis | Q33742314 |
| | Developing mouse models of aging: a consideration of strain differences in age-related behavioral and neural parameters | Q33760943 |
| | Complications associated with genetic background effects in research using knockout mice | Q33791038 |
| | Comparative and correlative neuroanatomy for the toxicologic pathologist | Q33834754 |
| | Cre-mediated somatic site-specific recombination in mice | Q39719850 |
| | Genetic knockouts in mice: an update | Q40382136 |
| | Chromosomal position effects and the modulation of transgene expression. | Q40418383 |
| | Neuropathogenic actions of cytokines assessed in transgenic mice | Q40420567 |
| | Use of transgenic mouse lacI/Z mutation assays in genetic toxicology | Q40637111 |
| | Genome manipulation in embryonic stem cells | Q40709310 |
| | High resolution MRI and MRS: a feasibility study for the investigation of focal cerebral ischemia in mice | Q40815581 |
| | Gene disruption in mice: models of development and disease | Q40861559 |
| | Initial experiences and future directions for transgenic mouse mutation assays | Q41033043 |
| | Transgenic animal models for measuring mutations in vivo | Q41053143 |
| | The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects | Q41059187 |
| | How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress | Q41378789 |
| | Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression | Q41419024 |
| | Impact of knockout mice in toxicology | Q41429411 |
| | Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies | Q41574239 |
| | Viral vectors for gene therapy | Q41704459 |
| | Quantification of target gene expression by imaging reporter gene expression in living animals. | Q41753201 |
| | Humanized xenobiotic response in mice expressing nuclear receptor SXR. | Q41753938 |
| | Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor | Q42528873 |
| | A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor | Q33888193 |
| | The use of genetically modified animals in carcinogenicity bioassays | Q33947665 |
| | Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase | Q34093519 |
| | Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene | Q34122961 |
| | Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector | Q34189858 |
| | Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice | Q34291227 |
| | A defect in nurturing in mice lacking the immediate early gene fosB. | Q34388993 |
| | Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? | Q34390023 |
| | Altering genes in animals by gene targeting | Q34420633 |
| | Temporally and spatially regulated somatic mutagenesis in mice | Q34659147 |
| | Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models | Q34836761 |
| | Transgenic animals in the evaluation of compound efficacy and toxicity: will they be as useful as they are novel? | Q35533243 |
| | Regulated expression of foreign genes in vivo after germline transfer. | Q35824617 |
| | In vivo analysis of Pim-1 deficiency | Q35859661 |
| | An inbred colony of oncogene transgenic mice: diversity of tumours and potential as a therapeutic model | Q36134361 |
| | The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats | Q36364133 |
| | Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis | Q36368706 |
| | Long-range disruption of gene expression by a selectable marker cassette | Q36687936 |
| | Age-related deposition of glia-associated fibrillar material in brains of C57BL/6 mice | Q36724424 |
| | Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice | Q36759748 |
| | Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells | Q36958779 |
| | RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism | Q37108966 |
| | Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes | Q37165445 |
| | Targeted mutagenesis: analysis of phenotype without germ line transmission | Q37352926 |
| | Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver | Q37360972 |
| | Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2 | Q37388131 |
| | Transgenesis by means of blastocyst-derived embryonic stem cell lines | Q37409515 |
| | FVB/N: an inbred mouse strain preferable for transgenic analyses | Q37425359 |
| | Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs | Q37545665 |
| | Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice | Q37577945 |
| | Ecdysone-inducible gene expression in mammalian cells and transgenic mice. | Q37651825 |
| | Transgenic mice as future tools in risk assessment | Q38675318 |
| | Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin | Q39116155 |
| | Quantitative evaluation of left ventricular function in a TransgenicMouse model of dilated cardiomyopathy with 2-dimensional contrast echocardiography. | Q39488684 |
| P433 | issue | 1 | |
| P921 | main subject | drug discovery | Q1418791 |
| P304 | page(s) | 55-64 | |
| P577 | publication date | 2002-01-01 | |
| P1433 | published in | International Journal of Toxicology | Q1307411 |
| P1476 | title | Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio | |
| P478 | volume | 21 | |