The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

scientific article (publication date: 29 September 2000)

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0092-8674(00)00103-3
P3181OpenCitations bibliographic resource ID1332982
P698PubMed publication ID11051546
P5875ResearchGate publication ID12274223

P50authorJosef PenningerQ1674391
P2093author name stringJ Li
Y Y Kong
R Elliott
S Scully
W J Boyle
T Sasaki
E B Voura
J E Fata
R A Moorehead
R Khokha
D L Lacey
J Irie-Sasaki
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouseQ24315716
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
Colony stimulating factor 1 is required for mammary gland development during pregnancyQ24563619
RANK is essential for osteoclast and lymph node developmentQ24598872
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-SrcQ28142620
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op MiceQ28593712
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalitiesQ29615568
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandQ29619331
Regulation of mammary gland development by tissue interactionQ33603542
Parathyroid hormone-related protein: a developmental regulatory molecule necessary for mammary gland developmentQ33603548
Prolactin and mammary gland developmentQ33603566
Cell biology of the osteoclastQ33700885
The genetic transformation of bone biologyQ33796568
Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotypeQ33939814
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
RANKing the importance of measles virus in Paget's diseaseQ40326890
Exploring the role of sex steroids through studies of receptor deficient miceQ47861980
Stat5a is mandatory for adult mammary gland development and lactogenesis.Q48055024
Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development.Q52175987
Breast cancer cells interact with osteoblasts to support osteoclast formationQ73025244
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cordQ73766127
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectTumor necrosis factor receptor superfamily, member 11a, NFKB activatorQ14900987
Tumor necrosis factor (ligand) superfamily, member 11Q14905570
P304page(s)41-50
P577publication date2000-09-29
P1433published inCellQ655814
P1476titleThe osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
P478volume103

Reverse relations

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Q90547034RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women
Q89666841RANKL biology: bone metabolism, the immune system, and beyond
Q37865171RANKL inhibition: a promising novel strategy for breast cancer treatment.
Q44590687RANKL regulates endothelial cell survival through the phosphatidylinositol 3′‐kinase/Akt signal transduction pathway
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Q89967663RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies
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Q34358320Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury
Q34302372Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2
Q39347131Receptor activator of NF-κB ligand promotes proliferation of a putative mammary stem cell unique to the lactating epithelium.
Q34117448Receptor activator of nuclear factor kappa B ligand (RANKL): another link between breast and bone
Q73904964Receptor activator of nuclear factor kappaB (RANK) is expressed as a late event during malignant progression in Barrett's metaplasia
Q36860987Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.
Q40298349Regulation of cancer cell migration and bone metastasis by RANKL.
Q34124144RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland
Q24802643Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development
Q64228473Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface
Q90450548Risk of Osteoporotic Fracture in Patients with Breast Cancer: Meta-Analysis
Q34963016Role of RANKL and RANK in bone loss and arthritis.
Q28283972Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system
Q37241255Role of RANKL/RANK in primary and secondary breast cancer
Q37978237Role of T cells in ovariectomy induced bone loss--revisited
Q36324952Role of interleukin-7 in bone and T-cell homeostasis
Q37143375Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice
Q34090842Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis.
Q45929205Serum osteoprotegrin (OPG) and receptor activator of nuclear factor kappaB (RANKL) in healthy children and adolescents.
Q92602305Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis
Q28513906Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
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Q61135621Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
Q97643643Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone
Q43036665Stem cells: Cues from steroid hormones
Q34344554Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice
Q37125950Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development
Q36045625Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand.
Q24645558Stromal effects on mammary gland development and breast cancer
Q35598825Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling
Q27311542T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer
Q38042619TNF receptor family signaling in the development and functions of medullary thymic epithelial cells
Q34126306TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women
Q92513362TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion
Q26849690Targeting RANKL in metastasis
Q34281611Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression.
Q44186063Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor
Q98771227Targeting the RANKL/RANK/OPG Axis for Cancer Therapy
Q36356112The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis.
Q41200607The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy.
Q28585870The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse
Q81414623The RANKL/RANK/OPG pathway
Q95643120The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Q28203717The TNF and TNF receptor superfamilies: integrating mammalian biology
Q35176348The TNF receptor superfamily: role in immune inflammation and bone formation
Q88954027The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid Cells
Q35012730The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
Q33869676The association between the baseline bone resorption marker CTX and incident dysglycemia after 4 years
Q35868802The biology of progesterone receptor in the normal mammary gland and in breast cancer
Q35012999The mammary gland microenvironment directs progenitor cell fate in vivo
Q36905332The physiological costs of reproduction in small mammals
Q54487255The role of TNF-α and TNF superfamily members in the pathogenesis of calcific aortic valvular disease.
Q34645503The role of growth factors in tooth development
Q36640852The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals
Q55117611Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Q39996337Transcriptional regulation of human RANK ligand gene expression by E2F1.
Q35001309Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers
Q37034915Transcriptional response of the murine mammary gland to acute progesterone exposure
Q35194008Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
Q33733718Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.
Q36521118Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL.
Q28250891Upregulation of ADAM19 in chronic allograft nephropathy
Q81673001Upregulation of receptor activator of nuclear factor-kappaB ligand expression in the thymic subcapsular, paraseptal, perivascular, and medullary epithelial cells during thymus regeneration
Q34590536Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio
Q50540673Uterine Progesterone Receptor Expression, Conceptus Development, and Ovarian Function in Pigs Treated with RU 486 During Early Pregnancy1
Q44534331Vascular endothelial growth factor up-regulates expression of receptor activator of NF-kappa B (RANK) in endothelial cells. Concomitant increase of angiogenic responses to RANK ligand
Q28078337What Is Breast in the Bone?
Q26849473Where Do Bone-Targeted Agents RANK in Breast Cancer Treatment?
Q91707946miR-636: A Newly-Identified Actor for the Regulation of Pulmonary Inflammation in Cystic Fibrosis
Q80439527sRANKL and OPG in serum and synovial fluid of patients with rheumatoid arthritis in comparison to non-destructive chronic arthritis
Q34429126t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism

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